ACE2 (angiotensin I converting enzyme 2) - Rat Genome Database
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Gene: ACE2 (angiotensin I converting enzyme 2) Canis lupus familiaris
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Symbol: ACE2
Name: angiotensin I converting enzyme 2
RGD ID: 12347307
Description: ENCODES a protein that exhibits metallocarboxypeptidase activity (ortholog); INVOLVED IN maternal process involved in female pregnancy (ortholog); negative regulation of ERK1 and ERK2 cascade (ortholog); negative regulation of smooth muscle cell proliferation (ortholog); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Lung Injury (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX11,798,839 - 11,900,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X11,798,839 - 11,839,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:25792125   PMID:32661139  


Genomics

Comparative Map Data
ACE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX11,798,839 - 11,900,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X11,798,839 - 11,839,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
ACE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX15,561,033 - 15,602,148 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 EnsemblX15,494,566 - 15,607,236 (-)EnsemblGRCh38hg38GRCh38
GRCh38X15,518,197 - 15,602,158 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X15,579,156 - 15,620,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,489,077 - 15,529,058 (-)NCBINCBI36hg18NCBI36
Build 34X15,338,812 - 15,378,794NCBI
CeleraX19,694,648 - 19,735,682 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX13,333,989 - 13,374,656 (-)NCBIHuRef
CHM1_1X15,610,102 - 15,651,154 (-)NCBICHM1_1
Ace2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,922,338 - 162,971,414 (+)NCBIGRCm39mm39
GRCm38X164,139,342 - 164,188,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,577,274 - 160,626,350 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X159,484,737 - 159,532,523 (+)NCBImm8
CeleraX147,353,722 - 147,402,904 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.12NCBI
Ace2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X32,050,734 - 32,095,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,049,931 - 32,096,016 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,422,286 - 32,469,137 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,051,758 - 51,096,036 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X51,105,228 - 51,149,505 (-)NCBI
CeleraX30,638,123 - 30,683,403 (-)NCBICelera
Cytogenetic MapXq14NCBI
Ace2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,591,248 - 2,633,495 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,591,229 - 2,643,705 (+)NCBIChiLan1.0ChiLan1.0
ACE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X15,470,896 - 15,510,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,470,896 - 15,510,891 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X8,189,267 - 8,229,415 (-)NCBIMhudiblu_PPA_v0panPan3
Ace2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364704,964,526 - 5,011,808 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,099,853 - 12,151,275 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,099,849 - 12,152,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,061,317 - 13,089,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACE2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,032,231 - 14,094,163 (-)NCBI
ChlSab1.1 EnsemblX14,030,233 - 14,077,785 (-)Ensembl
Ace2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624829344,823 - 391,451 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 5 5 5 6
Low 1 3 1 1 1 2 1 3
Below cutoff 2 16 6 6 10 7 10 3

Sequence


Reference Sequences
RefSeq Acc Id: NM_001165260   ⟹   NP_001158732
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X11,799,764 - 11,838,565 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005640992   ⟹   XP_005641049
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X11,798,839 - 11,838,787 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014111329   ⟹   XP_013966804
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X11,798,839 - 11,839,591 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022415506   ⟹   XP_022271214
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X11,798,839 - 11,839,588 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001158732 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABA40749 (Get FASTA)   NCBI Sequence Viewer  
  ACT66277 (Get FASTA)   NCBI Sequence Viewer  
  QJS40032 (Get FASTA)   NCBI Sequence Viewer  
  QLF98519 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013966804   ⟸   XM_014111329
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005641049   ⟸   XM_005640992
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001158732   ⟸   NM_001165260
- Peptide Label: precursor
- UniProtKB: C7ECV0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022271214   ⟸   XM_022415506
- Peptide Label: isoform X2
- Sequence:
Protein Domains
Collectrin

Promoters
RGD ID:13689267
Promoter ID:EPDNEW_C7335
Type:multiple initiation site
Name:ACE2_1
Description:angiotensin I converting enzyme 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X11,838,595 - 11,838,655EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012112 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000017867 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000017872 UniProtKB/TrEMBL
  ENSCAFP00000041771 UniProtKB/TrEMBL
  ENSCAFP00000044301 UniProtKB/TrEMBL
  ENSCAFP00000044676 UniProtKB/TrEMBL
  ENSCAFP00000051955 UniProtKB/TrEMBL
  ENSCAFP00000059054 UniProtKB/TrEMBL
  ENSCAFP00000060369 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019262 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000019271 UniProtKB/TrEMBL
  ENSCAFT00000050182 UniProtKB/TrEMBL
  ENSCAFT00000066545 UniProtKB/TrEMBL
  ENSCAFT00000070501 UniProtKB/TrEMBL
  ENSCAFT00000071783 UniProtKB/TrEMBL
  ENSCAFT00000078759 UniProtKB/TrEMBL
  ENSCAFT00000081503 UniProtKB/TrEMBL
InterPro Collectrin UniProtKB/TrEMBL
  Collectrin_dom UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/TrEMBL
KEGG Report cfa:480847 UniProtKB/TrEMBL
NCBI Gene ACE2 ENTREZGENE
PANTHER PTHR10514 UniProtKB/TrEMBL
  PTHR46884 UniProtKB/TrEMBL
Pfam Collectrin UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/TrEMBL
PRINTS PEPDIPTASEA UniProtKB/TrEMBL
UniGene Cfa.14509 ENTREZGENE
UniProt A0A5F4BR84_CANLF UniProtKB/TrEMBL
  A0A5F4BS93_CANLF UniProtKB/TrEMBL
  A0A5F4CCF9_CANLF UniProtKB/TrEMBL
  A0A5F4CXG9_CANLF UniProtKB/TrEMBL
  A0A5F4D149_CANLF UniProtKB/TrEMBL
  A0A6M4S156_CANLF UniProtKB/TrEMBL
  C7ECV0 ENTREZGENE, UniProtKB/TrEMBL
  E2RR65_CANLF UniProtKB/TrEMBL
  F1P7C5_CANLF UniProtKB/TrEMBL
  J9P7Y2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:37503 ENTREZGENE