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Gene: Thra (thyroid hormone receptor alpha) Rattus norvegicus
Symbol: Thra
Name: thyroid hormone receptor alpha
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including animal organ development; digestive tract development; and regulation of transcription, DNA-templated. Localizes to cytosol; mitochondrion; and nucleus. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Orthologous to human THRA (thyroid hormone receptor alpha); INTERACTS WITH 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1; c-erb-A thyroid hormone receptor; c-erbA-1; C-erbA-alpha; c-erbA-alpha2; c-erbAalpha2; ERBA1; nuclear receptor subfamily 1 group A member 1; Thra1; thyroid hormone receptor; Thyroid hormone receptor alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1 formerly ERBA1); Thyroid hormone receptor, alpha 1 (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 1, formerly ERBA1)
Homo sapiens (human) : THRA (thyroid hormone receptor alpha)  HGNC  Alliance
Mus musculus (house mouse) : Thra (thyroid hormone receptor alpha)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Thra (thyroid hormone receptor alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : THRA (thyroid hormone receptor alpha)
Canis lupus familiaris (dog) : THRA (thyroid hormone receptor alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Thra (thyroid hormone receptor alpha)
Sus scrofa (pig) : THRA (thyroid hormone receptor alpha)
Chlorocebus sabaeus (African green monkey) : THRA (thyroid hormone receptor alpha)
Heterocephalus glaber (naked mole-rat) : Thra (thyroid hormone receptor alpha)
more info ...
Allele / Splice: Thra_v2   Thra_v1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01086,657,285 - 86,684,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,657,285 - 86,684,933 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,453,436 - 86,480,928 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,514,443 - 87,542,306 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11087,540,629 - 87,556,674 (+)NCBI
Celera1082,449,971 - 82,477,615 (+)NCBICelera
Cytogenetic Map10q31NCBI
RH 3.4 Map10839.79RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Thra
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3857
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.