RGD Reference Report - ACE2-angiotensin-(1-7)-Mas axis in renal ischaemia/reperfusion injury in rats. - Rat Genome Database

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ACE2-angiotensin-(1-7)-Mas axis in renal ischaemia/reperfusion injury in rats.

Authors: Da Silveira, KD  Pompermayer Bosco, KS  Diniz, LR  Carmona, AK  Cassali, GD  Bruna-Romero, O  De Sousa, LP  Teixeira, MM  Santos, RA  Simoes e Silva, AC  Ribeiro Vieira, MA 
Citation: da Silveira KD, etal., Clin Sci (Lond). 2010 Jul 23;119(9):385-94. doi: 10.1042/CS20090554.
RGD ID: 9685432
Pubmed: PMID:20528771   (View Abstract at PubMed)
DOI: DOI:10.1042/CS20090554   (Journal Full-text)

AngII (angiotensin II), ACE (angiotensin I-converting enzyme) and the AT1 receptor (AngII type 1 receptor) are associated with the inflammatory process and microvascular dysfunction of AKI (acute kidney injury) induced by renal I/R (ischaemia/reperfusion). However, Ang-(1-7) [angiotensin-(1-7)], ACE2 (angiotensin I-converting enzyme 2) and the Mas receptor also play a role in renal disease models. Therefore, in the present study, we have examined the renal profile of Ang-(1-7), ACE2 and the Mas receptor in renal I/R and compared them with that of AngII, ACE and the AT1 receptor. Male Wistar rats were submitted to left nephrectomy and ischaemia (45 min) followed by reperfusion (2 or 4 h) in the right kidney. At 4 h of reperfusion, renal AngII was increased (P<0.01) and renal Ang-(1-7) was decreased substantially (P<0.05), although plasma levels of both angiotensins were unchanged. In addition, renal I/R decreased the renal mRNA expression of renin (P<0.05), AT1 receptors (P<0.001) and ACE2 (P<0.05). At 2 and 4 h of reperfusion, renal ACE activity was reduced (P<0.05). On the other hand, renal expression of the Mas receptor was greatly increased at 4 h of reperfusion (P<0.01), which was confirmed by immunohistochemical and Western blot analysis. In conclusion, increased renal expression of the Mas receptor associated with changes in the RAS (renin-angiotensin system)-related peptidases support an important role for the ACE2-Ang-(1-7)-Mas axis in AKI.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
ACE2HumanKidney Reperfusion Injury  ISOAce2 (Rattus norvegicus)mRNA:decreased expression:kidneyRGD 
Ace2RatKidney Reperfusion Injury  IEP mRNA:decreased expression:kidneyRGD 
Ace2MouseKidney Reperfusion Injury  ISOAce2 (Rattus norvegicus)mRNA:decreased expression:kidneyRGD 


Genes (Rattus norvegicus)
Ace2  (angiotensin converting enzyme 2)

Genes (Mus musculus)
Ace2  (angiotensin converting enzyme 2)

Genes (Homo sapiens)
ACE2  (angiotensin converting enzyme 2)