Gsk3b (glycogen synthase kinase 3 beta) - Rat Genome Database
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Gene: Gsk3b (glycogen synthase kinase 3 beta) Rattus norvegicus
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Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
RGD ID: 70982
Description: Exhibits several functions, including ATP binding activity; protein kinase activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of nervous system development; and response to peptide. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; beta-catenin destruction complex; and glutamatergic synapse. Used to study several diseases, including middle cerebral artery infarction; myocardial infarction; neurodegenerative disease (multiple); sciatic neuropathy; and vascular dementia. Biomarker of several diseases, including artery disease (multiple); diabetic encephalopathy; mental depression; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta); PARTICIPATES IN long term depression; Wnt signaling, canonical pathway; Bone morphogenetic proteins signaling pathway; INTERACTS WITH (R)-Salsolinol; (S)-colchicine; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: FA; factor A; glycogen synthase kinase-3 beta; GSK-3 beta; serine/threonine-protein kinase GSK3B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01165,060,884 - 65,208,842 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,066,235 - 65,209,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01166,873,291 - 67,016,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,284,731 - 64,428,698 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11164,342,319 - 64,486,287 (-)NCBI
Celera1162,004,680 - 62,147,081 (-)NCBICelera
Cytogenetic Map11q21NCBI
RH 3.4 Map11501.41RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(R)-lipoic acid  (ISO)
(R)-Salsolinol  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,8-cineole  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (EXP,ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (EXP)
2,6-dinitrotoluene  (EXP)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-methylcholine  (ISO)
2-nitrotoluene  (EXP)
20-hydroxyecdysone  (EXP)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
3-methyladenine  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5alpha-pregnane-3,20-dione  (EXP)
6-aminonicotinamide  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (EXP,ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
alachlor  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alsterpaullone  (ISO)
amino acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
andrographolide  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
baicalein  (ISO)
BAPTA  (EXP)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bortezomib  (ISO)
brazilein  (ISO)
bromochloroacetic acid  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calyculin a  (EXP)
capsaicin  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
chaetoglobosin A  (EXP)
CHIR 99021  (ISO)
chitosan  (EXP)
chloroethene  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin 5,7-dimethyl ether  (EXP)
cilostazol  (ISO)
Cinobufagin  (ISO)
cisplatin  (EXP,ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (EXP)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
Deguelin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desmopressin  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
Di-n-hexyl phthalate  (EXP)
diallyl disulfide  (ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
dioxygen  (EXP,ISO)
disodium cromoglycate  (EXP)
disodium selenite  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
entinostat  (ISO)
enzacamene  (ISO)
erlotinib hydrochloride  (ISO)
Estragole  (EXP)
ethanol  (EXP,ISO)
ethosuximide  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
excitatory amino acid agonist  (EXP,ISO)
famotidine  (ISO)
fipronil  (ISO)
fisetin  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
Fusaric acid  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
geraniol  (EXP)
gingerol  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg2  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
GSK690693  (ISO)
haloperidol  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
IC-87114  (ISO)
icariside II  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoprenaline  (EXP,ISO)
kaempferol  (EXP)
kahweol  (ISO)
kainic acid  (ISO)
ketamine  (EXP)
KT 5823  (ISO)
L-ascorbic acid  (EXP)
L-glutamic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
lead nitrate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
liraglutide  (ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP,ISO)
lithocholic acid  (ISO)
lonafarnib  (ISO)
losartan  (EXP)
lovastatin  (EXP,ISO)
lupeol  (EXP)
LY294002  (EXP,ISO)
lysophosphatidylethanolamine  (ISO)
magnesium atom  (ISO)
Magnolol  (EXP)
malathion  (EXP)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
melatonin  (ISO)
memantine  (EXP)
menadione  (ISO)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
Mizoribine  (EXP)
MK-2206  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (EXP)
monodansylcadaverine  (ISO)
