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Gene: Axin2 (axin 2) Rattus norvegicus
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Symbol: Axin2
Name: axin 2
Description: Exhibits beta-catenin binding activity and protein kinase binding activity. Involved in several processes, including negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; negative regulation of cell population proliferation; and positive regulation of protein kinase activity. Localizes to the protein-containing complex. Human ortholog(s) of this gene implicated in endometrial adenocarcinoma. Orthologous to human AXIN2 (axin 2); PARTICIPATES IN altered Wnt signaling, canonical pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH (+)-schisandrin B; (RS)-amphetamine; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: axil; axin-2; axin-like; axis inhibition protein 2; conductin
Orthologs:
Homo sapiens (human) : AXIN2 (axin 2)  HGNC  Alliance
Mus musculus (house mouse) : Axin2 (axin 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Axin2 (axin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AXIN2 (axin 2)
Canis lupus familiaris (dog) : AXIN2 (axin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Axin2 (axin 2)
Sus scrofa (pig) : AXIN2 (axin 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01097,212,483 - 97,238,824 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01096,933,422 - 96,959,748 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41098,294,466 - 98,321,830 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11098,308,835 - 98,336,196 (+)NCBI
Celera1092,540,720 - 92,589,078 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Axin2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69259
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.