Ace2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2) - Rat Genome Database
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Gene: Ace2 (angiotensin I converting enzyme (peptidyl-dipeptidase A) 2) Mus musculus
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Symbol: Ace2
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
RGD ID: 1550521
MGI Page MGI
Description: Predicted to have peptidase activity and virus receptor activity. Involved in positive regulation of cardiac muscle contraction and tryptophan transport. Localizes to brush border membrane and cytoplasm. Is expressed in several structures, including brain; cardiovascular system; extraembryonic component; genitourinary system; and respiratory system. Used to study COVID-19 and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; avian influenza; diabetic retinopathy; respiratory syncytial virus infectious disease; and severe acute respiratory syndrome. Orthologous to human ACE2 (angiotensin I converting enzyme 2); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH 1,2-dimethylhydrazine; 14,15-EET; Benzo[k]fluoranthene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2010305L05Rik; ACE-related carboxypeptidase; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,922,338 - 162,971,414 (+)NCBIGRCm39mm39
GRCm38X164,139,342 - 164,188,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,577,274 - 160,626,350 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X159,484,737 - 159,532,523 (+)NCBImm8
CeleraX147,353,722 - 147,402,904 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Lung Injury  (IEP,IMP,ISO)
adult respiratory distress syndrome  (ISO)
autistic disorder  (ISO)
avian influenza  (IMP,ISO)
bacterial pneumonia  (IEP)
Cardiac Fibrosis  (ISO)
cardiomyopathy  (ISO)
Cardiovirus Infections  (IEP)
cerebral malaria  (ISO)
chemical colitis  (IMP)
congestive heart failure  (IEA,ISO)
Coronary Disease  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (IEA,ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (IAGP,ISO)
diabetic retinopathy  (ISO)
endomyocardial fibrosis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
glaucoma  (ISO)
hypertension  (IMP,ISO)
Hypertensive Nephrosclerosis  (ISO)
hypertrophic cardiomyopathy  (ISO)
Inflammation  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Neurodevelopmental Disorders  (ISO)
pancreatic ductal carcinoma  (ISO)
Pleural Effusion  (ISO)
Pregnancy-Induced Hypertension  (ISO)
primary biliary cholangitis  (ISO)
pulmonary fibrosis  (IMP,ISO)
pulmonary hypertension  (ISO)
respiratory syncytial virus infectious disease  (IMP,ISO)
severe acute respiratory syndrome  (HEP,IEP,IMP,ISO)
Spontaneous Abortions  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
thrombosis  (ISO)
Ventricular Remodeling  (IMP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S,S,S)-nicotianamine  (ISO)
1,2-dimethylhydrazine  (EXP)
14,15-EET  (EXP)
3-chloropropane-1,2-diol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
amphetamine  (ISO)
ampicillin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aprindine  (ISO)
atorvastatin calcium  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (ISO)
bleomycin A2  (ISO)
cadmium dichloride  (ISO)
candesartan  (ISO)
Candesartan cilexetil  (ISO)
captopril  (ISO)
carbon nanotube  (EXP)
ceftriaxone  (ISO)
chromium(6+)  (EXP)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diminazene  (ISO)
diminazene diaceturate  (EXP,ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
ethanol  (ISO)
etoposide  (ISO)
gentamycin  (ISO)
GW 4064  (EXP)
hydroquinone  (ISO)
hydroxyzine  (ISO)
imidapril  (ISO)
Iodine aqueous  (ISO)
irbesartan  (ISO)
isoprenaline  (EXP,ISO)
L-ascorbic acid  (ISO)
labetalol  (ISO)
lead diacetate  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
lisinopril dihydrate  (ISO)
losartan  (EXP,ISO)
Magnolol  (ISO)
metronidazole  (ISO)
monocrotaline  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nicotianamine  (ISO)
olmesartan  (ISO)
orphenadrine  (ISO)
paraquat  (ISO)
PD123319  (ISO)
pentanal  (ISO)
perindopril  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
pregabalin  (ISO)
quercetin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
spironolactone  (ISO)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
telmisartan  (EXP,ISO)
testosterone undecanoate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trandolapril  (EXP)
tributylstannane  (EXP)
triclosan  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vancomycin  (ISO)
xanthone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cardiovascular system physiology  (IAGP)
abnormal circulating angiotensinogen level  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal corneal epithelium morphology  (IAGP)
abnormal corneal wound healing  (IAGP)
