ACE2 (angiotensin converting enzyme 2) - Rat Genome Database

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Gene: ACE2 (angiotensin converting enzyme 2) Sus scrofa
Analyze
Symbol: ACE2
Name: angiotensin converting enzyme 2
RGD ID: 13917869
Description: ENCODES a protein that exhibits carboxypeptidase activity (ortholog); metallocarboxypeptidase activity (ortholog); virus receptor activity (ortholog); INVOLVED IN angiotensin maturation (ortholog); maternal process involved in female pregnancy (ortholog); negative regulation of ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Lung Injury (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog); INTERACTS WITH zearalenone
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2; anigotensin I converting enzyme 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,093,242 - 12,151,286 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,099,849 - 12,152,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,061,317 - 13,089,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (ISO)
Alveolar Bone Loss  (ISO)
anxiety disorder  (ISO)
autistic disorder  (ISO)
avian influenza  (ISO)
bacterial pneumonia  (ISO)
Cardiac Fibrosis  (ISO)
cardiomyopathy  (ISO)
Cardiovirus Infections  (ISO)
cerebral malaria  (ISO)
chemical colitis  (ISO)
congestive heart failure  (ISO)
Coronary Disease  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
endomyocardial fibrosis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fanconi anemia  (ISO)
focal segmental glomerulosclerosis  (ISO)
glaucoma  (ISO)
hypertension  (ISO)
Hypertensive Nephrosclerosis  (ISO)
hypertrophic cardiomyopathy  (ISO)
Inflammation  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
middle cerebral artery infarction  (ISO)
multiple congenital anomalies-hypotonia-seizures syndrome 2  (ISO)
myocardial infarction  (ISO)
Neurodevelopmental Disorders  (ISO)
pancreatic ductal carcinoma  (ISO)
Pleural Effusion  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
respiratory syncytial virus infectious disease  (ISO)
severe acute respiratory syndrome  (ISO)
Spontaneous Abortions  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
thrombosis  (ISO)
Ventricular Remodeling  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:20622181   PMID:22301074   PMID:27449068   PMID:29328448   PMID:30032202   PMID:30816437   PMID:33756342   PMID:35641567   PMID:36932971  


Genomics

Comparative Map Data
ACE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,093,242 - 12,151,286 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,099,849 - 12,152,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,061,317 - 13,089,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,518,197 - 15,607,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX15,494,566 - 15,607,236 (-)EnsemblGRCh38hg38GRCh38
GRCh37X15,536,320 - 15,625,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,489,077 - 15,529,058 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X15,338,812 - 15,378,794NCBI
CeleraX19,694,648 - 19,735,682 (-)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX13,333,989 - 13,374,656 (-)NCBIHuRef
CHM1_1X15,610,102 - 15,651,154 (-)NCBICHM1_1
T2T-CHM13v2.0X15,101,170 - 15,190,203 (-)NCBIT2T-CHM13v2.0
Ace2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,922,338 - 162,971,414 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX162,922,328 - 162,971,416 (+)EnsemblGRCm39 Ensembl
GRCm38X164,139,342 - 164,188,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,577,274 - 160,626,350 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X159,484,737 - 159,532,523 (+)NCBIMGSCv36mm8
CeleraX147,353,722 - 147,402,904 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.12NCBI
Ace2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X33,925,458 - 33,972,851 (-)NCBIGRCr8
mRatBN7.2X30,293,597 - 30,340,961 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX30,293,589 - 30,340,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX31,326,034 - 31,372,619 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X34,763,480 - 34,809,624 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X30,950,895 - 30,996,838 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X32,050,734 - 32,095,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX32,049,931 - 32,096,016 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X32,422,286 - 32,469,137 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,051,758 - 51,096,036 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X51,105,228 - 51,149,505 (-)NCBI
CeleraX30,638,123 - 30,683,403 (-)NCBICelera
Cytogenetic MapXq14NCBI
Ace2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,591,248 - 2,633,495 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,591,229 - 2,643,705 (+)NCBIChiLan1.0ChiLan1.0
ACE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X17,358,905 - 17,402,027 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X17,362,290 - 17,405,412 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X8,189,267 - 8,229,415 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X15,470,896 - 15,510,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,470,896 - 15,510,891 (-)Ensemblpanpan1.1panPan2
ACE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,798,839 - 11,839,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,798,839 - 11,900,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,706,330 - 11,745,360 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X11,760,479 - 11,822,897 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX11,759,554 - 11,789,618 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X11,824,224 - 11,862,960 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X11,818,311 - 11,856,868 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X11,843,799 - 11,882,613 (-)NCBIUU_Cfam_GSD_1.0
Ace2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X4,964,502 - 5,012,706 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364704,965,332 - 5,011,702 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364704,964,526 - 5,011,808 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,032,231 - 14,094,163 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX14,030,233 - 14,077,785 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605615,866,608 - 15,915,985 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ace2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624829344,933 - 391,527 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624829344,823 - 391,451 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ACE2
972 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 13 3 5 13 11 13 3 5 1

