Ace2 (angiotensin I converting enzyme 2) - Rat Genome Database
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Gene: Ace2 (angiotensin I converting enzyme 2) Rattus norvegicus
Analyze
Symbol: Ace2
Name: angiotensin I converting enzyme 2
RGD ID: 728890
Description: Exhibits carboxypeptidase activity. Involved in maternal process involved in female pregnancy; negative regulation of ERK1 and ERK2 cascade; and negative regulation of smooth muscle cell proliferation. Localizes to extracellular space and membrane. Used to study glaucoma; myocardial infarction; and thrombosis. Biomarker of hypertension; lung disease; middle cerebral artery infarction; myocardial infarction; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; avian influenza; diabetic retinopathy; respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin I converting enzyme 2); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 3-chloropropane-1,2-diol; 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; renal angiotensin-converting enzyme 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X30,293,597 - 30,340,961 (-)NCBI
Rnor_6.0 EnsemblX32,049,931 - 32,096,016 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X32,050,734 - 32,095,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X32,422,286 - 32,469,137 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,051,758 - 51,096,036 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X51,105,228 - 51,149,505 (-)NCBI
CeleraX30,638,123 - 30,683,403 (-)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S,S,S)-nicotianamine  (ISO)
1,2-dimethylhydrazine  (ISO)
14,15-EET  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
3-chloropropane-1,2-diol  (EXP)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (EXP)
8-Br-cAMP  (ISO)
aflatoxin B1  (EXP,ISO)
amphetamine  (EXP)
ampicillin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
aprindine  (ISO)
atorvastatin calcium  (EXP)
benazepril  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP)
bleomycin A2  (EXP)
cadmium dichloride  (EXP)
candesartan  (EXP)
Candesartan cilexetil  (EXP)
captopril  (EXP,ISO)
carbon nanotube  (ISO)
ceftriaxone  (EXP)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP)
DDE  (EXP)
diminazene  (ISO)
diminazene diaceturate  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
ethanol  (EXP)
etoposide  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
hydroquinone  (ISO)
hydroxyzine  (ISO)
imidapril  (ISO)
Iodine aqueous  (ISO)
irbesartan  (ISO)
isoprenaline  (EXP,ISO)
L-ascorbic acid  (ISO)
labetalol  (ISO)
lead diacetate  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP,ISO)
lisinopril dihydrate  (EXP)
losartan  (EXP,ISO)
Magnolol  (EXP)
metronidazole  (EXP)
monocrotaline  (EXP)
neomycin  (EXP)
nickel atom  (ISO)
nicotianamine  (ISO)
olmesartan  (EXP)
orphenadrine  (EXP)
paraquat  (EXP)
PD123319  (EXP)
pentanal  (ISO)
perindopril  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (EXP)
pirfenidone  (EXP)
pirinixic acid  (ISO)
pregabalin  (EXP)
quercetin  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (EXP)
spironolactone  (EXP)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
telmisartan  (EXP,ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trandolapril  (ISO)
tributylstannane  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vancomycin  (EXP)
xanthone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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15. Ferreira AJ, etal., Exp Physiol. 2011 Mar;96(3):287-94. doi: 10.1113/expphysiol.2010.055277. Epub 2010 Dec 10.
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17. Fraga-Silva RA, etal., Mol Med. 2010 May-Jun;16(5-6):210-5. doi: 10.2119/molmed.2009.00160. Epub 2010 Jan 22.
18. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. GOA data from the GO Consortium
