Ren2 (renin 2 tandem duplication of Ren1) - Rat Genome Database

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Gene: Ren2 (renin 2 tandem duplication of Ren1) Mus musculus
Analyze
No known orthologs.
Symbol: Ren2
Name: renin 2 tandem duplication of Ren1
RGD ID: 1622375
MGI Page MGI
Description: Enables endopeptidase activity. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within positive regulation of blood pressure. Located in extracellular space. Is expressed in several structures, including adrenal medulla; embryo mesenchyme; medulla oblongata alar plate mantle layer; metanephros; and submandibular gland. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: angiotensinogenase; R; Ren; Ren-2; Ren-B; renin-2; Rn; Rn-2; Rnr; submandibular gland renin
RGD Orthologs
Alliance Genes
More Info homologs ...
Is Marker For: Strains:   F344-Tg(Cyp1a1-Ren2)10Jmul  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Celera1177,256,233 - 177,265,990 (+)NCBICelera
Cytogenetic Map1E4NCBI


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Pipeline to import KEGG annotations from KEGG into RGD
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15253   PMID:281712   PMID:1350294   PMID:1358796   PMID:1608447   PMID:1672292   PMID:1673105   PMID:1683707   PMID:1685136   PMID:1970330   PMID:1981051   PMID:2172970  
PMID:2307472   PMID:2571577   PMID:2574151   PMID:2574991   PMID:2691339   PMID:2833727   PMID:2882954   PMID:2894402   PMID:2895697   PMID:2971731   PMID:2993224   PMID:3384439  
PMID:3416634   PMID:3898081   PMID:4042679   PMID:6089205   PMID:6095203   PMID:6171818   PMID:6283373   PMID:6327268   PMID:6327270   PMID:6357783   PMID:6378791   PMID:6389258  
PMID:6392850   PMID:6751556   PMID:6812055   PMID:6934364   PMID:7028030   PMID:7031061   PMID:7165695   PMID:7692390   PMID:8188220   PMID:8203556   PMID:8482578   PMID:8952516  
PMID:8952610   PMID:9622149   PMID:9693135   PMID:10729219   PMID:11145610   PMID:11161799   PMID:11395546   PMID:11457727   PMID:11751275   PMID:12397037   PMID:12477932   PMID:12512695  
PMID:15489334   PMID:15795515   PMID:16446393   PMID:16522658   PMID:17083061   PMID:17386351   PMID:17425782   PMID:17630347   PMID:17641813   PMID:17898695   PMID:18424632   PMID:18456730  
PMID:18483625   PMID:18486983   PMID:18826488   PMID:19252086   PMID:19293336   PMID:19307186   PMID:19403863   PMID:19531557   PMID:19710239   PMID:19749160   PMID:20007350   PMID:20462965  
PMID:20666571   PMID:20884641   PMID:21078594   PMID:21267068   PMID:21389089   PMID:21565284   PMID:21873635   PMID:22328091   PMID:22526299   PMID:25194129   PMID:25194138   PMID:25224811  
PMID:25407269   PMID:26180185   PMID:27754863   PMID:28527294   PMID:29358217   PMID:32199017   PMID:32507043   PMID:35103284  


Genomics


Related Rat Strains
The following Strains have been annotated to Ren2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_031193   ⟹   NP_112470
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
Celera1177,256,233 - 177,265,990 (+)ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112470   ⟸   NM_031193
- UniProtKB: P00796 (UniProtKB/Swiss-Prot)
- Sequence:
Protein Domains
Peptidase A1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure Video
AF-P00796-F1-model_v2 AlphaFold P00796 1-401 view protein structure  
Renin2 pdb 2x0b P00796 64-401 view protein structure view video


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97899 AgrOrtholog
Gene3D-CATH 2.40.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aspartic_peptidase_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aspartic_peptidase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aspartic_peptidase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_aspartic_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Renin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19702 UniProtKB/Swiss-Prot
MGD MGI:97899 ENTREZGENE
NCBI Gene 19702 ENTREZGENE
PANTHER PTHR47966 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A1_Propeptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Asp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ren2 PhenoGen
PRINTS PEPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASP_PROTEASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50630 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P00796 ENTREZGENE
  Q91X66_MOUSE UniProtKB/TrEMBL
  RENI2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P70229 UniProtKB/Swiss-Prot
  P97955 UniProtKB/Swiss-Prot
  Q62155 UniProtKB/Swiss-Prot