Sequence


Ensembl Acc Id: ENSSSCT00000034032   ⟹   ENSSSCP00000028755
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX12,099,853 - 12,151,275 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000103737   ⟹   ENSSSCP00000076249
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX12,093,242 - 12,151,286 (-)Ensembl
RefSeq Acc Id: NM_001123070   ⟹   NP_001116542
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X12,100,712 - 12,151,227 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021079374   ⟹   XP_020935033
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X12,099,849 - 12,152,199 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021079375   ⟹   XP_020935034
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X12,100,927 - 12,152,204 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021079376   ⟹   XP_020935035
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X12,099,869 - 12,152,198 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021079377   ⟹   XP_020935036
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X12,099,869 - 12,149,230 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020935033   ⟸   XM_021079374
- Peptide Label: isoform X1
- UniProtKB: A0A8D0JCB2 (UniProtKB/TrEMBL),   A0A220QT48 (UniProtKB/TrEMBL),   A0A8D0TDK7 (UniProtKB/TrEMBL),   K7GLM4 (UniProtKB/TrEMBL),   A0A8D0JFQ5 (UniProtKB/TrEMBL),   A0A8D1DI65 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020935035   ⟸   XM_021079376
- Peptide Label: isoform X3
- UniProtKB: A0A4X1UXU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020935036   ⟸   XM_021079377
- Peptide Label: isoform X3
- UniProtKB: A0A4X1UXU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001116542   ⟸   NM_001123070
- Peptide Label: precursor
- UniProtKB: B1PZW5 (UniProtKB/TrEMBL),   A0A8D0JCB2 (UniProtKB/TrEMBL),   A0A8D0JFQ5 (UniProtKB/TrEMBL),   A0A8D1DI65 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020935034   ⟸   XM_021079375
- Peptide Label: isoform X2
- UniProtKB: A0A8W4FA96 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000028755   ⟸   ENSSSCT00000034032
Ensembl Acc Id: ENSSSCP00000076249   ⟸   ENSSSCT00000103737
Protein Domains
Collectrin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012138 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015007905 UniProtKB/TrEMBL
  ENSSSCG00025070292 UniProtKB/TrEMBL
  ENSSSCG00040013535 UniProtKB/TrEMBL
  ENSSSCG00055005558 UniProtKB/TrEMBL
  ENSSSCG00070019966 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000034032 ENTREZGENE
  ENSSSCT00000034032.2 UniProtKB/TrEMBL
  ENSSSCT00000103737.1 UniProtKB/TrEMBL
  ENSSSCT00015010509.1 UniProtKB/TrEMBL
  ENSSSCT00025096644.1 UniProtKB/TrEMBL
  ENSSSCT00040018081.1 UniProtKB/TrEMBL
  ENSSSCT00055010861.1 UniProtKB/TrEMBL
  ENSSSCT00070039621.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1370.30 UniProtKB/TrEMBL
InterPro Collectrin_dom UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/TrEMBL
KEGG Report ssc:100144303 UniProtKB/TrEMBL
NCBI Gene ACE2 ENTREZGENE
PANTHER ANGIOTENSIN-CONVERTING ENZYME 2 UniProtKB/TrEMBL
  PTHR10514 UniProtKB/TrEMBL
Pfam Collectrin UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/TrEMBL
PRINTS PEPDIPTASEA UniProtKB/TrEMBL
PROSITE COLLECTRIN_LIKE UniProtKB/TrEMBL
  PEPTIDASE_M2 UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A0A220QT48 ENTREZGENE
  A0A4X1UXU4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0JCB2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0JFQ5 ENTREZGENE
  A0A8D0TDK7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1DI65 ENTREZGENE
  A0A8W4FA96 ENTREZGENE, UniProtKB/TrEMBL
  B1PZW5 ENTREZGENE, UniProtKB/TrEMBL
  K7GLM4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:85008 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-18 ACE2  angiotensin converting enzyme 2  ACE2  angiotensin I converting enzyme 2  Symbol and/or name change 19259463 PROVISIONAL