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Gene: ACE (angiotensin I converting enzyme) Homo sapiens
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Symbol: ACE
Name: angiotensin I converting enzyme
RGD ID: 737323
Description: Exhibits several functions, including chloride ion binding activity; peptidase activity; and protein kinase binding activity. Involved in several processes, including arachidonic acid secretion; peptide metabolic process; and regulation of angiotensin metabolic process. Localizes to several cellular components, including external side of plasma membrane; extracellular exosome; and lysosome. Implicated in several diseases, including Coronavirus infectious disease (multiple); artery disease (multiple); autoimmune disease (multiple); lung disease (multiple); and nephritis (multiple). Biomarker of several diseases, including chronic myeloid leukemia; intermediate coronary syndrome; lung disease (multiple); pancreatic ductal carcinoma; and renal fibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACE1; angiotensin 1 converting enzyme 1; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript; angiotensin-converting enzyme; carboxycathepsin; CD143; CD143 antigen; DCP; DCP1; dipeptidyl carboxypeptidase 1; dipeptidyl carboxypeptidase I; ICH; kininase II; MGC26566; MVCD3; peptidase P; testicular ECA
Orthologs:
Mus musculus (house mouse) : Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ace (angiotensin I converting enzyme)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : ACE (angiotensin I converting enzyme)
Canis lupus familiaris (dog) : ACE (angiotensin I converting enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101968921 (angiotensin-converting enzyme)
Sus scrofa (pig) : ACE (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1)
Heterocephalus glaber (naked mole-rat) : Ace (angiotensin I converting enzyme)
more info ...
Related Pseudogenes: ACE3P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1763,477,061 - 63,498,380 (+)EnsemblGRCh38hg38GRCh38
GRCh381763,477,061 - 63,498,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371761,554,422 - 61,575,741 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361758,908,166 - 58,928,711 (+)NCBINCBI36hg18NCBI36
Build 341758,915,908 - 58,952,935NCBI
Celera1755,942,475 - 55,963,778 (+)NCBI
Cytogenetic Map17q23.3NCBI
HuRef1756,922,781 - 56,944,100 (+)NCBIHuRef
CHM1_11761,618,550 - 61,639,869 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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