Gsk3b (glycogen synthase kinase 3 beta) - Rat Genome Database

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Gene: Gsk3b (glycogen synthase kinase 3 beta) Rattus norvegicus
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
RGD ID: 70982
Description: Enables several functions, including ATP binding activity; protein kinase activity; and signaling receptor binding activity. Involved in several processes, including regulation of neuron projection development; regulation of synapse organization; and response to peptide. Located in several cellular components, including dendritic spine; membrane raft; and microtubule. Part of beta-catenin destruction complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study several diseases, including middle cerebral artery infarction; myocardial infarction; neurodegenerative disease (multiple); sciatic neuropathy; and vascular dementia. Biomarker of several diseases, including artery disease (multiple); diabetic encephalopathy; mental depression; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta); PARTICIPATES IN long term depression; Wnt signaling, canonical pathway; Bone morphogenetic proteins signaling pathway; INTERACTS WITH (R)-Salsolinol; (S)-colchicine; 1,2-dimethylhydrazine.
Type: protein-coding
Previously known as: FA; factor A; glycogen synthase kinase-3 beta; GSK-3 beta; serine/threonine-protein kinase GSK3B
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21162,498,997 - 62,648,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,504,316 - 62,648,646 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,316,816 - 71,460,263 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01163,979,039 - 64,122,494 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01163,029,506 - 63,172,937 (-)NCBIRnor_WKY
Rnor_6.01165,060,884 - 65,208,842 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,066,235 - 65,209,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01166,873,291 - 67,016,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,284,731 - 64,428,698 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,342,319 - 64,486,287 (-)NCBI
Celera1162,004,680 - 62,147,081 (-)NCBICelera
RH 3.4 Map11501.41RGD
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-lipoic acid  (ISO)
(R)-Salsolinol  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,8-cineole  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (EXP,ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-methylcholine  (ISO)
2-nitrotoluene  (EXP)
20-hydroxyecdysone  (EXP)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
3-methyladenine  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-methoxypsoralen  (ISO)
5alpha-pregnane-3,20-dione  (EXP)
6-aminonicotinamide  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
AH23848  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alsterpaullone  (ISO)
amino acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
andrographolide  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
baicalein  (ISO)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
betulin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
brazilein  (ISO)
bromochloroacetic acid  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calyculin a  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
chaetoglobosin A  (EXP)
Chikusetsusaponin-V  (ISO)
CHIR 99021  (EXP,ISO)
chitosan  (EXP)
chloroethene  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin 5,7-dimethyl ether  (EXP)
cilostazol  (ISO)
Cinobufagin  (ISO)
cisplatin  (EXP,ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
columbamine  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corynoline  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
desmopressin  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
Di-n-hexyl phthalate  (EXP)
diallyl disulfide  (ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
Didymin  (ISO)
dioxygen  (EXP,ISO)
disodium cromoglycate  (EXP)
disodium selenite  (ISO)
dizocilpine maleate  (EXP,ISO)
dobutamine  (ISO)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
entinostat  (ISO)
enzacamene  (ISO)
erlotinib hydrochloride  (ISO)
Estragole  (EXP)
ethanol  (EXP,ISO)
ethosuximide  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
excitatory amino acid agonist  (EXP,ISO)
famotidine  (ISO)
fipronil  (ISO)
fisetin  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
Fusaric acid  (ISO)
gefitinib  (ISO)
geraniol  (EXP)
gingerol  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (EXP)
ginsenoside Rg2  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
Glutathione ethyl ester  (ISO)
GSK690693  (ISO)
haloperidol  (EXP)
hesperetin  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
IC-87114  (ISO)
icariside II  (ISO)
indirubin-3'-monoxime  (ISO)
indometacin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoorientin  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
kaempferol  (EXP)
kahweol  (ISO)
kainic acid  (ISO)
kenpaullone  (EXP,ISO)
ketamine  (EXP)
KT 5823  (ISO)
L-ascorbic acid  (EXP)
L-glutamic acid  (EXP)
L-methionine  (ISO)
L-serine  (EXP)
lead diacetate  (EXP)
lead nitrate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
liraglutide  (ISO)
lithium atom  (EXP,ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP,ISO)
lithocholic acid  (ISO)
lonafarnib  (ISO)
losartan  (EXP)
lovastatin  (EXP,ISO)
lupeol  (EXP)
LY294002  (EXP,ISO)
lysophosphatidylethanolamine  (ISO)
