Axin2 (axin 2) - Rat Genome Database
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Gene: Axin2 (axin 2) Mus musculus
Analyze
Symbol: Axin2
Name: axin 2
RGD ID: 735540
MGI Page MGI
Description: Exhibits I-SMAD binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including animal organ development; negative regulation of osteoblast differentiation; and regulation of chondrocyte development. Localizes to centrosome and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb bud; and sensory organ. Used to study craniosynostosis. Human ortholog(s) of this gene implicated in colorectal cancer and endometrial adenocarcinoma. Orthologous to human AXIN2 (axin 2); PARTICIPATES IN altered Wnt signaling, canonical pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH 17beta-hydroxy-5alpha-androstan-3-one; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A; Axi1; Axil; axin-2; axin-like protein; axis inhibition protein 2; Condu; Conductin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911108,808,654 - 108,841,609 (+)NCBIGRCm39mm39
GRCm39 Ensembl11108,811,175 - 108,841,609 (+)Ensembl
GRCm3811108,917,828 - 108,950,783 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11108,920,349 - 108,950,783 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711108,781,663 - 108,812,097 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611108,736,456 - 108,766,873 (+)NCBImm8
Celera11120,655,477 - 120,686,142 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1171.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-formyltetrahydrofolic acid  (ISO)
acetaldehyde  (EXP)
Aeroplysinin 1  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (ISO)
cannabidiol  (ISO)
carbamazepine  (EXP,ISO)
casticin  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
clozapine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP)
fluoranthene  (EXP)
flusilazole  (EXP)
folic acid  (EXP)
gemcitabine  (ISO)
glyphosate  (ISO)
haloperidol  (ISO)
harmine  (EXP)
L-methionine  (EXP)
lithium chloride  (EXP,ISO)
manganese(II) chloride  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
mifepristone  (ISO)
N,N-dimethylaniline  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
panobinostat  (ISO)
paraoxon  (ISO)
paraquat  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phosgene  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (EXP)
pravastatin  (EXP,ISO)
Pristimerin  (EXP)
progesterone  (ISO)
pyrvinium  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
senecionine  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP)
Tesaglitazar  (ISO)
tetrachloromethane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vitamin K  (ISO)
vorinostat  (ISO)
warfarin  (ISO)
XAV939  (ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IDA,ISO)
cytoplasm  (ISO)
nucleus  (IDA,ISO)
protein-containing complex  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auditory brainstem response  (IEA)
abnormal body wall morphology  (IEA)
abnormal craniofacial morphology  (IEA)
abnormal cranium morphology  (IAGP)
abnormal embryo size  (IEA)
abnormal eye morphology  (IAGP)
abnormal facial morphology  (IEA)
abnormal head shape  (IEA)
abnormal head size  (IEA)
abnormal heart morphology  (IAGP)
abnormal limb morphology  (IEA)
abnormal neural plate morphology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal optic cup morphology  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal outer ear morphology  (IEA)
abnormal pericardium morphology  (IEA)
abnormal primitive streak morphology  (IAGP)
abnormal sex gland morphology  (IAGP)
abnormal skeleton development  (IAGP)
abnormal skin coloration  (IEA)
abnormal tail development  (IAGP)
abnormal tail morphology  (IAGP)
abnormal vibrissa morphology  (IEA)
absent jugum limitans  (IAGP)
cardia bifida  (IAGP)
coloboma  (IAGP)
curly tail  (IAGP)
decreased cell proliferation  (IAGP)
decreased cranium height  (IAGP)
embryonic growth arrest  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enhanced osteoblast differentiation  (IAGP)
exencephaly  (IAGP)
increased osteoblast proliferation  (IAGP)
kinked tail  (IEA)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
postnatal growth retardation  (IAGP)
premature intramembranous bone ossification  (IAGP)
premature metopic suture closure  (IAGP)
prenatal lethality, incomplete penetrance  (IEA)
preweaning lethality, complete penetrance  (IEA)
shortened head  (IAGP)
small lens  (IAGP)
References

Additional References at PubMed
