ACE2 (angiotensin converting enzyme 2) - Rat Genome Database

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Pathways
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Gene: ACE2 (angiotensin converting enzyme 2) Chlorocebus sabaeus
Analyze
Symbol: ACE2
Name: angiotensin converting enzyme 2
RGD ID: 18634684
Description: ENCODES a protein that exhibits carboxypeptidase activity (ortholog); endopeptidase activity (ortholog); identical protein binding (ortholog); INVOLVED IN angiotensin-mediated drinking behavior (ortholog); entry receptor-mediated virion attachment to host cell (ortholog); maternal process involved in female pregnancy (ortholog); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Lung Injury (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN brush border membrane (ortholog); cell surface (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: angiotensin I converting enzyme 2; angiotensin-converting enzyme 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,032,231 - 14,094,163 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX14,030,233 - 14,077,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605615,866,608 - 15,915,985 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (ISO)
Alveolar Bone Loss  (ISO)
anxiety disorder  (ISO)
autistic disorder  (ISO)
avian influenza  (ISO)
bacterial pneumonia  (ISO)
Cardiac Fibrosis  (ISO)
cardiomyopathy  (ISO)
Cardiovirus Infections  (ISO)
cerebral malaria  (ISO)
chemical colitis  (ISO)
congestive heart failure  (ISO)
Coronary Disease  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
endomyocardial fibrosis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fanconi anemia  (ISO)
focal segmental glomerulosclerosis  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
hypertension  (ISO)
Hypertensive Nephrosclerosis  (ISO)
hypertrophic cardiomyopathy  (ISO)
Inflammation  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
middle cerebral artery infarction  (ISO)
multiple congenital anomalies-hypotonia-seizures syndrome 2  (ISO)
myocardial infarction  (ISO)
Neurodevelopmental Disorders  (ISO)
pancreatic ductal carcinoma  (ISO)
Pleural Effusion  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
respiratory syncytial virus infectious disease  (ISO)
severe acute respiratory syndrome  (ISO)
Spontaneous Abortions  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
thrombosis  (ISO)
Ventricular Remodeling  (ISO)
Weight Loss  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202   PMID:32574196   PMID:35414393   PMID:35700214   PMID:35813876  


Genomics

Comparative Map Data
ACE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,032,231 - 14,094,163 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX14,030,233 - 14,077,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605615,866,608 - 15,915,985 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ACE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,518,197 - 15,607,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX15,494,566 - 15,607,236 (-)EnsemblGRCh38hg38GRCh38
GRCh37X15,536,320 - 15,625,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,489,077 - 15,529,058 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X15,338,812 - 15,378,794NCBI
CeleraX19,694,648 - 19,735,682 (-)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX13,333,989 - 13,374,656 (-)NCBIHuRef
CHM1_1X15,610,102 - 15,651,154 (-)NCBICHM1_1
T2T-CHM13v2.0X15,101,170 - 15,190,203 (-)NCBIT2T-CHM13v2.0
Ace2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,922,338 - 162,971,414 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX162,922,328 - 162,971,416 (+)EnsemblGRCm39 Ensembl
GRCm38X164,139,342 - 164,188,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,577,274 - 160,626,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X159,484,737 - 159,532,523 (+)NCBIMGSCv36mm8
CeleraX147,353,722 - 147,402,904 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.12NCBI
Ace2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,925,458 - 33,972,851 (-)NCBIGRCr8
mRatBN7.2X30,293,597 - 30,340,961 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,293,589 - 30,340,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX31,326,034 - 31,372,619 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,763,480 - 34,809,624 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,950,895 - 30,996,838 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X32,050,734 - 32,095,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,049,931 - 32,096,016 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,422,286 - 32,469,137 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,051,758 - 51,096,036 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X51,105,228 - 51,149,505 (-)NCBI
CeleraX30,638,123 - 30,683,403 (-)NCBICelera
Cytogenetic MapXq14NCBI
Ace2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,591,248 - 2,633,495 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,591,229 - 2,643,705 (+)NCBIChiLan1.0ChiLan1.0
ACE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X17,358,905 - 17,402,027 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X17,362,290 - 17,405,412 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X8,189,267 - 8,229,415 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X15,470,896 - 15,510,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,470,896 - 15,510,891 (-)Ensemblpanpan1.1panPan2
ACE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,798,839 - 11,839,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,798,839 - 11,900,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,706,330 - 11,745,360 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X11,760,479 - 11,822,897 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX11,759,554 - 11,789,618 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X11,824,224 - 11,862,960 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X11,818,311 - 11,856,868 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X11,843,799 - 11,882,613 (-)NCBIUU_Cfam_GSD_1.0
Ace2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X4,964,502 - 5,012,706 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364704,965,332 - 5,011,702 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364704,964,526 - 5,011,808 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,093,242 - 12,151,286 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,099,849 - 12,152,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,061,317 - 13,089,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ace2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624829344,933 - 391,527 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624829344,823 - 391,451 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 4 16 16
Below cutoff 29 3 43

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000013014   ⟹   ENSCSAP00000011029
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 EnsemblX14,030,233 - 14,077,785 (-)Ensembl
RefSeq Acc Id: XM_007991113   ⟹   XP_007989304
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1X14,032,231 - 14,094,163 (-)NCBI
Vero_WHO_p1.0NW_02366605615,866,608 - 15,915,985 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037986357   ⟹   XP_037842285
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605615,866,608 - 15,912,312 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007989304 (Get FASTA)   NCBI Sequence Viewer  
  XP_037842285 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000011029.1
Reference Protein Sequences
RefSeq Acc Id: XP_007989304   ⟸   XM_007991113
- UniProtKB: A0A0D9RQZ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000011029   ⟸   ENSCSAT00000013014
RefSeq Acc Id: XP_037842285   ⟸   XM_037986357
- UniProtKB: A0A0D9RQZ0 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014921 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013014.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1370.30 UniProtKB/TrEMBL
InterPro Collectrin_dom UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/TrEMBL
KEGG Report csab:103231639 UniProtKB/TrEMBL
NCBI Gene ACE2 ENTREZGENE
PANTHER ANGIOTENSIN-CONVERTING ENZYME 2 UniProtKB/TrEMBL
  PTHR10514 UniProtKB/TrEMBL
Pfam Collectrin UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/TrEMBL
PRINTS PEPDIPTASEA UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A0A0D9RQZ0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-19 ACE2  angiotensin converting enzyme 2  ACE2  angiotensin I converting enzyme 2  Symbol and/or name change 5135510 APPROVED