ACE (angiotensin I converting enzyme) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: ACE (angiotensin I converting enzyme) Pan paniscus
Analyze
Symbol: ACE
Name: angiotensin I converting enzyme
RGD ID: 11900117
Description: ENCODES a protein that exhibits actin binding (ortholog); heterocyclic compound binding (ortholog); metallopeptidase activity (ortholog); INVOLVED IN aging (ortholog); angiogenesis involved in coronary vascular morphogenesis (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway; benazepril pharmacodynamics pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN basal plasma membrane (ortholog); brush border membrane (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: angiotensin-converting enzyme; angiotensin-converting enzyme-like; LOC100980711; LOC103784926
RGD Orthologs
Human
Mouse
Rat
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11762,710,398 - 62,724,018 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1762,702,341 - 62,733,853 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01757,556,294 - 57,577,294 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
Alcoholic Liver Diseases  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
Angiotensin I-Converting Enzyme, Benign Serum Increase  (ISO)
ankylosing spondylitis  (ISO)
Aortic Coarctation  (ISO)
Arteriovenous Fistula  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Banti's Syndrome  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
CAKUT  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (ISO)
cardiovascular system disease  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chemical colitis  (ISO)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
cholestasis  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
congenital diaphragmatic hernia  (ISO)
Congenital Hepatic Fibrosis  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
Cough  (ISO)
COVID-19  (ISO)
Cytomegalovirus Infections  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diastolic heart failure  (ISO)
diffuse cystic renal dysplasia  (ISO)
dilated cardiomyopathy  (ISO)
drug allergy  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrinsic allergic alveolitis  (ISO)
Fabry disease  (ISO)
Familial Cerebral Cavernous Malformation  (ISO)
familial Mediterranean fever  (ISO)
Fetal Death  (ISO)
Fetal Growth Retardation  (ISO)
focal segmental glomerulosclerosis 1  (ISO)
gallbladder adenocarcinoma  (ISO)
Gaucher's disease  (ISO)
Genetic Predisposition to Disease  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
glycogen storage disease V  (ISO)
heart valve disease  (ISO)
Helicobacter Infections  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatitis A  (ISO)
hepatocellular carcinoma  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
Hypertensive Nephrosclerosis  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
in situ carcinoma  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
leukemia  (ISO)
leukostasis  (ISO)
liver cirrhosis  (ISO)
Liver Metastasis  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
malaria  (ISO)
male infertility  (ISO)
Memory Disorders  (ISO)
Meningococcal Infections  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
mitral valve disease  (ISO)
mitral valve prolapse  (ISO)
multiple myeloma  (ISO)
Mycobacterium Infections  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
ocular hypotension  (ISO)
osteoporosis  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Peritoneal Fibrosis  (ISO)
Pleural Effusion  (ISO)
pneumonia  (ISO)
polycythemia  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Infant Diseases  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
pyelonephritis  (ISO)
Radiation Nephropathy  (ISO)
renal fibrosis  (ISO)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory system disease  (ISO)
Right Ventricular Hypertrophy  (ISO)
sarcoidosis  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Staphylococcal Infections  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
subacute sclerosing panencephalitis  (ISO)
substance-induced psychosis  (ISO)
Sudden Death  (ISO)
systemic scleroderma  (ISO)
toxic shock syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
uveitis  (ISO)
Vascular System Injuries  (ISO)
Venous Thromboembolism  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Remodeling  (ISO)
viral pneumonia  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
