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RENIN-ANGIOTENSIN CASCADE PATHWAY (PW:0000492)

View Ontology Report

Description

Renin-angiotensin system (RAS) signaling pathway is well known for its cardiovascular roles primarily via the circulating or 'classical' route and also, has become recognized as a complex system with pleiotropic effects that engages both the circulating and the local or 'tissue' routes. Originally viewed as solely endocrine, the system is now regarded as an endocrine, paracrine and autocrine one producing an array of diverse and many times opposing actions. Underlying the system's ability of pro

Pathway Diagram:

Ariadne Genomics Inc. Ren Agtr2 Agtr1a Agtr1b Mas1 Lnpep angiotensin III signaling via AT2 receptor angiotensin III signaling pathway angiotensin (1-7) signaling pathway angiotensin IV signaling pathway angiotensin II signaling pathway angiotensin II signaling via AT2 receptor angiotensin II signaling via AT1 receptor Enpep Anpep Mme Ace2 Ace renin receptor mediated intracellular signaling angiotensin IV signaling pathway ---> cognition AgtIII ---- Agtr1a Renbp ---| Ren Renbp Agt ---> AgtI AgtIII ---- Agtr2 cognition AgtII ---- Agtr1b AgtIV ---- Lnpep AgtII ---- Agtr2 AgtI ---> AgtII Igf2r ---- Ren angiotensin III signaling via AT1 receptor ---> cell proliferation vasodilation AgtII ---- Agtr1a angiotensin III signaling via AT2 receptor ---> vasodilation angiotensin II signaling via AT2 receptor ---> vasodilation Atp6ap2 ---- Ren Cma1 Atp6ap2 ---> renin receptor mediated intracellular signaling Igf2r cell proliferation vasoconstriction angiotensin II signaling via AT1 receptor ---> cell proliferation Igf2r ---> complex internalization complex internalization AgtII ---> AgtIII Agt AgtI ---> Agt(1-7) AgtIII ---> AgtIV AgtII ---> Agt(1-7) AgtIII ---- Agtr1b AgtI Agt(1-7) AgtIII AgtIV AgtII Ren ---- Renbp Ren ---> renin receptor mediated intracellular signaling angiotensin III signaling via AT1 receptor angiotensin III signaling via AT1 receptor ---> vasoconstriction angiotensin II signaling via AT1 receptor ---> vasoconstriction angiotensin (1-7) signaling pathway ---> vasodilation Atp6ap2 Agt(1-7) ---- Mas1
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Genes in Pathway:


show annotations for term's descendants           Sort by:
renin-angiotensin cascade pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO
IEA
IMP
KEGG
RGD
PMID:15638741 PMID:10642323 rno:04614, RGD:1581742, RGD:1581953 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 ISO
IEA
KEGG
RGD
PMID:15638741 PMID:16520407 rno:04614, RGD:1581742, RGD:1581931 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Agt angiotensinogen IDA
IEA
IMP
ISO
KEGG
RGD
PMID:12242043 PMID:11282364 PMID:15638741 rno:04614, RGD:1581651, RGD:1582105, RGD:1581742 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS
IEA
KEGG
RGD
PMID:16141358 rno:04614, RGD:1581847 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS
IEA
KEGG
RGD
PMID:16141358 rno:04614, RGD:1581847 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS
IEA
KEGG
RGD
PMID:15158138 rno:04614, RGD:1581855 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Anpep alanyl aminopeptidase, membrane IDA
IEA
KEGG
RGD
PMID:16537183 rno:04614, RGD:1581649 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 ISO RGD PMID:18376005 RGD:5132617 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918
JBrowse link
G Cma1 chymase 1 TAS
IEA
KEGG
RGD
PMID:15638741 rno:04614, RGD:1581742 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
JBrowse link
G Cpa3 carboxypeptidase A3 IEA KEGG rno:04614 NCBI chr 2:102,712,483...102,744,219
Ensembl chr 2:102,712,589...102,744,203
JBrowse link
G Ctsa cathepsin A IEA KEGG rno:04614 NCBI chr 3:153,569,106...153,574,983
