CCL4 (C-C motif chemokine ligand 4) - Rat Genome Database

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Gene: CCL4 (C-C motif chemokine ligand 4) Homo sapiens
Analyze
Symbol: CCL4
Name: C-C motif chemokine ligand 4
RGD ID: 1353278
HGNC Page HGNC
Description: Enables CCR1 chemokine receptor binding activity; CCR5 chemokine receptor binding activity; and identical protein binding activity. Involved in several processes, including negative regulation by host of viral transcription; positive regulation of calcium-mediated signaling; and positive regulation of natural killer cell chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in acquired immunodeficiency syndrome. Biomarker of several diseases, including Plasmodium falciparum malaria; autoimmune disease (multiple); cystic fibrosis; lung disease (multiple); and nose disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACT2; AT744.1; C-C motif chemokine 4; CC chemokine ligand 4; chemokine (C-C motif) ligand 4; G-26; G-26 T-lymphocyte-secreted protein; HC21; LAG-1; LAG1; lymphocyte activation gene 1 protein; lymphocyte-activation gene 1; macrophage inflammatory protein 1-beta; MGC104418; MGC126025; MGC126026; MIP-1-beta; MIP-1-beta(1-69); MIP1B; MIP1B1; PAT 744; SCYA2; SCYA4; secreted protein G-26; SIS-gamma; small inducible cytokine A4 (homologous to mouse Mip-1b); small-inducible cytokine A4; T-cell activation protein 2
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1736,103,827 - 36,105,621 (+)EnsemblGRCh38hg38GRCh38
GRCh381736,103,827 - 36,105,614 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371734,431,220 - 34,433,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,455,333 - 31,457,127 (+)NCBINCBI36hg18NCBI36
Build 341731,455,332 - 31,457,127NCBI
Celera1731,340,772 - 31,342,566 (+)NCBI
Cytogenetic Map17q12NCBI
HuRef1730,615,959 - 30,617,753 (+)NCBIHuRef
CHM1_11734,495,398 - 34,497,192 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-anisomycin  (EXP)
(-)-demecolcine  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(R)-mevalonic acid  (EXP)
1,3-benzothiazole-2-thiol  (EXP)
1,4-benzoquinone  (EXP)
1,4-phenylenediamine  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
15-acetyldeoxynivalenol  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2,6-dichloroindophenol  (EXP)
2-hydroxypropanoic acid  (EXP)
26-hydroxycholesterol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
7-ketocholesterol  (EXP)
7alpha-hydroxycholesterol  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
alclometasone dipropionate  (EXP)
alexidine  (EXP)
all-trans-retinoic acid  (EXP)
alpha-hexylcinnamaldehyde  (EXP)
aluminium hydroxide  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
antimycin A  (EXP)
antirheumatic drug  (EXP)
aripiprazole  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
asperentin  (ISO)
Bandrowski's base  (EXP)
Bardoxolone methyl  (ISO)
barium sulfate  (ISO)
beclomethasone  (EXP)
benzalkonium chloride  (EXP,ISO)
benzene  (ISO)
benzene-1,2,4-triol  (EXP)
benzethonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzocaine  (EXP)
beryllium sulfate  (EXP)