amyloid-beta metabolic process  (IEA)
angiogenesis involved in coronary vascular morphogenesis  (ISO)
angiotensin maturation  (IEA)
animal organ regeneration  (ISO)
arachidonic acid secretion  (IEA)
bradykinin catabolic process  (IEA,ISO)
brain development  (ISO)
cell proliferation in bone marrow  (IEA)
cellular response to aldosterone  (ISO)
cellular response to glucose stimulus  (ISO)
eating behavior  (ISO)
embryo development ending in birth or egg hatching  (ISO)
female pregnancy  (ISO)
heart contraction  (IEA,ISO)
hormone catabolic process  (IEA)
hormone metabolic process  (IEA)
kidney development  (IEA,ISO)
lung alveolus development  (ISO)
lung development  (ISO)
male gonad development  (IEA,ISO)
negative regulation of calcium ion import  (ISO)
negative regulation of gap junction assembly  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of glucose import  (ISO)
negative regulation of protein binding  (IEA)
negative regulation of renal sodium excretion  (ISO)
neutrophil mediated immunity  (IEA,ISO)
peptide catabolic process  (IEA,ISO)
peptide metabolic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of peptidyl-cysteine S-nitrosylation  (IEA)
positive regulation of peptidyl-tyrosine autophosphorylation  (IEA)
positive regulation of protein binding  (IEA)
positive regulation of protein tyrosine kinase activity  (IEA)
positive regulation of systemic arterial blood pressure  (IEA,ISO)
positive regulation of vasoconstriction  (ISO)
post-transcriptional regulation of gene expression  (IEA)
proteolysis  (IEA)
regulation of angiotensin metabolic process  (IEA)
regulation of blood pressure  (IEA)
regulation of hematopoietic stem cell proliferation  (IEA)
regulation of smooth muscle cell migration  (ISO)
regulation of synaptic plasticity  (IEA)
regulation of systemic arterial blood pressure by renin-angiotensin  (IEA)
response to dexamethasone  (ISO)
response to hypoxia  (ISO)
response to laminar fluid shear stress  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to thyroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of pain  (ISO)
spermatogenesis  (IEA,ISO)
substance P catabolic process  (IEA)
vasoconstriction  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
ACE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11762,710,398 - 62,724,018 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1762,702,341 - 62,733,853 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01757,556,294 - 57,577,294 (+)NCBIMhudiblu_PPA_v0panPan3
ACE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,477,061 - 63,498,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1763,477,061 - 63,498,380 (+)EnsemblGRCh38hg38GRCh38
GRCh371761,554,422 - 61,575,734 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361758,908,166 - 58,928,711 (+)NCBINCBI36hg18NCBI36
Build 341758,915,908 - 58,952,935NCBI
Celera1755,942,475 - 55,963,778 (+)NCBI
Cytogenetic Map17q23.3NCBI
HuRef1756,922,781 - 56,944,100 (+)NCBIHuRef
CHM1_11761,618,550 - 61,639,869 (+)NCBICHM1_1
T2T-CHM13v2.01764,347,269 - 64,368,872 (+)NCBI
Ace
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,858,774 - 105,880,790 (+)NCBIGRCm39mm39
GRCm39 Ensembl11105,858,771 - 105,880,790 (+)Ensembl
GRCm3811105,967,948 - 105,989,964 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11105,967,945 - 105,989,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,829,261 - 105,851,259 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611105,784,049 - 105,805,350 (+)NCBImm8
Celera11117,699,475 - 117,721,491 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.84NCBI
Ace
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21090,910,316 - 90,930,437 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1090,910,316 - 90,931,131 (+)Ensembl
Rnor_6.01094,170,766 - 94,213,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,170,766 - 94,187,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01093,922,062 - 93,965,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,361,338 - 95,381,455 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1089,588,544 - 89,608,666 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
ACE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,497,182 - 11,516,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,497,182 - 11,516,358 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,457,866 - 12,477,045 (+)NCBI