Ensembl chr 3:153,568,381...153,576,215
JBrowse link
G Ctsg cathepsin G IEA KEGG rno:04614 NCBI chr15:29,930,988...29,937,353
Ensembl chr15:29,931,003...29,937,353
JBrowse link
G Enpep glutamyl aminopeptidase IDA
IEA
ISO
KEGG
RGD
PMID:16537183 PMID:15638741 rno:04614, RGD:1581649, RGD:1581742 NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947
JBrowse link
G Igf2r insulin-like growth factor 2 receptor IDA
TAS
RGD PMID:11247783 PMID:16672920 RGD:1581738, RGD:1581739 NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
JBrowse link
G Lnpep leucyl and cystinyl aminopeptidase TAS
IEA
IMP
KEGG
RGD
PMID:15687842 PMID:11282364 rno:04614, RGD:1581849, RGD:1582105 NCBI chr 1:58,258,642...58,355,532
Ensembl chr 1:58,258,642...58,354,544
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor TAS
IEA
ISO
KEGG
RGD
PMID:15687842 PMID:16520407 rno:04614, RGD:1581849, RGD:1581931 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
JBrowse link
G Mcpt8l2 mast cell protease 8-like 2 IEA KEGG rno:04614
G Mcpt8l3 mast cell protease 8-like 3 IEA KEGG rno:04614
G Mme membrane metallo-endopeptidase ISO
IEA
IMP
KEGG
RGD
PMID:15638741 PMID:10642323 PMID:16520407 rno:04614, RGD:1581742, RGD:1581953, RGD:1581931 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Nln neurolysin IEA KEGG rno:04614 NCBI chr 2:35,133,634...35,232,927
Ensembl chr 2:35,134,145...35,232,914
JBrowse link
G Ren renin IDA
IEA
ISO
TAS
KEGG
RGD
PMID:12242043 PMID:15638741 PMID:16672920 PMID:11247783 rno:04614, RGD:1581651, RGD:1581742, RGD:1581739, RGD:1581738 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Renbp renin binding protein IDA RGD PMID:11726282 RGD:5132613 NCBI chr  X:151,661,463...151,670,538
Ensembl chr  X:151,661,458...151,670,516
JBrowse link
G Rnpep arginyl aminopeptidase IDA RGD PMID:16537183 RGD:1581649 NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998
JBrowse link
G Thop1 thimet oligopeptidase 1 IEA KEGG rno:04614 NCBI chr 7:8,632,911...8,645,339
Ensembl chr 7:8,632,916...8,645,275
JBrowse link
angiotensin (1-7) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IMP
ISO
RGD PMID:10642323 PMID:15283675 RGD:1581953, RGD:1598433 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 ISO RGD PMID:15638741 RGD:1581742 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Agt angiotensinogen IMP RGD PMID:15951342 RGD:1581938 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor IMP
ISO
RGD PMID:15951342 PMID:16520407 RGD:1581938, RGD:1581931 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
JBrowse link
G Mme membrane metallo-endopeptidase ISO
IMP
RGD PMID:15638741 PMID:10642323 PMID:16520407 RGD:1581742, RGD:1581953, RGD:1581931 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
angiotensin II signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO RGD PMID:15638741 RGD:1581742 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Agt angiotensinogen TAS RGD PMID:16141358 RGD:1581847 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS RGD PMID:15590154 RGD:1579760 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS RGD PMID:14657020 RGD:1566502 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP RGD PMID:14684844 RGD:1582323 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cma1 chymase 1 IMP RGD PMID:15869764 RGD:1581745 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
JBrowse link
G Jak2 Janus kinase 2 IMP RGD PMID:16269269 RGD:1600094 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 IEP RGD PMID:12661921 RGD:1580992 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 IDA RGD PMID:14585963 RGD:1581775 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Pla2g6 phospholipase A2 group VI IMP RGD PMID:17613534 RGD:12910844 NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114
JBrowse link