PMID:7760812   PMID:9554852   PMID:10049590   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11336703   PMID:11809808   PMID:11809809   PMID:11829488   PMID:12477932  
PMID:12636920   PMID:12798297   PMID:12923052   PMID:14623818   PMID:15042511   PMID:15057752   PMID:15170214   PMID:15367660   PMID:15511637   PMID:15527894   PMID:15545629   PMID:15731404  
PMID:15755804   PMID:15769945   PMID:15782199   PMID:15790973   PMID:15800025   PMID:15857914   PMID:15899843   PMID:16107537   PMID:16127714   PMID:16141072   PMID:16141073   PMID:16168404  
PMID:16169491   PMID:16291790   PMID:16341242   PMID:16459298   PMID:16510873   PMID:16516838   PMID:16601693   PMID:16602821   PMID:16678101   PMID:16769906   PMID:16815967   PMID:17013874  
PMID:17095659   PMID:17113065   PMID:17123792   PMID:17150208   PMID:17198701   PMID:17295603   PMID:17331723   PMID:17360769   PMID:17362910   PMID:17596282   PMID:17644613   PMID:17681174  
PMID:17687036   PMID:17785439   PMID:17855428   PMID:17881490   PMID:17904116   PMID:17916349   PMID:17951031   PMID:18000065   PMID:18038450   PMID:18045842   PMID:18083923   PMID:18157121  
PMID:18250098   PMID:18287559   PMID:18351662   PMID:18367164   PMID:18367557   PMID:18385740   PMID:18397997   PMID:18403408   PMID:18448089   PMID:18452912   PMID:18480159   PMID:18480165  
PMID:18489003   PMID:18505822   PMID:18563716   PMID:18708576   PMID:18775421   PMID:18776145   PMID:18927154   PMID:18927156   PMID:18957545   PMID:19036983   PMID:19060336   PMID:19093031  
PMID:19116665   PMID:19149881   PMID:19165927   PMID:19233133   PMID:19268448   PMID:19364920   PMID:19394326   PMID:19530172   PMID:19539783   PMID:19571879   PMID:19591821   PMID:19596317  
PMID:19619491   PMID:19623616   PMID:19653310   PMID:19690384   PMID:19701191   PMID:19718259   PMID:19720827   PMID:19737815   PMID:19769959   PMID:19779553   PMID:19805295   PMID:19806668  
PMID:19841259   PMID:19877272   PMID:19884258   PMID:19890917   PMID:19906857   PMID:19906864   PMID:19913006   PMID:19924825   PMID:19932774   PMID:19939939   PMID:20027618   PMID:20107508  
PMID:20122913   PMID:20145239   PMID:20159597   PMID:20160075   PMID:20185815   PMID:20200943   PMID:20211162   PMID:20237272   PMID:20300119   PMID:20308569   PMID:20346939   PMID:20359476  
PMID:20427820   PMID:20454682   PMID:20501936   PMID:20532162   PMID:20547147   PMID:20569694   PMID:20627076   PMID:20630950   PMID:20637749   PMID:20660756   PMID:20883686   PMID:20890044  
PMID:20965161   PMID:20980404   PMID:20981831   PMID:21049041   PMID:21108844   PMID:21113151   PMID:21185284   PMID:21203428   PMID:21205789   PMID:21246660   PMID:21256124   PMID:21267068  
PMID:21300886   PMID:21303850   PMID:21375603   PMID:21384471   PMID:21402740   PMID:21452227   PMID:21472479   PMID:21490069   PMID:21502507   PMID:21523854   PMID:21539826   PMID:21541292  
PMID:21554866   PMID:21555575   PMID:21600200   PMID:21606200   PMID:21636786   PMID:21652647   PMID:21652651   PMID:21654186   PMID:21664580   PMID:21677750   PMID:21690300   PMID:21704027  
PMID:21706018   PMID:21750544   PMID:21752936   PMID:21757651   PMID:21795391   PMID:21799763   PMID:21806977   PMID:21811467   PMID:21841791   PMID:21858009   PMID:21896628   PMID:21925491  
PMID:21935430   PMID:21936019   PMID:21982234   PMID:21991325   PMID:22022457   PMID:22116255   PMID:22232070   PMID:22322943   PMID:22351753   PMID:22365545   PMID:22366192   PMID:22457761  
PMID:22461561   PMID:22479388   PMID:22564414   PMID:22575959   PMID:22627288   PMID:22711842   PMID:22745311   PMID:22753148   PMID:22766025   PMID:22771246   PMID:22819339   PMID:22863533  
PMID:22923088   PMID:22939930   PMID:22960283   PMID:23042737   PMID:23085236   PMID:23095882   PMID:23123965   PMID:23154457   PMID:23190887   PMID:23260145   PMID:23275340   PMID:23293290  
PMID:23300083   PMID:23302695   PMID:23334328   PMID:23341776   PMID:23354049   PMID:23364326   PMID:23396189   PMID:23431057   PMID:23444352   PMID:23449471   PMID:23454480   PMID:23469192  
PMID:23475960   PMID:23487311   PMID:23523683   PMID:23562159   PMID:23589866   PMID:23606270   PMID:23614009   PMID:23616926   PMID:23637336   PMID:23645682   PMID:23648512   PMID:23671110  
PMID:23727932   PMID:23760955   PMID:23830865   PMID:23863479   PMID:23863482   PMID:23871604   PMID:23884445   PMID:23936395   PMID:23940359   PMID:24000064   PMID:24012369   PMID:24045232  
PMID:24055172   PMID:24055345   PMID:24120136   PMID:24139799   PMID:24151333   PMID:24161848   PMID:24164629   PMID:24174533   PMID:24191021   PMID:24204695   PMID:24211207   PMID:24251807  
