RGD Reference Report - ACE/ACE2 ratio and MMP-9 activity as potential biomarkers in tuberculous pleural effusions. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ACE/ACE2 ratio and MMP-9 activity as potential biomarkers in tuberculous pleural effusions.

Authors: Hsieh, Wen-Yeh  Kuan, Tang-Ching  Cheng, Kun-Shan  Liao, Yan-Chiou  Chen, Mu-Yuan  Lin, Pei-Heng  Hsu, Yuan-Chang  Huang, Chen-Yi  Hsu, Wei-Hua  Yu, Sheng-Yao  Lin, Chih-Sheng 
Citation: Hsieh WY, etal., Int J Biol Sci. 2012;8(8):1197-205. doi: 10.7150/ijbs.5087. Epub 2012 Oct 17.
RGD ID: 40818411
Pubmed: PMID:23091417   (View Abstract at PubMed)
PMCID: PMC3477689   (View Article at PubMed Central)
DOI: DOI:10.7150/ijbs.5087   (Journal Full-text)


OBJECTIVE: Pleural effusion is common problem, but the rapid and reliable diagnosis for specific pathogenic effusions are lacking. This study aimed to identify the diagnosis based on clinical variables to differentiate pleural tuberculous exudates from other pleural effusions. We also investigated the role of renin-angiotensin system (RAS) and matrix metalloproteinase (MMPs) in the pathogenesis of pleural exudates.
EXPERIMENTAL DESIGN: The major components in RAS and extracellular matrix metabolism, including angiotensin converting enzyme (ACE), ACE2, MMP-2 and MMP-9 activities, were measured and compared in the patients with transudative (n = 45) and exudative (n = 80) effusions. The exudative effusions were come from the patients with tuberculosis (n = 20), pneumonia (n = 32), and adenocarcinoma (n = 28).
RESULTS: Increased ACE and equivalent ACE2 activities, resulting in a significantly increased ACE/ACE2 ratio in exudates, were detected compared to these values in transudates. MMP-9 activity in exudates was significantly higher than that in transudates. The significant correlation between ACE and ACE2 activity that was found in transudates was not found in exudates. Advanced analyses showed significantly increased ACE and MMP-9 activities, and decreased ACE2 activity in tuberculous pleural effusions compared with those in pneumonia and adenocarcinoma effusions. The results indicate that increased ACE and MMP-9 activities found in the exudates were mainly contributed from a higher level of both enzyme activities in the tuberculous pleural effusions.
CONCLUSION: Interplay between ACE and ACE2, essential functions in the RAS, and abnormal regulation of MMP-9 probably play a pivotal role in the development of exudative effusions. Moreover, the ACE/ACE2 ratio combined with MMP-9 activity in pleural fluid may be potential biomarkers for diagnosing tuberculous pleurisy.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
ACEHumanPleural Effusion  IEP associated with tuberculosis and protein:increased activity:pleural fluid (human)RGD 
ACE2HumanPleural Effusion  IEP associated with tuberculosis and protein:decreased activity:pleural fluid (human)RGD 
AceRatPleural Effusion  ISOACE (Homo sapiens)associated with tuberculosis and protein:increased activity:pleural fluid (human)RGD 
AceMousePleural Effusion  ISOACE (Homo sapiens)associated with tuberculosis and protein:increased activity:pleural fluid (human)RGD 
Ace2RatPleural Effusion  ISOACE2 (Homo sapiens)associated with tuberculosis and protein:decreased activity:pleural fluid (human)RGD 
Ace2MousePleural Effusion  ISOACE2 (Homo sapiens)associated with tuberculosis and protein:decreased activity:pleural fluid (human)RGD 


Genes (Rattus norvegicus)
Ace  (angiotensin I converting enzyme) Ace2  (angiotensin converting enzyme 2)

Genes (Mus musculus)
Ace  (angiotensin I converting enzyme) Ace2  (angiotensin converting enzyme 2)

Genes (Homo sapiens)
ACE  (angiotensin I converting enzyme) ACE2  (angiotensin converting enzyme 2)