RGD Reference Report - Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. - Rat Genome Database

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Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat.

Authors: Deng, AY  Rapp, JP 
Citation: Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
RGD ID: 61039
Pubmed: (View Article at PubMed) PMID:7537756
DOI: Full-text: DOI:10.1172/JCI117906

Alleles of the inducible nitric oxide synthase locus (Nos2) cosegregated highly significantly (P < 0.0001) with blood pressure in an F2 population [F2(S x MNS), n = 171] derived from a cross of inbred Dahl salt-sensitive (S) rats with Milan normotensive rats (MNS). In contrast, alleles at the constitutive brain nitric oxide synthase locus (Nos1) did not cosegregate with blood pressure in several F2 populations. Nos2 was mapped on rat chromosome 10. Nine genetic markers, including the angiotensin-converting enzyme (Ace) and Nos2 loci spanning roughly 46 cM on rat chromosome 10, all cosegregated strongly with blood pressure in the F2(S x MNS) population. Nos2 showed the highest LOD score of 6.3. Ace and Nos2 are 30 cM apart. In an F2 population [F2(S x WKY), n = 159] derived from a cross of S rats with Wistar-Kyoto (WKY) rats, Nos2 alleles did (P = 0.0070), but Ace alleles did not (P = 0.91), cosegregate with blood pressure. We conclude that the Nos2 locus rather than the Nos1 locus is a candidate for influencing blood pressure in the S rat. There are probably two separate but linked quantitative trait loci (QTL) for blood pressure on rat chromosome 10, one marked by Ace and the other marked by Nos2. In F2(S x MNS) functionally variant alleles at both QTL influence blood pressure, but in F2(S x WKY) only the QTL marked by Nos2 is segregating alleles influencing blood pressure.

Annotation

Objects Annotated

QTLs
Bp12  (Blood pressure QTL 12)
Bp76  (Blood pressure QTL 76)
Bp9  (Blood pressure QTL 9)

Objects referenced in this article
Marker D10Mit10 D10Mit10 Rattus norvegicus
Marker D10Wox6 D10Wox6 Rattus norvegicus
Marker D10Mco8 D10Mco8 Rattus norvegicus
Gene Ace angiotensin I converting enzyme Rattus norvegicus
Gene Acly ATP citrate lyase Rattus norvegicus
Gene Aldoc aldolase, fructose-bisphosphate C Rattus norvegicus
Gene Asgr1 asialoglycoprotein receptor 1 Rattus norvegicus
QTL Eae7 Experimental allergic encephalomyelitis QTL 7 Rattus norvegicus
Gene Grm6 glutamate metabotropic receptor 6 Rattus norvegicus
Gene Il3 interleukin 3 Rattus norvegicus
Strain LEW Lewis Rattus norvegicus
Strain MNS Milan normotensive strain Rattus norvegicus
Gene Myh3 myosin heavy chain 3 Rattus norvegicus
Gene Ngfr nerve growth factor receptor Rattus norvegicus
Gene Nos1 nitric oxide synthase 1 Rattus norvegicus
Gene Nos2 nitric oxide synthase 2 Rattus norvegicus
Gene Nos3 nitric oxide synthase 3 Rattus norvegicus
Gene Ppy pancreatic polypeptide Rattus norvegicus
Gene Shbg sex hormone binding globulin Rattus norvegicus
Strain SR/Jr Salt Resistant Rattus norvegicus
Strain SS/Jr Salt Sensitive Rattus norvegicus
Gene Vamp2 vesicle-associated membrane protein 2 Rattus norvegicus
Strain WKY null Rattus norvegicus

Additional Information