Gene: Ace2 (angiotensin I converting enzyme 2) Rattus norvegicus
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Symbol:
Ace2
Name:
angiotensin I converting enzyme 2
Description:
Exhibits carboxypeptidase activity. Involved in maternal process involved in female pregnancy; negative regulation of ERK1 and ERK2 cascade; and negative regulation of smooth muscle cell proliferation. Localizes to the extracellular space and membrane. Used to study glaucoma; myocardial infarction; and thrombosis. Biomarker of hypertension; lung disease; middle cerebral artery infarction; myocardial infarction; and primary biliary cirrhosis. Human ortholog(s) of this gene implicated in diabetic retinopathy and hypertension. Orthologous to human ACE2 (angiotensin I converting enzyme 2); PARTICIPATES IN renin-angiotensin cascade pathway; INTERACTS WITH 3-chloropropane-1,2-diol; 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile; aflatoxin B1.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; renal angiotensin-converting enzyme 2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ACE2 (angiotensin I converting enzyme 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):
Ace2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2) HGNC
EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ace2 (angiotensin I converting enzyme 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ACE2 (angiotensin I converting enzyme 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ACE2 (angiotensin I converting enzyme 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ace2 (angiotensin I converting enzyme 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ACE2 (angiotensin I converting enzyme 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
ACE2 (angiotensin I converting enzyme 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Ace2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
ace2 (angiotensin I converting enzyme 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
acn-1
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
Ance-5
Alliance
DIOPT (Ensembl Compara, PANTHER, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 32,050,734 - 32,095,860 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 32,049,931 - 32,096,016 (-) Ensembl Rnor_5.0 X 32,422,286 - 32,469,137 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 51,051,758 - 51,096,036 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 X 51,105,228 - 51,149,505 (-) NCBI Celera X 30,638,123 - 30,683,403 (-) NCBI Celera Cytogenetic Map X q14 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
Cardiac Fibrosis treatment IEP 9685434 associated with Hypertension RGD Coronary Disease susceptibility ISO RGD:1347174 2313798 associated with Diabetes Mellitus, Non-Insulin-Dependent, DNA:polymorphism: :8790G>A (human) RGD Diabetes Mellitus, Experimental IEP 2313799 protein:altered expression:kidney RGD Diabetic Cardiomyopathies treatment IDA 9685456 associated with Diabetes Mellitus, Experimental RGD Diabetic Nephropathies ISO RGD:1347174 2313796 mRNA, protein:altered expression:kidney RGD Diabetic Nephropathies ISO RGD:1347174 2313797 associated with Diabetes Mellitus, Non-Insulin Dependent, mRNA, protein:decreased expression:kidney RGD Diabetic Nephropathies ISO RGD:1550521 2313800 associated with Diabetes Mellitus, Experimental RGD Diabetic Nephropathies no_association ISO RGD:1347174 2313800 associated with Diabetes Mellitus, Insulin-Dependent, DNA:polymorphisms: :multiple (human) RGD diabetic retinopathy treatment ISO RGD:1347174 8548900 associated with Diabetes Mellitus, Experimental RGD Experimental Liver Cirrhosis IEP 2316776 protein:increased expression:liver RGD glaucoma treatment IDA 9685447 RGD hypertension IEP 9685442 mRNA, protein:decreased expression:aorta RGD hypertension ISO RGD:1347174 1642828 associated with Metabolic Syndrome X (MeSH:D024821) RGD hypertension treatment ISO RGD:1550521 9685435 RGD hypertension treatment IEP 9685433 RGD Hypertension, Pregnancy-Induced IEP 8548898 RGD Kidney Reperfusion Injury IEP 9685432 mRNA:decreased expression:kidney RGD Left Ventricular Hypertrophy IEP 9685455 RGD lung disease IEP 4140485 associated with Poisoning, mRNA:decreased expression:lung RGD middle cerebral artery infarction IEP 9685436 mRNA, protein:increased expression:brain RGD myocardial infarction treatment IDA 9685449 RGD