abnormal cytokine level  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal heart echocardiography feature  (IAGP)
abnormal hormone level  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal pulmonary alveolus epithelial cell morphology  (IAGP)
abnormal susceptibility to injury induced morbidity/mortality  (IAGP)
cardiac fibrosis  (IAGP)
cardiac hypertrophy  (IAGP)
cardiac interstitial fibrosis  (IAGP)
congestive heart failure  (IAGP)
corneal opacity  (IAGP)
corneal vascularization  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased colon length  (IAGP)
decreased heart rate  (IAGP)
decreased pulmonary artery pressure  (IAGP)
decreased susceptibility to Coronaviridae infection  (IAGP)
decreased susceptibility to injury  (IAGP)
decreased ventricle muscle contractility  (IAGP)
diarrhea  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated heart left ventricle  (IAGP)
dilated heart ventricle  (IAGP)
heart inflammation  (IAGP)
hypertension  (IAGP)
hypotension  (IAGP)
increased angiotensin I-converting enzyme activity  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased circulating angiotensinogen level  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-9 level  (IAGP)
increased heart weight  (IAGP)
increased incidence of corneal inflammation  (IAGP)
increased left ventricle diastolic pressure  (IAGP)
increased lung elastance  (IAGP)
increased lung weight  (IAGP)
increased NAD(P)H oxidase activity  (IAGP)
increased neutrophil cell number  (IAGP)
increased pulmonary respiratory rate  (IAGP)
increased sensitivity to induced morbidity/mortality  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to Coronaviridae infection  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to injury  (IAGP)
increased susceptibility to Orthomyxoviridae infection  (IAGP)
increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality  (IAGP)
increased susceptibility to pulmonary hyaline membrane formation  (IAGP)
increased susceptibility to weight loss  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased vascular permeability  (IAGP)
interstitial pneumonia  (IAGP)
lung hemorrhage  (IAGP)
lung inflammation  (IAGP)
oxidative stress  (IAGP)
pulmonary edema  (IAGP)
pulmonary hypertension  (IAGP)
pulmonary vascular congestion  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thin ventricular wall  (IAGP)
yellow coat color  (IEA)
References

References - curated
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Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12487024   PMID:12967627   PMID:15356152   PMID:15452268   PMID:15489334   PMID:15561968   PMID:15949646   PMID:16141072  
PMID:16141073   PMID:16505206   PMID:16723697   PMID:16738017   PMID:16804085   PMID:16878172   PMID:16946085   PMID:17198697   PMID:17340620   PMID:17499227   PMID:17579661   PMID:17600118  
PMID:18164957   PMID:18192335   PMID:18263657   PMID:18287559   PMID:18310259   PMID:18356559   PMID:18376006   PMID:18403726   PMID:18441099   PMID:18448662   PMID:18554416   PMID:18650320  
PMID:18660448   PMID:18956256   PMID:19004932   PMID:19015603   PMID:19124678   PMID:19185582   PMID:19334288   PMID:19478081   PMID:19521566   PMID:19650157   PMID:19759332   PMID:19808375  
PMID:19880118   PMID:19926873   PMID:19948988   PMID:20186149   PMID:20357030   PMID:20562862   PMID:20671240   PMID:20679547   PMID:20798044   PMID:21188549   PMID:21208466   PMID:21252069  
PMID:21267068   PMID:21285291   PMID:21481527   PMID:21677750   PMID:21814048   PMID:21818366   PMID:21873635   PMID:21880865   PMID:21946695   PMID:21968754   PMID:22036945   PMID:22246130  
PMID:22288735   PMID:22289845   PMID:22330342   PMID:22460555   PMID:22474255   PMID:22508831   PMID:22518292   PMID:22580272   PMID:22616805   PMID:22665126   PMID:22677001   PMID:22693641  
PMID:22790597   PMID:22933108   PMID:22947377   PMID:23043153   PMID:23127535   PMID:23160880   PMID:23328447   PMID:23392115   PMID:23535237   PMID:23608725   PMID:23671869   PMID:23761674  
PMID:23951161   PMID:24048198   PMID:24067190   PMID:24161906   PMID:24177423   PMID:24193738   PMID:24379178   PMID:24400109   PMID:24414175   PMID:24446061   PMID:24454948   PMID:24464749  
PMID:24477684   PMID:24581232   PMID:24695436   PMID:24728465   PMID:24756097   PMID:24760518   PMID:24799609   PMID:24911884   PMID:25175177   PMID:25249154   PMID:25291359   PMID:25301841  
PMID:25448263   PMID:25484288   PMID:25489058   PMID:25519733   PMID:25650385   PMID:25721616   PMID:25867182   PMID:25890286   PMID:25968123   PMID:25968580   PMID:26029927   PMID:26078188  
PMID:26144375   PMID:26224885   PMID:26245758   PMID:26389599   PMID:26441236   PMID:26498282   PMID:26767952   PMID:26883384   PMID:27018342   PMID:27019629   PMID:27053009   PMID:27070147  
