RGD Reference Report - Angiotensin-converting enzyme is a modifier of hypertensive end organ damage. - Rat Genome Database

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Angiotensin-converting enzyme is a modifier of hypertensive end organ damage.

Authors: Liu, X  Bellamy, CO  Bailey, MA  Mullins, LJ  Dunbar, DR  Kenyon, CJ  Brooker, G  Kantachuvesiri, S  Maratou, K  Ashek, A  Clark, AF  Fleming, S  Mullins, JJ 
Citation: Liu X, etal., J Biol Chem. 2009 Jun 5;284(23):15564-72. Epub 2009 Mar 23.
RGD ID: 2313695
Pubmed: PMID:19307186   (View Abstract at PubMed)
PMCID: PMC2708853   (View Article at PubMed Central)
DOI: DOI:10.1074/jbc.M806584200   (Journal Full-text)

Severe forms of hypertension are characterized by high blood pressure combined with end organ damage. Through the development and refinement of a transgenic rat model of malignant hypertension incorporating the mouse renin gene, we previously identified a quantitative trait locus on chromosome 10, which affects malignant hypertension severity and morbidity. We next generated an inducible malignant hypertensive model where the timing, severity, and duration of hypertension was placed under the control of the researcher, allowing development of and recovery from end organ damage to be investigated. We have now generated novel consomic Lewis and Fischer rat strains with inducible hypertension and additional strains that are reciprocally congenic for the refined chromosome 10 quantitative trait locus. We have captured a modifier of end organ damage within the congenic region and, using a range of bioinformatic, biochemical and molecular biological techniques, have identified angiotensin-converting enzyme as the modifier of hypertension-induced tissue microvascular injury. Reciprocal differences between angiotensin-converting enzyme and the anti-inflammatory tetrapeptide, N-acetyl-Ser-Asp-Lys-Pro in the kidney, a tissue susceptible to end organ damage, suggest a mechanism for the amelioration of hypertension-dependent damage.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AceRatextracellular space  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

Genes (Rattus norvegicus)
Ace  (angiotensin I converting enzyme)

QTLs
Bp342  (Blood pressure QTL 342)

Objects referenced in this article
Strain F344-Tg(Cyp1a1-Ren2)10Jmul null Rattus norvegicus
Strain LEW-Chr YF344-Tg(Cyp1a1-Ren2)10/Jmul null Rattus norvegicus

Additional Information