myocardial infarction IEP 1558664 mRNA:increased expression:myocardium RGD pancreatic ductal carcinoma ISO RGD:1347174 2325210 protein:decreased expression:pancreas RGD primary biliary cirrhosis IEP 9685452 mRNA, protein:increased expression:liver RGD pulmonary fibrosis ISO RGD:1550521 4140483 associated with Lung Injury, protein:decreased expression:lung RGD thrombosis treatment IDA 9685451 RGD Ventricular Remodeling treatment IEP 9685440 associated with Acute Kidney Injury RGD Ventricular Remodeling treatment ISO RGD:1550521 9685439 associated with Myocardial Infarction RGD Ventricular Remodeling treatment ISO RGD:1550521 9685428 associated with Diabetic Cardiomyopathies RGD
Imported Annotations - ClinVar
autistic disorder ISO RGD:1347174 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 Neurodevelopmental Disorders ISO RGD:1347174 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868 syndromic X-linked intellectual disability Lubs type ISO RGD:1347174 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868
Imported Annotations - CTD
abdominal aortic aneurysm ISO RGD:1347174 11554173 CTD Direct Evidence: therapeutic CTD PMID:25301841 Diabetic Nephropathies ISO RGD:1347174 11554173 CTD Direct Evidence: therapeutic CTD PMID:20844835 endomyocardial fibrosis ISO RGD:1347174 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19221212 hypertension ISO RGD:1347174 11554173 CTD Direct Evidence: marker/mechanism, therapeutic CTD PMID:15833808 more ... Spontaneous Abortions ISO RGD:1347174 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18539642 Imported Annotations - MGI
congestive heart failure ISS RGD:1550521 13592920 MouseDO
14,15-EET multiple interactions ISO RGD:1550521 6480464 14 more ... CTD PMID:27428043 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of ACE2 mRNA CTD PMID:28522335 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile increases expression EXP 6480464 Fadrozole results in increased expression of ACE2 protein CTD PMID:18586661 8-bromo-3',5'-cyclic AMP increases expression ISO RGD:1347174 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ACE2 mRNA CTD PMID:22079614 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of ACE2 mRNA CTD PMID:23630614 aflatoxin B1 decreases methylation ISO RGD:1347174 6480464 Aflatoxin B1 results in decreased methylation of ACE2 gene CTD PMID:27153756 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of ACE2 mRNA CTD PMID:30779732 ampicillin multiple interactions EXP 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ACE2 protein CTD PMID:30545405 benazepril affects response to substance ISO RGD:1347174 6480464 ACE2 gene SNP affects the susceptibility to benazepril CTD PMID:20559404 benazepril multiple interactions ISO RGD:1347174 6480464 [AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril CTD PMID:21449848 Benzo[k]fluoranthene decreases expression ISO RGD:1550521 6480464 benzo(k)fluoranthene results in decreased expression of ACE2 mRNA CTD PMID:26377693 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ACE2 mRNA CTD PMID:25181051 cadmium dichloride increases methylation EXP 6480464 Cadmium Chloride results in increased methylation of ACE2 promoter CTD PMID:22457795 candesartan decreases expression EXP 6480464 candesartan results in decreased expression of ACE2 mRNA CTD PMID:18796534 Candesartan cilexetil increases expression EXP 6480464 candesartan cilexetil results in increased expression of ACE2 protein CTD PMID:22120037 carbon nanotube decreases expression ISO RGD:1550521 6480464 Nanotubes, Carbon analog results in decreased expression of ACE2 mRNA CTD PMID:25554681 chromium(6+) affects expression ISO RGD:1550521 6480464 chromium hexavalent ion affects the expression of ACE2 mRNA CTD PMID:28472532 cobalt dichloride decreases expression ISO RGD:1550521 6480464 cobaltous chloride results in decreased expression of ACE2 mRNA, cobaltous chloride results in decreased expression of ACE2 protein CTD PMID:25511041 cobalt dichloride increases expression ISO RGD:1347174 6480464 cobaltous chloride results in increased expression of ACE2 protein CTD PMID:29673971 copper(II) sulfate decreases expression ISO RGD:1347174 6480464 Copper Sulfate results in decreased expression of ACE2 mRNA CTD PMID:19549813 copper(II) sulfate decreases expression ISO RGD:1550521 6480464 Copper Sulfate results in decreased expression of ACE2 