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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550521
Species: Mus musculus
RGD Object: Gene
Symbol: Ace2
Name: angiotensin converting enzyme 2
Acc ID: CHEBI:64356
Term: pregabalin
Definition: A gamma-amino acid that is gamma-aminobutyric acid (GABA) carrying an isobutyl substitutent at the beta-position (the S-enantiomer). Binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues.
Chemical ID: MESH:D000069583
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ace2decreases expressionISOAce2 (Rattus norvegicus)6480464CTDPregabalin results in decreased expression of ACE2 proteinPMID:31629013
Ace2multiple interactionsISOAce2 (Rattus norvegicus)6480464CTDCaptopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]PMID:31629013
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