G Prkcz protein kinase C, zeta IMP RGD PMID:16113073 RGD:1642674 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G test test1 TAS
IDA
ISS
RGD PMID:12446719 PMID:12446719 PMID:12446719 RGD:629553, RGD:629553, RGD:629553
angiotensin II signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen TAS RGD PMID:16141358 RGD:1581847 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS
IMP
IDA
RGD PMID:10977869 PMID:12446719 PMID:9287353 PMID:14559250 RGD:1581825, RGD:629553, RGD:5133683, RGD:2316188 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS RGD PMID:10977869 RGD:1581825 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
G Agtrap angiotensin II receptor-associated protein IMP RGD PMID:17875818 RGD:2314353 NCBI chr 5:158,507,427...158,519,036
Ensembl chr 5:158,508,749...158,519,036
JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 IDA RGD PMID:14559250 RGD:2316188 NCBI chr 1:155,748,622...155,814,186
Ensembl chr 1:155,748,652...155,814,184
JBrowse link
G Arrb1 arrestin, beta 1 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Arrb2 arrestin, beta 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:16141358 RGD:1581847 NCBI chr 7:8,163,752...8,177,636
Ensembl chr 7:8,162,750...8,179,812
JBrowse link
G Gnaq G protein subunit alpha q ISO RGD PMID:16141358 RGD:1581847 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:16304060 RGD:5133417 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:16304060 RGD:5133417 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:16304060 RGD:5133417 NCBI chr17:9,177,018...9,192,644
Ensembl chr17:9,177,019...9,192,644
JBrowse link
G Jak2 Janus kinase 2 IDA
IMP
RGD PMID:9287353 PMID:9314843 RGD:5133683, RGD:6478796 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:12588881 RGD:5133418 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Tyk2 tyrosine kinase 2 IMP RGD PMID:9314843 RGD:6478796 NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044
JBrowse link
angiotensin II signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IMP
ISO
TAS
RGD PMID:16286564 PMID:22949090 PMID:16286568 RGD:1582434, RGD:7401256, RGD:1582435 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS
ISO
RGD PMID:10977869 PMID:22949090 RGD:1581825, RGD:7401256 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 5:146,447,495...146,458,332
Ensembl chr 5:146,447,497...146,458,212
JBrowse link
G Dusp1 dual specificity phosphatase 1 TAS RGD PMID:18804122 RGD:5133675 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gnai3 G protein subunit alpha i3 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
JBrowse link
G Mtus1 microtubule associated scaffold protein 1 ISO RGD PMID:20889352 RGD:5133679 NCBI chr16:51,202,497...51,347,791
Ensembl chr16:51,253,562...51,347,793
JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 ISO RGD PMID:18804122 RGD:5133675 NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984
JBrowse link
G Slc9a6 solute carrier family 9 member A6 ISO RGD PMID:20889352 RGD:5133679 NCBI chr  X:134,430,588...134,486,747
Ensembl chr  X:134,420,756...134,485,375
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 7:17,520,827...17,571,871
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 ISO RGD PMID:20889352 RGD:5133679 NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
JBrowse link
angiotensin III signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen TAS RGD PMID:11295571 RGD:1582124 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a TAS RGD PMID:11295571 RGD:1582124 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr1b angiotensin II receptor, type 1b TAS RGD PMID:11295571 RGD:1582124 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS RGD PMID:11295571 RGD:1582124 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Enpep glutamyl aminopeptidase IDA RGD PMID:16537183 RGD:1581649 NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947
