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Strain: F344-Tg(Cyp1a1-Ren2)10Jmul

Symbol: F344-Tg(Cyp1a1-Ren2)10Jmul
Strain: F344-Tg(Cyp1a1-Ren2)10
Substrain: Jmul
RGD ID: 2302141
Citation ID: RRID:RGD_2302141
Ontology ID: RS:0001685
Alleles: Ren2;   Cyp1a1
Also known as: Ren2.F; TGR(Cyp1a1-Ren2)/TG10
Type: transgenic
Source: University of Edinburgh Medical School, Edinburgh, UK
Origin: Generated by using cytochrome P-450 promoter, rat Cyp1a1 to drive mouse Ren2 gene expression. The integration site was on Y chromosome as suggested by Southern blot analysis.
Last Known Status: Unknown

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Mammalian Phenotype



Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease High levels of circulating prorenin do not cause glomerulosclerosis 2302144
strain_life_disease Decrease in blood pressure after 10 days of induction reflect onset of renal/heart failure 2313695
strain_other The transgene is integrated into the Y chromosome 2313695
strain_phys_biochem Transgene expressed in the liver, transgene expression is regulated by the dose of xenobiotic indole-3 carbinol 2302140
strain_phys_biochem 7 days after induction with indole-3 carbinol all components of plasma RAS were increased 2302140
strain_phys_biochem thickening of renal arteries and distal tubular hyperplasia were noticed 4 days after induction 2302140