Gene: Ace2 (angiotensin I converting enzyme 2) Rattus norvegicus
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Symbol:
Ace2
Name:
angiotensin I converting enzyme 2
RGD ID:
728890
Description:
Exhibits carboxypeptidase activity. Involved in maternal process involved in female pregnancy; negative regulation of ERK1 and ERK2 cascade; and negative regulation of smooth muscle cell proliferation. Localizes to extracellular space and membrane. Used to study glaucoma; myocardial infarction; and thrombosis. Biomarker of hypertension; lung disease; middle cerebral artery infarction; myocardial infarction; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; avian influenza; diabetic retinopathy; respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin I converting enzyme 2); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH 3-chloropropane-1,2-diol; 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile; aflatoxin B1.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; renal angiotensin-converting enzyme 2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ACE2 (angiotensin I converting enzyme 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):
Ace2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2) HGNC
EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ace2 (angiotensin I converting enzyme 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ACE2 (angiotensin I converting enzyme 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ACE2 (angiotensin I converting enzyme 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ace2 (angiotensin I converting enzyme 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ACE2 (angiotensin I converting enzyme 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
ACE2 (angiotensin I converting enzyme 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Ace2 (angiotensin I converting enzyme 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
ACE2 (angiotensin I converting enzyme 2)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Mus musculus (house mouse):
Ace2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Danio rerio (zebrafish):
ace2 (angiotensin I converting enzyme 2)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Drosophila melanogaster (fruit fly):
Acer
Alliance
DIOPT (InParanoid|OMA|OrthoFinder|PANTHER|PhylomeDB)
Drosophila melanogaster (fruit fly):
Ance
Alliance
DIOPT (InParanoid|OMA|OrthoFinder|PANTHER|PhylomeDB)
Drosophila melanogaster (fruit fly):
Ance-3
Alliance
DIOPT (Ensembl Compara|InParanoid|OMA|OrthoFinder|PANTHER|PhylomeDB)
Caenorhabditis elegans (roundworm):
acn-1
Alliance
DIOPT (Ensembl Compara|InParanoid|OMA|OrthoFinder|OrthoInspector|PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 32,050,734 - 32,095,860 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 32,049,931 - 32,096,016 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 X 32,422,286 - 32,469,137 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 51,051,758 - 51,096,036 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 X 51,105,228 - 51,149,505 (-) NCBI Celera X 30,638,123 - 30,683,403 (-) NCBI Celera Cytogenetic Map X q14 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
RGD Manual Annotations
Acute Lung Injury ISO RGD:1550521 40818412 associated with avian influenza, protein:decreased expression:lung (mouse) RGD Acute Lung Injury severity ISO RGD:1550521 32716389 RGD Acute Lung Injury treatment ISO RGD:1347174 32716389 human protein in a mouse model RGD Acute Lung Injury treatment ISO RGD:1550521 40400897 associated with Escherichia coli Infections RGD avian influenza treatment ISO RGD:1347174 32716391 human protein in a mouse model RGD avian influenza severity ISO RGD:1550521 32716391 RGD bacterial pneumonia ISO RGD:1550521 40818279 associated with Pseudomonas Infections, mRNA, protein:altered expression, altered activity:lung (mouse) RGD Cardiac Fibrosis treatment IEP 9685434 associated with Hypertension RGD Cardiovirus Infections ISO RGD:1550521 40818405 encephalomyocarditis virus, mRNA, protein:decreased expression, increased expression:heart (mouse) RGD cerebral malaria susceptibility ISO RGD:1347174 40818420 DNA:SNP:intron 1: C>T RGD chemical colitis severity ISO RGD:1550521 40818307 Ace2 knockout RGD chemical colitis severity ISO RGD:1550521 40818410 Ace2 inhibitor RGD congestive heart failure ISO RGD:1347174 40818416 mRNA, protein:increased expression:heart (human) RGD Coronary Disease susceptibility ISO RGD:1347174 2313798 associated with Diabetes Mellitus, Non-Insulin-Dependent, DNA:polymorphism: :8790G>A (human) RGD COVID-19 severity ISO RGD:1347174 32716393 DNA:insertion/deletion:intron 16: RGD COVID-19 ISO RGD:1347174 30310239 human gene in a mouse model RGD Diabetes Mellitus, Experimental IEP 2313799 protein:altered expression:kidney RGD Diabetic Cardiomyopathies treatment IDA 9685456 associated with Diabetes Mellitus, Experimental RGD Diabetic Nephropathies ISO RGD:1347174 2313796 mRNA, protein:altered expression:kidney RGD Diabetic Nephropathies ISO RGD:1347174 2313797 associated with Diabetes Mellitus, Non-Insulin Dependent, mRNA, protein:decreased expression:kidney RGD Diabetic Nephropathies ISO RGD:1550521 2313800 associated with Diabetes Mellitus, Experimental RGD Diabetic Nephropathies no_association ISO RGD:1347174 2313800 associated with Diabetes Mellitus, Insulin-Dependent, DNA:polymorphisms: :multiple (human) RGD diabetic retinopathy treatment ISO RGD:1347174 8548900 associated with Diabetes Mellitus, Experimental RGD diabetic retinopathy treatment ISO RGD:1347174 40818278 human gene in a mouse model RGD Experimental Autoimmune Uveoretinitis treatment ISO RGD:1347174 40818264 human gene in a mouse model RGD Experimental Liver Cirrhosis IEP 2316776 protein:increased expression:liver RGD Experimental Liver Cirrhosis IEP 40818265 mRNA, protein:increased expression, increased activity:liver (rat) RGD glaucoma treatment IDA 9685447 RGD hypertension IEP 629626 mRNA, protein:decreased expression:kidney (rat) RGD hypertension ISO RGD:1347174 1642828 associated with Metabolic Syndrome X (MeSH:D024821) RGD hypertension treatment ISO RGD:1550521 9685435 RGD hypertension treatment IEP 9685433 RGD hypertension IEP 9685442 mRNA, protein:decreased expression:aorta RGD Hypertensive Nephrosclerosis severity ISO RGD:1347174 40818408 mRNA, protein:decreased expression, increased expression:nephron tubule, kidney interstitium (human) RGD hypertrophic cardiomyopathy ISO RGD:1347174 40818260 mRNA, protein:increased expression:myocardium (human) RGD Kidney Reperfusion Injury IEP 9685432 mRNA:decreased expression:kidney RGD Left Ventricular Hypertrophy IEP 9685455 RGD lung disease IEP 4140485 associated with Poisoning, mRNA:decreased expression:lung RGD middle cerebral artery infarction IEP 9685436 mRNA, protein:increased expression:brain RGD myocardial infarction treatment IDA 9685449 RGD myocardial infarction IEP 1558664 mRNA:increased expression:myocardium RGD pancreatic ductal carcinoma ISO RGD:1347174 2325210 protein:decreased expression:pancreas RGD Pleural Effusion ISO RGD:1347174 40818411 associated with tuberculosis, protein:decreased activity:pleural fluid (human) RGD Pregnancy-Induced Hypertension IEP 8548898 RGD primary biliary cholangitis IEP 9685452 mRNA, protein:increased expression:liver RGD pulmonary fibrosis ISO RGD:1550521 4140483 associated with Lung Injury, protein:decreased expression:lung RGD pulmonary hypertension treatment ISO RGD:1347174 40818280 human protein in a rat model RGD respiratory syncytial virus infectious disease severity ISO RGD:1550521 32716392 RGD respiratory syncytial virus infectious disease treatment ISO RGD:1347174 32716392 human protein in a mouse model RGD severe acute respiratory syndrome ISO RGD:1550521 40818405 mRNA, protein:decreased expression:heart (mouse) RGD severe acute respiratory syndrome susceptibility ISO RGD:1347174 30309965 human gene in a mouse model RGD severe acute respiratory syndrome treatment ISO RGD:1347174 32716426 human gene in a mouse model RGD severe acute respiratory syndrome severity ISO RGD:1550521 30309202 RGD thrombosis treatment IDA 9685451 RGD Ventricular Remodeling treatment IEP 9685440 associated with Acute Kidney Injury RGD Ventricular Remodeling treatment ISO RGD:1550521 9685439 associated with Myocardial Infarction RGD Ventricular Remodeling treatment ISO RGD:1550521 9685428 associated with Diabetic Cardiomyopathies RGD