PMID:24260306   PMID:24284205   PMID:24302887   PMID:24311688   PMID:24315444   PMID:24324671   PMID:24394376   PMID:24463605   PMID:24479159   PMID:24553287   PMID:24586192   PMID:24609463  
PMID:24631216   PMID:24659776   PMID:24661562   PMID:24680895   PMID:24706781   PMID:24706806   PMID:24727668   PMID:24785830   PMID:24835991   PMID:24859004   PMID:24899573   PMID:24911145  
PMID:24930703   PMID:24948802   PMID:24952961   PMID:24973690   PMID:24982181   PMID:24997521   PMID:25043473   PMID:25082703   PMID:25114215   PMID:25139858   PMID:25158167   PMID:25327250  
PMID:25329657   PMID:25336744   PMID:25341799   PMID:25376721   PMID:25422376   PMID:25422448   PMID:25428587   PMID:25451153   PMID:25599332   PMID:25603931   PMID:25715394   PMID:25727890  
PMID:25753732   PMID:25758227   PMID:25796186   PMID:25805134   PMID:25810530   PMID:25818302   PMID:25866367   PMID:25873176   PMID:25917818   PMID:25926459   PMID:25977363   PMID:26015543  
PMID:26035863   PMID:26056233   PMID:26071364   PMID:26073433   PMID:26093309   PMID:26113728   PMID:26116176   PMID:26159615   PMID:26164566   PMID:26220362   PMID:26235626   PMID:26245375  
PMID:26278035   PMID:26297872   PMID:26305214   PMID:26333992   PMID:26371318   PMID:26443636   PMID:26460010   PMID:26493106   PMID:26526197   PMID:26528816   PMID:26534985   PMID:26542012  
PMID:26542706   PMID:26550799   PMID:26653852   PMID:26655896   PMID:26661618   PMID:26671461   PMID:26677825   PMID:26759176   PMID:26779814   PMID:26811377   PMID:26856660   PMID:26856890  
PMID:26893350   PMID:26903625   PMID:26929341   PMID:26969725   PMID:26974334   PMID:27018594   PMID:27046831   PMID:27088858   PMID:27109869   PMID:27117872   PMID:27122169   PMID:27141870  
PMID:27144473   PMID:27151576   PMID:27203244   PMID:27264700   PMID:27270435   PMID:27302397   PMID:27302476   PMID:27313318   PMID:27320915   PMID:27321946   PMID:27405641   PMID:27411055  
PMID:27414999   PMID:27445154   PMID:27480121   PMID:27510977   PMID:27528615   PMID:27559308   PMID:27578179   PMID:27668462   PMID:27701636   PMID:27713059   PMID:27720610   PMID:27736991  
PMID:27765763   PMID:27782124   PMID:27789627   PMID:27827819   PMID:27853243   PMID:27918563   PMID:27918915   PMID:28028137   PMID:28031172   PMID:28031177   PMID:28052057   PMID:28069701  
PMID:28069795   PMID:28069946   PMID:28077488   PMID:28154153   PMID:28219675   PMID:28237967   PMID:28250050   PMID:28334989   PMID:28370670   PMID:28438836   PMID:28467820   PMID:28501478  
PMID:28520221   PMID:28589954   PMID:28595998   PMID:28605600   PMID:28637242   PMID:28669819   PMID:28692808   PMID:28695824   PMID:28705898   PMID:28729440   PMID:28790015   PMID:28797033  
PMID:28800889   PMID:28808228   PMID:28813421   PMID:28859094   PMID:28870287   PMID:28875532   PMID:28886382   PMID:28893950   PMID:28894084   PMID:28911199   PMID:28942365   PMID:28943241  
PMID:28993399   PMID:29037931   PMID:29056552   PMID:29168693   PMID:29180744   PMID:29211850   PMID:29212953   PMID:29217752   PMID:29386246   PMID:29420258   PMID:29428562   PMID:29437780  
PMID:29451339   PMID:29466737   PMID:29474908   PMID:29735715   PMID:29771971   PMID:29787744   PMID:29852132   PMID:29859889   PMID:29874594   PMID:29879378   PMID:29882512   PMID:29891676  
PMID:29928002   PMID:29950483   PMID:29981310   PMID:29986157   PMID:30044987   PMID:30084950   PMID:30089258   PMID:30177510   PMID:30201295   PMID:30206360   PMID:30224759   PMID:30235284  
PMID:30254141   PMID:30256984   PMID:30352686   PMID:30366904   PMID:30389913   PMID:30478225   PMID:30485816   PMID:30500538   PMID:30500539   PMID:30504774   PMID:30504829   PMID:30509557  
PMID:30568578   PMID:30571485   PMID:30595533   PMID:30615824   PMID:30651295   PMID:30651296   PMID:30653268   PMID:30658984   PMID:30692221   PMID:30760729   PMID:30884041   PMID:30894540  
PMID:30916783   PMID:31038803   PMID:31042081   PMID:31068622   PMID:31104943   PMID:31167144   PMID:31220272   PMID:31222549   PMID:31235634   PMID:31351040   PMID:31524221   PMID:31604927  
PMID:31613912   PMID:31719045   PMID:31729356   PMID:31747615   PMID:31772170   PMID:31789450   PMID:31845891   PMID:31924786   PMID:32001436   PMID:32253237   PMID:32324134   PMID:32369449  
PMID:32390226   PMID:32464196   PMID:32515350   PMID:32521258   PMID:32541007   PMID:32643876   PMID:32715478   PMID:32759216   PMID:32840212   PMID:32855415   PMID:32878924   PMID:33020269  
PMID:33046507   PMID:33177537   PMID:33214242  


Genomics

Comparative Map Data
Axin2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911108,808,654 - 108,841,609 (+)NCBIGRCm39mm39
GRCm39 Ensembl11108,811,175 - 108,841,609 (+)Ensembl
GRCm3811108,917,828 - 108,950,783 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11108,920,349 - 108,950,783 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711108,781,663 - 108,812,097 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611108,736,456 - 108,766,873 (+)NCBImm8
Celera11120,655,477 - 120,686,142 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1171.83NCBI
AXIN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1765,528,563 - 65,561,648 (-)EnsemblGRCh38hg38GRCh38
GRCh381765,528,563 - 65,561,648 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371763,524,681 - 63,557,766 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361760,955,143 - 60,988,227 (-)NCBINCBI36hg18NCBI36
Build 341760,956,105 - 60,985,289NCBI
Celera1760,094,914 - 60,128,039 (-)NCBI
Cytogenetic Map17q24.1NCBI
HuRef1758,916,746 - 58,949,692 (-)NCBIHuRef
CHM1_11763,588,742 - 63,621,757 (-)NCBICHM1_1
Axin2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21093,893,830 - 93,927,042 (+)NCBI
Rnor_6.0 Ensembl1097,212,432 - 97,239,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01097,212,483 - 97,238,824 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01096,933,422 - 96,959,748 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41098,294,466 - 98,321,830 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11098,308,835 - 98,336,196 (+)NCBI
Celera1092,540,720 - 92,589,078 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Axin2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554784,952,488 - 4,982,225 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554784,952,551 - 4,982,223 (-)NCBIChiLan1.0ChiLan1.0
AXIN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11764,688,416 - 64,720,086 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1764,688,416 - 64,720,086 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01759,476,336 - 59,509,358 (-)NCBIMhudiblu_PPA_v0panPan3
AXIN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1914,559,476 - 14,588,950 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl914,559,388 - 14,588,530 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha915,451,561 - 15,482,654 (+)NCBI
ROS_Cfam_1.0916,221,743 - 16,252,811 (+)NCBI
UMICH_Zoey_3.1915,167,377 - 15,198,389 (+)NCBI
UNSW_CanFamBas_1.0912,335,210 - 12,366,239 (-)NCBI
UU_Cfam_GSD_1.0912,336,357 - 12,367,417 (-)NCBI
Axin2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_02440560211,952,128 - 11,986,668 (-)NCBI
SpeTri2.0NW_0049365417,155,963 - 7,242,466 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AXIN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1212,311,293 - 12,343,200 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11212,311,293 - 12,343,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,654,639 - 12,662,408 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AXIN2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11655,874,043 - 55,906,739 (+)NCBI
ChlSab1.1 Ensembl1655,874,072 - 55,907,281 (+)Ensembl
Axin2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248702,803,743 - 2,832,489 (+)NCBI

Position Markers
Axin2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811108,923,307 - 108,923,411UniSTSGRCm38
MGSCv3711108,784,621 - 108,784,725UniSTSGRCm37
Celera11120,658,563 - 120,658,667UniSTS
Cytogenetic Map11E1UniSTS
cM Map1170.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177172953111173092Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177546357111546496Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177546357111546496Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177880152111880273Mouse
14746970Manh71_mmandible shape 71 (mouse)1179525431113525431Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181683655115683810Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181683655115683810Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181919441115919441Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182486872116486994Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185954085119954085Mouse
15039374Adip29_madiposity 29 (mouse)1186717494120717494Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186717494120717494Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186717494120717494Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187600000126900000Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187611774121611872Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189978425122082543Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191713782122082543Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191713782122082543Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1193048547112653728Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193338357122082543Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194172953118131898Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194300000119000000Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94546357118131898Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195513139122082543Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195513139122082543Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196246848122082543Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196919310122082543Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1197006867110713165Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198461783122082543Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198609643122082543Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199363361122082543Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100167277122082543Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100363360120996339Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101131764122082543Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101613994114581537Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101613994114581537Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101613994114581537Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101613994114581537Mouse
1300957Pbd1_mpeak bone density 1 (mouse)Not determined11102453297112493297Mouse
4141612Cia40_mcollagen induced arthritis 40 (mouse)Not determined11103383166115130618Mouse
4141702Hmtb6_mhemostasis and thrombosis rebleeding time 6 (mouse)Not determined107725518110629004Mouse
25394549Skmw73_mskeletal muscle weight 73, TA (mouse)11108184643109792775Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1309
Count of miRNA genes:660
Interacting mature miRNAs:807
Transcripts:ENSMUST00000052915, ENSMUST00000106711, ENSMUST00000139682, ENSMUST00000140821, ENSMUST00000144130, ENSMUST00000144511, ENSMUST00000152909
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_015732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006532060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF073788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF205889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000052915   ⟹   ENSMUSP00000051331
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11108,920,349 - 108,950,783 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106711   ⟹   ENSMUSP00000102322
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11108,923,181 - 108,949,511 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139682
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11108,943,621 - 108,950,783 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140821   ⟹   ENSMUSP00000120664
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11108,920,800 - 108,923,583 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144130
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11108,938,874 - 108,942,559 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144511   ⟹   ENSMUSP00000119915
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11108,921,648 - 108,923,494 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152909   ⟹   ENSMUSP00000116956
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11108,921,336 - 108,923,598 (+)Ensembl
RefSeq Acc Id: NM_015732   ⟹   NP_056547
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911108,811,175 - 108,841,609 (+)NCBI
GRCm3811108,920,349 - 108,950,783 (+)NCBI
MGSCv3711108,781,663 - 108,812,097 (+)RGD
Celera11120,655,477 - 120,686,142 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006532057   ⟹   XP_006532120
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911108,811,625 - 108,841,609 (+)NCBI
GRCm3811108,920,805 - 108,950,783 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532058   ⟹   XP_006532121
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911108,808,654 - 108,841,537 (+)NCBI
GRCm3811108,917,828 - 108,950,711 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532059   ⟹   XP_006532122
