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Strain: F344-Tg(Cyp1a1-Ren2)10Jmul

Symbol: F344-Tg(Cyp1a1-Ren2)10Jmul
Strain: F344-Tg(Cyp1a1-Ren2)10
Substrain: Jmul
RGD ID: 2302141
Citation ID: RRID:RGD_2302141
Ontology ID: RS:0001685
Alleles: Ren2;   Cyp1a1
Also Known As: Ren2.F; TGR(Cyp1a1-Ren2)/TG10
Type: transgenic
Available Source: Not Available
Origination: University of Edinburgh Medical School, Edinburgh, UK
Description: Generated by using cytochrome P-450 promoter, rat Cyp1a1 to drive mouse Ren2 gene expression. The integration site was on Y chromosome as suggested by Southern blot analysis.
Last Known Status: Unknown






  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
F344-Tg(Cyp1a1-Ren2)10JmulRathypertension MODEL: inducedIMP 2302140indole-3 carbinol inducedRGD 
F344-Tg(Cyp1a1-Ren2)10JmulRatmalignant hypertension MODELIMP 2302144indole-3 carbinol inducedRGD 
F344-Tg(Cyp1a1-Ren2)10JmulRatproteinuria MODEL: inducedIMP 2302140indole-3 carbinol inducedRGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
F344-Tg(Cyp1a1-Ren2)10JmulRatincreased circulating renin level MODEL: inducedIMP 2302140indole-3 carbinol inducedRGD 
F344-Tg(Cyp1a1-Ren2)10JmulRatincreased systemic arterial systolic blood pressure MODEL: inducedIMP 2302140indole-3 carbinol inducedRGD 
F344-Tg(Cyp1a1-Ren2)10JmulRatincreased urine protein level MODEL: inducedIMP 2302140 RGD 
F344-Tg(Cyp1a1-Ren2)10JmulRatpolyuria MODEL: inducedIMP 2302140indole-3 carbinol inducedRGD 
F344-Tg(Cyp1a1-Ren2)10JmulRatweight loss MODEL: inducedIMP 2302140indole-3 carbinol inducedRGD 

#
Reference Title
Reference Citation
1. Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease. Kantachuvesiri S, etal., J Biol Chem. 2001 Sep 28;276(39):36727-33. Epub 2001 Jul 11.
2. Angiotensin-converting enzyme is a modifier of hypertensive end organ damage. Liu X, etal., J Biol Chem. 2009 Jun 5;284(23):15564-72. Epub 2009 Mar 23.
3. Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosis. Peters B, etal., J Hypertens. 2008 Jan;26(1):102-9.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines




Note Type Note Reference
strain_life_disease High levels of circulating prorenin do not cause glomerulosclerosis 2302144
strain_life_disease Decrease in blood pressure after 10 days of induction reflect onset of renal/heart failure 2313695
strain_other The transgene is integrated into the Y chromosome 2313695
strain_phys_biochem Transgene expressed in the liver, transgene expression is regulated by the dose of xenobiotic indole-3 carbinol 2302140
strain_phys_biochem 7 days after induction with indole-3 carbinol all components of plasma RAS were increased 2302140
strain_phys_biochem thickening of renal arteries and distal tubular hyperplasia were noticed 4 days after induction 2302140