20. Gu H, etal., Sci Rep. 2016 Jan 27;6:19840. doi: 10.1038/srep19840.
21. Hashimoto T, etal., Nature. 2012 Jul 25;487(7408):477-81. doi: 10.1038/nature11228.
22. Hassan AO, etal., Cell. 2020 Jun 10. pii: S0092-8674(20)30742-X. doi: 10.1016/j.cell.2020.06.011.
23. Hayashi N, etal., Hypertens Res. 2010 Nov;33(11):1182-5. doi: 10.1038/hr.2010.147. Epub 2010 Aug 12.
24. Herath CB, etal., J Hepatol. 2007 Sep;47(3):387-95. Epub 2007 Apr 2.
25. Hsieh WY, etal., Int J Biol Sci. 2012;8(8):1197-205. doi: 10.7150/ijbs.5087. Epub 2012 Oct 17.
26. Huang ML, etal., Clin Exp Pharmacol Physiol. 2009 Sep 28.
27. Imai Y, etal., Nature. 2005 Jul 7;436(7047):112-6. doi: 10.1038/nature03712.
28. Kuba K, etal., Nat Med. 2005 Aug;11(8):875-9. doi: 10.1038/nm1267. Epub 2005 Jul 10.
29. Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
30. Lee DK, etal., Endocrinology. 2005 Jan;146(1):231-6. Epub 2004 Oct 14.
31. Li W, etal., EMBO J. 2005 Apr 20;24(8):1634-43. doi: 10.1038/sj.emboj.7600640. Epub 2005 Mar 24.
32. Liu J, etal., Life Sci. 2018 Sep 1;208:139-148. doi: 10.1016/j.lfs.2018.07.013. Epub 2018 Jul 7.
33. Lu J, etal., Neuropeptides. 2013 Oct;47(5):289-95. doi: 10.1016/j.npep.2013.09.002. Epub 2013 Sep 18.
34. MGD data from the GO Consortium
35. Moon JY, etal., Nephron Exp Nephrol. 2008;110(1):e8-e16. Epub 2008 Aug 4.
36. Murca TM, etal., Regul Pept. 2012 Aug 20;177(1-3):107-15. doi: 10.1016/j.regpep.2012.05.093. Epub 2012 May 14.
37. Neves LA, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R151-61. Epub 2007 Oct 31.
38. Ocaranza MP, etal., Hypertension. 2006 Oct;48(4):572-8. Epub 2006 Aug 14.
39. Oudit GY, etal., Eur J Clin Invest. 2009 Jul;39(7):618-25. doi: 10.1111/j.1365-2362.2009.02153.x. Epub 2009 May 6.
40. Paizis G, etal., Gut. 2005 Dec;54(12):1790-6. doi: 10.1136/gut.2004.062398. Epub 2005 Sep 15.
41. Pipeline to import KEGG annotations from KEGG into RGD
42. Qi Y, etal., Hypertension. 2013 Oct;62(4):746-52. doi: 10.1161/HYPERTENSIONAHA.113.01337. Epub 2013 Aug 19.
43. Qin XT, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 May;33(5):438-42.
44. Qiu QM, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010 Apr;28(4):275-9.
45. Reich HN, etal., Kidney Int. 2008 Dec;74(12):1610-6. Epub 2008 Oct 1.
46. Reudelhuber TL Hypertension. 2006 May;47(5):811-5. Epub 2006 Mar 6.
47. RGD automated data pipeline
48. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
49. RGD automated import pipeline for gene-chemical interactions
50. Riviere G, etal., Hypertension. 2005 Nov;46(5):1169-74. Epub 2005 Oct 3.
51. Shenoy V, etal., Am J Respir Crit Care Med. 2010 Jun 25.
52. Shenoy V, etal., Hypertension. 2014 Dec;64(6):1248-59. doi: 10.1161/HYPERTENSIONAHA.114.03871. Epub 2014 Sep 15.
53. Shil PK, etal., Mol Ther. 2014 Dec;22(12):2069-2082. doi: 10.1038/mt.2014.179. Epub 2014 Sep 17.
54. Sodhi CP, etal., J Immunol. 2019 Dec 1;203(11):3000-3012. doi: 10.4049/jimmunol.1900579. Epub 2019 Oct 23.
55. Tikellis C, etal., Diabetes. 2008 Apr;57(4):1018-25. Epub 2008 Jan 30.
56. Towler P, etal., J Biol Chem. 2004 Apr 23;279(17):17996-8007. Epub 2004 Jan 30.
57. Verma A, etal., Mol Ther Methods Clin Dev. 2019 Jul 10;14:161-170. doi: 10.1016/j.omtm.2019.06.007. eCollection 2019 Sep 13.