PMID:27113764   PMID:27379538   PMID:27592222   PMID:27601681   PMID:27612496   PMID:27649628   PMID:27806985   PMID:27917469   PMID:27927599   PMID:28101297   PMID:28142259   PMID:28249676  
PMID:28273875   PMID:28721275   PMID:28808068   PMID:28842425   PMID:28845018   PMID:28935640   PMID:28935757   PMID:29128354   PMID:29138810   PMID:29196099   PMID:29211853   PMID:29225087  
PMID:29266779   PMID:29363860   PMID:29559844   PMID:29570986   PMID:29679094   PMID:29706566   PMID:29761600   PMID:29884907   PMID:30207087   PMID:30604460   PMID:31393582   PMID:31440756  
PMID:31484552   PMID:31519791   PMID:31564162   PMID:31610731   PMID:31775868   PMID:31786979   PMID:31805278   PMID:31853045   PMID:31861139   PMID:31987854   PMID:32015507   PMID:32275855  
PMID:32316719   PMID:32322207   PMID:32338605   PMID:32368013   PMID:32379417   PMID:32404477   PMID:32413319   PMID:32441816   PMID:32472097   PMID:32485164   PMID:32511354   PMID:32513532  
PMID:32525008   PMID:32558150   PMID:32564694   PMID:32607866   PMID:32669323   PMID:32725927   PMID:32750141   PMID:32820248   PMID:32837584   PMID:32966801   PMID:32967005   PMID:33008593  
PMID:33057007   PMID:33097186   PMID:33106680   PMID:33284956  


Genomics

Comparative Map Data
Ace2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,922,338 - 162,971,414 (+)NCBIGRCm39mm39
GRCm38X164,139,342 - 164,188,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,577,274 - 160,626,350 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X159,484,737 - 159,532,523 (+)NCBImm8
CeleraX147,353,722 - 147,402,904 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.12NCBI
ACE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX15,561,033 - 15,602,148 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 EnsemblX15,494,566 - 15,607,236 (-)EnsemblGRCh38hg38GRCh38
GRCh38X15,518,197 - 15,602,158 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X15,579,156 - 15,620,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,489,077 - 15,529,058 (-)NCBINCBI36hg18NCBI36
Build 34X15,338,812 - 15,378,794NCBI
CeleraX19,694,648 - 19,735,682 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX13,333,989 - 13,374,656 (-)NCBIHuRef
CHM1_1X15,610,102 - 15,651,154 (-)NCBICHM1_1
Ace2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X32,050,734 - 32,095,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,049,931 - 32,096,016 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,422,286 - 32,469,137 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,051,758 - 51,096,036 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X51,105,228 - 51,149,505 (-)NCBI
CeleraX30,638,123 - 30,683,403 (-)NCBICelera
Cytogenetic MapXq14NCBI
Ace2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,591,248 - 2,633,495 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,591,229 - 2,643,705 (+)NCBIChiLan1.0ChiLan1.0
ACE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X15,470,896 - 15,510,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,470,896 - 15,510,891 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X8,189,267 - 8,229,415 (-)NCBIMhudiblu_PPA_v0panPan3
ACE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX11,798,839 - 11,900,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X11,798,839 - 11,839,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ace2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364704,964,526 - 5,011,808 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,099,853 - 12,151,275 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,099,849 - 12,152,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,061,317 - 13,089,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACE2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,032,231 - 14,094,163 (-)NCBI
ChlSab1.1 EnsemblX14,030,233 - 14,077,785 (-)Ensembl
Ace2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624829344,823 - 391,451 (-)NCBI

Position Markers
Ace2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF5UniSTS
cM MapX70.5UniSTS
cM MapX70.5UniSTS
BE098785  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X164,188,229 - 164,188,387UniSTSGRCm38
MGSCv37X160,626,161 - 160,626,319UniSTSGRCm37
CeleraX147,402,715 - 147,402,873UniSTS
Cytogenetic MapXF5UniSTS
cM MapX70.5UniSTS
D1S2869  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38193,688,356 - 93,689,529UniSTSGRCm38
GRCm38X164,153,557 - 164,154,374UniSTSGRCm38
MGSCv37195,584,933 - 95,586,106UniSTSGRCm37
MGSCv37X160,591,489 - 160,592,306UniSTSGRCm37
CeleraX147,367,932 - 147,368,749UniSTS
Celera196,633,400 - 96,634,573UniSTS
Cytogenetic MapXF5UniSTS
Cytogenetic Map1DUniSTS
cM MapX70.5UniSTS
Ace2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF5UniSTS
cM MapX70.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX145691384171031299Mouse