JBrowse link
angiotensin III signaling pathway via AT1 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IMP RGD PMID:11100981 RGD:1582152 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:11100981 RGD:1582152 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr1b angiotensin II receptor, type 1b IMP RGD PMID:11100981 RGD:1582152 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
angiotensin III signaling pathway via AT2 receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IMP RGD PMID:16380540 RGD:1582118 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP RGD PMID:16380540 RGD:1582118 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
angiotensin IV signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen IMP RGD PMID:11282364 RGD:1582105 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Anpep alanyl aminopeptidase, membrane IDA RGD PMID:16537183 RGD:1581649 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
JBrowse link
G Lnpep leucyl and cystinyl aminopeptidase TAS
IMP
RGD PMID:12591177 PMID:11282364 RGD:1581864, RGD:1582105 NCBI chr 1:58,258,642...58,355,532
Ensembl chr 1:58,258,642...58,354,544
JBrowse link
G Rnpep arginyl aminopeptidase IDA RGD PMID:16537183 RGD:1581649 NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998
JBrowse link
angiotensin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen ISS RGD PMID:12676165 RGD:1566511 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ProteinAgt(1-7)angiotensinogen derived peptide
ProteinAgtIIangiotensinogen derived peptide
ProteinAgtIIIangiotensinogen derived peptide
ProteinAgtIVangiotensinogen derived peptide

Pathway Gene Annotations

Disease Annotations Associated with Genes in the renin-angiotensin cascade pathway
Disease TermsGene Symbols
abdominal aortic aneurysmAce , Ace2 , Agt , Agtr1a
aceruloplasminemiaAgtr1a , Cpa3
Acute HepatitisAce
acute kidney failureAce , Ren
Acute Lung InjuryAce , Ace2
adenocarcinomaAce
adrenoleukodystrophyRenbp
adult respiratory distress syndromeAce , Ace2
AIDS-Associated NephropathyAgtr1a , Agtr2
AlbuminuriaAce , Agt , Ren
alcoholic cardiomyopathyAce , Agt
alcoholic hepatitisAgt
Alcoholic Liver DiseasesAce
AlkalosisAgt
allergic diseaseAce , Agt
allergic rhinitisAce
Alzheimer's diseaseAce , Agt , Agtr1a , Igf2r , Mme
amyotrophic lateral sclerosisIgf2r
AnaphylaxisAgt , Cma1
anemiaAce , Agt , Ren
Angiotensin I-Converting Enzyme, Benign Serum IncreaseAce
ankylosing spondylitisAce
anti-basement membrane glomerulonephritisAgt , Agtr1a
anuriaAgt
anxiety disorderAce2
aortic aneurysmAgt
Aortic CalcificationAgt
Aortic CoarctationAce , Agt
Arteriovenous FistulaAce
aspiration pneumoniaAce
asthmaAce , Agtr1a , Agtr2 , Cma1
atherosclerosisAgt
atopic dermatitisCma1
atrial fibrillationAce , Agt , Agtr1a , Ren
autistic disorderAce , Ace2 , Agtr2 , Atp6ap2 , Ren , Renbp
Autosomal Dominant Tubulointerstitial Kidney Disease 4Ren
autosomal recessive polycystic kidney diseaseAce
avian influenzaAce2
AzotemiaRen
bacterial pneumoniaAce2
Banti's SyndromeAce
Bartter diseaseRen
Behcet's diseaseAce
berylliosisAce
bipolar disorderAce , Agt
Bloom syndromeAnpep
BradycardiaAgt
Brain Hypoxia-IschemiaAgtr2
brain ischemiaAce
Brain-Lung-Thyroid SyndromeCma1 , Ctsg
breast cancerAce , Agt , Agtr1a , Lnpep
breast carcinomaIgf2r
breast carcinoma in situIgf2r
breast lobular carcinomaAgtr1a , Agtr2
Breast NeoplasmsMme
bronchiolitis obliteransAce
CAKUTAce
Cardiac ArrhythmiasAce , Agt , Agtr1a
Cardiac FibrosisAce2
CardiomegalyAce , Agt , Agtr1a , Agtr1b , Cma1 , Ren
cardiomyopathyAce2 , Agt
CardiotoxicityAgt
Cardiovascular AbnormalitiesAgt
cardiovascular system diseaseAce , Agt
Cardiovirus InfectionsAce2
carotid artery diseaseAce , Agt , Agtr1a