morin  (EXP)
morphine  (ISO)
mycophenolic acid  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naloxone  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
Niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitrofurazone  (EXP)
nitroprusside  (EXP,ISO)
notoginsenoside R1  (EXP,ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleic acid  (ISO)
omethoate  (ISO)
oxaliplatin  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentetrazol  (EXP)
perfluorododecanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phloretin  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phytoestrogen  (EXP)
pioglitazone  (ISO)
Plantamajoside  (EXP,ISO)
potassium atom  (EXP)
potassium chromate  (ISO)
Pristimerin  (ISO)
procyanidin B2  (ISO)
progesterone  (EXP,ISO)
propofol  (EXP)
propranolol  (EXP)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
pyrithione  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quinacrine  (ISO)
raffinose  (EXP,ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
risperidone  (EXP)
Ro 31-8220  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP)
rubimaillin  (ISO)
ruthenium atom  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 415286  (ISO)
SB 431542  (ISO)
SB-239063  (EXP)
selenium atom  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sesquiterpene  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
sorafenib  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfasalazine  (EXP)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
syringic acid  (ISO)
T-2 toxin  (EXP)
tacrolimus hydrate  (ISO)
tadalafil  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
taurine  (ISO)
taurochenodeoxycholic acid  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
toluene 2,4-diisocyanate  (ISO)
topiramate  (EXP)
topotecan  (EXP)
Triptolide  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vitamin K  (EXP)
warfarin  (EXP)
wogonin  (EXP,ISO)
wortmannin  (EXP,ISO)
XAV939  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
animal organ morphogenesis  (ISO)
axonogenesis  (ISO)
bone remodeling  (IDA)
canonical Wnt signaling pathway  (ISO)
cell growth involved in cardiac muscle cell development  (IDA)
cell migration  (ISO)
cellular response to amyloid-beta  (IDA)
cellular response to dopamine  (IEP)
cellular response to erythropoietin  (IEP)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (IEP)
cellular response to interleukin-3  (ISO,ISS)
cellular response to iron(II) ion  (IEP)
cellular response to lithium ion  (IEP)
cellular response to mechanical stimulus  (IDA)
circadian rhythm  (ISO,ISS)
epithelial to mesenchymal transition  (ISO,ISS)
ER overload response  (ISO)
establishment of cell polarity  (IDA,IMP)
establishment or maintenance of cell polarity  (IDA)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,ISO,ISS)
fat cell differentiation  (ISO)
glycogen metabolic process  (IEA,ISO)
hepatic stellate cell activation  (IMP)
hepatocyte apoptotic process  (IDA)
hippocampus development  (ISO)
hypermethylation of CpG island  (ISO)
insulin receptor signaling pathway  (IBA,ISO)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
maintenance of cell polarity  (IMP)
myoblast fusion  (ISO)
myotube differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of calcineurin-NFAT signaling cascade  (ISO,ISS)
negative regulation of canonical Wnt signaling pathway  (IBA,ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of dendrite development  (IMP)
negative regulation of dendrite morphogenesis  (IMP)
negative regulation of dopaminergic neuron differentiation  (IMP)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO,ISS)
negative regulation of MAP kinase activity  (IMP)
negative regulation of neuron death  (ISO,ISS)
negative regulation of neuron maturation  (ISO)
negative regulation of neuron migration  (IMP)
negative regulation of neuron projection development  (ISO)
negative regulation of nitric-oxide synthase activity  (IMP)
negative regulation of protein acetylation  (IMP)
negative regulation of protein binding  (ISO)
negative regulation of protein localization to centrosome  (ISO)
negative regulation of protein localization to nucleus  (IMP)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of signal transduction  (IEA)
negative regulation of smooth muscle cell apoptotic process  (IMP)
negative regulation of synaptic growth at neuromuscular junction  (IMP)
negative regulation of TOR signaling  (ISO)
neuron projection development  (ISO,ISS)
neuron projection organization  (IMP)
peptidyl-serine phosphorylation  (ISO,ISS)
peptidyl-threonine phosphorylation  (ISO)
phosphorylation  (ISO)
positive regulation of apoptotic process  (IDA,IMP)
positive regulation of autophagy  (ISO,ISS)
positive regulation of axon extension  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of DNA biosynthetic process  (IMP)
positive regulation of excitatory postsynaptic potential  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of GTPase activity  (ISO)
positive regulation of mitochondrial membrane potential  (IMP)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO,ISS)
