Gsk3b (glycogen synthase kinase 3 beta) - Rat Genome Database

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Gene: Gsk3b (glycogen synthase kinase 3 beta) Rattus norvegicus
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Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
RGD ID: 70982
Description: Enables several functions, including ATP binding activity; protein kinase activity; and signaling receptor binding activity. Involved in several processes, including regulation of neuron projection development; regulation of synapse organization; and response to peptide. Located in several cellular components, including axon; dendritic spine; and microtubule. Part of beta-catenin destruction complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study several diseases, including middle cerebral artery infarction; myocardial infarction; neurodegenerative disease (multiple); sciatic neuropathy; and vascular dementia. Biomarker of several diseases, including artery disease (multiple); depressive disorder; diabetic encephalopathy; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta); PARTICIPATES IN long term depression; Wnt signaling, canonical pathway; Bone morphogenetic proteins signaling pathway; INTERACTS WITH (R)-lipoic acid; (R)-salsolinol; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FA; factor A; glycogen synthase kinase-3 beta; GSK-3 beta; serine/threonine-protein kinase GSK3B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,004,502 - 76,154,665 (-)NCBIGRCr8
mRatBN7.21162,498,997 - 62,648,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,504,316 - 62,648,646 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,316,816 - 71,460,263 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,979,039 - 64,122,494 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,029,506 - 63,172,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,060,884 - 65,208,842 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,066,235 - 65,209,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01166,873,291 - 67,016,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,284,731 - 64,428,698 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,342,319 - 64,486,287 (-)NCBI
Celera1162,004,680 - 62,147,081 (-)NCBICelera
RH 3.4 Map11501.41RGD
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (IDA)
acute kidney failure  (ISO)
acute myocardial infarction  (IEP)
Alzheimer's disease  (IDA,ISO)
amyotrophic lateral sclerosis  (ISO)
bipolar disorder  (ISO)
Brain Injuries  (IEP,ISO)
Breast Neoplasms  (ISO)
Burns  (IEP)
Cardiomegaly  (IEP,ISO)
cognitive disorder  (ISO)
colon cancer  (IEP)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
congestive heart failure  (ISO)
degenerative disc disease  (ISO)
depressive disorder  (IEP,ISO)
diabetic encephalopathy  (IEP)
Diabetic Nephropathies  (IMP)
dilated cardiomyopathy  (ISO)
Drug-Induced Dyskinesia  (IMP)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Mammary Neoplasms  (IDA)
genetic disease  (ISO)
Hearing Loss, Cisplatin-Induced  (ISO)
heart disease  (IMP)
hypertension  (IEP,ISO)
Intestinal Neoplasms  (ISO)
Liver Reperfusion Injury  (IDA)
mantle cell lymphoma  (ISO)
middle cerebral artery infarction  (IDA)
Multiple Abnormalities  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (IMP,ISO)
Myocardial Reperfusion Injury  (IDA,IEP)
Neoplastic Cell Transformation  (ISO)
neuronal ceroid lipofuscinosis 6A  (ISO)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
Parkinson's disease  (IDA)
peritonitis  (ISO)
Poisoning  (ISO)
Prostatic Neoplasms  (ISO)
schizophrenia  (IEP,ISO)
sciatic neuropathy  (IDA)
Sepsis  (IEP)
status epilepticus  (IEP)
Subarachnoid Hemorrhage  (IDA)
substance-related disorder  (IMP)
Tachycardia  (IDA)
tauopathy  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
urinary bladder cancer  (ISO)
vascular dementia  (IDA)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-salsolinol  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,8-cineole  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (EXP,ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (ISO)
2-methylcholine  (ISO)
2-nitrotoluene  (EXP)
20-hydroxyecdysone  (EXP)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
3-methyladenine  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-methoxypsoralen  (ISO)
5alpha-pregnane-3,20-dione  (EXP)
6-aminonicotinamide  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (EXP)
adenosine  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
alsterpaullone  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
andrographolide  (ISO)
antirheumatic drug  (ISO)
Antrocin  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
baicalein  (ISO)
BAPTA  (EXP)
Bardoxolone methyl  (ISO)
belinostat  (ISO)
bellidifolin  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
brazilein  (ISO)
bromochloroacetic acid  (EXP)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calycosin  (EXP)
calyculin a  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
chaetoglobosin A  (EXP)
Chikusetsusaponin-V  (ISO)
CHIR 99021  (EXP,ISO)
chitosan  (EXP)
chloroethene  (ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (ISO)
chrysin 5,7-dimethyl ether  (EXP)
cilostazol  (ISO)
Cinobufagin  (ISO)
cisplatin  (EXP,ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
columbamine  (ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (ISO)
corynoline  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cryptotanshinone  (ISO)
curcumin  (EXP,ISO)
cycloastragenol  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
DDE  (ISO)
DDT  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP,ISO)
desmopressin  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
Di-n-hexyl phthalate  (EXP)
diallyl disulfide  (ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
Dictamnine  (ISO)
Didymin  (ISO)
dioxygen  (EXP,ISO)
disodium cromoglycate  (EXP)
disodium selenite  (ISO)
dizocilpine maleate  (EXP,ISO)
dobutamine  (ISO)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
entinostat  (ISO)
enzacamene  (ISO)
erlotinib hydrochloride  (ISO)
estragole  (EXP)
ethanol  (EXP,ISO)
ethosuximide  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
excitatory amino acid agonist  (EXP,ISO)