Ace2 (angiotensin converting enzyme 2) - Rat Genome Database

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Gene: Ace2 (angiotensin converting enzyme 2) Ictidomys tridecemlineatus
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Symbol: Ace2
Name: angiotensin converting enzyme 2
RGD ID: 12475054
Description: ENCODES a protein that exhibits carboxypeptidase activity (ortholog); endopeptidase activity (ortholog); identical protein binding (ortholog); INVOLVED IN angiotensin-mediated drinking behavior (ortholog); maternal process involved in female pregnancy (ortholog); negative regulation of ERK1 and ERK2 cascade (ortholog); PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Lung Injury (ortholog); adult respiratory distress syndrome (ortholog); FOUND IN apical plasma membrane (ortholog); brush border membrane (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: angiotensin I converting enzyme 2; angiotensin-converting enzyme 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X4,964,502 - 5,012,706 (-)NCBI
SpeTri2.0NW_0049364704,964,526 - 5,011,808 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Ace2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X4,964,502 - 5,012,706 (-)NCBI
SpeTri2.0NW_0049364704,964,526 - 5,011,808 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX15,494,566 - 15,607,236 (-)EnsemblGRCh38hg38GRCh38
GRCh38X15,518,197 - 15,607,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X15,536,320 - 15,620,281 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,489,077 - 15,529,058 (-)NCBINCBI36hg18NCBI36
Build 34X15,338,812 - 15,378,794NCBI
CeleraX19,694,648 - 19,735,682 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX13,333,989 - 13,374,656 (-)NCBIHuRef
CHM1_1X15,610,102 - 15,651,154 (-)NCBICHM1_1
Ace2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X162,922,338 - 162,971,414 (+)NCBIGRCm39mm39
GRCm39 EnsemblX162,922,328 - 162,971,416 (+)Ensembl
GRCm38X164,139,342 - 164,188,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX164,139,332 - 164,188,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X160,577,274 - 160,626,350 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X159,484,737 - 159,532,523 (+)NCBImm8
CeleraX147,353,722 - 147,402,904 (+)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX76.12NCBI
Ace2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X30,293,597 - 30,340,961 (-)NCBI
Rnor_6.0 EnsemblX32,049,931 - 32,096,016 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X32,050,734 - 32,095,860 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X32,422,286 - 32,469,137 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X51,051,758 - 51,096,036 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X51,105,228 - 51,149,505 (-)NCBI
CeleraX30,638,123 - 30,683,403 (-)NCBICelera
Cytogenetic MapXq14NCBI
Ace2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555192,591,248 - 2,633,495 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555192,591,229 - 2,643,705 (+)NCBIChiLan1.0ChiLan1.0
ACE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X15,470,896 - 15,510,891 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX15,470,896 - 15,510,891 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X8,189,267 - 8,229,415 (-)NCBIMhudiblu_PPA_v0panPan3
ACE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X11,798,839 - 11,839,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX11,798,839 - 11,900,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX11,706,330 - 11,745,360 (-)NCBI
ROS_Cfam_1.0X11,760,479 - 11,822,897 (-)NCBI
UMICH_Zoey_3.1X11,824,224 - 11,862,960 (-)NCBI
UNSW_CanFamBas_1.0X11,818,311 - 11,856,868 (-)NCBI
UU_Cfam_GSD_1.0X11,843,799 - 11,882,613 (-)NCBI
ACE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX12,099,853 - 12,151,275 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X12,099,849 - 12,152,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X13,061,317 - 13,089,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACE2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X14,032,231 - 14,094,163 (-)NCBI
ChlSab1.1 EnsemblX14,030,233 - 14,077,785 (-)Ensembl
Vero_WHO_p1.0NW_02366605615,866,608 - 15,915,985 (-)NCBI
Ace2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624829344,823 - 391,451 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005315994   ⟹   XP_005316051
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X4,964,502 - 5,012,706 (-)NCBI
SpeTri2.0NW_0049364704,964,526 - 5,011,808 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040290338   ⟹   XP_040146272
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X4,964,502 - 5,012,706 (-)NCBI
RefSeq Acc Id: XM_040290398   ⟹   XP_040146332
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X4,965,425 - 5,012,706 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_005316051   ⟸   XM_005315994
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_040146272   ⟸   XM_040290338
- Peptide Label: isoform X1
RefSeq Acc Id: XP_040146332   ⟸   XM_040290398
- Peptide Label: isoform X2
Protein Domains
Collectrin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000006588 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000005914 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000006614 UniProtKB/TrEMBL
InterPro Collectrin_dom UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/TrEMBL
NCBI Gene Ace2 ENTREZGENE
PANTHER PTHR10514 UniProtKB/TrEMBL
Pfam Collectrin UniProtKB/TrEMBL
  Peptidase_M2 UniProtKB/TrEMBL
PRINTS PEPDIPTASEA UniProtKB/TrEMBL
UniProt I3M887_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-19 Ace2  angiotensin converting enzyme 2  Ace2  angiotensin I converting enzyme 2  Symbol and/or name change 5135510 APPROVED