Imported Annotations - ClinVar
autistic disorder ISO RGD:1347174 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 Neurodevelopmental Disorders ISO RGD:1347174 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868 syndromic X-linked intellectual disability Lubs type ISO RGD:1347174 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868
Imported Annotations - CTD
abdominal aortic aneurysm ISO RGD:1347174 11554173 CTD Direct Evidence: therapeutic CTD PMID:25301841 adult respiratory distress syndrome ISO RGD:1347174 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22009550 cardiomyopathy ISO RGD:1347174 11554173 CTD Direct Evidence: therapeutic CTD PMID:28445944 congestive heart failure ISO RGD:1347174 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25973029 Coronavirus infectious disease ISO RGD:1347174 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14647384 more ... Diabetic Nephropathies ISO RGD:1347174 11554173 CTD Direct Evidence: marker/mechanism, therapeutic CTD PMID:12623933 more ... diabetic retinopathy ISO RGD:1347174 11554173 CTD Direct Evidence: therapeutic CTD PMID:31380462 endomyocardial fibrosis ISO RGD:1347174 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19221212 focal segmental glomerulosclerosis ISO RGD:1347174 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16723697 hypertension ISO RGD:1347174 11554173 CTD Direct Evidence: marker/mechanism, therapeutic CTD PMID:12075344 more ... Inflammation ISO RGD:1347174 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19453650 Lung Injury ISO RGD:1347174 11554173 CTD Direct Evidence: marker/mechanism, therapeutic CTD PMID:16001071 more ... pulmonary fibrosis ISO RGD:1347174 11554173 CTD Direct Evidence: therapeutic CTD PMID:27550926 pulmonary hypertension ISO RGD:1347174 11554173 CTD Direct Evidence: therapeutic CTD PMID:31931441 severe acute respiratory syndrome ISO RGD:1347174 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14647384 more ... Spontaneous Abortions ISO RGD:1347174 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18539642 Imported Annotations - MGI
COVID-19 ISS RGD:1550521 13592920 MouseDO
1,2-dimethylhydrazine decreases expression ISO RGD:1550521 6480464 1, 2-Dimethylhydrazine results in decreased expression of ACE2 mRNA CTD PMID:22206623 14,15-EET multiple interactions ISO RGD:1550521 6480464 14 more ... CTD PMID:27428043 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of ACE2 mRNA CTD PMID:28522335 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile increases expression EXP 6480464 Fadrozole results in increased expression of ACE2 protein CTD PMID:18586661 8-Br-cAMP increases expression ISO RGD:1347174 6480464 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ACE2 mRNA CTD PMID:22079614 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of ACE2 mRNA CTD PMID:23630614 aflatoxin B1 decreases methylation ISO RGD:1347174 6480464 Aflatoxin B1 results in decreased methylation of ACE2 gene CTD PMID:27153756 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of ACE2 mRNA CTD PMID:30779732 ampicillin multiple interactions EXP 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ACE2 protein CTD PMID:30545405 aprindine increases activity ISO RGD:1347174 6480464 Aprindine results in increased activity of ACE2 protein CTD PMID:21859683 atorvastatin calcium increases expression EXP 6480464 Atorvastatin results in increased expression of ACE2 mRNA CTD PMID:23390189 benazepril affects response to substance ISO RGD:1347174 6480464 ACE2 gene SNP affects the susceptibility to benazepril CTD PMID:20559404 benazepril increases response to substance ISO RGD:1347174 6480464 ACE2 gene SNP results in increased susceptibility to benazepril CTD PMID:27121444 benazepril multiple interactions ISO RGD:1347174 6480464 [AGT gene polymorphism co-treated with ACE2 gene polymorphism] affects the susceptibility to benazepril CTD PMID:21449848 benzo[a]pyrene affects methylation ISO RGD:1347174 6480464 Benzo(a)pyrene affects the methylation of ACE2 promoter CTD PMID:27901495 Benzo[k]fluoranthene decreases expression ISO RGD:1550521 6480464 benzo(k)fluoranthene results in decreased expression of ACE2 mRNA CTD PMID:26377693 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ACE2 mRNA CTD PMID:25181051 bleomycin A2 multiple interactions EXP 6480464 angiotensin I (1-7) inhibits the reaction [Bleomycin results in decreased expression of ACE2 mRNA] CTD PMID:20581171 bleomycin A2 decreases expression EXP 6480464 Bleomycin results in decreased expression of ACE2 mRNA CTD PMID:20581171 cadmium dichloride increases methylation EXP 6480464 Cadmium Chloride results in increased methylation of ACE2 promoter CTD PMID:22457795 candesartan decreases expression EXP 6480464 candesartan results in decreased expression of ACE2 mRNA CTD PMID:18796534 Candesartan cilexetil increases expression EXP 6480464 candesartan cilexetil results in increased expression of ACE2 protein CTD PMID:22120037 captopril multiple interactions EXP 6480464 Captopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein] CTD PMID:31629013 captopril decreases response to substance ISO RGD:1347174 6480464 ACE2 gene SNP results in decreased susceptibility to Captopril CTD PMID:17473847 carbon nanotube decreases expression ISO RGD:1550521 6480464 Nanotubes, Carbon analog results in decreased expression of ACE2 mRNA CTD PMID:25554681 ceftriaxone decreases expression EXP 6480464 Ceftriaxone results in decreased expression of ACE2 mRNA CTD PMID:29745864 chromium(6+) affects expression ISO RGD:1550521 6480464 chromium hexavalent ion affects the expression of ACE2 mRNA CTD PMID:28472532 cobalt dichloride decreases expression ISO RGD:1550521 6480464 cobaltous chloride results in decreased expression of ACE2 mRNA, cobaltous chloride results in decreased expression of ACE2 protein CTD PMID:25511041 cobalt dichloride increases expression ISO RGD:1347174 6480464 cobaltous chloride results in increased expression of ACE2 protein CTD PMID:29673971 copper(II) sulfate decreases expression ISO RGD:1347174 6480464 Copper Sulfate results in decreased expression of ACE2 mRNA CTD PMID:19549813 copper(II) sulfate decreases expression ISO RGD:1550521 6480464 Copper Sulfate results in decreased expression of ACE2 mRNA CTD PMID:18579281 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of ACE2 mRNA CTD PMID:21865292 DDE multiple interactions EXP 6480464 [Dietary Fats co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of ACE2 mRNA CTD PMID:30415545 diminazene increases activity ISO RGD:1347174 6480464 Diminazene results in increased activity of ACE2 protein CTD PMID:21859683 diminazene diaceturate increases expression ISO RGD:1550521 6480464 diminazene aceturate results in increased expression of ACE2 mRNA, diminazene aceturate results in increased expression of ACE2 protein CTD PMID:25301841 diminazene diaceturate increases expression EXP 6480464 diminazene aceturate results in increased expression of ACE2 protein CTD PMID:28688122 diminazene diaceturate multiple interactions EXP 6480464 PD 123319 inhibits the reaction [diminazene aceturate results in increased expression of ACE2 protein] CTD PMID:28688122 diminazene diaceturate increases activity ISO RGD:1550521 6480464 diminazene aceturate results in increased activity of ACE2 protein CTD PMID:27550926 , PMID:31982938 dioxygen decreases expression ISO RGD:1550521 6480464 Oxygen deficiency results in decreased expression of ACE2 mRNA, Oxygen deficiency results in decreased expression of ACE2 protein CTD PMID:25511041 dioxygen multiple interactions ISO RGD:1550521 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of ACE2 mRNA, Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of ACE2 protein] CTD PMID:25511041 , PMID:30529165 dorsomorphin multiple interactions ISO RGD:1347174 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACE2 mRNA CTD PMID:27188386 doxorubicin increases expression ISO RGD:1347174 6480464 Doxorubicin results in increased expression of ACE2 mRNA CTD PMID:28940058 , PMID:30031762 doxorubicin decreases response to substance EXP 6480464 ACE2 protein results in decreased susceptibility to Doxorubicin CTD PMID:28445944 doxorubicin decreases expression ISO RGD:1347174 6480464 Doxorubicin results in decreased expression of ACE2 mRNA CTD PMID:29803840 EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor increases expression ISO RGD:1347174 6480464 Angiotensin-Converting Enzyme Inhibitors results in