mRNA CTD PMID:18579281 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of ACE2 mRNA CTD PMID:21865292 diminazene diaceturate increases expression ISO RGD:1550521 6480464 diminazene aceturate results in increased expression of ACE2 mRNA, diminazene aceturate results in increased expression of ACE2 protein CTD PMID:25301841 dioxygen decreases expression ISO RGD:1550521 6480464 Oxygen deficiency results in decreased expression of ACE2 mRNA, Oxygen deficiency results in decreased expression of ACE2 protein CTD PMID:25511041 dioxygen multiple interactions ISO RGD:1550521 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ACE2 mRNA, Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of ACE2 protein] CTD PMID:25511041 , PMID:30529165 dorsomorphin multiple interactions ISO RGD:1347174 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACE2 mRNA CTD PMID:27188386 doxorubicin increases expression ISO RGD:1347174 6480464 Doxorubicin results in increased expression of ACE2 mRNA CTD PMID:28940058 , PMID:30031762 doxorubicin decreases expression ISO RGD:1347174 6480464 Doxorubicin results in decreased expression of ACE2 mRNA CTD PMID:29803840 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of ACE2 mRNA CTD PMID:29548890 etoposide increases expression ISO RGD:1347174 6480464 Etoposide results in increased expression of ACE2 mRNA CTD PMID:29397400 gentamycin multiple interactions EXP 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ACE2 protein CTD PMID:30545405 GW 4064 increases expression ISO RGD:1550521 6480464 GW 4064 results in increased expression of ACE2 mRNA CTD PMID:26655953 hydroquinone decreases expression ISO RGD:1347174 6480464 hydroquinone results in decreased expression of ACE2 mRNA CTD PMID:31256213 Iodine aqueous multiple interactions ISO RGD:1347174 6480464 Lugol's solution inhibits the reaction [potassium perchlorate results in increased expression of ACE2 protein] CTD PMID:29673971 irbesartan affects response to substance ISO RGD:1347174 6480464 ACE2 gene polymorphism affects the susceptibility to irbesartan CTD PMID:11593098 isoprenaline increases expression ISO RGD:1550521 6480464 Isoproterenol results in increased expression of ACE2 mRNA CTD PMID:20003209 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of ACE2 protein CTD PMID:20409916 L-ascorbic acid multiple interactions ISO RGD:1347174 6480464 [Quercetin co-treated with Ascorbic Acid] results in decreased expression of ACE2 mRNA CTD PMID:17639512 lead diacetate decreases expression ISO RGD:1550521 6480464 lead acetate results in decreased expression of ACE2 mRNA CTD PMID:22613225 levonorgestrel multiple interactions ISO RGD:1347174 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of ACE2 mRNA CTD PMID:19074003 losartan multiple interactions EXP 6480464 Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA] more ... CTD PMID:16176966 , PMID:20178811 losartan multiple interactions ISO RGD:1550521 6480464 Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of ACE2 protein] CTD PMID:25511041 metronidazole multiple interactions EXP 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ACE2 protein CTD PMID:30545405 neomycin multiple interactions EXP 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ACE2 protein CTD PMID:30545405 nickel atom increases expression ISO RGD:1347174 6480464 Nickel results in increased expression of ACE2 mRNA CTD PMID:24768652 olmesartan increases expression EXP 6480464 olmesartan results in increased expression of ACE2 mRNA CTD PMID:19171689 orphenadrine affects expression EXP 6480464 Orphenadrine affects the expression of ACE2 mRNA CTD PMID:23665939 paraquat multiple interactions EXP 6480464 Unithiol inhibits the reaction [Paraquat results in decreased expression of ACE2 mRNA] CTD PMID:20465954 paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of ACE2 mRNA CTD PMID:20465954 pentanal increases expression ISO RGD:1347174 6480464 pentanal results in increased expression of ACE2 mRNA CTD PMID:26079696 phenylmercury acetate increases expression ISO RGD:1347174 6480464 Phenylmercuric Acetate results in increased expression of ACE2 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1347174 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACE2 mRNA CTD PMID:27188386 pirinixic acid multiple interactions ISO RGD:1347174 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ACE2 mRNA