positive regulation of mitochondrion organization  (ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neuron death  (ISO)
positive regulation of osteoblast proliferation  (IMP)
positive regulation of osteoclast differentiation  (IMP)
positive regulation of osteoclast proliferation  (IMP)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein binding  (ISO,ISS)
positive regulation of protein catabolic process  (IMP)
positive regulation of protein export from nucleus  (ISO)
positive regulation of protein localization to centrosome  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of stem cell differentiation  (ISO)
positive regulation of synaptic growth at neuromuscular junction  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
protein autophosphorylation  (ISO)
protein export from nucleus  (ISO)
protein localization to microtubule  (ISO)
protein phosphorylation  (IDA,IEA,ISO)
re-entry into mitotic cell cycle  (ISO)
regulation of apoptotic process  (ISO)
regulation of axon extension  (IMP)
regulation of axonogenesis  (IMP)
regulation of cell growth  (ISO)
regulation of circadian rhythm  (ISO,ISS)
regulation of dendrite morphogenesis  (IMP)
regulation of gene expression by genetic imprinting  (ISO)
regulation of long-term synaptic potentiation  (ISO,ISS)
regulation of microtubule anchoring at centrosome  (ISO)
regulation of microtubule cytoskeleton organization  (IBA,IMP)
regulation of microtubule-based process  (ISO,ISS)
regulation of modification of postsynaptic structure  (IDA,IMP)
regulation of neuron projection development  (IBA,ISO)
regulation of neuronal synaptic plasticity  (IMP)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (IDA,IMP)
regulation of osteoblast differentiation  (IMP)
regulation of synaptic vesicle exocytosis  (ISO)
response to activity  (IEP)
response to angiotensin  (IEP)
response to drug  (IEP)
response to epinephrine  (IEP)
response to estradiol  (IEP)
response to insulin  (IEP)
response to insulin-like growth factor stimulus  (IEP)
response to L-glutamate  (IEP)
response to lithium ion  (IEP)
response to ultrasound  (IEP)
response to zinc ion  (IDA)
signal transduction  (IBA)
superior temporal gyrus development  (ISO)
Wnt signaling pathway  (IEA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
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17. Cuesto G, etal., PLoS One. 2015 Mar 12;10(3):e0118475. doi: 10.1371/journal.pone.0118475. eCollection 2015.
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19. Emamian ES, etal., Nat Genet 2004 Feb;36(2):131-7. Epub 2004 Jan 25.
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PMID:31197456   PMID:31234955   PMID:31467921   PMID:31561361   PMID:31916218  


Genomics

Comparative Map Data
Gsk3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01165,060,884 - 65,208,842 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,066,235 - 65,209,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01166,873,291 - 67,016,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,284,731 - 64,428,698 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11164,342,319 - 64,486,287 (-)NCBI
Celera1162,004,680 - 62,147,081 (-)NCBICelera
Cytogenetic Map11q21NCBI
RH 3.4 Map11501.41RGD
GSK3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3119,821,321 - 120,094,447 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl3119,821,323 - 120,094,417 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl3119,821,321 - 120,094,994 (-)EnsemblGRCh38hg38GRCh38
GRCh383119,821,321 - 120,095,823 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373119,540,800 - 119,813,264 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363121,028,233 - 121,295,203 (-)NCBINCBI36hg18NCBI36
Build 343121,028,237 - 121,295,203NCBI
Celera3117,949,905 - 118,223,017 (-)NCBI
Cytogenetic Map3q13.33NCBI
HuRef3116,916,542 - 117,189,344 (-)NCBIHuRef
CHM1_13119,504,331 - 119,776,722 (-)NCBICHM1_1
Gsk3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391637,909,363 - 38,066,446 (+)NCBIGRCm39mm39
GRCm381638,089,001 - 38,246,084 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,089,001 - 38,246,084 (+)EnsemblGRCm38mm10GRCm38
MGSCv371638,089,087 - 38,246,165 (+)NCBIGRCm37mm9NCBIm37
MGSCv361638,008,240 - 38,165,318 (+)NCBImm8
Celera1638,497,488 - 38,655,086 (+)NCBICelera
Cytogenetic Map16B3NCBI
Gsk3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,495,422 - 19,671,137 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,489,972 - 19,671,137 (-)NCBIChiLan1.0ChiLan1.0
GSK3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13123,856,047 - 124,126,747 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,861,379 - 124,126,771 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03116,943,205 - 117,215,001 (-)NCBIMhudiblu_PPA_v0panPan3