58. Verma A, etal., Mol Ther. 2012 Jan;20(1):28-36. doi: 10.1038/mt.2011.155. Epub 2011 Jul 26.
59. Wang G, etal., Am J Nephrol. 2009;29(6):524-31. Epub 2008 Dec 12.
60. Wang G, etal., Kidney Blood Press Res. 2011;34(3):141-9. doi: 10.1159/000324521. Epub 2011 Feb 24.
61. Yan QN, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2008 Aug;28(8):1365-8.
62. Yang P, etal., Sci Rep. 2014 Nov 13;4:7027. doi: 10.1038/srep07027.
63. Yang XH, etal., Comp Med. 2007 Oct;57(5):450-9.
64. Zhao YX, etal., Hum Gene Ther. 2010 Nov;21(11):1545-54. doi: 10.1089/hum.2009.160.
65. Zhong J, etal., J Lab Clin Med. 2006 Feb;147(2):91-5.
66. Zhong JC, etal., Regul Pept. 2011 Jan 17;166(1-3):90-7. doi: 10.1016/j.regpep.2010.09.005. Epub 2010 Sep 18.
67. Zhou L, etal., Tohoku J Exp Med. 2009 Feb;217(2):123-31.
68. Zou Z, etal., Nat Commun. 2014 May 6;5:3594. doi: 10.1038/ncomms4594.
Additional References at PubMed
PMID:10924499   PMID:10969042   PMID:11815627   PMID:12623933   PMID:12874086   PMID:12967627   PMID:14647384   PMID:15007027   PMID:15283675   PMID:15380922   PMID:15452268   PMID:15833808  
PMID:15949646   PMID:16009784   PMID:16027241   PMID:16176966   PMID:16710353   PMID:17308000   PMID:17903697   PMID:18250366   PMID:18258853   PMID:18296494   PMID:18343844   PMID:18419956  
PMID:18497476   PMID:18654024   PMID:18768926   PMID:18809792   PMID:18849338   PMID:18926065   PMID:18945956   PMID:19056867   PMID:19185582   PMID:19221212   PMID:19389807   PMID:19424597  
PMID:19927150   PMID:20518313   PMID:20584672   PMID:21053061   PMID:21068237   PMID:21186379   PMID:21351633   PMID:21436210   PMID:21536991   PMID:21880865   PMID:21952934   PMID:21963832  
PMID:22198016   PMID:22286369   PMID:22378820   PMID:22613639   PMID:22715807   PMID:22811473   PMID:22943692   PMID:23141017   PMID:23174757   PMID:23533145   PMID:23535237   PMID:23652350  
PMID:23706365   PMID:23823602   PMID:23873801   PMID:24114819   PMID:24168260   PMID:24227843   PMID:24417403   PMID:24558317   PMID:24741027   PMID:24781988   PMID:24782646   PMID:24877125  
PMID:25031298   PMID:25194129   PMID:25194138   PMID:25217176   PMID:25426615   PMID:25575522   PMID:25766467   PMID:25768373   PMID:25941346   PMID:26010093   PMID:26016560   PMID:26196539  
PMID:27050934   PMID:27085217   PMID:27302421   PMID:28423630   PMID:28656296   PMID:28748720   PMID:29146157   PMID:30006298   PMID:30318562   PMID:30335496   PMID:30628484   PMID:30816157  
PMID:31346990   PMID:32513532   PMID:32979558  


Genomics

Comparative Map Data
Ace2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X30,293,597 - 30,340,961 (-)NCBI
Rnor_6.0 EnsemblX32,049,931 - 32,096,016 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X32,050,734 - 32,095,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X32,422,286 - 32,469,137 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,051,758 - 51,096,036 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X51,105,228 - 51,149,505 (-)NCBI
CeleraX30,638,123 - 30,683,403 (-)NCBICelera
Cytogenetic MapXq14NCBI
ACE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX15,494,566 - 15,607,236 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 EnsemblX15,561,033 - 15,602,148 (-)EnsemblGRCh38hg38GRCh38
GRCh38X15,518,197 - 15,602,158 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X15,579,156 - 15,620,192 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37X15,536,320 - 15,620,281 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,489,077 - 15,529,058 (-)NCBINCBI36hg18NCBI36
Build 34X15,338,812 - 15,378,794NCBI
CeleraX19,694,648 - 19,735,682 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX13,333,989 - 13,374,656 (-)NCBIHuRef
CHM1_1X15,610,102 - 15,651,154 (-)NCBICHM1_1
Ace2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,922,338 - 162,971,414 (+)NCBIGRCm39mm39
GRCm38X164,139,342 - 164,188,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,577,274 - 160,626,350 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X159,484,737 - 159,532,523 (+)NCBImm8
CeleraX147,353,722 - 147,402,904 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.12NCBI
Ace2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,591,248 - 2,633,495 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,591,229 - 2,643,705 (+)NCBIChiLan1.0ChiLan1.0
ACE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X15,470,896 - 15,510,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,470,896 - 15,510,891 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X8,189,267 - 8,229,415 (-)NCBIMhudiblu_PPA_v0panPan3