CTD PMID:19710929 quercetin multiple interactions ISO RGD:1347174 6480464 [Quercetin co-treated with Ascorbic Acid] results in decreased expression of ACE2 mRNA CTD PMID:17639512 SB 431542 multiple interactions ISO RGD:1347174 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACE2 mRNA CTD PMID:27188386 silver atom increases expression EXP 6480464 Silver results in increased expression of ACE2 mRNA CTD PMID:26277626 silver(0) increases expression EXP 6480464 Silver results in increased expression of ACE2 mRNA CTD PMID:26277626 sirolimus decreases expression EXP 6480464 Sirolimus results in decreased expression of ACE2 mRNA CTD PMID:21865292 spironolactone increases expression EXP 6480464 Spironolactone results in increased expression of ACE2 protein CTD PMID:18586661 streptozocin decreases expression ISO RGD:1550521 6480464 Streptozocin results in decreased expression of ACE2 protein CTD PMID:21381899 streptozocin multiple interactions EXP 6480464 ACE2 inhibits the reaction [Streptozocin results in increased expression of AGT protein modified form] more ... CTD PMID:20844835 streptozocin multiple interactions ISO RGD:1550521 6480464 telmisartan inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein] CTD PMID:21381899 tacrolimus hydrate decreases expression EXP 6480464 Tacrolimus results in decreased expression of ACE2 mRNA CTD PMID:21865292 telmisartan multiple interactions ISO RGD:1550521 6480464 telmisartan inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein] CTD PMID:21381899 testosterone undecanoate multiple interactions ISO RGD:1347174 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of ACE2 mRNA CTD PMID:19074003 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of ACE2 mRNA, titanium dioxide results in increased expression of ACE2 protein CTD PMID:26277626 trandolapril multiple interactions ISO RGD:1550521 6480464 trandolapril promotes the reaction [REN2 protein results in increased expression of ACE2 protein] CTD PMID:27428043 triclosan decreases expression ISO RGD:1347174 6480464 Triclosan results in decreased expression of ACE2 mRNA CTD PMID:28940058 valproic acid affects expression ISO RGD:1347174 6480464 Valproic Acid affects the expression of ACE2 mRNA CTD PMID:25979313 valsartan multiple interactions EXP 6480464 Valsartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA] CTD PMID:16176966 vancomycin multiple interactions EXP 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ACE2 protein CTD PMID:30545405 xanthone multiple interactions EXP 6480464 xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein], xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] CTD PMID:25205467
Biological Process angiotensin-mediated drinking behavior ISO RGD:1347174 1624291 (PMID:18258853) RGD PMID:18258853 angiotensin-mediated drinking behavior IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 maternal process involved in female pregnancy IEP 8548898 RGD negative regulation of ERK1 and ERK2 cascade IMP 9685431 RGD negative regulation of smooth muscle cell proliferation IMP 9685431 RGD positive regulation of amino acid transport IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of amino acid transport ISO RGD:1347174 1624291 (PMID:19185582) RGD PMID:19185582 positive regulation of cardiac muscle contraction ISO RGD:1550521 1624291 (MGI:MGI:2181229, PMID:12075344) RGD MGI:MGI:2181229 , PMID:12075344 positive regulation of cardiac muscle contraction IEA UniProtKB:Q8R0I0 , ensembl:ENSMUSP000001078901600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of gap junction assembly ISO RGD:1347174 1624291 (PMID:12967627) RGD PMID:12967627 positive regulation of gap junction assembly IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 proteolysis IEA UniRule:UR000127453 1600115 GO_REF:0000104 UniProt GO_REF:0000104 proteolysis IEA UniProtKB-KW:KW-0645 1600115 GO_REF:0000037 UniProt GO_REF:0000037 receptor biosynthetic process ISO RGD:1347174 1624291 (PMID:18258853) RGD PMID:18258853 receptor biosynthetic process IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 receptor-mediated virion attachment to host cell ISO RGD:1347174 1624291 (PMID:18343844) RGD PMID:18343844 receptor-mediated virion attachment to host cell IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of cardiac conduction ISO RGD:1347174 1624291 (PMID:12967627) RGD PMID:12967627 regulation