ACE (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) - Rat Genome Database

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Gene: ACE (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) Sus scrofa
Analyze
Symbol: ACE
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
RGD ID: 13933940
Description: ENCODES a protein that exhibits actin binding (ortholog); exopeptidase activity (ortholog); metallodipeptidase activity (ortholog); INVOLVED IN aging (ortholog); angiogenesis involved in coronary vascular morphogenesis (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway; benazepril pharmacodynamics pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN basal plasma membrane (ortholog); brush border membrane (ortholog); cytoplasm (ortholog); INTERACTS WITH nitric oxide
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: angiotensin-converting enzyme; angiotensin-I converting enzyme
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,394,487 - 15,414,639 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,394,487 - 15,414,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,381,362 - 15,401,171 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
Alcoholic Liver Diseases  (ISO)
Allanson Pantzar McLeod Syndrome  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
Angiotensin I-Converting Enzyme, Benign Serum Increase  (ISO)
ankylosing spondylitis  (ISO)
Aortic Coarctation  (ISO)
Arteriovenous Fistula  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Banti's Syndrome  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
CAKUT  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (ISO)
cardiovascular system disease  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chemical colitis  (ISO)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
cholestasis  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
congenital diaphragmatic hernia  (ISO)
Congenital Hepatic Fibrosis  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
Cough  (ISO)
COVID-19  (ISO)
Cytomegalovirus Infections  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diastolic heart failure  (ISO)
dilated cardiomyopathy  (ISO)
drug allergy  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrinsic allergic alveolitis  (ISO)
Fabry disease  (ISO)
Familial Cerebral Cavernous Malformation  (ISO)
familial Mediterranean fever  (ISO)
Fetal Death  (ISO)
Fetal Growth Retardation  (ISO)
focal segmental glomerulosclerosis 1  (ISO)
gallbladder adenocarcinoma  (ISO)
Gaucher's disease  (ISO)
Genetic Predisposition to Disease  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
glycogen storage disease V  (ISO)
heart valve disease  (ISO)
Helicobacter Infections  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatitis A  (ISO)
hepatocellular carcinoma  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
Hypertensive Nephrosclerosis  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
in situ carcinoma  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
leukemia  (ISO)
leukostasis  (ISO)
liver cirrhosis  (ISO)
Liver Metastasis  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
malaria  (ISO)
male infertility  (ISO)
Memory Disorders  (ISO)
Meningococcal Infections  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
mitral valve disease  (ISO)
mitral valve prolapse  (ISO)
multiple myeloma  (ISO)
Mycobacterium Infections  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
ocular hypotension  (ISO)
osteoporosis  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Peritoneal Fibrosis  (ISO)
Pleural Effusion  (ISO)
pneumonia  (ISO)
polycythemia  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Infant Diseases  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
pyelonephritis  (ISO)
Radiation Nephropathy  (ISO)
renal fibrosis  (ISO)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory system disease  (ISO)
Right Ventricular Hypertrophy  (ISO)
sarcoidosis  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Staphylococcal Infections  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
subacute sclerosing panencephalitis  (ISO)
substance-induced psychosis  (ISO)
Sudden Death  (ISO)
systemic scleroderma  (ISO)
toxic shock syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
uveitis  (ISO)
Vascular System Injuries  (ISO)
Venous Thromboembolism  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Remodeling  (ISO)
viral pneumonia  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
nitric oxide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
amyloid-beta metabolic process  (IEA)
angiogenesis involved in coronary vascular morphogenesis  (ISO)
animal organ regeneration  (ISO)
arachidonic acid secretion  (IEA)
bradykinin catabolic process  (ISO)
brain development  (ISO)
cell proliferation in bone marrow  (IEA)
cellular response to aldosterone  (ISO)
cellular response to glucose stimulus  (ISO)
eating behavior  (ISO)
embryo development ending in birth or egg hatching  (ISO)
female pregnancy  (ISO)
heart contraction  (IEA,ISO)
hormone catabolic process  (IEA)
kidney development  (IEA,ISO)
lung alveolus development  (ISO)
lung development  (ISO)
male gonad development  (ISO)
negative regulation of calcium ion import  (ISO)
negative regulation of gap junction assembly  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of glucose import  (ISO)
negative regulation of protein binding  (IEA)
negative regulation of renal sodium excretion  (ISO)
neutrophil mediated immunity  (IEA,ISO)
peptide catabolic process  (IEA,ISO)
peptide metabolic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of peptidyl-cysteine S-nitrosylation  (IEA)
positive regulation of peptidyl-tyrosine autophosphorylation  (IEA)
positive regulation of protein binding  (IEA)
positive regulation of protein tyrosine kinase activity  (IEA)
positive regulation of systemic arterial blood pressure  (IBA,ISO)
positive regulation of vasoconstriction  (ISO)
posttranscriptional regulation of gene expression  (IEA)
proteolysis  (IEA)
regulation of angiotensin metabolic process  (IEA)
regulation of blood pressure  (ISO)
regulation of hematopoietic stem cell proliferation  (IEA)
regulation of smooth muscle cell migration  (ISO)
regulation of systemic arterial blood pressure by renin-angiotensin  (IBA)
response to dexamethasone  (ISO)
response to hypoxia  (ISO)
response to laminar fluid shear stress  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to thyroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of pain  (ISO)
spermatogenesis  (IEA,ISO)
vasoconstriction  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:15583077   PMID:17145192   PMID:18327080   PMID:20427191   PMID:29328448  


