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Gene: ACE (angiotensin I converting enzyme) Homo sapiens
Symbol: ACE
Name: angiotensin I converting enzyme
Description: Exhibits several functions, including chloride ion binding activity; peptidase activity, acting on L-amino acid peptides; and protein kinase binding activity. Involved in several processes, including arachidonic acid secretion; peptide metabolic process; and regulation of angiotensin metabolic process. Localizes to several cellular components, including the external side of plasma membrane; extracellular exosome; and lysosome. Implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); hematologic cancer (multiple); lung disease (multiple); and nephritis (multiple). Biomarker of several diseases, including chronic myeloid leukemia; intermediate coronary syndrome; lung disease (multiple); pancreatic ductal carcinoma; and renal fibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACE1; angiotensin 1 converting enzyme 1; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript; angiotensin-converting enzyme; carboxycathepsin; CD143; CD143 antigen; DCP; DCP1; dipeptidyl carboxypeptidase 1; dipeptidyl carboxypeptidase I; ICH; kininase II; MGC26566; MVCD3; peptidase P; testicular ECA
Mus musculus (house mouse) : Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ace (angiotensin I converting enzyme)  Alliance
Canis lupus familiaris (dog) : ACE (angiotensin I converting enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101968921 (angiotensin-converting enzyme)
Sus scrofa (pig) : ACE (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1)
more info ...
Related Pseudogenes: ACE3P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381763,477,061 - 63,498,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371761,554,422 - 61,575,741 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361758,908,166 - 58,928,711 (+)NCBINCBI36hg18NCBI36
Build 341758,915,908 - 58,952,935NCBI
Celera1755,942,475 - 55,963,778 (+)NCBI
Cytogenetic Map17q23.3NCBI
HuRef1756,922,781 - 56,944,100 (+)NCBIHuRef
CHM1_11761,618,550 - 61,639,869 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Protein Structures
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ACE
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737323
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.