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Strain Registration

Strain: LEW-Chr YF344-Tg(Cyp1a1-Ren2)10.F344-(D10Rat99-D10Rat11)/Jmul

Symbol: LEW-Chr YF344-Tg(Cyp1a1-Ren2)10.F344-(D10Rat99-D10Rat11)/Jmul
Strain: LEW-Chr YF344-Tg(Cyp1a1-Ren2)10.F344-(D10Rat99-D10Rat11)
Substrain: Jmul
RGD ID: 2313923
Citation ID: RRID:RGD_2313923
Ontology ID: RS:0002064
Previously known as: Ren2.L-MOD-F;LEW.F344-(D10Rat99-D10Rat11)/Jmul; LEW.F344-(D10Rat99-D10Rat11)/Jmul; LEW-Chr YF344-Tg(Cyp1a1-Ren2)10.F344-(D10Rat99-D10Rat11)/Jmul
Type: congenic
Source: Molecular Physiology Lab, CVS, QMRI, University of Edinburgh, Edinburgh, UK
Origin: F344-Tg(Cyp1a1-Ren2)10Jmul (also named Ren2.F) males (carrying the transgene Ren2 on chr Y) and Lewis females were bred to produce F1 rats.F1 males were backcrossed to Lew females to produce BC-Lew. After 12 backcross generations, males and females heterozygous for F344/Lew in the MOD QTLregion were brother-sister mated to generate aimals that were homozygous F344/F344 for the MOD QTL region but homozygous LEW/LEW for the rest of the genome.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,269,536 - 96,121,100RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01088,250,522 - 99,492,409RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01088,043,769 - 99,184,250RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41089,278,229 - 100,633,982RGD_MAPPER_PIPELINERGSC3.4





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Angiotensin-converting enzyme is a modifier of hypertensive end organ damage. Liu X, etal., J Biol Chem. 2009 Jun 5;284(23):15564-72. Epub 2009 Mar 23.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D10Rat99)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,269,536 - 85,269,708 (+)MAPPER
Rnor_6.01088,250,522 - 88,250,693NCBI
Rnor_5.01088,043,769 - 88,043,940UniSTS
RGSC_v3.41089,278,230 - 89,278,401UniSTS
RGSC_v3.41089,278,229 - 89,278,401RGD
RGSC_v3.11089,292,600 - 89,292,771RGD
Celera1083,987,979 - 83,988,150UniSTS
RH 3.4 Map10857.8RGD
RH 3.4 Map10857.8UniSTS
RH 2.0 Map10962.9RGD
SHRSP x BN Map1064.27RGD

Flank 2 / 1 (D10Rat11)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21096,120,911 - 96,121,100 (+)MAPPER
Rnor_6.01099,492,217 - 99,492,409NCBI
Rnor_5.01099,184,058 - 99,184,250UniSTS
RGSC_v3.410100,633,512 - 100,633,982RGD
RGSC_v3.410100,633,654 - 100,633,848UniSTS
RGSC_v3.110100,648,024 - 100,648,218RGD
Celera1094,766,403 - 94,766,596UniSTS
RH 3.4 Map101084.8UniSTS
RH 3.4 Map101084.8RGD
RH 2.0 Map101218.2RGD
SHRSP x BN Map1077.15RGD
FHH x ACI Map1082.4RGD

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other This congenic strain contains Bp342 QTL 2313695

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-31 LEW-Chr YF344-Tg(Cyp1a1-Ren2)10.F344-(D10Rat99-D10Rat11)/Jmul    LEW.F344-(D10Rat99-D10Rat11)/Jmul    Symbol updated 68687 APPROVED
2017-03-31 LEW-Chr YF344-Tg(Cyp1a1-Ren2)10.F344-(D10Rat99-D10Rat11)/Jmul    LEW.F344-(D10Rat99-D10Rat11)/Jmul    Symbol updated 68687 APPROVED