betamethasone  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (ISO)
bleomycin A2  (ISO)
budesonide  (EXP)
C.I. Natural Red 20  (ISO)
Calcimycin  (ISO)
camptothecin  (EXP)
carbon nanotube  (ISO)
catechol  (EXP)
cefaloridine  (ISO)
cephaeline  (EXP)
ceric oxide  (ISO)
chloromethylisothiazolinone  (EXP)
chlorothalonil  (EXP)
chlorpyrifos  (ISO)
cholesterol  (EXP)
choline  (ISO)
chrysene  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clopidogrel  (EXP)
cobalt atom  (ISO)
cobalt(2+) sulfate  (EXP)
cortisol  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP)
D-penicillamine  (EXP,ISO)
daunorubicin  (EXP)
Decursin  (ISO)
deoxynivalenol  (EXP,ISO)
dequalinium  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dichromium trioxide  (EXP)
digitoxigenin  (EXP)
digoxigenin  (EXP)
digoxin  (EXP)
dihydroxyacetone  (EXP)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (ISO)
emetine  (EXP)
endosulfan  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
eugenol  (EXP)
farnesol  (EXP)
ferric oxide  (EXP,ISO)
fludrocortisone  (EXP)
flumequine  (ISO)
folic acid  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gadodiamide hydrate  (ISO)
genistein  (EXP)
gentamycin  (ISO)
geraniol  (EXP)
glutaraldehyde  (EXP)
graphene oxide  (ISO)
graphite  (ISO)
hydralazine  (EXP)
hydrogen chloride  (ISO)
hydroquinone  (EXP)
indirubin-3'-monoxime  (EXP)
indole-3-methanol  (ISO)
indometacin  (EXP)
ionomycin  (EXP)
L-methionine  (ISO)
lanatoside C  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
meclocycline  (EXP)
MeIQx  (ISO)
metam  (ISO)
methamphetamine  (ISO)
methionine sulfoximine  (EXP)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
Methylbenzethonium chloride  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (ISO)
minocycline  (EXP)
Muraglitazar  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-methyl-N-nitrosourea  (ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
nickel atom  (EXP,ISO)
nickel sulfate  (EXP)
oxaliplatin  (ISO)
oxytetracycline  (EXP)
ozone  (EXP,ISO)
palmatine  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalic anhydride  (ISO)
poly(I:C)  (EXP,ISO)
potassium dichromate  (EXP,ISO)
prednisolone  (EXP)
propidium  (EXP)
Proscillaridin  (EXP)
prostaglandin E2  (EXP,ISO)
puromycin  (EXP)
pyrrolidine dithiocarbamate  (ISO)
rac-lactic acid  (EXP)
resveratrol  (EXP,ISO)
ritonavir  (EXP)
roflumilast  (EXP)
SB 203580  (EXP)
serpentine asbestos  (EXP,ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (ISO)
Soman  (ISO)
succimer  (EXP,ISO)
sunitinib  (ISO)
tamibarotene  (EXP)
taurocholic acid  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thiostrepton  (EXP)
tigecycline  (EXP)
titanium dioxide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trans-caffeic acid  (ISO)
tremolite asbestos  (ISO)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
tungsten  (ISO)
tunicamycin  (EXP)
usnic acid  (EXP)
valproic acid  (EXP)
vincristine  (EXP)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA,TAS)
extracellular space  (IBA,IEA,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Arankalle VA, etal., PLoS One. 2010 Oct 1;5(10). pii: e13099.