Carotid Artery InjuriesAgtr1a
CatalepsyAgt
celiac diseaseAce
cerebellar ataxia type 43Mme
cerebral amyloid angiopathyMme
Cerebral HemorrhageAce
cerebral infarctionAce
cerebral malariaAce2
cerebrovascular diseaseAgt , Agtr1a
Charcot-Marie-Tooth disease axonal type 2TMme
Charcot-Marie-Tooth disease type 2Mme
Chemical and Drug Induced Liver InjuryAce , Agt
chemical colitisAce , Ace2
Chemotherapy-Induced Febrile NeutropeniaAce
cholestasisAce , Agt
chronic fatigue syndromeRen
Chronic Hepatitis CAce
Chronic Intermittent HypoxiaAce , Agt
chronic kidney diseaseAgtr1a , Agtr2
chronic myeloid leukemiaAce , Agt
chronic obstructive pulmonary diseaseAce , Cma1
cleidocranial dysplasiaAgt
cognitive disorderAgt
colitisRen
colon carcinomaIgf2r
colorectal cancerAnpep
congenital adrenal hyperplasiaRen
congenital diaphragmatic herniaAce , Agtr2 , Igf2r
Congenital Disorder of Glycosylation Type IIrAtp6ap2
congenital heart diseaseCma1
Congenital Hepatic FibrosisAce
congestive heart failureAce , Ace2 , Agt , Agtr1a , Agtr2 , Mas1 , Mme , Ren
corneal neovascularizationAgt , Agtr1a
coronary artery diseaseAce , Agt , Agtr1a
Coronary DiseaseAce , Ace2 , Agtr1a
coronary restenosisAce
Coronavirus infectious diseaseAce , Ace2
CoughAce
COVID-19Ace , Ace2 , Agt , Agtr1a , Cpa3 , Mme , Nln , Renbp
Craniofacial AbnormalitiesAtp6ap2
Critical IllnessRen
Crohn's diseaseAgt
Cryopyrin-Associated Periodic SyndromesMme
Cytomegalovirus InfectionsAce
diabetic angiopathyAce
Diabetic CardiomyopathiesAce , Ace2 , Agt , Agtr2
Diabetic NephropathiesAce , Ace2 , Agt , Agtr1a , Agtr2 , Enpep , Lnpep , Ren
diabetic neuropathyMme
diabetic retinopathyAce , Ace2 , Agt , Agtr1a
Diaphragmatic HerniaAgt , Agtr1a , Agtr1b
diarrheaMme
diastolic heart failureAce
diffuse cystic renal dysplasiaAce , Agtr1a
diffuse sclerodermaAgt
dilated cardiomyopathyAce , Agt , Agtr1a , Agtr2 , Mas1 , Renbp
Dissecting AneurysmAgt
drug allergyAce
Drug OverdoseAgt
Drug-Related Side Effects and Adverse ReactionsRen
Ductal CarcinomaAgtr1a
Emery-Dreifuss muscular dystrophyRenbp
end stage renal diseaseAce , Agt , Agtr2
Endometrial NeoplasmsLnpep
Endometrioid CarcinomasLnpep
endomyocardial fibrosisAce , Ace2 , Agt , Igf2r
EndotoxemiaAce , Agtr2 , Mme , Ren
epilepsyCtsa
essential hypertensionAgt , Agtr1a , Ren
Experimental ArthritisAce
Experimental Autoimmune UveoretinitisAce2
Experimental ColitisAce
Experimental Diabetes MellitusAce , Ace2 , Agt , Agtr2 , Cma1 , Igf2r , Mas1 , Ren
Experimental Liver CirrhosisAce , Ace2 , Agt , Agtr1a , Enpep , Igf2r , Mas1 , Mme
Experimental Liver NeoplasmsIgf2r
Experimental Mammary NeoplasmsAgt , Agtr1a , Agtr2 , Lnpep , Rnpep
Experimental Radiation InjuriesAgtr1a , Agtr2
extrinsic allergic alveolitisAce
Fabry diseaseAce , Agt
familial adenomatous polyposis 1Lnpep
Familial Cerebral Cavernous MalformationAce
familial Mediterranean feverAce
Fetal DeathAce
Fetal Growth RetardationAce , Agt , Agtr1a , Agtr2 , Igf2r , Ren
FibrosisAgt , Agtr1a , Agtr2 , Atp6ap2 , Ren
focal segmental glomerulosclerosisAce2 , Agt , Agtr1a , Agtr2
focal segmental glomerulosclerosis 1Ace
galactosialidosisCtsa
gallbladder adenocarcinomaAce
gastric ulcerAgt
gastrointestinal stromal tumorAgt , Ren , Rnpep
Gaucher's diseaseAce
genetic diseaseAgtr2 , Atp6ap2 , Mme
Genetic Predisposition to DiseaseAce
glaucomaAce2 , Mas1
glomerulonephritisAce , Agt , Agtr2
glomerulosclerosisAce , Agtr1a , Agtr2
glucose intoleranceAgt , Agtr1a
glycogen storage disease VAce
GranulomaCma1
hand, foot and mouth diseaseRen
heart diseaseAgt
heart valve diseaseAce
Helicobacter InfectionsAce
HemorrhageAgt , Ren
Henoch-Schoenlein purpuraAce , Agt
hepatitis AAce
hepatoblastomaRen
hepatocellular carcinomaAce , Igf2r , Mme
hereditary breast ovarian cancer syndromeMme
Hereditary Neoplastic SyndromesLnpep