magnesium atom  (ISO)
Magnolol  (EXP)
malathion  (EXP)
malvidin  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
melatonin  (ISO)
memantine  (EXP)
menadione  (ISO)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (EXP)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
Mizoribine  (EXP)
MK-2206  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (EXP)
monodansylcadaverine  (ISO)
morin  (EXP)
morphine  (ISO)
mycophenolic acid  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-D-aspartic acid  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-phosphocreatine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naloxone  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitrofurazone  (EXP)
nitroprusside  (EXP,ISO)
notoginsenoside R1  (EXP,ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleic acid  (ISO)
omethoate  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paclitaxel  (ISO)
Panaxadiol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentetrazol  (EXP)
perfluorododecanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phloretin  (ISO)
phloroglucinol  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phytoestrogen  (EXP)
pioglitazone  (ISO)
Plantamajoside  (EXP,ISO)
potassium atom  (EXP)
potassium chromate  (ISO)
procyanidin B2  (ISO)
progesterone  (EXP,ISO)
propofol  (EXP)
propranolol  (EXP)
prostaglandin E2  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyrithione  (EXP)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quinacrine  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raffinose  (EXP,ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
risperidone  (EXP)
Ro 31-8220  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP)
rubimaillin  (ISO)
ruthenium atom  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 415286  (EXP,ISO)
SB 431542  (ISO)
SB-239063  (EXP)
sclareol  (ISO)
selenium atom  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sesquiterpene  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
streptozocin  (EXP,ISO)
succimer  (ISO)
sulfasalazine  (EXP)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
syringic acid  (ISO)
T-2 toxin  (EXP)
tacrolimus hydrate  (ISO)
tadalafil  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
taurine  (ISO)
taurochenodeoxycholic acid  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
thymoquinone  (ISO)
tideglusib  (ISO)
toluene 2,4-diisocyanate  (ISO)
topiramate  (EXP)
topotecan  (EXP)
Triptolide  (EXP)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vanillic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vitamin K  (EXP)
warfarin  (EXP)
wogonin  (EXP,ISO)
wortmannin  (EXP,ISO)
XAV939  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
animal organ morphogenesis  (ISO)
axon extension  (ISO)
axonogenesis  (ISO)
beta-catenin destruction complex disassembly  (IEA,ISO)
bone remodeling  (IDA)
canonical Wnt signaling pathway  (ISO)
cell growth involved in cardiac muscle cell development  (IDA)
cell migration  (ISO)
cellular response to amyloid-beta  (IDA)
cellular response to dopamine  (IEP)
cellular response to erythropoietin  (IEP)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (IEP)
cellular response to interleukin-3  (ISO,ISS)
cellular response to iron(II) ion  (IEP)
cellular response to lithium ion  (IEP)
cellular response to mechanical stimulus  (IDA)
cellular response to retinoic acid  (IEA,ISO)
circadian rhythm  (ISO,ISS)
epithelial to mesenchymal transition  (IEA,ISO,ISS)
ER overload response  (IEA,ISO)
establishment of cell polarity  (IDA,IMP)
establishment or maintenance of cell polarity  (IDA)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA,ISO,ISS)
fat cell differentiation  (ISO)
glycogen metabolic process  (IEA,ISO)
hepatic stellate cell activation  (IMP)
hepatocyte apoptotic process  (IDA)
hippocampus development  (IEA,ISO)
insulin receptor signaling pathway  (IBA,ISO)
intracellular signal transduction  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
maintenance of cell polarity  (IMP)
myoblast fusion  (ISO)
myotube differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of calcineurin-NFAT signaling cascade  (IEA,ISO,ISS)
negative regulation of canonical Wnt signaling pathway  (IBA,ISO)
negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation  (IEA,ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of dendrite development  (IMP)
negative regulation of dendrite morphogenesis  (IMP)
negative regulation of developmental process  (IEA)
negative regulation of dopaminergic neuron differentiation  (IMP)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO,ISS)
negative regulation of gene expression  (IEA,ISO)
negative regulation of gene expression via CpG island methylation  (ISO)
negative regulation of insulin receptor signaling pathway  (IDA)
negative regulation of MAP kinase activity  (IMP)
negative regulation of mesenchymal stem cell differentiation  (IEA,ISO)
negative regulation of neuron death  (IEA,ISO,ISS)
negative regulation of neuron maturation  (ISO)
negative regulation of neuron migration  (IMP)
negative regulation of neuron projection development  (ISO)
negative regulation of nitric-oxide synthase activity  (IMP)
negative regulation of protein acetylation  (IMP)
negative regulation of protein binding  (IEA,ISO)
negative regulation of protein localization to centrosome  (ISO)
negative regulation of protein localization to nucleus  (IMP)
negative regulation of protein-containing complex assembly  (IEA,ISO)
negative regulation of signal transduction  (IEA)
negative regulation of smooth muscle cell apoptotic process  (IMP)
negative regulation of synaptic assembly at neuromuscular junction  (IMP)
negative regulation of TOR signaling  (ISO)
neuron projection development  (IEA,ISO,ISS)
neuron projection organization  (IMP)
peptidyl-serine phosphorylation  (IEA,ISO,ISS)
peptidyl-threonine phosphorylation  (IEA,ISO)
phosphorylation  (ISO)
positive regulation of apoptotic process  (IDA,IMP)
positive regulation of autophagy  (ISO,ISS)
positive regulation of axon extension  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cell differentiation  (IEA,ISO)
positive regulation of cell-matrix adhesion  (IEA,ISO)
positive regulation of cilium assembly  (ISO,ISS)
positive regulation of DNA biosynthetic process  (IMP)
positive regulation of excitatory postsynaptic potential  (IMP)
positive regulation of gene expression  (IEA,ISO)
positive regulation of GTPase activity  (IEA,ISO)
positive regulation of mitochondrial membrane potential  (IMP)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO,ISS)
positive regulation of mitochondrion organization  (IEA,ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neuron death  (IEA,ISO)
positive regulation of osteoblast proliferation  (IMP)
positive regulation of osteoclast differentiation  (IMP)
positive regulation of osteoclast proliferation  (IMP)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
positive regulation of protein binding  (ISO,ISS)
positive regulation of protein catabolic process  (IMP)
positive regulation of protein export from nucleus  (IEA,ISO)
positive regulation of protein localization to centrosome  (IEA,ISO)
positive regulation of protein localization to cilium  (ISO,ISS)
positive regulation of protein-containing complex assembly  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of stem cell differentiation  (ISO)
positive regulation of synaptic assembly at neuromuscular junction  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
presynaptic modulation of chemical synaptic transmission  (IEA,ISO)
protein autophosphorylation  (IEA,ISO)
protein export from nucleus  (ISO)
protein localization to microtubule  (ISO)
protein phosphorylation  (IDA,IEA,ISO)
re-entry into mitotic cell cycle  (ISO)
regulation of apoptotic process  (ISO)
regulation of axon extension  (IMP)
regulation of axonogenesis  (IMP)
regulation of cell growth  (ISO)
regulation of cellular component organization  (IEA)
regulation of circadian rhythm  (ISO,ISS)
regulation of dendrite morphogenesis  (IMP)
regulation of gene expression by genomic imprinting  (ISO)
regulation of long-term synaptic potentiation  (ISO,ISS)
regulation of microtubule anchoring at centrosome  (IEA,ISO)
regulation of microtubule cytoskeleton organization  (IBA,IMP)
regulation of microtubule-based process  (ISO,ISS)
regulation of modification of postsynaptic structure  (IDA,IMP)
regulation of neuron projection development  (IBA,ISO)
regulation of neuronal synaptic plasticity  (IMP)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (IDA,IMP)
regulation of osteoblast differentiation  (IMP)
regulation of protein binding  (ISO)
regulation of protein export from nucleus  (ISO)
regulation of synaptic vesicle exocytosis  (ISO)
response to activity  (IEP)
response to angiotensin  (IEP)
response to epinephrine  (IEP)
response to estradiol  (IEP)
response to insulin  (IEP)
response to insulin-like growth factor stimulus  (IEP)
response to L-glutamate  (IEP)
response to lithium ion  (IEP)
response to ultrasound  (IEP)
response to xenobiotic stimulus  (IEP)
response to zinc ion  (IDA)
rhythmic process  (IEA)
signal transduction  (IBA)
stem cell differentiation  (ISO)
superior temporal gyrus development  (IEA,ISO)
transcription by RNA polymerase II  (ISO)
Wnt signaling pathway  (IEA,ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
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109. Upregulation of glycogen synthase kinase 3ß in human colorectal adenocarcinomas correlates with accumulation of CTNNB1. Wang HL, etal., Clin Colorectal Cancer. 2011 Mar 1;10(1):30-6. doi: 10.3816/CCC.2011.n.004.
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113. Molecular cloning and expression of glycogen synthase kinase-3/factor A. Woodgett JR EMBO J 1990 Aug;9(8):2431-8.
114. Purinergic P2X7 receptor mediates acetaldehyde-induced hepatic stellate cells activation via PKC-dependent GSK3ß pathway. Wu X, etal., Int Immunopharmacol. 2017 Feb;43:164-171. doi: 10.1016/j.intimp.2016.12.017. Epub 2017 Jan 3.
115. Zinc stimulates glucose consumption by modulating the insulin signaling pathway in L6 myotubes: essential roles of Akt-GLUT4, GSK3ß and mTOR-S6K1. Wu Y, etal., J Nutr Biochem. 2016 Aug;34:126-35. doi: 10.1016/j.jnutbio.2016.05.008. Epub 2016 May 31.
116. Protective Effect of Antenatal Antioxidant on Nicotine-Induced Heart Ischemia-Sensitive Phenotype in Rat Offspring. Xiao D, etal., PLoS One. 2016 Feb 26;11(2):e0150557. doi: 10.1371/journal.pone.0150557. eCollection 2016.
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119. Caspase-dependent and caspase-independent induction of apoptosis in breast cancer by fucoidan via the PI3K/AKT/GSK3ß pathway in vivo and in vitro. Xue M, etal., Biomed Pharmacother. 2017 Oct;94:898-908. doi: 10.1016/j.biopha.2017.08.013. Epub 2017 Aug 12.
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