GSK3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3323,463,767 - 23,659,666 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13323,458,369 - 23,659,878 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gsk3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365366,730,070 - 6,893,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSK3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,136,158 - 140,369,574 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113140,136,109 - 140,370,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213149,599,661 - 149,702,154 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.213149,431,156 - 149,510,315 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSK3B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12260,732,449 - 61,002,735 (+)NCBI
ChlSab1.1 Ensembl2260,733,465 - 60,997,239 (+)Ensembl
Gsk3b
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473128,178,647 - 28,368,784 (+)NCBI

Position Markers
RH129577  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01165,157,244 - 65,157,432NCBIRnor6.0
Rnor_5.01166,926,325 - 66,926,513UniSTSRnor5.0
RGSC_v3.41164,376,234 - 64,376,422UniSTSRGSC3.4
Celera1162,095,610 - 62,095,798UniSTS
Cytogenetic Map11q21UniSTS
RH 3.4 Map11500.3UniSTS
BE114445  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01165,108,966 - 65,109,118NCBIRnor6.0
Rnor_5.01166,973,636 - 66,973,788UniSTSRnor5.0
RGSC_v3.41164,327,687 - 64,327,839UniSTSRGSC3.4
Celera1162,047,384 - 62,047,536UniSTS
Cytogenetic Map11q21UniSTS
RH 3.4 Map11499.4UniSTS
RH94787  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q21UniSTS
RH 3.4 Map11501.41UniSTS
BM387580  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01165,205,664 - 65,205,830NCBIRnor6.0
Rnor_5.01166,877,003 - 66,877,169UniSTSRnor5.0
RGSC_v3.41164,425,525 - 64,425,691UniSTSRGSC3.4
Celera1162,143,908 - 62,144,074UniSTS
Cytogenetic Map11q21UniSTS
RH 3.4 Map11500.4UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116010984287141948Rat
4889859Pur28Proteinuria QTL 2819.50.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114790104978471527Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112572003870720038Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112572003870720038Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)116265336586714475Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)114444434769649708Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112572003870720038Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115994302390463843Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112572003870720038Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)113043533986714631Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114309033886714631Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11172720192Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116449467190463843Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112540112970401129Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114726402386994547Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)112194422966944229Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)112194422966944229Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113590063480900634Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116265336586714483Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111901627290463843Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115785881090463843Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112831466586994795Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113215552082443118Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)1132503169342559Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111947517979734728Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114658320986714631Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:42
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000003867
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 45 29 19 29 8 11 74 35 41 11 8
Low 2 12 12 12
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_032080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07072239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01069611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC121672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X73653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000003867   ⟹   ENSRNOP00000003867
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1165,066,235 - 65,208,837 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077612   ⟹   ENSRNOP00000075708
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1165,073,691 - 65,209,268 (-)Ensembl
RefSeq Acc Id: NM_032080   ⟹   NP_114469
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,066,199 - 65,208,837 (-)NCBI
Rnor_5.01166,873,291 - 67,016,640 (+)NCBI
RGSC_v3.41164,284,731 - 64,428,698 (-)RGD
Celera1162,004,680 - 62,147,081 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248373   ⟹   XP_006248435
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,060,884 - 65,208,842 (-)NCBI
Rnor_5.01166,873,291 - 67,016,640 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248374   ⟹   XP_006248436
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,066,301 - 65,208,842 (-)NCBI
Rnor_5.01166,873,291 - 67,016,640 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248375   ⟹   XP_006248437
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01165,074,519 - 65,208,842 (-)NCBI
Rnor_5.01166,873,291 - 67,016,640 (+)NCBI
Sequence: