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Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats.

Authors: Deng, Y  Rapp, JP 
Citation: Deng Y and Rapp JP, Nat Genet 1992 Jul;1(4):267-72
Pubmed: (View Article at PubMed) PMID:1363813
DOI: Full-text: DOI:10.1038/ng0792-267

We have evaluated the genes for angiotensin converting enzyme (ACE) and guanylyl cyclase A/atrial natriuretic peptide receptor (GCA) for genetic effects on blood pressure response to high salt diet. In F2 rats derived from Milan normotensive and Dahl salt-hypertension sensitive (S) rats, both ACE and GCA cosegregated with blood pressure, and rats that were homozygous for the S allele at both the ACE and GCA loci had inordinately high blood pressure. In F2 derived from Wistar Kyoto (WKY) and S rats, GCA revealed positive cosegregation with blood pressure, but ACE did not. We conclude that certain alleles at the GCA and ACE loci (or at loci closely linked to them) have a significant genetic impact on blood pressure response to high salt in specific rat strains.


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RGD Object Information
RGD ID: 61037
Created: 2000-12-21
Species: All species
Last Modified: 2001-12-18
Status: ACTIVE


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