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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2493
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ace
Name: angiotensin I converting enzyme
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acedecreases expression EXP 401793709RGDresveratrol decreases expression of mRNA in kidney of male offspring from pregnant dams treated with 2,3,7,8-tetrachlorodibenzodioxine and dexamethasone 
Acedecreases expressionEXP 6480464CTDresveratrol results in decreased expression of ACE proteinPMID:21962734
Acemultiple interactionsEXP 6480464CTDResveratrol inhibits the reaction [Colchicine results in decreased activity of ACE protein]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]PMID:17135773 PMID:22191573
Acemultiple interactionsISOAce (Mus musculus)6480464CTDresveratrol affects the reaction [Dietary Fats affects the activity of ACE protein]; resveratrol affects the reaction [Dietary Fats affects the expression of ACE mRNA]PMID:27260466
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