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View Ontology Report


Agiotensin II (AgtII), the product of Ace action in the renin-angiotensin system, is probably the most potent of the biologically active peptides the pathway generates. The system, originally viewed as solely endocrine, is now regarded as an endocrine, paracrine and autocrine one, producing an array of diverse and many times opposing actions via both the 'classical' or circulatory and the local or 'tissue' routes. Overall AgtII elicits distinct responses through signaling via receptor type 1 and

Pathway Diagram:

Ariadne Genomics Inc. Agtr1b ---> Agtr1, G protein/ligand independent signaling protein kinase C (PKC) signaling pathway AgtII renin-angiotensin system signaling pathway Agtr1a ---> Agtr1, G protein/ligand independent signaling fluid homeostasis hormone release Agtr2 ---> Agtr2, G protein/ligand independent signaling vasoconstriction antiproliferation vasodilation Agtr2, G protein/ligand independent signaling angiotensin II signaling pathway via AT2 receptor angiotensin II signaling pathway via AT1 receptor AgtII ---> hormone release AgtII ---> fluid homeostasis AgtII ---> antiproliferation AgtII ---> vasoconstriction AgtII ---- Agtr2 AgtII ---- Agtr1b Agtr2 Agtr1a Agtr1b Agt Agt ---> AgtII Agtr1, G protein/ligand independent signaling G protein mediated signaling pathway via Galphai family G protein mediated signaling pathway via Galphaq family AgtII ---- Agtr1a AgtII ---> vasodilation

Genes in Pathway:

show annotations for term's descendants           Sort by:
angiotensin II signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO RGD PMID:15638741 RGD:1581742 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Agt angiotensinogen TAS RGD PMID:16141358 RGD:1581847 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS RGD PMID:15590154 RGD:1579760 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS RGD PMID:14657020 RGD:1566502 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP RGD PMID:14684844 RGD:1582323 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cma1 chymase 1 IMP RGD PMID:15869764 RGD:1581745 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:16269269 RGD:1600094 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 IEP RGD PMID:12661921 RGD:1580992 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 IDA RGD PMID:14585963 RGD:1581775 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Pla2g6 phospholipase A2 group VI IMP RGD PMID:17613534 RGD:12910844 NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114
JBrowse link
G Prkcz protein kinase C, zeta IMP RGD PMID:16113073 RGD:1642674 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen TAS RGD PMID:16141358 RGD:1581847 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS
RGD PMID:10977869 PMID:12446719 PMID:9287353 PMID:14559250 RGD:1581825, RGD:629553, RGD:5133683, RGD:2316188 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS RGD PMID:10977869 RGD:1581825 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
G Agtrap angiotensin II receptor-associated protein IMP RGD PMID:17875818 RGD:2314353 NCBI chr 5:158,507,427...158,519,036
Ensembl chr 5:158,508,749...158,519,036
JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 IDA RGD PMID:14559250 RGD:2316188 NCBI chr 1:155,748,622...155,814,186
Ensembl chr 1:155,748,652...155,814,184
JBrowse link
G Arrb1 arrestin, beta 1 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:16141358 RGD:1581847 NCBI chr 7:8,163,752...8,177,636