of cardiac conduction IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of systemic arterial blood pressure by renin-angiotensin ISO RGD:1347174 1624291 (PMID:18258853) RGD PMID:18258853 tryptophan transport ISO RGD:1550521 1624291 (MGI:MGI:5433234, PMID:22837003) RGD MGI:MGI:5433234 , PMID:22837003 tryptophan transport IEA UniProtKB:Q8R0I0 , ensembl:ENSMUSP000001078901600115 GO_REF:0000107 Ensembl GO_REF:0000107 viral entry into host cell IEA GO:0001618 1600115 GO_REF:0000108 GOC GO_REF:0000108 Cellular Component brush border membrane IEA UniProtKB:Q8R0I0 , ensembl:ENSMUSP000001078901600115 GO_REF:0000107 Ensembl GO_REF:0000107 brush border membrane ISO RGD:1550521 1624291 (MGI:MGI:3838678, PMID:19185582) RGD MGI:MGI:3838678 , PMID:19185582 cell surface ISO RGD:1347174 1624291 (PMID:18343844), (PMID:24227843) RGD PMID:18343844 , PMID:24227843 cell surface ISS UniProtKB:Q9BYF1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cell surface IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytoplasm ISO RGD:1550521 1624291 (MGI:MGI:5582870, PMID:23535237) RGD MGI:MGI:5582870 , PMID:23535237 cytoplasm IEA UniProtKB-SubCell:SL-0086 1600115 GO_REF:0000039 UniProt GO_REF:0000039 cytoplasm IEA UniProtKB:Q8R0I0 , ensembl:ENSMUSP000001078901600115 GO_REF:0000107 Ensembl GO_REF:0000107 extracellular region ISO RGD:1347174 1624291 (PMID:10969042) RGD PMID:10969042 extracellular space IDA 9685440 RGD extracellular space IBA FB:FBgn0012037 more ... 13792537 PMID:21873635 GO_Central extracellular space ISO RGD:1347174 1624291 (PMID:18258853) RGD PMID:18258853 extracellular space IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000037 UniProt GO_REF:0000037 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000038 UniProt GO_REF:0000038 membrane IDA 2313801 RGD plasma membrane ISO RGD:1347174 1624291 (PMID:21068237) RGD PMID:21068237 plasma membrane IBA MGI:MGI:1917258 more ... 13792537 PMID:21873635 GO_Central plasma membrane ISS UniProtKB:Q9BYF1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 plasma membrane ISO RGD:1550521 1624291 (MGI:MGI:5582870, PMID:23535237) RGD MGI:MGI:5582870 , PMID:23535237 Molecular Function carboxypeptidase activity ISO RGD:1347174 1624291 (PMID:10924499), (PMID:10969042), (PMID:15283675), (PMID:15380922), (PMID:18258853) RGD PMID:10924499 more ... carboxypeptidase activity IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 carboxypeptidase activity IEA UniProtKB-KW:KW-0121 1600115 GO_REF:0000038 UniProt GO_REF:0000038 carboxypeptidase activity IDA 9685456 PMID:22595130 CACAO dipeptidyl-peptidase activity IBA PANTHER:PTN000053976 more ... 13792537 PMID:21873635 GO_Central endopeptidase activity ISO RGD:1347174 1624291 (PMID:15283675) RGD PMID:15283675 endopeptidase activity IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 exopeptidase activity IBA FB:FBgn0012037 more ... 13792537 PMID:21873635 GO_Central exopeptidase activity IBA PANTHER:PTN001630211 , UniProtKB:P12821 13792537 PMID:21873635 GO_Central metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000037 UniProt GO_REF:0000037 metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000038 UniProt GO_REF:0000038 metallocarboxypeptidase activity ISO RGD:1347174 1624291 (PMID:10924499), (PMID:10969042), (PMID:11815627) RGD PMID:10924499 more ... metallopeptidase activity NOT ISO RGD:1347174 1624291 (PMID:10924499) RGD PMID:10924499 metallopeptidase activity IBA MGI:MGI:87874 more ... 13792537 PMID:21873635 GO_Central metallopeptidase activity IEA UniProtKB-KW:KW-0482 1600115 GO_REF:0000038 UniProt GO_REF:0000038 peptidyl-dipeptidase activity IEA InterPro:IPR001548 1600115 GO_REF:0000002 InterPro GO_REF:0000002 peptidyl-dipeptidase activity IBA FB:FBgn0012037 more ... 13792537 PMID:21873635 GO_Central peptidyl-dipeptidase activity NOT ISO RGD:1347174 1624291 (PMID:10924499) RGD PMID:10924499 protein binding ISO RGD:1347174 1624291 UniProtKB:O15393 more ... RGD PMID:18343844 more ... protein binding ISO RGD:1550521 1624291 UniProtKB:Q9D687 (MGI:MGI:3838678 , PMID:19185582) RGD MGI:MGI:3838678 , PMID:19185582 virus receptor activity ISO RGD:1347174 1624291 (PMID:18343844), (PMID:24227843) RGD PMID:18343844 , PMID:24227843 virus receptor activity ISS UniProtKB:Q9BYF1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 virus receptor activity IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
