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GENE - TERM ANNOTATION REPORT

RGD ID: 1550521
Species: Mus musculus
RGD Object: Gene
Symbol: Ace2
Name: angiotensin converting enzyme 2
Acc ID: DOID:10763
Term: hypertension
Definition: An artery disease characterized by chronic elevated blood pressure in the arteries. (DO)
Definition Source(s): https://en.wikipedia.org/wiki/Hypertension "DO" "DO", https://www.ncbi.nlm.nih.gov/pubmed/24352797 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ace2treatmentIMP 9685435RGD  
Ace2 ISOACE2 (Homo sapiens)1642828RGDassociated with Metabolic Syndrome X (MeSH:D024821) 
Ace2 ISOAce2 (Rattus norvegicus)629626RGDmRNA, protein:decreased expression:kidney (rat) 
Ace2 ISOAce2 (Rattus norvegicus)9685442RGDmRNA, protein:decreased expression:aorta 
Ace2treatmentISOAce2 (Rattus norvegicus)9685433RGD  
Ace2 ISOACE2 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanism|therapeuticPMID:12075344 PMID:15833808 PMID:17473847 PMID:18391097 PMID:19221212 PMID:20559404 PMID:21859683
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