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Polymorphism of angiotensin converting enzyme is associated with severe circulatory compromise in febrile neutropenic children with cancer.

Authors: Bardi, E  Jenei, C  Kiss, C 
Citation: Bardi E, etal., Pediatr Blood Cancer. 2005 Aug;45(2):217-21.
Pubmed: (View Article at PubMed) PMID:15806540
DOI: Full-text: DOI:10.1002/pbc.20400

Angiotensin converting enzyme (ACE) gene insertion(I)/deletion(D) polymorphism influences the outcome of a number of cardiovascular diseases. ACE I/D polymorphism was investigated by PCR in 207 pediatric cancer patients and 144 controls. ACE I/D distribution of patients and controls was similar. The frequency of the D allele and the prevalence of the deletion (DD) genotype were significantly (P < 0.05) higher among patients with severe circulatory compromise requiring treatment in the intensive care unit (ICU) than among the other patients and controls. Patients with the DD and ID genotypes spent significantly (P < 0.05) longer time in the ICU than patients with the II genotype.


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RGD Object Information
RGD ID: 11038917
Created: 2016-02-29
Species: All species
Last Modified: 2016-02-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.