increased expression of ACE2 mRNA CTD PMID:25534429 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of ACE2 mRNA CTD PMID:29548890 etoposide increases expression ISO RGD:1347174 6480464 Etoposide results in increased expression of ACE2 mRNA CTD PMID:29397400 gentamycin multiple interactions EXP 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ACE2 protein CTD PMID:30545405 GW 4064 increases expression ISO RGD:1550521 6480464 GW 4064 results in increased expression of ACE2 mRNA CTD PMID:26655953 hydroquinone decreases expression ISO RGD:1347174 6480464 hydroquinone results in decreased expression of ACE2 mRNA CTD PMID:31256213 hydroxyzine increases activity ISO RGD:1347174 6480464 Hydroxyzine results in increased activity of ACE2 protein CTD PMID:21859683 imidapril increases response to substance ISO RGD:1347174 6480464 ACE2 gene SNP results in increased susceptibility to imidapril CTD PMID:27121444 Iodine aqueous multiple interactions ISO RGD:1347174 6480464 Lugol's solution inhibits the reaction [potassium perchlorate results in increased expression of ACE2 protein] CTD PMID:29673971 irbesartan affects response to substance ISO RGD:1347174 6480464 ACE2 gene polymorphism affects the susceptibility to irbesartan CTD PMID:11593098 isoprenaline increases expression ISO RGD:1550521 6480464 Isoproterenol results in increased expression of ACE2 mRNA CTD PMID:20003209 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of ACE2 protein CTD PMID:20409916 L-ascorbic acid multiple interactions ISO RGD:1347174 6480464 [Quercetin co-treated with Ascorbic Acid] results in decreased expression of ACE2 mRNA CTD PMID:17639512 labetalol increases activity ISO RGD:1347174 6480464 Labetalol results in increased activity of ACE2 protein CTD PMID:21859683 lead diacetate decreases expression ISO RGD:1550521 6480464 lead acetate results in decreased expression of ACE2 mRNA CTD PMID:22613225 levonorgestrel multiple interactions ISO RGD:1347174 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of ACE2 mRNA CTD PMID:19074003 lisinopril dihydrate increases expression EXP 6480464 Lisinopril results in increased expression of ACE2 mRNA CTD PMID:15897343 lisinopril dihydrate increases activity EXP 6480464 Lisinopril results in increased activity of ACE2 protein CTD PMID:16221218 losartan multiple interactions EXP 6480464 Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA] more ... CTD PMID:16176966 , PMID:20178811 losartan increases activity EXP 6480464 Losartan results in increased activity of ACE2 protein CTD PMID:15897343 more ... losartan increases expression ISO RGD:1550521 6480464 Losartan results in increased expression of ACE2 protein CTD PMID:25655897 losartan increases expression EXP 6480464 Losartan results in increased expression of ACE2 mRNA, Losartan results in increased expression of ACE2 protein CTD PMID:15897343 , PMID:28091615 losartan multiple interactions ISO RGD:1550521 6480464 Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of ACE2 protein] CTD PMID:25511041 Magnolol multiple interactions EXP 6480464 magnolol inhibits the reaction [Monocrotaline results in decreased expression of ACE2 protein] CTD PMID:30466619 metronidazole multiple interactions EXP 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ACE2 protein CTD PMID:30545405 monocrotaline decreases expression EXP 6480464 Monocrotaline results in decreased expression of ACE2 protein CTD PMID:30466619 monocrotaline multiple interactions EXP 6480464 [Monocrotaline co-treated with angiotensin I (1-7)] results in increased expression of ACE2 mRNA, magnolol inhibits the reaction [Monocrotaline results in decreased expression of ACE2 protein] CTD PMID:20581171 , PMID:30466619 neomycin multiple interactions EXP 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ACE2 protein CTD PMID:30545405 nickel atom increases expression ISO RGD:1347174 6480464 Nickel results in increased expression of ACE2 mRNA CTD PMID:24768652 olmesartan increases expression EXP 6480464 olmesartan results in increased expression of ACE2 mRNA, olmesartan results in increased expression of ACE2 protein CTD PMID:19171689 , PMID:28656296 orphenadrine affects expression EXP 6480464 Orphenadrine affects the expression of ACE2 mRNA CTD PMID:23665939 paraquat multiple interactions EXP 6480464 Unithiol inhibits the reaction [Paraquat results in decreased expression of ACE2 mRNA] CTD PMID:20465954 paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of ACE2 mRNA CTD PMID:20465954 PD123319 multiple interactions EXP 6480464 PD 123319 inhibits the reaction [diminazene aceturate results in increased expression of ACE2 protein] CTD PMID:28688122 pentanal increases expression ISO RGD:1347174 6480464 pentanal results in increased expression of ACE2 mRNA CTD PMID:26079696 perindopril multiple interactions EXP 6480464 Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of ACE2 mRNA], Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of ACE2 protein] CTD PMID:19793108 phenylmercury acetate increases expression ISO RGD:1347174 6480464 Phenylmercuric Acetate results in increased expression of ACE2 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1347174 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACE2 mRNA CTD PMID:27188386 pioglitazone increases expression EXP 6480464 Pioglitazone results in increased expression of ACE2 protein CTD PMID:24114819 , PMID:24558317 pioglitazone increases secretion EXP 6480464 Pioglitazone results in increased secretion of ACE2 protein CTD PMID:24114819 pirfenidone increases expression EXP 6480464 pirfenidone results in increased expression of ACE2 protein CTD PMID:28091615 pirinixic acid multiple interactions ISO RGD:1347174 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ACE2 mRNA CTD PMID:19710929 pregabalin multiple interactions EXP 6480464 Captopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein], Telmisartan inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein] CTD PMID:31629013 pregabalin decreases expression EXP 6480464 Pregabalin results in decreased expression of ACE2 protein CTD PMID:31629013 quercetin multiple interactions ISO RGD:1347174 6480464 [Quercetin co-treated with Ascorbic Acid] results in decreased expression of ACE2 mRNA CTD PMID:17639512 SB 431542 multiple interactions ISO RGD:1347174 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ACE2 mRNA CTD PMID:27188386 silver atom increases expression EXP 6480464 Silver results in increased expression of ACE2 mRNA CTD PMID:26277626 silver(0) increases expression EXP 6480464 Silver results in increased expression of ACE2 mRNA CTD PMID:26277626 sirolimus decreases expression EXP 6480464 Sirolimus results in decreased expression of ACE2 mRNA CTD PMID:21865292 spironolactone increases expression EXP 6480464 Spironolactone results in increased expression of ACE2 protein CTD PMID:18586661 spironolactone affects expression EXP 6480464 Spironolactone affects the expression of ACE2 protein CTD PMID:30734886 streptozocin decreases expression ISO RGD:1550521 6480464 Streptozocin results in decreased expression of ACE2 protein CTD PMID:21381899 streptozocin multiple interactions EXP 6480464 ACE2 inhibits the reaction [Streptozocin results in increased expression of AGT protein modified form] more ... CTD PMID:20844835 streptozocin multiple interactions ISO RGD:1550521 6480464 telmisartan inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein] CTD PMID:21381899 sunitinib decreases expression ISO RGD:1347174 6480464 Sunitinib results in decreased expression of ACE2 mRNA CTD PMID:31533062 tacrolimus hydrate decreases expression EXP 6480464 Tacrolimus results in decreased expression of ACE2 mRNA CTD PMID:21865292 telmisartan multiple interactions ISO RGD:1550521 6480464 telmisartan inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein] CTD PMID:21381899 telmisartan multiple interactions EXP 6480464 Telmisartan inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein] CTD PMID:31629013 telmisartan decreases expression EXP 6480464 Telmisartan results in decreased expression of ACE2 mRNA, Telmisartan results in decreased expression of ACE2 protein CTD PMID:25973029 telmisartan increases expression EXP 6480464 Telmisartan results in increased expression of ACE2 mRNA, Telmisartan results in increased expression of ACE2 protein CTD PMID:28656296 , PMID:29909460 testosterone undecanoate multiple interactions ISO RGD:1347174 6480464 [testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of ACE2 mRNA CTD PMID:19074003 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of ACE2 mRNA, Carbon Tetrachloride results in increased expression of ACE2 protein CTD PMID:19793108 tetrachloromethane multiple interactions EXP 6480464 Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of ACE2 mRNA], Perindopril promotes the reaction [Carbon Tetrachloride results in increased expression of ACE2 protein] CTD PMID:19793108 thioacetamide increases response to substance ISO RGD:1550521 6480464 ACE2 gene mutant form results in increased susceptibility to Thioacetamide CTD PMID:28845018 thioacetamide multiple interactions ISO RGD:1550521 6480464 ACE2 gene mutant form promotes the reaction [Thioacetamide results in increased activity of MMP9 protein] more ... CTD PMID:28845018 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of ACE2 mRNA, titanium dioxide results in increased expression of ACE2 protein CTD PMID:26277626 trandolapril multiple interactions ISO RGD:1550521 6480464 trandolapril promotes the reaction [REN2 protein results in increased expression of ACE2 protein] CTD PMID:27428043 tributylstannane increases expression ISO RGD:1550521 6480464 tributyltin results in increased expression of ACE2 mRNA CTD PMID:31939706 triclosan decreases expression ISO RGD:1347174 6480464 Triclosan results in decreased expression of ACE2 mRNA CTD PMID:28940058 valproic acid affects expression ISO RGD:1347174 6480464 Valproic Acid affects the expression of ACE2 mRNA CTD PMID:25979313 valsartan multiple interactions EXP 6480464 Valsartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA] CTD PMID:16176966 vancomycin multiple interactions EXP 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of ACE2 protein CTD PMID:30545405 xanthone multiple interactions EXP 6480464 xanthone inhibits the reaction [LEP protein results in increased activity of ACE2 protein], xanthone inhibits the reaction [LEP protein results in increased expression of ACE2] CTD PMID:25205467
Biological Process angiotensin-mediated drinking behavior ISO RGD:1347174 1624291 (PMID:18258853) RGD PMID:18258853 angiotensin-mediated drinking behavior IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 maternal process involved in female pregnancy IEP 8548898 RGD negative regulation of ERK1 and ERK2 cascade IMP 9685431 RGD negative regulation of smooth muscle cell proliferation IMP 9685431 RGD positive regulation of amino acid transport ISO RGD:1347174 1624291 (PMID:19185582) RGD PMID:19185582 positive regulation of cardiac muscle contraction IEA UniProtKB:Q8R0I0 , ensembl:ENSMUSP000001078901600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cardiac muscle contraction ISO RGD:1550521 1624291 (MGI:2181229, PMID:12075344) RGD MGI:2181229 , PMID:12075344 positive regulation of gap junction assembly ISO RGD:1347174 1624291 (PMID:12967627) RGD PMID:12967627 positive regulation of gap junction assembly IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of L-proline import across plasma membrane ISO RGD:1347174 1624291 UniProtKB:Q9NP91 (PMID:25534429) RGD PMID:25534429 positive regulation of L-proline import across plasma membrane IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 proteolysis IEA UniRule:UR000127453 1600115 GO_REF:0000104 UniProt GO_REF:0000104 proteolysis IEA UniProtKB-KW:KW-0645 1600115 GO_REF:0000043 UniProt GO_REF:0000043 receptor-mediated virion attachment to host cell IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 receptor-mediated virion attachment to host cell ISO RGD:1347174 1624291 (PMID:18343844), (PMID:32221306) RGD PMID:18343844 , PMID:32221306 regulation of cardiac conduction ISO RGD:1347174 1624291 (PMID:12967627) RGD PMID:12967627 regulation of cardiac conduction IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of systemic arterial blood pressure by renin-angiotensin ISO RGD:1347174 1624291 (PMID:18258853) RGD PMID:18258853 regulation of transmembrane transporter activity ISO RGD:1347174 1624291 UniProtKB:Q9NP91 (PMID:25534429) RGD PMID:25534429 regulation of transmembrane transporter activity IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 tryptophan transport IEA UniProtKB:Q8R0I0 , ensembl:ENSMUSP000001078901600115 