Ace2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2) - Rat Genome Database

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Gene: Ace2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2) Mus musculus
Symbol: Ace2
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
RGD ID: 1550521
Description: Predicted to enable identical protein binding activity; peptidase activity; and virus receptor activity. Involved in positive regulation of cardiac muscle contraction and tryptophan transport. Located in brush border membrane and cytoplasm. Is expressed in several structures, including brain; cardiovascular system; extraembryonic component; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; avian influenza; cerebral malaria; hypertension (multiple); and respiratory syncytial virus infectious disease. Orthologous to human ACE2 (angiotensin converting enzyme 2); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH 1,2-dimethylhydrazine; 14,15-EET; Ac-Ser-Asp-Lys-Pro-OH.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2010305L05Rik; ACE-related carboxypeptidase; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39X162,922,338 - 162,971,414 (+)NCBIGRCm39mm39
GRCm39 EnsemblX162,922,328 - 162,971,416 (+)Ensembl
GRCm38X164,139,342 - 164,188,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,577,274 - 160,626,350 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X159,484,737 - 159,532,523 (+)NCBImm8
CeleraX147,353,722 - 147,402,904 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Lung Injury  (IEP,IMP,ISO)
adult respiratory distress syndrome  (ISO)
autistic disorder  (ISO)
avian influenza  (IMP,ISO)
bacterial pneumonia  (IEP)
Cardiac Fibrosis  (ISO)
cardiomyopathy  (ISO)
Cardiovirus Infections  (IEP)
cerebral malaria  (ISO)
chemical colitis  (IMP)
congestive heart failure  (IEA,ISO)
Coronary Disease  (ISO)
Coronavirus infectious disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (IAGP,ISO)
diabetic retinopathy  (ISO)
endomyocardial fibrosis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
glaucoma  (ISO)
hypertension  (IMP,ISO)
Hypertensive Nephrosclerosis  (ISO)
hypertrophic cardiomyopathy  (ISO)
Inflammation  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Neurodevelopmental Disorders  (ISO)
pancreatic ductal carcinoma  (ISO)
Pleural Effusion  (ISO)
Pregnancy-Induced Hypertension  (ISO)
primary biliary cholangitis  (ISO)
pulmonary fibrosis  (IMP,ISO)
pulmonary hypertension  (ISO)
respiratory syncytial virus infectious disease  (IMP,ISO)
severe acute respiratory syndrome  (HEP,IEP,IMP,ISO)
Spontaneous Abortions  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
thrombosis  (ISO)
Ventricular Remodeling  (IMP,ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (ISO)
(S,S,S)-nicotianamine  (ISO)
1,2-dimethylhydrazine  (EXP)
14,15-EET  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
3-chloropropane-1,2-diol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (ISO)
Ac-Ser-Asp-Lys-Pro-OH  (EXP)
acarbose  (ISO)
acetic acid [4-[2-(dimethylamino)ethoxy]-2-methyl-5-propan-2-ylphenyl] ester  (ISO)
aflatoxin B1  (ISO)
all-trans-retinol  (ISO)
amitriptyline  (ISO)
amphetamine  (ISO)
ampicillin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aprindine  (ISO)
atorvastatin calcium  (ISO)
azathioprine  (ISO)
benazepril  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (ISO)
bleomycin A2  (ISO)
cadmium dichloride  (ISO)
candesartan  (ISO)
Candesartan cilexetil  (ISO)
captopril  (EXP,ISO)
carbon nanotube  (EXP)
ceftriaxone  (ISO)
chloramphenicol  (ISO)
Chlormadinone acetate  (ISO)
chlorpromazine  (ISO)
chlorpropamide  (ISO)
chromium(6+)  (EXP)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-penicillamine  (ISO)
danazol  (ISO)
dantrolene  (ISO)
desloratadine  (ISO)
dexamethasone  (ISO)
diazepam  (ISO)
diclofenac  (ISO)
diminazene  (ISO)
diminazene diaceturate  (EXP,ISO)
dioxygen  (EXP)
disopyramide  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxepin  (ISO)
doxorubicin  (ISO)
EC (peptidyl-dipeptidase A) inhibitor  (ISO)
ethambutol  (ISO)
ethanol  (ISO)
ethionamide  (ISO)
etoposide  (ISO)
flutamide  (ISO)
gemfibrozil  (ISO)
gentamycin  (ISO)
glyburide  (ISO)
griseofulvin  (ISO)
GW 4064  (EXP)
hydroquinone  (ISO)
hydroxyzine  (ISO)
imidapril  (ISO)
imipramine  (ISO)
Iodine aqueous  (ISO)
irbesartan  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
labetalol  (ISO)
lead diacetate  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
lisinopril dihydrate  (ISO)
lomustine  (ISO)
Loratadine  (ISO)
losartan  (EXP,ISO)
