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Gene: Gsk3b (glycogen synthase kinase 3 beta) Rattus norvegicus
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Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Description: Exhibits several functions, including kinase activity; signaling receptor binding activity; and transcription factor binding activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of neurogenesis; and response to peptide. Localizes to several cellular components, including the Schaffer collateral - CA1 synapse; cytoplasm; and neuron projection. Used to study several diseases, including artery disease (multiple); neurodegenerative disease (multiple); sciatic neuropathy; substance-related disorder; and vascular dementia. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); colon cancer; mental depression; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta); PARTICIPATES IN long term depression; Wnt signaling, canonical pathway; Bone morphogenetic proteins signaling pathway; INTERACTS WITH (R)-Salsolinol; (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: FA; factor A; glycogen synthase kinase-3 beta; GSK-3 beta; serine/threonine-protein kinase GSK3B
Orthologs:
Homo sapiens (human) : GSK3B (glycogen synthase kinase 3 beta)  HGNC  Alliance
Mus musculus (house mouse) : Gsk3b (glycogen synthase kinase 3 beta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gsk3b (glycogen synthase kinase 3 beta)
Pan paniscus (bonobo/pygmy chimpanzee) : GSK3B (glycogen synthase kinase 3 beta)
Canis lupus familiaris (dog) : GSK3B (glycogen synthase kinase 3 beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gsk3b (glycogen synthase kinase 3 beta)
Sus scrofa (pig) : GSK3B (glycogen synthase kinase 3 beta)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01165,060,884 - 65,208,842 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01166,873,291 - 67,016,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,284,731 - 64,428,698 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11164,342,319 - 64,486,287 (-)NCBI
Celera1162,004,680 - 62,147,081 (-)NCBICelera
Cytogenetic Map11q21NCBI
RH 3.4 Map11501.41RGD
JBrowse: View Region in Genome Browser (JBrowse)
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Strain Sequence Variants (Rnor 5.0)