LOC101968921 (angiotensin-converting enzyme) - Rat Genome Database

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Gene: LOC101968921 (angiotensin-converting enzyme) Ictidomys tridecemlineatus
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Symbol: LOC101968921
Name: angiotensin-converting enzyme
RGD ID: 12702217
Description: ENCODES a protein that exhibits actin binding (ortholog); bradykinin receptor binding (ortholog); chloride ion binding (ortholog); INVOLVED IN aging (ortholog); amyloid-beta metabolic process (ortholog); angiogenesis involved in coronary vascular morphogenesis (ortholog); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway; benazepril pharmacodynamics pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Hepatitis (ortholog); acute kidney failure (ortholog); FOUND IN basal plasma membrane (ortholog); brush border membrane (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: Ace; angiotensin I converting enzyme; angiotensin-converting enzyme, transcript variant X1; angiotensin-converting enzyme, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560215,017,159 - 15,036,742 (-)NCBI
SpeTri2.0NW_0049365414,157,847 - 4,178,156 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Hepatitis  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
Alcoholic Liver Diseases  (ISO)
Allanson Pantzar McLeod Syndrome  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
Angiotensin I-Converting Enzyme, Benign Serum Increase  (ISO)
ankylosing spondylitis  (ISO)
Aortic Coarctation  (ISO)
Arteriovenous Fistula  (ISO)
aspiration pneumonia  (ISO)
asthma  (ISO)
atrial fibrillation  (ISO)
autistic disorder  (ISO)
autosomal recessive polycystic kidney disease  (ISO)
Banti's Syndrome  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
bronchiolitis obliterans  (ISO)
CAKUT  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (ISO)
cardiovascular system disease  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chemical colitis  (ISO)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
cholestasis  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
congenital diaphragmatic hernia  (ISO)
Congenital Hepatic Fibrosis  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
Coronavirus infectious disease  (ISO)
Cough  (ISO)
COVID-19  (ISO)
Cytomegalovirus Infections  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diastolic heart failure  (ISO)
dilated cardiomyopathy  (ISO)
drug allergy  (ISO)
end stage renal disease  (ISO)
endomyocardial fibrosis  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrinsic allergic alveolitis  (ISO)
Fabry disease  (ISO)
Familial Cerebral Cavernous Malformation  (ISO)
familial Mediterranean fever  (ISO)
Fetal Death  (ISO)
Fetal Growth Retardation  (ISO)
focal segmental glomerulosclerosis 1  (ISO)
gallbladder adenocarcinoma  (ISO)
Gaucher's disease  (ISO)
Genetic Predisposition to Disease  (ISO)
glomerulonephritis  (ISO)
glomerulosclerosis  (ISO)
glycogen storage disease V  (ISO)
heart valve disease  (ISO)
Helicobacter Infections  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatitis A  (ISO)
hepatocellular carcinoma  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
Hypertensive Nephrosclerosis  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
in situ carcinoma  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
leukemia  (ISO)
leukostasis  (ISO)
liver cirrhosis  (ISO)
Liver Metastasis  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
malaria  (ISO)
male infertility  (ISO)
Memory Disorders  (ISO)
Meningococcal Infections  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
mitral valve disease  (ISO)
mitral valve prolapse  (ISO)
multiple myeloma  (ISO)
Mycobacterium Infections  (ISO)
myocardial infarction  (ISO)
myocarditis  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
nephrosis  (ISO)
nephrotic syndrome  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
ocular hypotension  (ISO)
osteoporosis  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Peritoneal Fibrosis  (ISO)
Pleural Effusion  (ISO)
pneumonia  (ISO)
polycythemia  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Premature Infant Diseases  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
pyelonephritis  (ISO)
Radiation Nephropathy  (ISO)
renal fibrosis  (ISO)
Renal Tubular Dysgenesis  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
respiratory system disease  (ISO)
Right Ventricular Hypertrophy  (ISO)
sarcoidosis  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Staphylococcal Infections  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
subacute sclerosing panencephalitis  (ISO)
substance-induced psychosis  (ISO)
Sudden Death  (ISO)
systemic scleroderma  (ISO)
toxic shock syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
uveitis  (ISO)
Vascular System Injuries  (ISO)
Venous Thromboembolism  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Remodeling  (ISO)
viral pneumonia  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
amyloid-beta metabolic process  (ISO)
angiogenesis involved in coronary vascular morphogenesis  (ISO)
animal organ regeneration  (ISO)
arachidonic acid secretion  (ISO)
bradykinin catabolic process  (ISO)
brain development  (ISO)
cell proliferation in bone marrow  (ISO)
cellular response to aldosterone  (ISO)
cellular response to glucose stimulus  (ISO)
eating behavior  (ISO)
embryo development ending in birth or egg hatching  (ISO)
female pregnancy  (ISO)
heart contraction  (ISO)
hormone catabolic process  (ISO)
kidney development  (ISO)
lung alveolus development  (ISO)