1357619Obsty5_mobesity 5 (mouse)Not determinedX161429897165366288Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX134639291166515599Mouse
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX145691384171031299Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1527
Count of miRNA genes:597
Interacting mature miRNAs:756
Transcripts:ENSMUST00000073973, ENSMUST00000112271, ENSMUST00000131543
Prediction methods:Microtar, Miranda, Pita, Pita,Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000073973   ⟹   ENSMUSP00000073626
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX164,140,478 - 164,188,420 (+)Ensembl
RefSeq Acc Id: ENSMUST00000112271   ⟹   ENSMUSP00000107890
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131543   ⟹   ENSMUSP00000123313
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX164,162,178 - 164,185,824 (+)Ensembl
RefSeq Acc Id: NM_001130513   ⟹   NP_001123985
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X162,922,338 - 162,971,414 (+)NCBI
GRCm38X164,139,342 - 164,188,418 (+)ENTREZGENE
MGSCv37X160,577,274 - 160,626,350 (+)RGD
CeleraX147,353,722 - 147,402,904 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_027286   ⟹   NP_081562
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X162,923,476 - 162,971,414 (+)NCBI
GRCm38X164,140,480 - 164,188,418 (+)NCBI
MGSCv37X160,577,274 - 160,626,350 (+)RGD
CeleraX147,353,722 - 147,402,904 (+)RGD
cM MapX ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_081562   ⟸   NM_027286
- Peptide Label: precursor
- UniProtKB: Q8R0I0 (UniProtKB/Swiss-Prot),   Q3URC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001123985   ⟸   NM_001130513
- Peptide Label: precursor
- UniProtKB: Q8R0I0 (UniProtKB/Swiss-Prot),   Q3URC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000073626   ⟸   ENSMUST00000073973
RefSeq Acc Id: ENSMUSP00000107890   ⟸   ENSMUST00000112271
RefSeq Acc Id: ENSMUSP00000123313   ⟸   ENSMUST00000131543
Protein Domains
Collectrin

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
ACE2 pdb 1r42 Q8R0I0 18-740 view protein structure  

Promoters
RGD ID:6845417
Promoter ID:MM_KWN:62686
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:ENSMUST00000073973
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X160,577,946 - 160,578,446 (+)MPROMDB
RGD ID:13681808
Promoter ID:EPDNEW_M25053
Type:initiation region
Name:Ace2_2
Description:Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidaseA) 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M25054  EPDNEW_M25055  EPDNEW_M25056  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X164,139,390 - 164,139,450EPDNEW
RGD ID:13681810
Promoter ID:EPDNEW_M25054
Type:initiation region
Name:Ace2_4
Description:Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidaseA) 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M25053  EPDNEW_M25055  EPDNEW_M25056  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X164,140,504 - 164,140,564EPDNEW
RGD ID:13681812
Promoter ID:EPDNEW_M25055
Type:multiple initiation site
Name:Ace2_1
Description:Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidaseA) 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M25053  EPDNEW_M25054  EPDNEW_M25056  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X164,140,632 - 164,140,692EPDNEW
RGD ID:13681814
Promoter ID:EPDNEW_M25056
Type:initiation region
Name:Ace2_3
Description:Mus musculus angiotensin I converting enzyme (peptidyl-dipeptidaseA) 2 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M25053  EPDNEW_M25054  EPDNEW_M25055  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X164,162,177 - 164,162,237EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917258 AgrOrtholog
Ensembl Genes ENSMUSG00000015405 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000073626 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000107890 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000123313 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000073973 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000112271 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000131543 UniProtKB/TrEMBL
InterPro Collectrin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:70008 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1917258 ENTREZGENE
NCBI Gene 70008 ENTREZGENE
PANTHER PTHR10514 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Collectrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ACE2 RGD
PhenoGen Ace2 PhenoGen
PRINTS PEPDIPTASEA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
UniGene Mm.13451 ENTREZGENE
UniProt ACE2_MOUSE UniProtKB/Swiss-Prot
  C7ECU2_MOUSE UniProtKB/TrEMBL
  F6X479_MOUSE UniProtKB/TrEMBL
  Q3URC9 ENTREZGENE, UniProtKB/TrEMBL
  Q3UXR1_MOUSE UniProtKB/TrEMBL
  Q8R0I0 ENTREZGENE
  Q9D836_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q99N70 UniProtKB/Swiss-Prot
  Q99N71 UniProtKB/Swiss-Prot