Ensembl chr 7:8,162,750...8,179,812
JBrowse link
G Gnaq G protein subunit alpha q ISO RGD PMID:16141358 RGD:1581847 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:16304060 RGD:5133417 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:16304060 RGD:5133417 NCBI chr17:9,177,018...9,192,644
Ensembl chr17:9,177,019...9,192,644
JBrowse link
G Jak2 Janus kinase 2 IDA
RGD PMID:9287353 PMID:9314843 RGD:5133683, RGD:6478796 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:12588881 RGD:5133418 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Tyk2 tyrosine kinase 2 IMP RGD PMID:9314843 RGD:6478796 NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044
JBrowse link
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IMP
RGD PMID:16286564 PMID:16286568 PMID:22949090 RGD:1582434, RGD:1582435, RGD:7401256 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS
RGD PMID:10977869 PMID:22949090 RGD:1581825, RGD:7401256 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 5:146,447,495...146,458,332
Ensembl chr 5:146,447,497...146,458,212
JBrowse link
G Dusp1 dual specificity phosphatase 1 TAS RGD PMID:18804122 RGD:5133675 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gnai3 G protein subunit alpha i3 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
JBrowse link
G Mtus1 microtubule associated scaffold protein 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr16:51,202,497...51,347,791
Ensembl chr16:51,253,562...51,347,793
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO RGD PMID:18804122 RGD:5133675 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
JBrowse link
G Slc9a6 solute carrier family 9 member A6 ISO RGD PMID:20889352 RGD:5133679 NCBI chr  X:134,430,588...134,486,747
Ensembl chr  X:134,420,756...134,485,375
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 7:17,520,827...17,571,871
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
JBrowse link

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ProteinAgtIIangiotensin II generated from Agt via the renin-angiotensin cascade pathway

Pathway Gene Annotations

Disease Annotations Associated with Genes in the angiotensin II signaling pathway
Disease TermsGene Symbols
abdominal aortic aneurysmAce , Agt , Agtr1a , Ccl2
Actin-Accumulation MyopathyAgt
Acute Anterior UveitisCcl2
Acute HepatitisAce
acute kidney failureAce , Jak2
Acute Liver FailureCcl2
Acute Lung InjuryAce , Ccl2
Acute Lymphoblastic Leukemia, with Lymphomatous FeaturesJak2
acute myeloid leukemiaCcl2 , Jak2
acute necrotizing pancreatitisCcl2
Acute-On-Chronic Liver FailureCcl2
adenylosuccinase lyase deficiencyPla2g6
adrenocortical carcinomaJak2
adult respiratory distress syndromeAce , Ccl2
age related macular degenerationCcl2
aggressive periodontitisCcl2
AIDS-Associated NephropathyAgtr1a , Agtr2
AlbuminuriaAce , Agt
alcoholic cardiomyopathyAce , Agt
Alcoholic Fatty LiverCcl2
alcoholic hepatitisAgt , Ccl2
alcoholic liver cirrhosisJak2
Alcoholic Liver DiseasesAce
allergic conjunctivitisCcl2
allergic diseaseAce , Agt , Ccl2
allergic rhinitisAce
Alzheimer's diseaseAce , Agt , Agtr1a , Jak2
AnaphylaxisAgt , Cma1
anemiaAce , Agt , Ccl2 , Jak2
Angiotensin I-Converting Enzyme, Benign Serum IncreaseAce
Animal HepatitisCcl2
ankylosing spondylitisAce , Jak2
anterior uveitisCcl2
anti-basement membrane glomerulonephritisAgt , Agtr1a , Ccl2
aortic aneurysmAgt
Aortic CalcificationAgt