ROS_Cfam_1.0913,160,704 - 13,179,888 (+)NCBI
ROS_Cfam_1.0 Ensembl913,160,704 - 13,200,795 (+)Ensembl
UMICH_Zoey_3.1912,105,344 - 12,124,523 (+)NCBI
UNSW_CanFamBas_1.0915,407,255 - 15,426,429 (-)NCBI
UU_Cfam_GSD_1.0915,410,134 - 15,429,354 (-)NCBI
LOC101968921
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560215,017,159 - 15,036,742 (-)NCBI
SpeTri2.0NW_0049365414,157,847 - 4,178,156 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,394,487 - 15,414,703 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,394,487 - 15,414,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,381,362 - 15,401,171 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ace
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624849998,277 - 1,019,521 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624849998,262 - 1,019,305 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000032712   ⟹   ENSPPAP00000010065
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1762,702,341 - 62,722,648 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032723   ⟹   ENSPPAP00000010076
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1762,703,517 - 62,723,009 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032729   ⟹   ENSPPAP00000010082
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1762,710,398 - 62,724,018 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032734   ⟹   ENSPPAP00000010087
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1762,710,442 - 62,733,853 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000032738   ⟹   ENSPPAP00000010091
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1762,710,442 - 62,723,009 (+)Ensembl
RefSeq Acc Id: XM_008963751   ⟹   XP_008961999
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11762,710,398 - 62,724,018 (+)NCBI
Mhudiblu_PPA_v01757,564,344 - 57,577,294 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034942682   ⟹   XP_034798573
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01757,556,294 - 57,577,294 (+)NCBI
RefSeq Acc Id: XM_034942683   ⟹   XP_034798574
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01757,556,703 - 57,577,294 (+)NCBI
RefSeq Acc Id: XM_034942684   ⟹   XP_034798575
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01757,557,632 - 57,577,294 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008961999 (Get FASTA)   NCBI Sequence Viewer  
  XP_034798573 (Get FASTA)   NCBI Sequence Viewer  
  XP_034798574 (Get FASTA)   NCBI Sequence Viewer  
  XP_034798575 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008961999   ⟸   XM_008963751
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_034798573   ⟸   XM_034942682
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034798574   ⟸   XM_034942683
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034798575   ⟸   XM_034942684
- Peptide Label: isoform X3
RefSeq Acc Id: ENSPPAP00000010087   ⟸   ENSPPAT00000032734
RefSeq Acc Id: ENSPPAP00000010082   ⟸   ENSPPAT00000032729
RefSeq Acc Id: ENSPPAP00000010076   ⟸   ENSPPAT00000032723
RefSeq Acc Id: ENSPPAP00000010065   ⟸   ENSPPAT00000032712
RefSeq Acc Id: ENSPPAP00000010091   ⟸   ENSPPAT00000032738


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028254 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000010065.1 UniProtKB/TrEMBL
  ENSPPAP00000010076.1 UniProtKB/TrEMBL
  ENSPPAP00000010082.1 UniProtKB/TrEMBL
  ENSPPAP00000010087.1 UniProtKB/TrEMBL
  ENSPPAP00000010091.1 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032712.1 UniProtKB/TrEMBL
  ENSPPAT00000032723.1 UniProtKB/TrEMBL
  ENSPPAT00000032729.1 UniProtKB/TrEMBL
  ENSPPAT00000032734.1 UniProtKB/TrEMBL
  ENSPPAT00000032738.1 UniProtKB/TrEMBL
InterPro Peptidase_M2 UniProtKB/TrEMBL
KEGG Report pps:100980711 UniProtKB/TrEMBL
NCBI Gene LOC100980711 ENTREZGENE
PANTHER PTHR10514 UniProtKB/TrEMBL
Pfam Peptidase_M2 UniProtKB/TrEMBL
PRINTS PEPDIPTASEA UniProtKB/TrEMBL
UniProt A0A2R8ZYL8_PANPA UniProtKB/TrEMBL
  A0A2R8ZYN2_PANPA UniProtKB/TrEMBL
  A0A2R8ZYP1_PANPA UniProtKB/TrEMBL
  A0A2R8ZYP4_PANPA UniProtKB/TrEMBL
  A0A2R9A455_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-07-01 ACE  angiotensin I converting enzyme  LOC100980711  angiotensin-converting enzyme  Symbol and/or name change 5135510 APPROVED
2020-06-11 LOC100980711  angiotensin-converting enzyme  LOC103784926  angiotensin-converting enzyme-like  Data Merged 737654 PROVISIONAL