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Losartan is a selective and competitive non-peptide antagonist of angiotensin II receptor type 1 (Agtr1) used in the treatment of hypertension and heart failure. Angiotensin II (AngII) is one of several and probably the most potent peptide generated by the renin-angiotensin cascade. AngII signals through two receptor types to elicit distinct responses. The Agtr1 mediated pathway is involved in vasoconstriction, proliferation, hormone release and fluid homeostasis. The powerful but potentially h

Pathway Diagram:

Ariadne Genomics Inc. losartan ---- Lys199 losartan ---- Ser109 Asn295 ---- E3174 losartan Lys199 E3174 losartan pharmacokinetics pathway Asn295 Ser109 Asn295 ---- losartan E3174 ---- Lys199 E3174 ---- Ser109 Heart Failure Hypertension angiotensin II signaling pathway via AT1 receptor angiotensin II signaling pathway via AT1 receptor ---| Heart Failure Agt Agt ---| Agtr1a angiotensin II signaling pathway via AT1 receptor ---| Hypertension Agtr1a ---| angiotensin II signaling pathway via AT1 receptor Agtr1a

Genes in Pathway:

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losartan pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:10402751
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:10402751
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:7364969
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:10402751

Pathway Gene Annotations

Disease Annotations Associated with Genes in the losartan pharmacodynamics pathway
Disease TermsGene Symbols
abdominal aortic aneurysmAce , Agt , Agtr1a
Abortion, SpontaneousAgtr1a
acute kidney failureAce
adult respiratory distress syndromeAce
AIDS-Associated NephropathyAgtr1a
AlbuminuriaAce , Agt , Ren
alcoholic cardiomyopathyAce , Agt
alcoholic hepatitisAgt
Allanson Pantzar McLeod SyndromeAce , Agt , Agtr1a , Ren
allergic hypersensitivity diseaseAce , Agt
allergic rhinitisAce
Alzheimer's diseaseAce , Agt , Agtr1a
anemiaAce , Agt , Ren
Angiotensin I-Converting Enzyme, Benign Serum IncreaseAce
ankylosing spondylitisAce
anti-basement membrane glomerulonephritisAgt , Agtr1a
aortic aneurysmAgt
Aortic CalcificationAgt
Aortic CoarctationAce , Agt
Arteriovenous FistulaAce
aspiration pneumoniaAce
asthmaAce , Agtr1a
atrial fibrillationAce , Agt , Agtr1a , Ren
autistic disorderAce , Ren
autosomal recessive polycystic kidney diseaseAce
Bartter diseaseRen
Behcet's diseaseAce
bipolar disorderAce , Agt
brain ischemiaAce
breast cancerAce , Agt , Agtr1a
bronchiolitis obliteransAce
Cardiac ArrhythmiasAce , Agt , Agtr1a
CardiomegalyAce , Agt , Agtr1a , Ren
Cardiovascular AbnormalitiesAgt
cardiovascular system diseaseAce , Agt
carotid artery diseaseAce , Agt , Agtr1a
Carotid Artery InjuriesAgtr1a
Cerebral HemorrhageAce
cerebral infarctionAce
cerebrovascular diseaseAgt , Agtr1a
Chemotherapy-Induced Febrile NeutropeniaAce
chronic fatigue syndromeRen
Chronic Intermittent HypoxiaAce , Agt
chronic kidney diseaseAgtr1a
chronic myeloid leukemiaAce , Agt
chronic obstructive pulmonary diseaseAce
cognitive disorderAgt
congenital diaphragmatic herniaAce
Congenital Hepatic FibrosisAce
congestive heart failureAce , Agt , Agtr1a , Ren
corneal neovascularizationAgt , Agtr1a
coronary artery diseaseAce , Agt , Agtr1a
Coronary DiseaseAce , Agtr1a
coronary restenosisAce
Coronavirus InfectionsAce
Crohn's diseaseAgt
Diabetes Mellitus, Experimental Ace , Agt , Ren
Diabetic CardiomyopathiesAce
Diabetic NephropathiesAce , Agt , Agtr1a , Ren
diabetic retinopathyAce , Agt , Agtr1a
Diaphragmatic HerniaAgt , Agtr1a
diffuse sclerodermaAgt
dilated cardiomyopathyAce , Agt , Agtr1a
Dissecting AneurysmAgt
drug allergyAce
Drug OverdoseAgt
Drug-Related Side Effects and Adverse ReactionsRen
Ductal CarcinomaAgtr1a
end stage renal failureAce , Agt
endomyocardial fibrosisAce , Agt
essential hypertensionAgt , Agtr1a
Experimental ArthritisAce
Experimental Liver CirrhosisAgt , Agtr1a
extrinsic allergic alveolitisAce
Fabry diseaseAce , Agt
Familial Cerebral Cavernous MalformationAce
familial juvenile hyperuricemic nephropathyRen
Familial Juvenile Hyperuricemic Nephropathy 2Ren
Fetal DeathAce
Fetal Growth RetardationAce , Agt , Agtr1a , Ren
