RGD Reference Report - Is angiotensin I-converting enzyme a "master" disease gene? - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Is angiotensin I-converting enzyme a "master" disease gene?

Authors: Moskowitz, David W 
Citation: Moskowitz DW, Diabetes Technol Ther. 2002;4(5):683-711. doi: 10.1089/152091502320798321.
RGD ID: 39939119
Pubmed: (View Article at PubMed) PMID:12458570
DOI: Full-text: DOI:10.1089/152091502320798321

Clustering of diseases has been appreciated by health insurers and epidemiologists for some time. Co-morbidity suggests shared pathways of disease. It is by now well agreed that common diseases have a strong genetic component. Here we present evidence that the angiotensin I-converting enzyme (ACE) deletion/deletion (D/D) genotype is associated with a large number of common adult diseases, including cardiovascular disease, cancer, and psychiatric disease. Since the ACE D/D genotype has been shown to be associated with increased levels of tissue ACE expression at the protein level, these data suggest that overactivity of ACE may be involved in the pathogenesis of common diseases, as well as the utility of effective ACE inhibition in their treatment and, perhaps, prevention.

Disease Annotations    
hepatitis A  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Ace  (angiotensin I converting enzyme)

Genes (Mus musculus)
Ace  (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1)

Genes (Homo sapiens)
ACE  (angiotensin I converting enzyme)

Additional Information