human cytomegalovirus infectionRen
Huntington's diseaseAgtr1a
hydronephrosisAgt
Hydrops FetalisCtsa
HyperalgesiaAgt
HyperemiaAgt
hyperhomocysteinemiaAgt
hyperinsulinismAgt , Agtr1a
HyperoxiaAce
hypertensionAce , Ace2 , Agt , Agtr1a , Agtr1b , Agtr2 , Atp6ap2 , Cma1 , Mas1 , Mme , Ren , Rnpep
Hypertensive NephropathyAgt , Agtr1a
Hypertensive NephrosclerosisAce , Ace2
hypertrophic cardiomyopathyAce , Ace2 , Agt , Cma1
HypertrophyAgt
Hypoglossal Nerve InjuriesMme
hypoglycemiaAgtr2
hypokalemiaAgt
HyponatremiaRen
HypotensionAce , Agt , Ren
HypoxiaMme
IgA glomerulonephritisAce , Agt , Agtr1a , Agtr2
immunodeficiency 33Renbp
impotenceAgt
in situ carcinomaAce , Igf2r
InflammationAce2 , Agt , Agtr1a , Agtr2
inflammatory bowel diseaseAgt
Insulin ResistanceAce , Agtr2
intellectual disabilityAgtr2
intermediate coronary syndromeAce , Agt , Agtr1a
interstitial lung diseaseCma1
Intestinal Reperfusion InjuryAce , Agt
intracranial aneurysmAce
ischemiaRen
kidney diseaseAce , Agt , Agtr1a , Ren
kidney failureAce , Agt , Mme , Ren
Kidney Reperfusion InjuryAce , Ace2
Left Ventricular HypertrophyAce , Ace2 , Agt , Agtr1a , Agtr2 , Cma1 , Ren
leiomyomaLnpep
leukemiaAce
leukostasisAce
Lewy body dementiaIgf2r
Liddle syndromeRen
limb ischemiaAgtr1a
liver cirrhosisAce , Agt , Ren
Liver MetastasisAce
lung adenocarcinomaIgf2r
lung cancerAce
lung carcinomaAce
lung diseaseAce , Ace2 , Agtr1a , Igf2r
Lung InjuryAce , Ace2 , Mme
Lung NeoplasmsAce
lysosomal storage diseaseCtsa
malariaAce
male infertilityAce
malignant hypertensionAgt , Ren
meconium aspiration syndromeAgt , Agtr2
membranous glomerulonephritisMme
Memory DisordersAce , Lnpep
Meningococcal InfectionsAce
mental depressionRen
Metabolic SyndromeAgt , Agtr1a
microcephalyAce , Agt
middle cerebral artery infarctionAce , Ace2 , Agt
mitral valve diseaseAce
mitral valve prolapseAce , Agt
multiple myelomaAce , Igf2r
multiple sclerosisAgt
Mycobacterium InfectionsAce
myocardial infarctionAce , Ace2 , Agt , Agtr1a , Ren
Myocardial IschemiaAgt
Myocardial Reperfusion InjuryAgt , Agtr1a
myocarditisAce , Cma1
myoepitheliomaIgf2r
NecrosisAgt
NeointimaAgt
Neoplasm MetastasisAce , Agtr1a , Agtr2
nephritisAce , Agtr1a
nephroblastomaIgf2r
nephrosisAce , Agt , Ren
nephrotic syndromeAce , Ren
Neurobehavioral ManifestationsAgt
Neurodevelopmental DisordersAce2 , Atp6ap2 , Lnpep , Nln , Thop1
neuropathyMme
non-alcoholic fatty liver diseaseAce
non-arteritic anterior ischemic optic neuropathyAce
non-Hodgkin lymphomaIgf2r
non-syndromic X-linked intellectual disability 88Agtr2
obesityAce , Agt , Agtr2 , Ren
obstructive sleep apneaAce
ocular hypotensionAce
oligohydramniosAgt
ornithine carbamoyltransferase deficiencyAtp6ap2
osteoporosisAce , Ren
otosclerosisAgt
ovarian cystAgtr2
Ovarian NeoplasmsLnpep
PainAce
pancreatic cancerAce , Agtr2
pancreatic ductal carcinomaAce , Ace2 , Agtr1a
parathyroid carcinomaAgt , Ren , Rnpep
Parkinson's diseaseAce , Agtr1a , Igf2r
patent ductus arteriosusAgtr1a
Peptic Ulcer HemorrhageAgt
periodontal diseaseRen
periodontitisMme
peripheral nervous system diseaseMme
Peritoneal FibrosisAce
periventricular nodular heterotopiaRenbp
Pituitary NeoplasmsAgtr1a
placental insufficiencyAgtr1a
Pleural EffusionAce , Ace2
pneumoniaAce , Agt
polycystic kidney diseaseAgt
polycythemiaAce
polyhydramniosLnpep
portal hypertensionRen
Postoperative Cognitive DysfunctionAgtr1a , Agtr1b
pre-eclampsiaAce , Agt
pre-malignant neoplasmAce
prediabetes syndromeAgt
Preeclamptic ToxemiaRen
Pregnancy-Induced HypertensionAce , Ace2 , Agt
Premature Infant DiseasesAce
Prenatal Exposure Delayed EffectsAgtr1b
primary biliary cholangitisAce , Ace2 , Agt , Mas1 , Ren
primary hyperaldosteronismRen
primary ovarian insufficiencyIgf2r
prostate cancerIgf2r
Prostatic NeoplasmsAce , Igf2r , Mme
proteinuriaAce , Agt , Agtr1a , Ren
psoriasisRen