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911108,812,219 - 108,841,537 (+)NCBI
GRCm3811108,921,397 - 108,950,711 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006532060   ⟹   XP_006532123
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911108,812,062 - 108,841,537 (+)NCBI
GRCm3811108,921,286 - 108,950,711 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030245493   ⟹   XP_030101353
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911108,812,219 - 108,841,537 (+)NCBI
GRCm3811108,921,477 - 108,950,711 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_056547   ⟸   NM_015732
- UniProtKB: O88566 (UniProtKB/Swiss-Prot),   Q3UQK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006532121   ⟸   XM_006532058
- Peptide Label: isoform X1
- UniProtKB: O88566 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532120   ⟸   XM_006532057
- Peptide Label: isoform X1
- UniProtKB: O88566 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532123   ⟸   XM_006532060
- Peptide Label: isoform X1
- UniProtKB: O88566 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006532122   ⟸   XM_006532059
- Peptide Label: isoform X1
- UniProtKB: O88566 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030101353   ⟸   XM_030245493
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000051331   ⟸   ENSMUST00000052915
RefSeq Acc Id: ENSMUSP00000119915   ⟸   ENSMUST00000144511
RefSeq Acc Id: ENSMUSP00000116956   ⟸   ENSMUST00000152909
RefSeq Acc Id: ENSMUSP00000102322   ⟸   ENSMUST00000106711
RefSeq Acc Id: ENSMUSP00000120664   ⟸   ENSMUST00000140821
Protein Domains
AXIN1_TNKS_BD   DIX   RGS

Promoters
RGD ID:6820451
Promoter ID:MM_KWN:10349
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:ENSMUST00000106712,   OTTMUST00000006621,   OTTMUST00000006624,   OTTMUST00000006625,   OTTMUST00000006626
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611108,781,564 - 108,782,064 (+)MPROMDB
RGD ID:6820452
Promoter ID:MM_KWN:10351
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000006627
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611108,799,466 - 108,800,467 (+)MPROMDB
RGD ID:8677156
Promoter ID:EPDNEW_M16609
Type:initiation region
Name:Axin2_1
Description:Mus musculus axin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16610  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811108,920,349 - 108,920,409EPDNEW
RGD ID:8677158
Promoter ID:EPDNEW_M16610
Type:multiple initiation site
Name:Axin2_2
Description:Mus musculus axin 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16609  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811108,921,678 - 108,921,738EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1270862 AgrOrtholog
Ensembl Genes ENSMUSG00000000142 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000051331 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000102322 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000116956 UniProtKB/TrEMBL
  ENSMUSP00000119915 UniProtKB/TrEMBL
  ENSMUSP00000120664 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000052915 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000106711 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000140821 UniProtKB/TrEMBL
  ENSMUST00000144511 UniProtKB/TrEMBL
  ENSMUST00000152909 UniProtKB/TrEMBL
Gene3D-CATH 1.10.196.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.20.380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Axin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Axin_b-cat-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Axin_TNKS-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIX_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12006 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1270862 ENTREZGENE
NCBI Gene 12006 ENTREZGENE
PANTHER PTHR46102 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AXIN1_TNKS_BD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Axin_b-cat_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Axin2 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DAX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2ABQ7_MOUSE UniProtKB/TrEMBL
  A2ABQ8_MOUSE UniProtKB/TrEMBL
  A2ABQ9_MOUSE UniProtKB/TrEMBL
  A2ABR0_MOUSE UniProtKB/TrEMBL
  AXIN2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UQK5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q6PFZ9 UniProtKB/Swiss-Prot
  Q9QXJ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 Axin2  axin 2    axin2  Symbol and/or name change 5135510 APPROVED