Aortic CoarctationAce , Agt
Arteriovenous FistulaAce
aspiration pneumoniaAce
asthmaAce , Agtr1a , Agtr2 , Ccl2 , Cma1
atherosclerosisAgt , Ccl2
atopic dermatitisCma1
atrial fibrillationAce , Agt , Agtr1a
autism spectrum disorderPrkcz
autistic disorderAce , Agtr2 , Ccl2 , Pla2g6
autoimmune hepatitisCcl2
autosomal recessive polycystic kidney diseaseAce
bacterial gastritisJak2
bacterial pneumoniaCcl2
Banti's SyndromeAce
Behcet's diseaseAce , Ccl2
bipolar disorderAce , Agt , Ccl2
Brain Hypoxia-IschemiaAgtr2 , Ccl2
Brain InjuriesCcl2 , Jak2
brain ischemiaAce , Ccl2
Brain-Lung-Thyroid SyndromeCma1
breast cancerAce , Agt , Agtr1a
breast lobular carcinomaAgtr1a , Agtr2
Breast NeoplasmsPdpk1
Bronchial HyperreactivityCcl2
bronchiolitis obliteransAce , Ccl2
Budd-Chiari syndromeJak2
calcinosisCcl2 , Jak2
Cancer PainJak2
Cardiac ArrhythmiasAce , Agt , Agtr1a
CardiomegalyAce , Agt , Agtr1a , Cma1 , Prkcz
cardiomyopathyAgt , Ccl2 , Olr1
CardiotoxicityAgt , Ccl2
Cardiovascular AbnormalitiesAgt
cardiovascular system diseaseAce , Agt , Ccl2
carotid artery diseaseAce , Agt , Agtr1a , Ccl2
Carotid Artery InjuriesAgtr1a , Ccl2
Carrington SyndromeCcl2
celiac diseaseAce
cerebellar hypoplasiaPla2g6
cerebral amyloid angiopathyOlr1
Cerebral HemorrhageAce
cerebral infarctionAce , Ccl2
cerebrovascular diseaseAgt , Agtr1a
Chagas diseaseCcl2
Chemical and Drug Induced Liver InjuryAce , Agt , Ccl2
chemical colitisAce
Chemotherapy-Induced Febrile NeutropeniaAce
cholestasisAce , Agt
Choroidal NeovascularizationCcl2
chromosome 1p36 deletion syndromePrkcz
chromosome 9p deletion syndromeJak2
Chronic Hepatitis BCcl2
Chronic Hepatitis CAce , Ccl2
Chronic Intermittent HypoxiaAce , Agt
chronic kidney diseaseAgtr1a , Agtr2
chronic myelogenous leukemia, BCR-ABL1 positiveJak2
chronic myeloid leukemiaAce , Agt , Jak2
chronic obstructive pulmonary diseaseAce , Ccl2 , Cma1
Chronic PeriodontitisCcl2
Chronic Relapsing Experimental Autoimmune EncephalomyelitisCcl2
Chronic Tubulointerstitial NephropathyCcl2
cleidocranial dysplasiaAgt
cognitive disorderAgt
colon adenocarcinomaJak2
colon cancerCcl2 , Jak2
Colonic NeoplasmsCcl2
colorectal carcinomaJak2
congenital diaphragmatic herniaAce , Agtr2 , Ccl2
congenital disorder of glycosylation type IIqAgt
congenital heart diseaseCma1
Congenital Hepatic FibrosisAce
congenital myasthenic syndrome 8Prkcz
congestive heart failureAce , Agt , Agtr1a , Agtr2 , Ccl2 , Olr1 , Pdpk1
contact dermatitisCcl2
corneal neovascularizationAgt , Agtr1a
coronary artery diseaseAce , Agt , Agtr1a , Ccl2 , Olr1
Coronary Artery Disease, Development of, in HIVCcl2
Coronary DiseaseAce , Agtr1a
coronary restenosisAce
Coronavirus infectious diseaseAce , Ccl2
COVID-19Ace , Agt , Agtr1a , Ccl2 , Jak2
crescentic glomerulonephritisCcl2
Crohn's diseaseAgt , Ccl2 , Jak2
cutaneous leishmaniasisCcl2
cystic fibrosisCcl2
Cytomegalovirus InfectionsAce
Delayed HypersensitivityCcl2
diabetic angiopathyAce , Ccl2
Diabetic CardiomyopathiesAce , Agt , Agtr2
Diabetic NephropathiesAce , Agt , Agtr1a , Agtr2 , Ccl2 , Jak2
diabetic retinopathyAce , Agt , Agtr1a , Ccl2
Diaphragmatic HerniaAgt , Agtr1a
diastolic heart failureAce
diffuse cystic renal dysplasiaAce , Agtr1a
diffuse large B-cell lymphomaPdpk1
diffuse sclerodermaAgt
dilated cardiomyopathyAce , Agt , Agtr1a , Agtr2
dilated cardiomyopathy 1LLPrkcz
Dissecting AneurysmAgt
drug allergyAce
Drug OverdoseAgt
Drug-Related Side Effects and Adverse ReactionsCcl2
Duchenne muscular dystrophyCcl2 , Pla2g6