GO_REF:0000107 Ensembl GO_REF:0000107 tryptophan transport ISO RGD:1550521 1624291 (MGI:5433234, PMID:22837003) RGD MGI:5433234 , PMID:22837003 viral entry into host cell ISO RGD:1347174 1624291 (PMID:32221306) RGD PMID:32221306 viral entry into host cell IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component apical plasma membrane ISO RGD:1347174 1624291 (PMID:25534429) RGD PMID:25534429 apical plasma membrane IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 brush border membrane IEA UniProtKB:Q8R0I0 , ensembl:ENSMUSP000001078901600115 GO_REF:0000107 Ensembl GO_REF:0000107 brush border membrane ISO RGD:1550521 1624291 (MGI:3838678, PMID:19185582) RGD MGI:3838678 , PMID:19185582 brush border membrane IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 brush border membrane ISO RGD:1347174 1624291 (PMID:25534429) RGD PMID:25534429 cell surface ISO RGD:1347174 1624291 (PMID:18343844), (PMID:24227843) RGD PMID:18343844 , PMID:24227843 cell surface ISS UniProtKB:Q9BYF1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cell surface IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytoplasm IEA UniProtKB-SubCell:SL-0086 1600115 GO_REF:0000044 UniProt GO_REF:0000044 cytoplasm ISO RGD:1550521 1624291 (MGI:5582870, PMID:23535237) RGD MGI:5582870 , PMID:23535237 extracellular region ISO RGD:1347174 1624291 (PMID:10969042) RGD PMID:10969042 extracellular region IEA UniProtKB-SubCell:SL-0243 1600115 GO_REF:0000044 UniProt GO_REF:0000044 extracellular space IDA 9685440 RGD extracellular space IBA PANTHER:PTN002575181 more ... 13792537 PMID:21873635 GO_Central extracellular space ISO RGD:1347174 1624291 (PMID:18258853) RGD PMID:18258853 extracellular space IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 integral component of membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000043 UniProt GO_REF:0000043 membrane IDA 2313801 RGD plasma membrane ISO RGD:1347174 1624291 (PMID:21068237) RGD PMID:21068237 plasma membrane ISO RGD:1550521 1624291 (MGI:5582870, PMID:23535237) RGD MGI:5582870 , PMID:23535237 plasma membrane IBA MGI:MGI:1917258 more ... 13792537 PMID:21873635 GO_Central plasma membrane ISS UniProtKB:Q9BYF1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 Molecular Function carboxypeptidase activity ISO RGD:1347174 1624291 (PMID:10924499), (PMID:10969042), (PMID:15283675), (PMID:15380922), (PMID:18258853) RGD PMID:10924499 more ... carboxypeptidase activity IEA UniProtKB-KW:KW-0121 1600115 GO_REF:0000043 UniProt GO_REF:0000043 carboxypeptidase activity IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 carboxypeptidase activity IDA 9685456 PMID:22595130 CACAO endopeptidase activity ISO RGD:1347174 1624291 (PMID:15283675) RGD PMID:15283675 endopeptidase activity IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000043 UniProt GO_REF:0000043 metallocarboxypeptidase activity ISO RGD:1347174 1624291 (PMID:10924499), (PMID:10969042), (PMID:11815627) RGD PMID:10924499 more ... metallopeptidase activity ISO RGD:1347174 1624291 (PMID:10924499) RGD PMID:10924499 metallopeptidase activity IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 metallopeptidase activity IBA FB:FBgn0012037 more ... 13792537 PMID:21873635 GO_Central metallopeptidase activity IEA UniProtKB-KW:KW-0482 1600115 GO_REF:0000043 UniProt GO_REF:0000043 peptidyl-dipeptidase activity IEA InterPro:IPR001548 1600115 GO_REF:0000002 InterPro GO_REF:0000002 peptidyl-dipeptidase activity IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-dipeptidase activity ISO RGD:1347174 1624291 (PMID:10924499) RGD PMID:10924499 protein binding IPI UniProtKB:P59594 30309928 PMID:15791205 IntAct protein binding ISO RGD:1550521 1624291 UniProtKB:Q9D687 (MGI:3838678 , PMID:19185582) RGD MGI:3838678 , PMID:19185582 protein binding ISO RGD:1347174 1624291 UniProtKB:O15393 more ... RGD PMID:10969042 more ... virus receptor activity ISO RGD:1347174 1624291 (PMID:18343844), (PMID:24227843) RGD PMID:18343844 , PMID:24227843 virus receptor activity ISS UniProtKB:Q9BYF1 1600115 GO_REF:0000024 UniProt GO_REF:0000024 virus receptor activity IEA UniProtKB:Q9BYF1 , ensembl:ENSP000003893261600115 GO_REF:0000107 Ensembl GO_REF:0000107
Gene-Chemical Interaction Annotations