Genomics

Comparative Map Data
ACE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,394,487 - 15,414,639 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,394,487 - 15,414,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,381,362 - 15,401,171 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1763,477,061 - 63,498,380 (+)EnsemblGRCh38hg38GRCh38
GRCh381763,477,061 - 63,498,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371761,554,422 - 61,575,734 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361758,908,166 - 58,928,711 (+)NCBINCBI36hg18NCBI36
Build 341758,915,908 - 58,952,935NCBI
Celera1755,942,475 - 55,963,778 (+)NCBI
Cytogenetic Map17q23.3NCBI
HuRef1756,922,781 - 56,944,100 (+)NCBIHuRef
CHM1_11761,618,550 - 61,639,869 (+)NCBICHM1_1
Ace
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,858,774 - 105,880,790 (+)NCBIGRCm39mm39
GRCm39 Ensembl11105,858,771 - 105,880,790 (+)Ensembl
GRCm3811105,967,948 - 105,989,964 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11105,967,945 - 105,989,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,829,261 - 105,851,259 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611105,784,049 - 105,805,350 (+)NCBImm8
Celera11117,699,475 - 117,721,491 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.84NCBI
Ace
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21090,910,316 - 90,930,437 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1094,170,766 - 94,187,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01094,170,766 - 94,213,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01093,922,062 - 93,965,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,361,338 - 95,381,455 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1089,588,544 - 89,608,666 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
ACE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11762,710,398 - 62,724,018 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1762,702,341 - 62,733,853 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01757,556,294 - 57,577,294 (+)NCBIMhudiblu_PPA_v0panPan3
ACE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,497,182 - 11,516,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,497,182 - 11,516,358 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,457,866 - 12,477,045 (+)NCBI
ROS_Cfam_1.0913,160,704 - 13,179,888 (+)NCBI
UMICH_Zoey_3.1912,105,344 - 12,124,523 (+)NCBI
UNSW_CanFamBas_1.0915,407,255 - 15,426,429 (-)NCBI
UU_Cfam_GSD_1.0915,410,134 - 15,429,354 (-)NCBI
LOC101968921
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560215,017,159 - 15,036,742 (-)NCBI
SpeTri2.0NW_0049365414,157,847 - 4,178,156 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Ace
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624849998,262 - 1,019,305 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1 2
Low 9 4 3 4 2 23 3 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000018828   ⟹   ENSSSCP00000018326
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1215,394,497 - 15,414,621 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000018829   ⟹   ENSSSCP00000018327
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1215,394,487 - 15,407,773 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000034527   ⟹   ENSSSCP00000030627
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1215,394,490 - 15,414,624 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000078015   ⟹   ENSSSCP00000063164
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1215,395,067 - 15,414,639 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000084374   ⟹   ENSSSCP00000061570
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1215,394,497 - 15,414,621 (-)Ensembl
RefSeq Acc Id: NM_001033015   ⟹   NP_001028187
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11215,394,487 - 15,407,773 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001083941   ⟹   NP_001077410
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11215,394,487 - 15,414,609 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001028187 (Get FASTA)   NCBI Sequence Viewer  
  NP_001077410 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABL73884 (Get FASTA)   NCBI Sequence Viewer  
  BAE16967 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001077410   ⟸   NM_001083941
- Peptide Label: isoform 2 precursor
- Sequence:
RefSeq Acc Id: NP_001028187   ⟸   NM_001033015
- Peptide Label: isoform 1 precursor
- Sequence:
RefSeq Acc Id: ENSSSCP00000030627   ⟸   ENSSSCT00000034527
RefSeq Acc Id: ENSSSCP00000063164   ⟸   ENSSSCT00000078015
RefSeq Acc Id: ENSSSCP00000061570   ⟸   ENSSSCT00000084374
RefSeq Acc Id: ENSSSCP00000018327   ⟸   ENSSSCT00000018829
RefSeq Acc Id: ENSSSCP00000018326   ⟸   ENSSSCT00000018828


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017296 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070006470 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000018326 UniProtKB/TrEMBL
  ENSSSCP00000018327 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000030627 UniProtKB/TrEMBL
  ENSSSCP00000061570 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000063164 UniProtKB/TrEMBL
  ENSSSCP00070010408 UniProtKB/TrEMBL
  ENSSSCP00070010428 UniProtKB/TrEMBL
  ENSSSCP00070010449 UniProtKB/TrEMBL
  ENSSSCP00070010468 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000018828 UniProtKB/TrEMBL
  ENSSSCT00000018829 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000034527 UniProtKB/TrEMBL
  ENSSSCT00000078015 UniProtKB/TrEMBL
  ENSSSCT00000084374 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070012661 UniProtKB/TrEMBL
  ENSSSCT00070012685 UniProtKB/TrEMBL
  ENSSSCT00070012706 UniProtKB/TrEMBL
  ENSSSCT00070012725 UniProtKB/TrEMBL
InterPro Peptidase_M2 UniProtKB/TrEMBL
NCBI Gene ACE ENTREZGENE
PANTHER PTHR10514 UniProtKB/TrEMBL
Pfam Peptidase_M2 UniProtKB/TrEMBL
PRINTS PEPDIPTASEA UniProtKB/TrEMBL
UniProt A0A480IQM9_PIG UniProtKB/TrEMBL
  A0A4X1T4V4_PIG UniProtKB/TrEMBL
  A0A4X1T4X4_PIG UniProtKB/TrEMBL
  A0A4X1T4Z5_PIG UniProtKB/TrEMBL
  A0A4X1T508_PIG UniProtKB/TrEMBL
  A0A5G2QTW5_PIG UniProtKB/TrEMBL
  A0A5G2QY75_PIG UniProtKB/TrEMBL
  F1RRW4_PIG UniProtKB/TrEMBL
  F1RRW5_PIG UniProtKB/TrEMBL
  K7GRU7_PIG UniProtKB/TrEMBL