Ductal CarcinomaAgtr1a
dystonia 12Pla2g6
Ehlers-Danlos syndrome spondylodysplastic type 2Prkcz
Emery-Dreifuss muscular dystrophyPla2g6
end stage renal diseaseAce , Agt , Agtr2 , Ccl2 , Olr1
Endometrial NeoplasmsCcl2
endomyocardial fibrosisAce , Agt , Ccl2
EndotoxemiaAce , Agtr2 , Ccl2
Endotoxin-Induced UveitisCcl2
esophageal carcinomaJak2
esophagus squamous cell carcinomaJak2
essential hypertensionAgt , Agtr1a
essential thrombocythemiaJak2
Experimental ArthritisAce , Ccl2 , Jak2
Experimental Autoimmune EncephalomyelitisCcl2 , Jak2
Experimental Autoimmune MyocarditisCcl2
Experimental Autoimmune OrchitisCcl2
Experimental Autoimmune UveitisCcl2
Experimental Autoimmune UveoretinitisCcl2
Experimental ColitisAce , Jak2
Experimental Diabetes MellitusAce , Agt , Agtr2 , Ccl2 , Cma1
Experimental Liver CirrhosisAce , Agt , Agtr1a , Ccl2 , Jak2
Experimental Liver NeoplasmsJak2
Experimental Mammary NeoplasmsAgt , Agtr1a , Agtr2
Experimental Radiation InjuriesAgtr1a , Agtr2
extrinsic allergic alveolitisAce
Eye NeoplasmsCcl2
Fabry diseaseAce , Agt
Familial Cerebral Cavernous MalformationAce
familial erythrocytosis 1Jak2
familial erythrocytosis 2Jak2
familial hyperlipidemiaCcl2
familial Mediterranean feverAce , Pdpk1
Fanconi anemiaPdpk1
fatty liver diseaseCcl2 , Jak2
Febrile NeutropeniaCcl2
Fetal DeathAce
Fetal Growth RetardationAce , Agt , Agtr1a , Agtr2
FibrosisAgt , Agtr1a , Agtr2
focal segmental glomerulosclerosisAgt , Agtr1a , Agtr2
focal segmental glomerulosclerosis 1Ace
fungal infectious diseaseCcl2
gallbladder adenocarcinomaAce
gastric ulcerAgt
gastrointestinal stromal tumorAgt
Gaucher's diseaseAce
genetic diseaseAce , Agt , Agtr1a , Agtr2 , Cma1 , Jak2 , Olr1 , Pdpk1 , Pla2g6 , Prkcz
Genetic Predisposition to DiseaseAce , Jak2
Geographic AtrophyCcl2
gestational diabetesCcl2
glomerulonephritisAce , Agt , Agtr2 , Ccl2
glomerulosclerosisAce , Agtr1a , Agtr2
glucose intoleranceAgt , Agtr1a , Jak2
glycogen storage disease VAce
glycogen storage disease XVAgtr1a
Goldberg-Shprintzen syndromePrkcz
Granulomatous Interstitial NephritisCcl2
Granulomatous VasculitisCcl2
Graves ophthalmopathyCcl2
Growth DisordersJak2
Guillain-Barre syndromeCcl2
Hearing Loss, Noise-InducedCcl2
heart diseaseAgt , Jak2
heart valve diseaseAce , Ccl2 , Jak2
Helicobacter InfectionsAce
hemolytic-uremic syndromeCcl2
Henoch-Schoenlein purpuraAce , Agt , Ccl2
hepatic encephalopathyCcl2
hepatitis AAce
hepatocellular carcinomaAce , Ccl2 , Jak2
hereditary breast ovarian cancer syndromeJak2
herpes simplexCcl2
herpes simplex virus keratitisCcl2
human immunodeficiency virus infectious diseaseCcl2
Human InfluenzaCcl2
Huntington's diseaseAgtr1a
HyperalgesiaAgt , Ccl2 , Jak2 , Prkcz
hyperglycemiaCcl2 , Prkcz
hyperhomocysteinemiaAgt , Ccl2
hyperinsulinismAgt , Agtr1a , Ccl2
hypertensionAce , Agt , Agtr1a , Agtr2 , Ccl2 , Cma1 , Olr1
Hypertensive NephropathyAgt , Agtr1a
Hypertensive NephrosclerosisAce
hypertrophic cardiomyopathyAce , Agt , Cma1
HypotensionAce , Agt
idiopathic generalized epilepsyPdpk1 , Prkcz
IgA glomerulonephritisAce , Agt , Agtr1a , Agtr2 , Ccl2
immunodeficiency 16Prkcz
immunodeficiency 38Prkcz
in situ carcinomaAce
InflammationAgt , Agtr1a , Agtr2 , Ccl2 , Jak2
inflammatory bowel diseaseAgt
Inflammatory Breast NeoplasmsCcl2
Insulin ResistanceAce , Agtr2 , Ccl2 , Prkcz
intellectual disabilityAgtr2
intermediate coronary syndromeAce , Agt , Agtr1a
interstitial lung diseaseCcl2 , Cma1
interstitial nephritisCcl2
Intestinal Reperfusion InjuryAce , Agt , Ccl2 , Jak2
