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Gene: CCL3 (C-C motif chemokine ligand 3) Homo sapiens
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Symbol: CCL3
Name: C-C motif chemokine ligand 3
Description: Exhibits several functions, including calcium-dependent protein kinase C activity; chemokine receptor binding activity; and molecular function regulator. Involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of intracellular signal transduction. Localizes to the cytosol and extracellular space. Implicated in human immunodeficiency virus infectious disease. Biomarker of acute kidney failure; crescentic glomerulonephritis; end stage renal failure; focal segmental glomerulosclerosis; and systemic scleroderma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-C motif chemokine 3; chemokine (C-C motif) ligand 3; G0/G1 switch regulatory protein 19-1; G0S19-1; LD78 alpha beta; LD78ALPHA; macrophage inflammatory protein 1-alpha; MIP-1-alpha; MIP1A; PAT 464.1; SCYA3; SIS-beta; small inducible cytokine A3 (homologous to mouse Mip-1a); small-inducible cytokine A3; tonsillar lymphocyte LD78 alpha protein
Orthologs:
Related Pseudogenes: CCL3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381736,088,256 - 36,090,143 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371734,415,602 - 34,417,506 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,439,715 - 31,441,619 (-)NCBINCBI36hg18NCBI36
Build 341731,439,717 - 31,441,600NCBI
Celera1731,325,155 - 31,327,059 (-)NCBI
Cytogenetic Map17q12NCBI
HuRef1730,600,149 - 30,602,053 (-)NCBIHuRef
CHM1_11734,479,827 - 34,481,731 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CCL3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735784
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.