pulmonary edemaAgt
pulmonary fibrosisAce , Ace2 , Agt , Agtr1a , Agtr2 , Cma1
pulmonary hypertensionAce , Ace2 , Agt , Agtr1a
Puromycin Aminonucleoside NephrosisAce , Agt , Ren
pyelonephritisAce
Radiation NephropathyAce
renal cell carcinomaAgtr1a , Agtr2 , Lnpep
renal fibrosisAce
renal hypertensionAgt , Agtr1a
Renal Tubular DysgenesisAce , Agt , Agtr1a , Ren
renovascular hypertensionAce , Agtr1a , Agtr1b , Agtr2 , Cma1 , Ren
Reoviridae InfectionsIgf2r
Reperfusion InjuryAce , Agt , Agtr2 , Ctsg
respiratory syncytial virus infectious diseaseAce2
respiratory system diseaseAce
Retina Reperfusion InjuryRen
retinal vasculitisAgt
retinopathy of prematurityAgt
Right Ventricular HypertrophyAce
sarcoidosisAce , Agtr1a , Cma1
schizophreniaAce
sciatic neuropathyAgt
Seasonal Allergic RhinitisCma1
SepsisAce
severe acute respiratory syndromeAce , Ace2 , Anpep
severe congenital encephalopathy due to MECP2 mutationRenbp
sick sinus syndromeAgt
skin melanomaAgt
Spinocerebellar AtaxiasMme
SplenomegalyRenbp
Spontaneous AbortionsAce2 , Agtr1a
Staphylococcal InfectionsAce
stomach cancerAce
Stomach NeoplasmsAce , Agtr2
StrokeAce , Agt , Agtr2
subacute sclerosing panencephalitisAce
substance-induced psychosisAce
Sudden DeathAce , Agt
syndromic microphthalmia 2Atp6ap2
syndromic X-linked intellectual disability Hedera typeAtp6ap2
syndromic X-linked intellectual disability Lubs typeAce2 , Agtr2 , Atp6ap2 , Renbp
systemic lupus erythematosusAce , Agtr2
systemic sclerodermaAce , Agt
temporal lobe epilepsyAgt
thrombosisAce2 , Agt , Mas1
toxic shock syndromeAce , Ren
transient cerebral ischemiaAgt
type 1 diabetes mellitusAce , Igf2r
type 2 diabetes mellitusAce , Agt , Agtr2 , Igf2r , Lnpep
ureteral obstructionAce , Agt
urinary bladder cancerAnpep
Urogenital AbnormalitiesAgtr2
uveitisAce
vascular diseaseAgt
Vascular MalformationsAgt
Vascular RemodelingAgt
Vascular System InjuriesAce , Agtr1a , Agtr2
Venous ThromboembolismAce
Ventricular DysfunctionIgf2r
Ventricular Dysfunction, LeftAgt
Ventricular FibrillationAce
Ventricular RemodelingAce , Ace2 , Agt , Agtr1a
vesicoureteral refluxAgtr1a , Agtr2
viral pneumoniaAce
visual epilepsyAgt , Ctsa
Weight GainAce
Weight LossAce , Ace2
withdrawal disorderRen
X-Linked Intellectual Developmental DisordersAgtr2
X-linked parkinsonism-spasticity syndromeAtp6ap2
Pathway Annotations Associated with Genes in the renin-angiotensin cascade pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAgtr1a
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAgtr1a
Alzheimer's disease pathwayMme
amino sugar metabolic pathwayRenbp
amiodarone pharmacodynamics pathwayAgtr1a
amlodipine pharmacodynamics pathwayAgtr1a
angiotensin (1-7) signaling pathwayAce , Ace2 , Agt , Mas1 , Mme
angiotensin II signaling pathwayAce , Agt , Agtr1a , Agtr2 , Cma1
angiotensin II signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b
angiotensin II signaling pathway via AT2 receptorAgt , Agtr2
angiotensin III signaling pathwayAgt , Agtr1a , Agtr1b , Agtr2 , Enpep
angiotensin III signaling pathway via AT1 receptorAgt , Agtr1a , Agtr1b
angiotensin III signaling pathway via AT2 receptorAgt , Agtr2
angiotensin IV signaling pathwayAgt , Anpep , Lnpep , Rnpep
angiotensin signaling pathwayAgt
atenolol pharmacodynamics pathwayAgtr1a
benazepril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
benazepril pharmacokinetics pathwayAce
betaxolol pharmacodynamics pathwayAgtr1a
bisoprolol pharmacodynamics pathwayAgtr1a
bupranolol drug pathwayAgtr1a
bupranolol pharmacodynamics pathwayAgtr1a
calcium/calcium-mediated signaling pathwayAgtr1a , Agtr1b
candesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
captopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
carvedilol pharmacodynamics pathwayAgtr1a
Chagas disease pathwayAce
cilazapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
cilazapril pharmacokinetics pathwayAce
diltiazem pharmacodynamics pathwayAgtr1a
disopyramide pharmacodynamics pathwayAgtr1a
dobutamine pharmacodynamics pathwayAgtr1a
enalapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
enalapril pharmacokinetics pathwayAce
Entamoebiasis pathwayCtsg , Mcpt8l2 , Mcpt8l3
eprosartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
esmolol pharmacodynamics pathwayAgtr1a
flecainde pharmacodynamics pathwayAgtr1a
forasartsn pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
fosinopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
fosinopril pharmacokinetics pathwayAce
fosphenytoin pharmacodynamics pathwayAgtr1a
french type sialuria pathwayRenbp
G protein mediated signaling pathway via Galpha12/Galpha13 familyAgtr1a
G protein mediated signaling pathway via Galphai familyAgtr2
G protein mediated signaling pathway via Galphaq familyAgtr1a
glutathione metabolic pathwayAnpep
glutathione synthase deficiency pathwayAnpep
glutathionuria disease pathwayAnpep
hypertrophic cardiomyopathy pathwayAce
ibutilide pharmacodynamics pathwayAgtr1a
insulin responsive facilitative sugar transporter mediated glucose transport pathwayLnpep
irbesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
isoprenaline pharmacodynamics pathwayAgtr1a
isradipine pharmacodynamics pathwayAgtr1a
kallikrein-kinin cascade pathwayAce , Mme
levobunolol pharmacodynamics pathwayAgtr1a
lidocaine pharmacodynamics pathwayAgtr1a
lisinopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
long term potentiationAgt , Lnpep
losartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
metoprolol pharmacodynamics pathwayAgtr1a
mexiletine pharmacodynamics pathwayAgtr1a
moexipril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
moexipril pharmacokinetics pathwayAce
myocardial infarction pathwayAgt
nadolol pharmacodynamics pathwayAgtr1a
nebivolol pharmacodynamics pathwayAgtr1a
nifedipine pharmacodynamics pathwayAgtr1a
nimodipine pharmacodynamics pathwayAgtr1a
nisoldipine pharmacodynamics pathwayAgtr1a
nitrendipine pharmacodynamics pathwayAgtr1a
nucleotide sugar metabolic pathwayRenbp
olmesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
penbutolol pharmacodynamics pathwayAgtr1a
perindopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
phenytoin pharmacodynamics pathwayAgtr1a
pindolol pharmacodynamics pathwayAgtr1a
procainamide pharmacodynamics pathwayAgtr1a
propranolol pharmacodynamics pathwayAgtr1a
quinapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
quinapril pharmacokinetics pathwayAce
quinidine pharmacodynamics pathwayAgtr1a
ramipril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
ramipril pharmacokinetics pathwayAce
renin-angiotensin cascade pathwayAce , Ace2 , Agt , Agtr1a , Agtr1b , Agtr2 , Anpep , Atp6ap2 , Cma1 , Cpa3 , Ctsa , Ctsg , Enpep , Igf2r , Lnpep , Mas1 , Mcpt8l2 , Mcpt8l3 , Mme , Nln , Ren , Renbp , Rnpep , Thop1
sialic acid storage disease pathwayRenbp
sleeping sickness pathwayThop1
sotalol pharmacodynamics pathwayAgtr1a
spirapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
spirapril pharmacokinetics pathwayAce
systemic lupus erythematosus pathwayCtsg , Mcpt8l2 , Mcpt8l3
Tay-Sachs disease pathwayRenbp
telmisartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
timolol pharmacodynamics pathwayAgtr1a
trandolapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
trandolapril pharmacokinetics pathwayAce
valsartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
verapamil pharmacodynamics pathwayAgtr1a
Phenotype Annotations Associated with Genes in the renin-angiotensin cascade pathway

References Associated with the renin-angiotensin cascade pathway:

Ontology Path Diagram:

paths to the root
paths to the root

Import into Pathway Studio: