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Gene: ACE2 (angiotensin I converting enzyme 2) Homo sapiens
Symbol: ACE2
Name: angiotensin I converting enzyme 2
Description: Exhibits endopeptidase activity; metallocarboxypeptidase activity; and virus receptor activity. Involved in several processes, including angiotensin-mediated drinking behavior; positive regulation of gap junction assembly; and receptor-mediated virion attachment to host cell. Localizes to the cell surface; extracellular space; and plasma membrane. Implicated in diabetic retinopathy and hypertension. Biomarker of pancreatic ductal carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACE-related carboxypeptidase; ACEH; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2; angiotensin-converting enzyme homolog; DKFZp434A014; metalloprotease MPROT15; peptidyl-dipeptidase A
Mus musculus (house mouse) : Ace2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ace2 (angiotensin I converting enzyme 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ace2 (angiotensin I converting enzyme 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ACE2 (angiotensin I converting enzyme 2)
Canis lupus familiaris (dog) : ACE2 (angiotensin I converting enzyme 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ace2 (angiotensin I converting enzyme 2)
Sus scrofa (pig) : ACE2 (angiotensin I converting enzyme 2)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: Strains:   SHRSP-Tg(Tagln-ACE2)6918Bdr  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X15,494,520 - 15,602,158 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X15,579,156 - 15,620,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,489,077 - 15,529,058 (-)NCBINCBI36hg18NCBI36
Build 34X15,338,812 - 15,378,794NCBI
CeleraX19,694,648 - 19,735,682 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX13,333,989 - 13,374,656 (-)NCBIHuRef
CHM1_1X15,610,102 - 15,651,154 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
Related Rat Strains
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Protein Structures
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ACE2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1347174
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.