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Gene: Ace2 (angiotensin I converting enzyme 2) Rattus norvegicus
Symbol: Ace2
Name: angiotensin I converting enzyme 2
RGD ID: 728890
Description: Exhibits carboxypeptidase activity. Involved in maternal process involved in female pregnancy; negative regulation of ERK1 and ERK2 cascade; and negative regulation of smooth muscle cell proliferation. Localizes to extracellular space and membrane. Used to study glaucoma; myocardial infarction; and thrombosis. Biomarker of hypertension; lung disease; middle cerebral artery infarction; myocardial infarction; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; avian influenza; diabetic retinopathy; respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin I converting enzyme 2); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH 3-chloropropane-1,2-diol; 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile; aflatoxin B1.
Type: protein-coding
Also known as: ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; renal angiotensin-converting enzyme 2
Homo sapiens (human) : ACE2 (angiotensin I converting enzyme 2)  HGNC  Alliance
Mus musculus (house mouse) : Ace2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ace2 (angiotensin I converting enzyme 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ACE2 (angiotensin I converting enzyme 2)
Canis lupus familiaris (dog) : ACE2 (angiotensin I converting enzyme 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ace2 (angiotensin I converting enzyme 2)
Sus scrofa (pig) : ACE2 (angiotensin I converting enzyme 2)
Chlorocebus sabaeus (African green monkey) : ACE2 (angiotensin I converting enzyme 2)
Heterocephalus glaber (naked mole-rat) : Ace2 (angiotensin I converting enzyme 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0X32,050,734 - 32,095,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,049,931 - 32,096,016 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,422,286 - 32,469,137 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,051,758 - 51,096,036 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X51,105,228 - 51,149,505 (-)NCBI
CeleraX30,638,123 - 30,683,403 (-)NCBICelera
Cytogenetic MapXq14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Protein Structures

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ace2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 728890
Created: 2003-11-21
Species: Rattus norvegicus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.