intracranial aneurysmAce , Ccl2
intracranial vasospasmCcl2
invasive aspergillosisCcl2
Invasive Pulmonary AspergillosisCcl2
Joubert syndrome 25Prkcz
juvenile rheumatoid arthritisOlr1
Karak SyndromePla2g6
kidney diseaseAce , Agt , Agtr1a , Ccl2
kidney failureAce , Agt
Kidney Reperfusion InjuryAce , Ccl2
Kuhnt-Junius degenerationCcl2
Left Ventricular HypertrophyAce , Agt , Agtr1a , Agtr2 , Cma1 , Prkcz
leukemiaAce , Jak2 , Prkcz
limb ischemiaAgtr1a
limited sclerodermaCcl2 , Jak2
liver cancerJak2
liver cirrhosisAce , Agt , Ccl2 , Jak2
liver diseaseCcl2
Liver InjuryJak2
Liver MetastasisAce , Ccl2
Liver Reperfusion InjuryCcl2 , Jak2
Lower Extremity Deep Vein ThrombosisCcl2
lung adenocarcinomaJak2
lung cancerAce
lung carcinomaAce , Jak2
lung diseaseAce , Agtr1a , Ccl2
Lung InjuryAce , Ccl2
Lung NeoplasmsAce
lung non-small cell carcinomaJak2 , Pdpk1
lupus nephritisCcl2
Lyme NeuroborreliosisCcl2
Lymphatic MetastasisPdpk1
lysinuric protein intoleranceCma1
macular degenerationCcl2
macular retinal edemaCcl2
male infertilityAce
malignant hypertensionAgt
meconium aspiration syndromeAgt , Agtr2
membranoproliferative glomerulonephritisCcl2
Memory DisordersAce
Meningococcal InfectionsAce
mesenteric vascular occlusionJak2
Metabolic SyndromeAgt , Agtr1a , Ccl2 , Pla2g6
microcephalyAce , Agt
middle cerebral artery infarctionAce , Agt , Ccl2
Middle East respiratory syndromeCcl2
mitral valve diseaseAce
mitral valve prolapseAce , Agt
Mouth NeoplasmsCcl2
multiple myelomaAce , Ccl2
Multiple Organ FailureCcl2
multiple sclerosisAgt , Ccl2
Mycobacterium InfectionsAce
myeloid neoplasmJak2
myeloproliferative neoplasmJak2
myocardial infarctionAce , Agt , Agtr1a , Ccl2 , Jak2 , Olr1
Myocardial IschemiaAgt , Ccl2 , Jak2
Myocardial Reperfusion InjuryAgt , Agtr1a , Ccl2 , Jak2 , Olr1
myocarditisAce , Ccl2 , Cma1
myoclonic dystonia 26Pla2g6
Nasal PolypsCcl2
nasopharynx carcinomaJak2
Neoplasm InvasivenessCcl2
Neoplasm MetastasisAce , Agtr1a , Agtr2 , Ccl2 , Jak2
Neoplastic Cell TransformationJak2
nephritisAce , Agtr1a , Ccl2
nephrosisAce , Agt
nephrotic syndromeAce , Jak2
Nervous System MalformationsPla2g6
neural tube defectCcl2
neuroaxonal dystrophyPla2g6
Neurobehavioral ManifestationsAgt
neurodegeneration with brain iron accumulationPla2g6
neurodegeneration with brain iron accumulation 2APla2g6
neurodegeneration with brain iron accumulation 2BPla2g6
neurodegenerative diseasePla2g6
Neurodevelopmental DisordersCcl2 , Prkcz
Niemann-Pick disease type C1Jak2
non-alcoholic fatty liver diseaseAce , Ccl2 , Jak2
non-alcoholic steatohepatitisCcl2 , Jak2
non-arteritic anterior ischemic optic neuropathyAce
non-syndromic X-linked intellectual disability 88Agtr2
obesityAce , Agt , Agtr2 , Ccl2 , Jak2
obstructive jaundiceCcl2
obstructive sleep apneaAce , Ccl2
ocular hypotensionAce
oral squamous cell carcinomaCcl2
ovarian cystAgtr2
Oxygen-Induced RetinopathyCcl2
PainAce , Ccl2
Painful NeuropathyCcl2
pancreatic cancerAce , Agtr2
pancreatic ductal carcinomaAce , Agtr1a
parathyroid carcinomaAgt
Parkinson's diseaseAce , Agtr1a , Pla2g6
Parkinson's disease 14Pla2g6
patent ductus arteriosusAgtr1a
Peptic Ulcer HemorrhageAgt
Perennial Allergic RhinitisCcl2
periapical periodontitisCcl2
Periodontal CystCcl2
Peripheral Nerve InjuriesCcl2
Peritoneal FibrosisAce , Ccl2
Peroxisome Biogenesis Disorder, Complementation Group 7Prkcz
Pituitary NeoplasmsAgtr1a
placental insufficiencyAgtr1a
pleural diseaseCcl2
Pleural EffusionAce
