RGD Reference Report - Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. - Rat Genome Database

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Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus.

Authors: Gu, Hongjing  Xie, Zhengde  Li, Tieling  Zhang, Shaogeng  Lai, Chengcai  Zhu, Ping  Wang, Keyu  Han, Lina  Duan, Yueqiang  Zhao, Zhongpeng  Yang, Xiaolan  Xing, Li  Zhang, Peirui  Wang, Zhouhai  Li, Ruisheng  Yu, Jane J  Wang, Xiliang  Yang, Penghui 
Citation: Gu H, etal., Sci Rep. 2016 Jan 27;6:19840. doi: 10.1038/srep19840.
RGD ID: 32716392
Pubmed: PMID:26813885   (View Abstract at PubMed)
PMCID: PMC4728398   (View Article at PubMed Central)
DOI: DOI:10.1038/srep19840   (Journal Full-text)

Respiratory syncytial virus (RSV) infection is a major cause of severe lower respiratory illness in infants and young children, but the underlying mechanisms responsible for viral pathogenesis have not been fully elucidated. To date, no drugs or vaccines have been employed to improve clinical outcomes for RSV-infected patients. In this paper, we report that angiotensin-converting enzyme-2 (ACE2) protected against severe lung injury induced by RSV infection in an experimental mouse model and in pediatric patients. Moreover, ACE2 deficiency aggravated RSV-associated disease pathogenesis, mainly by its action on the angiotensin II type 1 receptor (AT1R). Furthermore, administration of a recombinant ACE2 protein alleviated the severity of RSV-induced lung injury. These findings demonstrate that ACE2 plays a critical role in preventing RSV-induced lung injury, and suggest that ACE2 is a promising potential therapeutic target in the management of RSV-induced lung disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
respiratory syncytial virus infectious disease severityISOAce2 (Mus musculus)32716392; 32716392 RGD 
respiratory syncytial virus infectious disease treatmentIDA 32716392human protein in a mouse modelRGD 
respiratory syncytial virus infectious disease treatmentISOACE2 (Homo sapiens)32716392; 32716392human protein in a mouse modelRGD 
respiratory syncytial virus infectious disease severityIMP 32716392 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ace2  (angiotensin converting enzyme 2)

Genes (Mus musculus)
Ace2  (angiotensin converting enzyme 2)

Genes (Homo sapiens)
ACE2  (angiotensin converting enzyme 2)


Additional Information