ACE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX11,798,839 - 11,900,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X11,798,839 - 11,839,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ace2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364704,964,526 - 5,011,808 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,099,853 - 12,151,275 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,099,849 - 12,152,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,061,317 - 13,089,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACE2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,032,231 - 14,094,163 (-)NCBI
ChlSab1.1 EnsemblX14,030,233 - 14,077,785 (-)Ensembl
Ace2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624829344,823 - 391,451 (-)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X144092703Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X166260933443848Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X428214049282140Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X595407850954078Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X15688119127888215Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1815335263153352Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2159262344320739Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2159262344468300Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:69
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000049947
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 4 31 16 11
Low 1 31 25 13 10 13 5 5 68 4 17 5
Below cutoff 6 26 26 9 26 3 5 6 8 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000049947   ⟹   ENSRNOP00000047913
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX32,050,736 - 32,095,867 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080730   ⟹   ENSRNOP00000070410
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX32,049,931 - 32,096,016 (-)Ensembl
RefSeq Acc Id: NM_001012006   ⟹   NP_001012006
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X30,294,401 - 30,339,688 (-)NCBI
Rnor_6.0X32,050,734 - 32,095,860 (-)NCBI
Rnor_5.0X32,422,286 - 32,469,137 (-)NCBI
RGSC_v3.4X51,051,758 - 51,096,036 (-)RGD
CeleraX30,638,123 - 30,683,403 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099654   ⟹   XP_038955582
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X30,293,597 - 30,340,961 (-)NCBI
RefSeq Acc Id: XM_039099655   ⟹   XP_038955583
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X30,293,597 - 30,340,961 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001012006   ⟸   NM_001012006
- Peptide Label: precursor
- UniProtKB: Q5EGZ1 (UniProtKB/Swiss-Prot),   C7ECU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070410   ⟸   ENSRNOT00000080730
RefSeq Acc Id: ENSRNOP00000047913   ⟸   ENSRNOT00000049947
RefSeq Acc Id: XP_038955583   ⟸   XM_039099655
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038955582   ⟸   XM_039099654
- Peptide Label: isoform X1
Protein Domains
Collectrin

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
ACE2 pdb 1r42 Q5EGZ1 18-708 view protein structure  

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701802
Promoter ID:EPDNEW_R12321
Type:single initiation site
Name:Ace2_1
Description:angiotensin I converting enzyme 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X32,095,833 - 32,095,893EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:728890 AgrOrtholog
Ensembl Genes ENSRNOG00000031665 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000047913 UniProtKB/TrEMBL
  ENSRNOP00000070410 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049947 UniProtKB/TrEMBL
  ENSRNOT00000080730 ENTREZGENE, UniProtKB/TrEMBL
InterPro Collectrin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:302668 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 302668 ENTREZGENE
PANTHER PTHR10514 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Collectrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ACE2 RGD
PhenoGen Ace2 PhenoGen
PRINTS PEPDIPTASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
UniProt A0A0G2JXU8_RAT UniProtKB/TrEMBL
  ACE2_RAT UniProtKB/Swiss-Prot
  C7ECU5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYK4_RAT UniProtKB/TrEMBL
  Q5EGZ1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-19 Ace2  angiotensin I converting enzyme 2  Ace2  angiotensin I converting enzyme (peptidyl-dipeptidase A) 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Ace2  angiotensin I converting enzyme (peptidyl-dipeptidase A) 2      Symbol and Name status set to approved 1299863 APPROVED
2005-02-22 Ace2        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process mouse homolog has a role in regulation of cardiac contractility, regulation of the expression of hypoxia-regulated genes and modulating the levels of Angiotesin 1 and 2 629626
gene_regulation expression is downregulated in hypertensive rats 629626