pneumoniaAce , Agt , Ccl2
polycystic kidney diseaseAgt
polycythemiaAce , Jak2
polycythemia veraJak2
portal hypertensionCcl2 , Jak2
Postoperative Cognitive DysfunctionAgtr1a
pre-eclampsiaAce , Agt
pre-malignant neoplasmAce
prediabetes syndromeAgt
Pregnancy ComplicationsJak2
Pregnancy-Induced HypertensionAce , Agt
Premature Infant DiseasesAce
Premature Obstetric LaborCcl2
primary biliary cholangitisAce , Agt , Jak2
Primary Ovarian FailureJak2
primary ovarian insufficiencyJak2
proliferative diabetic retinopathyCcl2
prostate adenocarcinomaPdpk1
prostate cancerPdpk1
Prostatic NeoplasmsAce , Jak2 , Prkcz
proteinuriaAce , Agt , Agtr1a
Pulmonary ContusionCcl2
pulmonary edemaAgt , Ccl2
pulmonary embolismCcl2
pulmonary emphysemaCcl2
pulmonary fibrosisAce , Agt , Agtr1a , Agtr2 , Ccl2 , Cma1
pulmonary hypertensionAce , Agt , Agtr1a , Ccl2
pulmonary tuberculosisCcl2
Puromycin Aminonucleoside NephrosisAce , Agt
Radiation NephropathyAce
renal cell carcinomaAgtr1a , Agtr2
renal fibrosisAce
renal hypertensionAgt , Agtr1a
Renal Tubular DysgenesisAce , Agt , Agtr1a
renovascular hypertensionAce , Agtr1a , Agtr2 , Cma1
Reperfusion InjuryAce , Agt , Agtr2 , Ccl2 , Jak2
respiratory system diseaseAce
Respiratory Tract GranulomaCcl2
Retina Reperfusion InjuryCcl2
retinal degenerationCcl2
retinal detachmentCcl2 , Jak2
retinal vasculitisAgt
retinopathy of prematurityAgt
rheumatoid arthritisCcl2 , Jak2
Right Ventricular HypertrophyAce
sarcoidosisAce , Agtr1a , Cma1
schizophreniaAce , Ccl2
sciatic neuropathyAgt , Ccl2
Seasonal Allergic RhinitisCma1
SepsisAce , Ccl2 , Jak2
Sepsis-Associated EncephalopathyJak2
severe acute respiratory syndromeAce , Ccl2
short-rib thoracic dysplasia 9 with or without polydactylyPdpk1
Shprintzen-Goldberg CraniosynostosisPrkcz
sick sinus syndromeAgt
skin melanomaAgt , Ccl2
spastic ataxiaPla2g6
Specific Granule DeficiencyCma1
spina bifidaCcl2
Spinal Cord CompressionCcl2
Spinal Cord InjuriesJak2 , Pla2g6
Spontaneous AbortionsAgtr1a , Jak2
squamous cell carcinomaCcl2
Staphylococcal InfectionsAce
status epilepticusCcl2
stomach cancerAce , Jak2
Stomach NeoplasmsAce , Agtr2
StrokeAce , Agt , Agtr2 , Ccl2 , Jak2
subacute sclerosing panencephalitisAce
substance-induced psychosisAce
Sudden DeathAce , Agt
syndromic X-linked intellectual disability Lubs typeAgtr2
systemic lupus erythematosusAce , Agtr2 , Ccl2 , Jak2
systemic sclerodermaAce , Agt , Ccl2
temporal arteritisCcl2
temporal lobe epilepsyAgt
Thrombocythemia 3Jak2
thrombosisAgt , Jak2
thyroid gland diseaseCcl2
Thyroid NeoplasmsCcl2
toxic shock syndromeAce , Ccl2
transient cerebral ischemiaAgt , Ccl2 , Jak2
Transplant RejectionCcl2
Triple Negative Breast NeoplasmsCcl2
type 1 diabetes mellitusAce , Ccl2
type 2 diabetes mellitusAce , Agt , Agtr2 , Ccl2 , Prkcz
ulcerative colitisJak2
ureteral obstructionAce , Agt , Ccl2
Urogenital AbnormalitiesAgtr2
Uterine Cervical NeoplasmsJak2
uveitisAce , Ccl2
vascular diseaseAgt
Vascular MalformationsAgt
Vascular RemodelingAgt
Vascular System InjuriesAce , Agtr1a , Agtr2
Vasculitis of the SkinCcl2
Venous ThromboembolismAce
Venous ThrombosisCcl2 , Jak2
Ventricular Dysfunction, LeftAgt
Ventricular FibrillationAce
Ventricular RemodelingAce , Agt , Agtr1a
vesicoureteral refluxAgtr1a , Agtr2
viral pneumoniaAce , Ccl2
Wallerian DegenerationPla2g6
Weight GainAce
Weight LossAce
X-Linked Intellectual Developmental DisordersAgtr2
Pathway Annotations Associated with Genes in the angiotensin II signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAgtr1a