lung development  (ISO)
male gonad development  (ISO)
negative regulation of calcium ion import  (ISO)
negative regulation of gap junction assembly  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glucose import  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of renal sodium excretion  (ISO)
neutrophil mediated immunity  (ISO)
peptide catabolic process  (ISO)
peptide metabolic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of peptidyl-cysteine S-nitrosylation  (ISO)
positive regulation of peptidyl-tyrosine autophosphorylation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of systemic arterial blood pressure  (ISO)
positive regulation of vasoconstriction  (ISO)
posttranscriptional regulation of gene expression  (ISO)
regulation of angiotensin metabolic process  (ISO)
regulation of blood pressure  (ISO)
regulation of hematopoietic stem cell proliferation  (ISO)
regulation of smooth muscle cell migration  (ISO)
regulation of systemic arterial blood pressure by renin-angiotensin  (ISO)
response to dexamethasone  (ISO)
response to hypoxia  (ISO)
response to laminar fluid shear stress  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to thyroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of pain  (ISO)
spermatogenesis  (ISO)
vasoconstriction  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
LOC101968921
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560215,017,159 - 15,036,742 (-)NCBI
SpeTri2.0NW_0049365414,157,847 - 4,178,156 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1763,477,061 - 63,498,380 (+)EnsemblGRCh38hg38GRCh38
GRCh381763,477,061 - 63,498,373 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371761,554,422 - 61,575,734 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361758,908,166 - 58,928,711 (+)NCBINCBI36hg18NCBI36
Build 341758,915,908 - 58,952,935NCBI
Celera1755,942,475 - 55,963,778 (+)NCBI
Cytogenetic Map17q23.3NCBI
HuRef1756,922,781 - 56,944,100 (+)NCBIHuRef
CHM1_11761,618,550 - 61,639,869 (+)NCBICHM1_1
Ace
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,858,774 - 105,880,790 (+)NCBIGRCm39mm39
GRCm39 Ensembl11105,858,771 - 105,880,790 (+)Ensembl
GRCm3811105,967,948 - 105,989,964 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11105,967,945 - 105,989,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,829,261 - 105,851,259 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611105,784,049 - 105,805,350 (+)NCBImm8
Celera11117,699,475 - 117,721,491 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.84NCBI
Ace
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21090,910,316 - 90,930,437 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1094,170,766 - 94,187,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01094,170,766 - 94,213,831 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01093,922,062 - 93,965,127 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,361,338 - 95,381,455 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1089,588,544 - 89,608,666 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
ACE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11762,710,398 - 62,724,018 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1762,702,341 - 62,733,853 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01757,556,294 - 57,577,294 (+)NCBIMhudiblu_PPA_v0panPan3
ACE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,497,182 - 11,516,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,497,182 - 11,516,358 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,457,866 - 12,477,045 (+)NCBI
ROS_Cfam_1.0913,160,704 - 13,179,888 (+)NCBI
UMICH_Zoey_3.1912,105,344 - 12,124,523 (+)NCBI
UNSW_CanFamBas_1.0915,407,255 - 15,426,429 (-)NCBI
UU_Cfam_GSD_1.0915,410,134 - 15,429,354 (-)NCBI
ACE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,394,487 - 15,414,639 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,394,487 - 15,414,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,381,362 - 15,401,171 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ace
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624849998,262 - 1,019,305 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005328185   ⟹   XP_005328242
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560215,017,159 - 15,036,742 (-)NCBI
SpeTri2.0NW_0049365414,157,847 - 4,178,156 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005328186   ⟹   XP_005328243
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560215,017,159 - 15,029,937 (-)NCBI
SpeTri2.0NW_0049365414,164,669 - 4,178,156 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040268616   ⟹   XP_040124550
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560215,017,159 - 15,035,720 (-)NCBI
RefSeq Acc Id: XM_040268617   ⟹   XP_040124551
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560215,017,159 - 15,029,938 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_005328242   ⟸   XM_005328185
- Peptide Label: isoform X1
- UniProtKB: I3MDG2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005328243   ⟸   XM_005328186
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_040124550   ⟸   XM_040268616
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040124551   ⟸   XM_040268617
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000009371 ENTREZGENE
Ensembl Protein ENSSTOP00000008421 ENTREZGENE
  ENSSTOP00000030139 ENTREZGENE
NCBI Gene Ace ENTREZGENE
UniProt I3MDG2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-13 LOC101968921  angiotensin-converting enzyme  Ace  angiotensin I converting enzyme  Symbol and/or name change 5135510 APPROVED