Magnolol  (ISO)
metformin  (ISO)
methimazole  (ISO)
metronidazole  (ISO)
monocrotaline  (ISO)
naproxen  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nicotianamine  (ISO)
nimesulide  (ISO)
olmesartan  (ISO)
omeprazole  (ISO)
orphenadrine  (ISO)
papaverine  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PD123319  (ISO)
pentanal  (ISO)
perindopril  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
pioglitazone  (ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
pregabalin  (ISO)
quercetin  (ISO)
quinidine  (ISO)
rifampicin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
spironolactone  (ISO)
streptozocin  (EXP,ISO)
sulfasalazine  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
telmisartan  (EXP,ISO)
testosterone  (ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trandolapril  (EXP)
tributylstannane  (EXP)
triclosan  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vancomycin  (ISO)
xanthone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cardiovascular system physiology  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal corneal epithelium morphology  (IAGP)
abnormal corneal wound healing  (IAGP)
abnormal cytokine level  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal feces composition  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal intestine physiology  (IAGP)
abnormal intestine regeneration  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal pulmonary alveolus epithelial cell morphology  (IAGP)
abnormal susceptibility to injury induced morbidity/mortality  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cardiac interstitial fibrosis  (IAGP)
congestive heart failure  (IAGP)
corneal opacity  (IAGP)
corneal vascularization  (IAGP)
decreased angiotensin II level  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased circulating angiotensin II level  (IAGP)
decreased colon length  (IAGP)
decreased heart rate  (IAGP)
decreased pulmonary artery pressure  (IAGP)
decreased susceptibility to Coronaviridae infection  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased ventricle muscle contractility  (IAGP)
diarrhea  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated heart left ventricle  (IAGP)
dilated heart ventricle  (IAGP)
heart inflammation  (IAGP)
hypertension  (IAGP)
hypotension  (IAGP)
increased angiotensin I-converting enzyme activity  (IAGP)
increased angiotensin II level  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased circulating angiotensin II level  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-9 level  (IAGP)
increased heart weight  (IAGP)
increased incidence of corneal inflammation  (IAGP)
increased left ventricle diastolic pressure  (IAGP)
increased lung elastance  (IAGP)
increased lung weight  (IAGP)
increased NAD(P)H oxidase activity  (IAGP)
increased neutrophil cell number  (IAGP)
increased pulmonary respiratory rate  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to Coronaviridae infection  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to injury  (IAGP)
increased susceptibility to Orthomyxoviridae infection  (IAGP)
increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality  (IAGP)
increased susceptibility to pulmonary hyaline membrane formation  (IAGP)
increased susceptibility to weight loss  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased vascular permeability  (IAGP)
interstitial pneumonia  (IAGP)
intestinal edema  (IAGP)
intestinal inflammation  (IAGP)
lung hemorrhage  (IAGP)
lung inflammation  (IAGP)
melena  (IAGP)
oxidative stress  (IAGP)
pulmonary edema  (IAGP)
pulmonary hypertension  (IAGP)
pulmonary vascular congestion  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thin ventricular wall  (IAGP)
yellow coat color  (IEA)

References - curated
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Additional References at PubMed
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PMID:28273875   PMID:28721275   PMID:28808068   PMID:28842425   PMID:28845018   PMID:28935640   PMID:28935757   PMID:29128354   PMID:29138810   PMID:29196099   PMID:29211853   PMID:29225087  
PMID:29266779   PMID:29363860   PMID:29559844   PMID:29570986   PMID:29679094   PMID:29706566   PMID:29761600   PMID:29884907   PMID:30207087   PMID:30604460   PMID:30628484   PMID:31393582  
PMID:31440756   PMID:31484552   PMID:31519791   PMID:31564162   PMID:31610731   PMID:31775868   PMID:31786979   PMID:31805278   PMID:31853045   PMID:31861139   PMID:31987854   PMID:32015507  
PMID:32275855   PMID:32316719   PMID:32322207   PMID:32338605   PMID:32368013   PMID:32379417   PMID:32404477   PMID:32413319   PMID:32418199   PMID:32441816   PMID:32472097   PMID:32485164  
PMID:32511354   PMID:32513532   PMID:32525008   PMID:32558150   PMID:32564694   PMID:32607866   PMID:32669323   PMID:32725927   PMID:32750141   PMID:32820248   PMID:32837584   PMID:32966801  
PMID:32967005   PMID:32971570   PMID:32991738   PMID:33008593   PMID:33057007   PMID:33078906   PMID:33097186   PMID:33106680   PMID:33168188   PMID:33275517   PMID:33284956   PMID:33372179  
PMID:33422505   PMID:33488611   PMID:33558541   PMID:33566370   PMID:33626084   PMID:33636719   PMID:33658332   PMID:33725024   PMID:33727353   PMID:33811970   PMID:33932339   PMID:33963249  
PMID:33991451   PMID:34290590   PMID:34305888  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39X162,922,338 - 162,971,414 (+)NCBIGRCm39mm39
GRCm39 EnsemblX162,922,328 - 162,971,416 (+)Ensembl
GRCm38X164,139,342 - 164,188,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,577,274 - 160,626,350 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X159,484,737 - 159,532,523 (+)NCBImm8
CeleraX147,353,722 - 147,402,904 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX15,494,566 - 15,607,236 (-)EnsemblGRCh38hg38GRCh38
GRCh38X15,518,197 - 15,607,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X15,536,320 - 15,620,281 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,489,077 - 15,529,058 (-)NCBINCBI36hg18NCBI36
Build 34X15,338,812 - 15,378,794NCBI
CeleraX19,694,648 - 19,735,682 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX13,333,989 - 13,374,656 (-)NCBIHuRef
CHM1_1X15,610,102 - 15,651,154 (-)NCBICHM1_1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2X30,293,597 - 30,340,961 (-)NCBImRatBN7.2
mRatBN7.2 EnsemblX30,293,589 - 30,340,977 (-)Ensembl
Rnor_6.0X32,050,734 - 32,095,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,049,931 - 32,096,016 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,422,286 - 32,469,137 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,051,758 - 51,096,036 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X51,105,228 - 51,149,505 (-)NCBI
CeleraX30,638,123 - 30,683,403 (-)NCBICelera
Cytogenetic MapXq14NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049555192,591,248 - 2,633,495 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,591,229 - 2,643,705 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1X15,470,896 - 15,510,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,470,896 - 15,510,891 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X8,189,267 - 8,229,415 (-)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1X11,798,839 - 11,839,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,798,839 - 11,900,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,706,330 - 11,745,360 (-)NCBI
ROS_Cfam_1.0X11,760,479 - 11,822,897 (-)NCBI
UMICH_Zoey_3.1X11,824,224 - 11,862,960 (-)NCBI
UNSW_CanFamBas_1.0X11,818,311 - 11,856,868 (-)NCBI
UU_Cfam_GSD_1.0X11,843,799 - 11,882,613 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2X4,964,502 - 5,012,706 (-)NCBI
SpeTri2.0NW_0049364704,964,526 - 5,011,808 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 EnsemblX12,099,853 - 12,151,275 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,099,849 - 12,152,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,061,317 - 13,089,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1X14,032,231 - 14,094,163 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX14,030,233 - 14,077,785 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605615,866,608 - 15,915,985 (-)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_004624829344,823 - 391,451 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF5UniSTS
cM MapX70.5UniSTS
cM MapX70.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X164,188,229 - 164,188,387UniSTSGRCm38
MGSCv37X160,626,161 - 160,626,319UniSTSGRCm37
CeleraX147,402,715 - 147,402,873UniSTS
Cytogenetic MapXF5UniSTS
cM MapX70.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38193,688,356 - 93,689,529UniSTSGRCm38
GRCm38X164,153,557 - 164,154,374UniSTSGRCm38
MGSCv37195,584,933 - 95,586,106UniSTSGRCm37
MGSCv37X160,591,489 - 160,592,306UniSTSGRCm37
CeleraX147,367,932 - 147,368,749UniSTS
Celera196,633,400 - 96,634,573UniSTS
Cytogenetic MapXF5UniSTS
Cytogenetic Map1DUniSTS
cM MapX70.5UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF5UniSTS
cM MapX70.5UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX145691384171031299Mouse
1357619Obsty5_mobesity 5 (mouse)Not determinedX161429897165366288Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX134639291166515599Mouse
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX145691384171031299Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1527
Count of miRNA genes:597
Interacting mature miRNAs:756
Transcripts:ENSMUST00000073973, ENSMUST00000112271, ENSMUST00000131543
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000073973   ⟹   ENSMUSP00000073626
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX162,923,474 - 162,971,416 (+)Ensembl
GRCm38.p6 EnsemblX164,140,478 - 164,188,420 (+)Ensembl
RefSeq Acc Id: ENSMUST00000112271   ⟹   ENSMUSP00000107890
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX162,922,328 - 162,971,416 (+)Ensembl
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131543   ⟹   ENSMUSP00000123313
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX162,945,174 - 162,968,820 (+)Ensembl
GRCm38.p6 EnsemblX164,162,178 - 164,185,824 (+)Ensembl
RefSeq Acc Id: NM_001130513   ⟹   NP_001123985
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39X162,922,338 - 162,971,414 (+)NCBI
GRCm38X164,139,342 - 164,188,418 (+)ENTREZGENE
MGSCv37X160,577,274 - 160,626,350 (+)RGD
CeleraX147,353,722 - 147,402,904 (+)RGD
RefSeq Acc Id: NM_027286   ⟹   NP_081562
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39X162,923,476 - 162,971,414 (+)NCBI
GRCm38X164,140,480 - 164,188,418 (+)NCBI
MGSCv37X160,577,274 - 160,626,350 (+)RGD
CeleraX147,353,722 - 147,402,904 (+)RGD
Reference Sequences
RefSeq Acc Id: NP_081562   ⟸   NM_027286
- Peptide Label: precursor
- UniProtKB: Q8R0I0 (UniProtKB/Swiss-Prot),   Q3URC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001123985   ⟸   NM_001130513
- Peptide Label: precursor
- UniProtKB: Q8R0I0 (UniProtKB/Swiss-Prot),   Q3URC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000073626   ⟸   ENSMUST00000073973
RefSeq Acc Id: ENSMUSP00000107890   ⟸   ENSMUST00000112271
RefSeq Acc Id: ENSMUSP00000123313   ⟸   ENSMUST00000131543
Protein Domains

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
ACE2 pdb 1r42 Q8R0I0 18-740 view protein structure  

RGD ID:6845417
Promoter ID:MM_KWN:62686
SO ACC ID:SO:0000170
Tissues & Cell Lines:Kidney
Mouse AssemblyChrPosition (strand)Source
MGSCv36X160,577,946 - 160,578,446 (+)MPROMDB
RGD ID:13681808
Promoter ID:EPDNEW_M25053
Type:initiation region
Description:Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidaseA) 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M25054  EPDNEW_M25055  EPDNEW_M25056  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38X164,139,390 - 164,139,450EPDNEW
RGD ID:13681810
Promoter ID:EPDNEW_M25054
Type:initiation region
Description:Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidaseA) 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M25053  EPDNEW_M25055  EPDNEW_M25056  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38X164,140,504 - 164,140,564EPDNEW
RGD ID:13681812
Promoter ID:EPDNEW_M25055
Type:multiple initiation site
Description:Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidaseA) 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M25053  EPDNEW_M25054  EPDNEW_M25056  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38X164,140,632 - 164,140,692EPDNEW
RGD ID:13681814
Promoter ID:EPDNEW_M25056
Type:initiation region
Description:Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidaseA) 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Alternative Promoters:null; see alsoEPDNEW_M25053  EPDNEW_M25054  EPDNEW_M25055  
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38X164,162,177 - 164,162,237EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917258 AgrOrtholog
Ensembl Genes ENSMUSG00000015405 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000073626 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000107890 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000123313 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000073973 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000112271 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000131543 UniProtKB/TrEMBL
InterPro Collectrin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:70008 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR10514 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Collectrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ace2 PhenoGen
  ZINC_PROTEASE UniProtKB/Swiss-Prot
UniProt ACE2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q99N70 UniProtKB/Swiss-Prot
  Q99N71 UniProtKB/Swiss-Prot