adenosine signaling pathwayPdpk1 , Prkcz
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAgtr1a
aldosterone signaling pathwayJak2 , Pdpk1
alpha-linolenic acid metabolic pathwayPla2g6
altered Jak-Stat signaling pathwayJak2
amiodarone pharmacodynamics pathwayAgtr1a
amlodipine pharmacodynamics pathwayAgtr1a
angiotensin (1-7) signaling pathwayAce , Agt
angiotensin II signaling pathwayAce , Agt , Agtr1a , Agtr2 , Ccl2 , Cma1 , Jak2 , Olr1 , Pdpk1 , Pla2g6 , Prkcz
angiotensin II signaling pathway via AT1 receptorAgt , Agtr1a , Jak2
angiotensin II signaling pathway via AT2 receptorAgt , Agtr2
angiotensin III signaling pathwayAgt , Agtr1a , Agtr2
angiotensin III signaling pathway via AT1 receptorAgt , Agtr1a
angiotensin III signaling pathway via AT2 receptorAgt , Agtr2
angiotensin IV signaling pathwayAgt
angiotensin signaling pathwayAgt
arachidonic acid metabolic pathwayPla2g6
atenolol pharmacodynamics pathwayAgtr1a
benazepril pharmacodynamics pathwayAce , Agt , Agtr1a
benazepril pharmacokinetics pathwayAce
betaxolol pharmacodynamics pathwayAgtr1a
bisoprolol pharmacodynamics pathwayAgtr1a
bupranolol drug pathwayAgtr1a
bupranolol pharmacodynamics pathwayAgtr1a
calcium/calcium-mediated signaling pathwayAgtr1a
candesartan pharmacodynamics pathwayAce , Agt , Agtr1a
captopril pharmacodynamics pathwayAce , Agt , Agtr1a
carvedilol pharmacodynamics pathwayAgtr1a
ceramide signaling pathwayPrkcz
Chagas disease pathwayAce
chemokine mediated signaling pathwayCcl2 , Jak2 , Prkcz
cilazapril pharmacodynamics pathwayAce , Agt , Agtr1a
cilazapril pharmacokinetics pathwayAce
diltiazem pharmacodynamics pathwayAgtr1a
disopyramide pharmacodynamics pathwayAgtr1a
dobutamine pharmacodynamics pathwayAgtr1a
eicosanoid signaling pathwayPrkcz
eicosanoid signaling pathway via peroxisome proliferator-activated receptor gammaOlr1 , Pdpk1
enalapril pharmacodynamics pathwayAce , Agt , Agtr1a
enalapril pharmacokinetics pathwayAce
endocytosis pathwayPrkcz
endometrial cancer pathwayPdpk1
endothelin signaling pathwayJak2
epidermal growth factor/neuregulin signaling pathwayPrkcz
eprosartan pharmacodynamics pathwayAce , Agt , Agtr1a
erythropoietin signaling pathwayJak2
esmolol pharmacodynamics pathwayAgtr1a
ether lipid metabolic pathwayPla2g6
ether lipid metabolic pathwayPla2g6
FasL mediated signaling pathwayPdpk1
Fc epsilon receptor mediated signaling pathwayPla2g6
Fc gamma receptor mediated signaling pathwayPla2g6
fibroblast growth factor signaling pathwayPdpk1
flecainde pharmacodynamics pathwayAgtr1a
forasartsn pharmacodynamics pathwayAce , Agt , Agtr1a
fosinopril pharmacodynamics pathwayAce , Agt , Agtr1a
fosinopril pharmacokinetics pathwayAce
fosphenytoin pharmacodynamics pathwayAgtr1a
G protein mediated signaling pathway via Galpha12/Galpha13 familyAgtr1a
G protein mediated signaling pathway via Galphai familyAgtr2
G protein mediated signaling pathway via Galphaq familyAgtr1a
glutamate signaling pathwayPla2g6
glycerophospholipid metabolic pathwayPla2g6
gonadotropin-releasing hormone signaling pathwayPla2g6
granulocyte-macrophage colony-stimulating factor signaling pathwayCcl2 , Jak2
growth hormone signaling pathwayJak2
hypertrophic cardiomyopathy pathwayAce
ibutilide pharmacodynamics pathwayAgtr1a
influenza A pathwayJak2
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPrkcz
insulin signaling pathwayPdpk1 , Prkcz
insulin-like growth factor signaling pathwayPdpk1 , Prkcz
interleukin-1 signaling pathwayPrkcz