FibrosisAgt , Agtr1a , Ren
focal segmental glomerulosclerosisAgt , Agtr1a
focal segmental glomerulosclerosis 1Ace
gallbladder adenocarcinomaAce
gastric ulcerAgt
Gaucher's diseaseAce
Genetic Predisposition to DiseaseAce
glomerulonephritisAce , Agt
glomerulosclerosisAce , Agtr1a
glucose intoleranceAgt , Agtr1a
glycogen storage disease VAce
heart diseaseAgt
HemorrhageAgt , Ren
Henoch-Schoenlein purpuraAce , Agt
hepatocellular carcinomaAce
Huntington's diseaseAgtr1a
hyperinsulinismAgt , Agtr1a
hypertensionAce , Agt , Agtr1a , Ren
Hypertension, Pregnancy-InducedAce , Agt
Hypertensive NephropathyAgt , Agtr1a
Hypertensive NephrosclerosisAce
hypertrophic cardiomyopathyAce , Agt
HypotensionAce , Agt , Ren
IgA glomerulonephritisAce , Agt , Agtr1a
in situ carcinomaAce
InflammationAgt , Agtr1a
inflammatory bowel diseaseAgt
Insulin ResistanceAce
intermediate coronary syndromeAce , Agt , Agtr1a
Intestinal Reperfusion InjuryAce , Agt
intracranial aneurysmAce
invasive lobular carcinomaAgtr1a
kidney diseaseAce , Agt , Agtr1a , Ren
kidney failureAce , Agt
Kidney Reperfusion InjuryAce
Left Ventricular HypertrophyAce , Agt , Agtr1a , Ren
Liddle syndromeRen
Limb IschemiaAgtr1a
liver cirrhosisAgt , Ren
lung cancerAce
lung diseaseAce , Agtr1a
Lung NeoplasmsAce
male infertilityAce
malignant hypertensionAgt , Ren
Mammary Neoplasms, ExperimentalAgt , Agtr1a
meconium aspiration syndromeAgt
Memory DisordersAce
Meningococcal InfectionsAce
Metabolic SyndromeAgt , Agtr1a
Microvascular Complications of Diabetes, Susceptibility to, 2Ace
Microvascular Complications of Diabetes, Susceptibility to, 3Ace
middle cerebral artery infarctionAce , Agt
mitral valve prolapseAce , Agt
multiple myelomaAce
multiple sclerosisAgt
myocardial infarctionAce , Agt , Agtr1a , Ren
Myocardial IschemiaAgt
Myocardial Reperfusion InjuryAgt , Agtr1a
Neoplasm MetastasisAce , Agtr1a
nephritisAce , Agtr1a
nephrosisAce , Agt , Ren
Nephrosis, Puromycin AminonucleosideAce , Agt , Ren
nephrotic syndromeAce
non-arteritic anterior ischemic optic neuropathyAce
nonalcoholic fatty liver diseaseAce
obesityAce , Agt , Ren
obstructive sleep apneaAce
ocular hypotensionAce
osteoporosisAce , Ren
pancreatic cancerAce
pancreatic ductal carcinomaAce , Agtr1a
Parkinson's diseaseAce , Agtr1a
patent ductus arteriosusAgtr1a
Peptic Ulcer HemorrhageAgt
Peritoneal FibrosisAce
Pituitary NeoplasmsAgtr1a
placental insufficiencyAgtr1a
pneumoniaAce , Agt
polycystic kidney diseaseAgt
portal hypertensionRen
Postoperative Cognitive DysfunctionAgtr1a
pre-eclampsiaAce , Agt
pre-malignant neoplasmAce
prediabetes syndromeAgt
Premature Infant DiseasesAce
primary biliary cirrhosisAce , Agt , Ren
Prostatic NeoplasmsAce
proteinuriaAce , Agt , Agtr1a , Ren
pulmonary edemaAgt
pulmonary fibrosisAce , Agt , Agtr1a
pulmonary hypertensionAce , Agt , Agtr1a
Radiation Injuries, ExperimentalAgtr1a
Radiation NephropathyAce
renal cell carcinomaAgtr1a
renal fibrosisAce
renal hypertensionAgt , Agtr1a
Renal Tubular DysgenesisAce , Agt , Agtr1a , Ren
renovascular hypertensionAce , Agtr1a , Ren
Reperfusion InjuryAce , Agt
respiratory system diseaseAce
Retina Reperfusion InjuryRen
retinal vasculitisAgt
retinopathy of prematurityAgt
Right Ventricular HypertrophyAce
sarcoidosisAce , Agtr1a
sciatic neuropathyAgt
sensorineural hearing lossAce
severe acute respiratory syndromeAce
sick sinus syndromeAgt
skin melanomaAgt
Staphylococcal InfectionsAce
Stomach NeoplasmsAce
StrokeAce , Agt
substance-induced psychosisAce
Sudden DeathAce , Agt
systemic lupus erythematosusAce
systemic sclerodermaAce , Agt
temporal lobe epilepsyAgt
transient cerebral ischemiaAgt
type 1 diabetes mellitusAce
type 2 diabetes mellitusAce , Agt
ureteral obstructionAce , Agt
Vascular RemodelingAgt
Vascular System InjuriesAce , Agtr1a
Venous ThromboembolismAce
Ventricular Dysfunction, LeftAgt
Ventricular FibrillationAce
Ventricular RemodelingAce , Agtr1a
vesicoureteral refluxAgtr1a
viral pneumoniaAce
visual epilepsyAgt
Weight GainAce
withdrawal disorderRen
Pathway Annotations Associated with Genes in the losartan pharmacodynamics pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayAgtr1a
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayAgtr1a
