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Gene: Ccl3 (C-C motif chemokine ligand 3) Rattus norvegicus
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Symbol: Ccl3
Name: C-C motif chemokine ligand 3
Description: Exhibits chemokine activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of cytosolic calcium ion concentration; and positive regulation of osteoclast differentiation. Predicted to localize to the cytosol and extracellular space. Biomarker of several diseases, including Chagas disease; anterior uveitis; nephritis (multiple); renal fibrosis; and status epilepticus. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to several human genes including CCL3 (C-C motif chemokine ligand 3); PARTICIPATES IN interleukin-12 signaling pathway; Chagas disease pathway; chemokine mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C-C motif chemokine 3; chemokine (C-C motif) ligand 3; macrophage inflammatory protein 1 alpha (Small inducible cytokine A3); macrophage inflammatory protein 1-alpha; MIP-1-alpha; MIP-1a; Scya3; small inducible cytokine A3; small-inducible cytokine A3
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01070,869,516 - 70,871,066 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01070,501,119 - 70,502,669 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,744,559 - 71,746,109 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11071,758,928 - 71,760,479 (-)NCBI
Celera1067,390,853 - 67,392,403 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Ccl3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3647
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.