interleukin-12 signaling pathwayJak2
interleukin-23 signaling pathwayCcl2 , Jak2
interleukin-27 signaling pathwayJak2
interleukin-3 signaling pathwayJak2
interleukin-4 signaling pathwayJak2
interleukin-5 signaling pathwayJak2
interleukin-6 signaling pathwayJak2
irbesartan pharmacodynamics pathwayAce , Agt , Agtr1a
isoprenaline pharmacodynamics pathwayAgtr1a
isradipine pharmacodynamics pathwayAgtr1a
Jak-Stat signaling pathwayJak2
kallikrein-kinin cascade pathwayAce
Leishmaniasis pathwayJak2
leptin system pathwayJak2
levobunolol pharmacodynamics pathwayAgtr1a
lidocaine pharmacodynamics pathwayAgtr1a
linoleic acid metabolic pathwayPla2g6
lisinopril pharmacodynamics pathwayAce , Agt , Agtr1a
long term depressionPla2g6
long term potentiationAgt
losartan pharmacodynamics pathwayAce , Agt , Agtr1a
measles pathwayJak2
metoprolol pharmacodynamics pathwayAgtr1a
mexiletine pharmacodynamics pathwayAgtr1a
mitogen activated protein kinase signaling pathwayPla2g6
moexipril pharmacodynamics pathwayAce , Agt , Agtr1a
moexipril pharmacokinetics pathwayAce
mTOR signaling pathwayPdpk1
myocardial infarction pathwayAgt
nadolol pharmacodynamics pathwayAgtr1a
nebivolol pharmacodynamics pathwayAgtr1a
nifedipine pharmacodynamics pathwayAgtr1a
nimodipine pharmacodynamics pathwayAgtr1a
nisoldipine pharmacodynamics pathwayAgtr1a
nitrendipine pharmacodynamics pathwayAgtr1a
non-small cell lung carcinoma pathwayPdpk1
olmesartan pharmacodynamics pathwayAce , Agt , Agtr1a
penbutolol pharmacodynamics pathwayAgtr1a
perindopril pharmacodynamics pathwayAce , Agt , Agtr1a
phagocytosis pathwayOlr1
phenytoin pharmacodynamics pathwayAgtr1a
phosphatidylinositol 3-kinase class I signaling pathwayPdpk1
phosphatidylinositol 3-kinase-Akt signaling pathwayPdpk1
pindolol pharmacodynamics pathwayAgtr1a
platelet-derived growth factor signaling pathwayJak2
procainamide pharmacodynamics pathwayAgtr1a
propranolol pharmacodynamics pathwayAgtr1a
prostate cancer pathwayPdpk1
protein kinase C (PKC) signaling pathwayPdpk1 , Prkcz
quinapril pharmacodynamics pathwayAce , Agt , Agtr1a
quinapril pharmacokinetics pathwayAce
quinidine pharmacodynamics pathwayAgtr1a
ramipril pharmacodynamics pathwayAce , Agt , Agtr1a
ramipril pharmacokinetics pathwayAce
renin-angiotensin cascade pathwayAce , Agt , Agtr1a , Agtr2 , Cma1
somatostatin signaling pathwayJak2
sotalol pharmacodynamics pathwayAgtr1a
sphingosine 1-phosphate signaling pathwayJak2
spirapril pharmacodynamics pathwayAce , Agt , Agtr1a
spirapril pharmacokinetics pathwayAce
telmisartan pharmacodynamics pathwayAce , Agt , Agtr1a
timolol pharmacodynamics pathwayAgtr1a
toxoplasmosis pathwayJak2 , Pla2g6
trandolapril pharmacodynamics pathwayAce , Agt , Agtr1a
trandolapril pharmacokinetics pathwayAce
transforming growth factor-beta Smad dependent signaling pathwayPdpk1
tuberculosis pathwayJak2
tumor necrosis factor mediated signaling pathwayPrkcz
type 2 diabetes mellitus pathwayPrkcz
type II interferon signaling pathwayJak2
valsartan pharmacodynamics pathwayAce , Agt , Agtr1a
vascular endothelial growth factor signaling pathwayCcl2 , Pdpk1 , Pla2g6 , Prkcz
verapamil pharmacodynamics pathwayAgtr1a
Wnt signaling, non-canonical pathwayPrkcz
Phenotype Annotations Associated with Genes in the angiotensin II signaling pathway

References Associated with the angiotensin II signaling pathway:

Ontology Path Diagram:

paths to the root
paths to the root

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