amiodarone pharmacodynamics pathwayAgtr1a
amlodipine pharmacodynamics pathwayAgtr1a
angiotensin (1-7) signaling pathwayAce , Agt
angiotensin II signaling pathwayAce , Agt , Agtr1a
angiotensin II signaling pathway via AT1 receptorAgt , Agtr1a
angiotensin II signaling pathway via AT2 receptorAgt
angiotensin III signaling pathwayAgt , Agtr1a
angiotensin III signaling pathway via AT1 receptorAgt , Agtr1a
angiotensin III signaling pathway via AT2 receptorAgt
angiotensin IV signaling pathwayAgt
angiotensin signaling pathwayAgt
atenolol pharmacodynamics pathwayAgtr1a
benazepril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
benazepril pharmacokinetics pathwayAce
betaxolol pharmacodynamics pathwayAgtr1a
bisoprolol pharmacodynamics pathwayAgtr1a
bupranolol drug pathwayAgtr1a
bupranolol pharmacodynamics pathwayAgtr1a
calcium/calcium-mediated signaling pathwayAgtr1a
candesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
captopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
carvedilol pharmacodynamics pathwayAgtr1a
Chagas disease pathwayAce
cilazapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
cilazapril pharmacokinetics pathwayAce
diltiazem pharmacodynamics pathwayAgtr1a
disopyramide pharmacodynamics pathwayAgtr1a
dobutamine pharmacodynamics pathwayAgtr1a
enalapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
enalapril pharmacokinetics pathwayAce
eprosartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
esmolol pharmacodynamics pathwayAgtr1a
flecainde pharmacodynamics pathwayAgtr1a
forasartsn pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
fosinopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
fosinopril pharmacokinetics pathwayAce
fosphenytoin pharmacodynamics pathwayAgtr1a
G protein mediated signaling pathway via Galpha12/Galpha13 familyAgtr1a
G protein mediated signaling pathway via Galphaq familyAgtr1a
hypertrophic cardiomyopathy pathwayAce
ibutilide pharmacodynamics pathwayAgtr1a
irbesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
isoprenaline pharmacodynamics pathwayAgtr1a
isradipine pharmacodynamics pathwayAgtr1a
kallikrein-kinin cascade pathwayAce
levobunolol pharmacodynamics pathwayAgtr1a
lidocaine pharmacodynamics pathwayAgtr1a
lisinopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
long term potentiationAgt
losartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
metoprolol pharmacodynamics pathwayAgtr1a
mexiletine pharmacodynamics pathwayAgtr1a
moexipril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
moexipril pharmacokinetics pathwayAce
myocardial infarction pathwayAgt
nadolol pharmacodynamics pathwayAgtr1a
nebivolol pharmacodynamics pathwayAgtr1a
nifedipine pharmacodynamics pathwayAgtr1a
nimodipine pharmacodynamics pathwayAgtr1a
nisoldipine pharmacodynamics pathwayAgtr1a
nitrendipine pharmacodynamics pathwayAgtr1a
olmesartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
penbutolol pharmacodynamics pathwayAgtr1a
perindopril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
phenytoin pharmacodynamics pathwayAgtr1a
pindolol pharmacodynamics pathwayAgtr1a
procainamide pharmacodynamics pathwayAgtr1a
propranolol pharmacodynamics pathwayAgtr1a
quinapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
quinapril pharmacokinetics pathwayAce
quinidine pharmacodynamics pathwayAgtr1a
ramipril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
ramipril pharmacokinetics pathwayAce
renin-angiotensin cascade pathwayAce , Agt , Agtr1a , Ren
sotalol pharmacodynamics pathwayAgtr1a
spirapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
spirapril pharmacokinetics pathwayAce
telmisartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
timolol pharmacodynamics pathwayAgtr1a
trandolapril pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
trandolapril pharmacokinetics pathwayAce
valsartan pharmacodynamics pathwayAce , Agt , Agtr1a , Ren
verapamil pharmacodynamics pathwayAgtr1a
Phenotype Annotations Associated with Genes in the losartan pharmacodynamics pathway

References Associated with the losartan pharmacodynamics pathway:

Ontology Path Diagram:

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