RGD Reference Report - Angiotensin converting enzyme activity is positively associated with IL-17a levels in patients with schizophrenia. - Rat Genome Database

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Angiotensin converting enzyme activity is positively associated with IL-17a levels in patients with schizophrenia.

Authors: Gadelha, A  Yonamine, CM  Nering, M  Rizzo, LB  Noto, C  Cogo-Moreira, H  Teixeira, AL  Bressan, R  Maes, M  Brietzke, E  Hayashi, MA 
Citation: Gadelha A, etal., Psychiatry Res. 2015 Oct 30;229(3):702-7. doi: 10.1016/j.psychres.2015.08.018. Epub 2015 Aug 12.
RGD ID: 11353163
Pubmed: PMID:26296754   (View Abstract at PubMed)
DOI: DOI:10.1016/j.psychres.2015.08.018   (Journal Full-text)

Previous studies of our group showed increased plasmatic Angiotensin-I Converting Enzyme (ACE) activity in schizophrenia (SCZ) patients compared to healthy controls, which was also associated to poor cognitive functioning. The ACE main product angiotensin II (Ang-II) has pro-inflammatory properties. Activated immune-inflammatory responses in SCZ and their association with disease progression and cognitive impairments are also well-described. Therefore, we examined here the association of plasma ACE activity and inflammatory mediators in 33 SCZ patients and 92 healthy controls. Non-parametric correlations were used to investigate the association of the enzyme activity and the peripheral levels of immune inflammatory markers as interleukins, tumor necrosis factor (TNF-alpha), and interferon (IFN-gamma). Although no significant correlations could be observed for ACE activity and measured cytokines levels in healthy controls, a significant positive correlation for ACE enzymatic activity and IL-17a levels was observed in SCZ patients. Correcting for gender did not change these results. Moreover, a significant association for ACE activity and IFN-gamma levels was also observed. To our knowledge, this is the first study to show a significant association between higher ACE activity and the levels of cytokines, namely IL-17a and IFN-gamma, in patients with SCZ.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ACEHumanschizophrenia  IEP protein:decreased activity:plasma (human)RGD 
AceRatschizophrenia  ISOACE (Homo sapiens)protein:decreased activity:plasma (human)RGD 
AceMouseschizophrenia  ISOACE (Homo sapiens)protein:decreased activity:plasma (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ace  (angiotensin I converting enzyme)

Genes (Mus musculus)
Ace  (angiotensin I converting enzyme)

Genes (Homo sapiens)
ACE  (angiotensin I converting enzyme)


Additional Information