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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2493
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ace
Name: angiotensin I converting enzyme
Acc ID: CHEBI:4784
Term: enalapril
Definition: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).
Chemical ID: MESH:D004656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acedecreases activityEXP 6480464CTDEnalapril results in decreased activity of ACE proteinPMID:15728788 PMID:15816410
Aceincreases expressionEXP 6480464CTDEnalapril results in increased expression of ACE mRNAPMID:15728788
Acemultiple interactionsEXP 6480464CTDEnalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Enalapril promotes the reaction [Folic Acid results in increased expression of ACE mRNA]PMID:15728788 PMID:23733546
Acedecreases activityISOACE (Homo sapiens)6480464CTDEnalapril results in decreased activity of ACE proteinPMID:20679179 PMID:28973481
Acemultiple interactionsISOAce (Mus musculus)6480464CTDEnalapril inhibits the reaction [Dexamethasone results in increased expression of ACE protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein]]; Enalapril inhibits the reaction [Formaldehyde results in increased expression of ACE protein]PMID:30940551 PMID:36706861
Acemultiple interactionsISOACE (Homo sapiens)6480464CTDACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride]; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]PMID:20829712
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