RGD Reference Report - Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1alpha in alcoholic liver disease. - Rat Genome Database

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Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1alpha in alcoholic liver disease.

Authors: Fisher, N C  Neil, D A  Williams, A  Adams, D H 
Citation: Fisher NC, etal., Gut. 1999 Sep;45(3):416-20. doi: 10.1136/gut.45.3.416.
RGD ID: 14995467
Pubmed: PMID:10446112   (View Abstract at PubMed)
PMCID: PMC1727646   (View Article at PubMed Central)
DOI: DOI:10.1136/gut.45.3.416   (Journal Full-text)


BACKGROUND: Alcoholic liver disease is associated with increased hepatic expression of monocyte chemoattractant protein 1 (MCP-1) and macrophage inflammatory protein 1alpha (MIP-1alpha).
AIMS: To determine whether concentrations of chemokines in the peripheral circulation reflect disease activity, and whether chemokine secretion is restricted to the liver or is part of a systemic inflammatory response in alcoholic liver disease.
PATIENTS: Fifty one patients with alcoholic liver disease and 12 healthy controls.
METHODS: Peripheral vein (and hepatic vein in patients undergoing transjugular liver biopsy) chemokine concentrations were measured by ELISA. Chemokine secretion and transcription in isolated peripheral mononuclear cells were assessed using ELISA and in situ hybridisation in patients with severe alcoholic hepatitis.
RESULTS: Serum MCP-1 concentrations were higher in alcoholic hepatitis compared with cirrhosis or healthy controls. MIP-1alpha concentrations were below the assay sensitivity in most patients. Serum MCP-1 concentrations correlated significantly with serum aspartate aminotransferase and creatinine. In severe alcoholic hepatitis, MCP-1 concentrations were higher in hepatic compared with peripheral veins; in mild alcoholic hepatitis there was no difference. Mononuclear cell secretion of both MCP-1 and MIP-1alpha was higher in severe alcoholic hepatitis compared with healthy controls, and chemokine mRNA was identified in monocytes.
CONCLUSIONS: Serum MCP-1 concentrations are raised in alcoholic liver disease and reflect severity of hepatic inflammation. Monocyte secretion of both MCP-1 and MIP-1alpha is increased in severe alcoholic hepatitis. Both intrahepatic sources and peripheral mononuclear cells contribute to the raised serum MCP-1 concentrations.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL2Humanalcoholic hepatitis severityIEP  RGD 
CCL3Humanalcoholic hepatitis severityIEP  RGD 
Ccl2Ratalcoholic hepatitis severityISOCCL2 (Homo sapiens) RGD 
Ccl2Mousealcoholic hepatitis severityISOCCL2 (Homo sapiens) RGD 
Ccl3Ratalcoholic hepatitis severityISOCCL3 (Homo sapiens) RGD 
Ccl3Mousealcoholic hepatitis severityISOCCL3 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl2  (C-C motif chemokine ligand 2)
Ccl3  (C-C motif chemokine ligand 3)

Genes (Mus musculus)
Ccl2  (C-C motif chemokine ligand 2)
Ccl3  (C-C motif chemokine ligand 3)

Genes (Homo sapiens)
CCL2  (C-C motif chemokine ligand 2)
CCL3  (C-C motif chemokine ligand 3)


Additional Information