RGD Reference Report - Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. - Rat Genome Database

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Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat.

Authors: Jacob, HJ  Lindpaintner, K  Lincoln, SE  Usumi K, K  Bunker, RK  Mao, YP  Ganten, D  Dzau, VJ  Lander, ES 
Citation: Jacob HJ, etal., Cell 1991 Oct 4;67(1):213-24
RGD ID: 61036
Pubmed: (View Article at PubMed) PMID:1655275

The stroke-prone spontaneously hypertensive rat (SHRSP) is a well-characterized model for primary hypertension in humans. High blood pressure in SHRSP shows polygenic inheritance, but none of the loci responsible have previously been identified. To locate genes controlling this quantitative trait, we mapped a large collection of DNA polymorphisms in a cross between SHRSP and the normotensive WKY strain. Here we report strong genetic evidence that a gene, Bp1, having a major effect on blood pressure maps to rat chromosome 10 with a LOD score of 5.10 and is closely linked to the rat gene encoding angiotensin-converting enzyme (ACE), an enzyme that plays a major role in blood pressure homeostasis and is an important target of anti-hypertensive drugs. We also find significant, albeit weaker, linkage to a locus, Bp2, on chromosome 18. We discuss the implications of genetic dissection of quantitative disease-related phenotypes in mammals.

Annotation

Disease Annotations    
hypertension  (IDA)

Gene Ontology Annotations    

Biological Process

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

Genes (Rattus norvegicus)
Ace  (angiotensin I converting enzyme)

QTLs
Bp1  (Blood pressure QTL 1)
Bp2  (Blood pressure QTL 2)

Objects referenced in this article
0 D18Mit7 D18Mit7 All species
0 Bp41 Blood pressure QTL 41 All species
0 SHRSP Spontaneously Hypertensive Rat, Stroke Prone All species
0 WKY null All species

Additional Information