2. Barczyk A, etal., Pneumonol Alergol Pol. 2001;69(1-2):40-9.
3. Bellastella G, etal., J Endocrinol Invest. 2010 Dec 15.
4. Bless NM, etal., J Immunol 2000 Mar 1;164(5):2650-9.
5. Brennan S, etal., Eur Respir J. 2009 Sep;34(3):655-61. Epub 2009 Apr 22.
6. Codullo V, etal., Ann Rheum Dis. 2011 Jun;70(6):1115-21. Epub 2011 Feb 1.
7. Farquhar C, etal., Curr HIV Res. 2005 Oct;3(4):361-9.
8. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
9. Garcia GE, etal., FASEB J. 2008 Feb;22(2):445-54. Epub 2007 Sep 26.
10. GOA_HUMAN data from the GO Consortium
11. Goleva E, etal., J Allergy Clin Immunol. 2008 Sep;122(3):550-9.e3.
12. Guzik-Kornacka A, etal., Acta Neurobiol Exp (Wars). 2011;71(2):193-207.
13. Hekiert AM, etal., Otolaryngol Head Neck Surg. 2009 Oct;141(4):448-53.
14. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
15. Kishi J, etal., Eur Respir J. 2011 Aug;38(2):415-24. Epub 2011 Jan 27.
16. Lee JS, etal., Respir Res. 2007 Sep 14;8:64.
17. Leifeld L, etal., J Pathol. 2003 Mar;199(3):335-44. doi: 10.1002/path.1298.
18. Lin FC, etal., Mayo Clin Proc. 2008 Dec;83(12):1344-9.
19. Liu J, etal., J Immunoassay Immunochem. 2010 Oct;31(4):279-89.
20. Maijo M, etal., Br J Nutr. 2011 Sep 12:1-9.
21. Mera S, etal., APMIS. 2011 Feb;119(2):155-63. doi: 10.1111/j.1600-0463.2010.02705.x. Epub 2010 Dec 10.
22. Meuronen A, etal., Respiration. 2008;75(4):450-8. Epub 2008 Jan 30.
23. Mittal N and Sanyal SN, J Immunotoxicol. 2011 Oct-Dec;8(4):274-83. Epub 2011 Jul 18.
24. Modi WS, etal., Am J Hum Genet. 2006 Jul;79(1):120-8. Epub 2006 May 30.
25. Mrugacz M J Interferon Cytokine Res. 2010 Jul;30(7):509-12.
26. Ochiel DO, etal., Infect Immun. 2005 Jul;73(7):4190-7.
27. Pattarini R, etal., Neuroscience. 2007 Mar 16;145(2):654-68. Epub 2007 Jan 29.
28. Pipeline to import KEGG annotations from KEGG into RGD
29. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. RGD automated import pipeline for gene-chemical interactions
32. Rodriguez N, etal., J Leukoc Biol. 2010 Sep;88(3):579-87. Epub 2010 May 18.
33. Schutz C, etal., PLoS Med. 2019 Jul 5;16(7):e1002840. doi: 10.1371/journal.pmed.1002840. eCollection 2019 Jul.
34. Shankar K, etal., Endocrinology. 2011 Nov;152(11):4158-70. Epub 2011 Aug 23.
35. Shin JJ, etal., Arthritis Rheum. 2007 Apr;56(4):1325-35.
36. Sisay Z, etal., Ethiop Med J. 2011 Jul;49(3):179-86.
37. Sun X, etal., Infect Immun. 2006 Oct;74(10):5943-54.
38. Szodoray P, etal., Rheumatology (Oxford). 2007 Mar;46(3):417-25. Epub 2006 Aug 27.
39. Tripathy AS, etal., J Viral Hepat. 2011 Oct;18(10):e415-22. doi: 10.1111/j.1365-2893.2011.01457.x. Epub 2011 May 18.
40. Vila LM, etal., Clin Rheumatol. 2007 May;26(5):718-22. Epub 2006 Aug 19.
41. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
42. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
43. Yuan TM, etal., J Perinat Med. 2005;33(5):415-22.
44. Zhou Z, etal., Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2. doi: 10.1016/j.chom.2020.04.017. Epub 2020 May 4.
Additional References at PubMed
PMID:1894635   PMID:1972563   PMID:2247088   PMID:2462251   PMID:2521353   PMID:2521882   PMID:2568930   PMID:2809212   PMID:7545673   PMID:7566098   PMID:7594543   PMID:7622448  
PMID:8077676   PMID:8134838   PMID:8525373   PMID:8661057   PMID:8663314   PMID:8699119   PMID:8898753   PMID:8906795   PMID:8906796   PMID:9256481   PMID:9359702   PMID:9405404  
PMID:9420238   PMID:9520456   PMID:9521068   PMID:9558100   PMID:9576751   PMID:9658081   PMID:9743377   PMID:9759849   PMID:9973507   PMID:10049593   PMID:10089882   PMID:10383387  
PMID:10395844   PMID:10470075   PMID:10540332   PMID:10608777   PMID:10644351   PMID:10679098   PMID:10751368   PMID:10820198   PMID:10841574   PMID:10900358   PMID:10929056   PMID:10938094  
PMID:10985253   PMID:11023526   PMID:11129109   PMID:11278300   PMID:11313374   PMID:11470920   PMID:11485305   PMID:11602715   PMID:11685466   PMID:11751963   PMID:12036855   PMID:12070155  
PMID:12089333   PMID:12200385   PMID:12218153   PMID:12370346   PMID:12377943   PMID:12393595   PMID:12393716   PMID:12401480   PMID:12411442   PMID:12427015   PMID:12445801   PMID:12477932  
PMID:12574335   PMID:12603824   PMID:12651610   PMID:12679478   PMID:14582706   PMID:14673550   PMID:14718574   PMID:14746807   PMID:14761932   PMID:15067078   PMID:15142381   PMID:15481145  
