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Strain: SD-Tg(Ren2)27

Symbol: SD-Tg(Ren2)27
Strain: SD
RGD ID: 629501
Citation ID: RRID:RGD_629501
Ontology ID: RS:0000687
Alleles: Ace;   Agtr1b
Also known as: TGRmRen2; TGRmRen2L27; TGR+/-
Type: transgenic
Source: Center for Genome Research, University of Edinburgh, UK
Origin: This is a hypertensive rat strain in which the mouse Ren2 renin gene along with its 5' and 3' flanking sequences were microinjected into fertilized eggs from a Hannover Sprague-Dawley (SD) background.
Last Known Status: Unknown





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References


Region

Strain QTL Data
Symbol Name Trait
Bp342 Blood pressure QTL 342 life span trait   (VT:0005372)    
Bp343 Blood pressure QTL 343 life span trait   (VT:0005372)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics A good model for low-renin hypertension, their blood pressure is elevated which leads to cardiovascular diseases and death due to cerebral haemorrhage. Both male and female of line 27 developed hypertension. 619627
strain_characteristics A good model for low-renin hypertension, their blood pressure is elevated which leads to cardiovascular diseases and death due to cerebral haemorrhage. Both male and female of line 27 developed hypertension. 628589
strain_drgs_chems Captopril a conversion of angiotensin I to angiotensin II this is sufficient to reduce the blood pressure of hypertensive rat 619627
strain_drgs_chems Captopril a conversion of angiotensin I to angiotensin II this is sufficient to reduce the blood pressure of hypertensive rat 628589
strain_life_disease suspectible to malignant hypertension and higher plasma angiotensin-converting enzyme activity in progeny receiving the Fischer allele than in progeny receiving the Lewis allele 619627
strain_life_disease suspectible to malignant hypertension and higher plasma angiotensin-converting enzyme activity in progeny receiving the Fischer allele than in progeny receiving the Lewis allele 628589
strain_phys_biochem Overexpression of active renin is not seen in the kidneys but they have low levels of active renin in their plasma. 619627
strain_phys_biochem Overexpression of active renin is not seen in the kidneys but they have low levels of active renin in their plasma. 628589