PMID:15489334   PMID:15529362   PMID:15585099   PMID:15588341   PMID:15638726   PMID:15645140   PMID:15780175   PMID:15817944   PMID:15831560   PMID:15843566   PMID:15897346   PMID:16160188  
PMID:16354571   PMID:16379602   PMID:16393999   PMID:16625196   PMID:16697675   PMID:16841089   PMID:16963564   PMID:17005260   PMID:17330138   PMID:17431094   PMID:17644519   PMID:17703412  
PMID:17765942   PMID:18076643   PMID:18203956   PMID:18346864   PMID:18368065   PMID:18623207   PMID:18802359   PMID:19047106   PMID:19057841   PMID:19074730   PMID:19103522   PMID:19234184  
PMID:19258923   PMID:19328808   PMID:19358850   PMID:19565503   PMID:19620252   PMID:19841187   PMID:19846870   PMID:19917679   PMID:20056178   PMID:20200978   PMID:20380698   PMID:20403075  
PMID:20482449   PMID:20503287   PMID:20504918   PMID:20598119   PMID:20702408   PMID:20817073   PMID:20855878   PMID:20952681   PMID:20959807   PMID:21030011   PMID:21082024   PMID:21264298  
PMID:21464938   PMID:21873635   PMID:21890375   PMID:21978000   PMID:22085486   PMID:22156348   PMID:22407921   PMID:23152559   PMID:23383108   PMID:23509148   PMID:23554973   PMID:23597562  
PMID:23692808   PMID:23760235   PMID:23898208   PMID:23996681   PMID:23998687   PMID:24116893   PMID:24227857   PMID:24370436   PMID:24489105   PMID:24500432   PMID:24797975   PMID:24899193  
PMID:24942586   PMID:25004830   PMID:25008917   PMID:25063291   PMID:25240755   PMID:25416956   PMID:25449536   PMID:25529283   PMID:25548252   PMID:25620312   PMID:25744730   PMID:25760046  
PMID:25809376   PMID:25889297   PMID:26074318   PMID:26115437   PMID:26158606   PMID:26270232   PMID:26284335   PMID:26285074   PMID:26786652   PMID:26786659   PMID:26854929   PMID:26874795  
PMID:26898119   PMID:27300476   PMID:27632174   PMID:27748906   PMID:28002786   PMID:28074184   PMID:28170001   PMID:28404909   PMID:28413983   PMID:28514442   PMID:28656247   PMID:28824325  
PMID:29023999   PMID:29705123   PMID:29722145   PMID:29739756   PMID:29764502   PMID:29807685   PMID:29927949   PMID:29955612   PMID:29987448   PMID:30123055   PMID:30419802   PMID:30561228  
PMID:30697694   PMID:30854716   PMID:30890699   PMID:30964608   PMID:31268406   PMID:31515488   PMID:31546972   PMID:31844672   PMID:31964786   PMID:32011520   PMID:32060843   PMID:32076268  
PMID:32296183   PMID:32502310   PMID:33026626   PMID:33361824   PMID:33630763   PMID:33961781   PMID:34497436  


Genomics

Comparative Map Data
CCL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1736,103,827 - 36,105,621 (+)EnsemblGRCh38hg38GRCh38
GRCh381736,103,827 - 36,105,614 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371734,431,220 - 34,433,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,455,333 - 31,457,127 (+)NCBINCBI36hg18NCBI36
Build 341731,455,332 - 31,457,127NCBI
Celera1731,340,772 - 31,342,566 (+)NCBI
Cytogenetic Map17q12NCBI
HuRef1730,615,959 - 30,617,753 (+)NCBIHuRef
CHM1_11734,495,398 - 34,497,192 (+)NCBICHM1_1
Ccl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,553,410 - 83,555,509 (+)NCBIGRCm39mm39
GRCm39 Ensembl1183,553,410 - 83,555,509 (+)Ensembl
GRCm381183,648,624 - 83,664,683 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,662,584 - 83,664,683 (+)EnsemblGRCm38mm10GRCm38
MGSCv371183,476,086 - 83,478,185 (+)NCBIGRCm37mm9NCBIm37
MGSCv361183,478,782 - 83,480,875 (+)NCBImm8
Celera1193,266,966 - 93,269,065 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.09NCBI
Ccl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21068,466,469 - 68,467,941 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1068,452,052 - 68,468,231 (+)Ensembl
Rnor_6.01070,870,926 - 70,886,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,884,531 - 70,886,355 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01070,502,606 - 70,518,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,759,643 - 71,761,115 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11071,774,012 - 71,775,485 (+)NCBI
Celera1067,405,932 - 67,407,404 (+)NCBICelera
Cytogenetic Map10q26NCBI
CCL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1937,681,342 - 37,682,691 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl937,676,966 - 37,710,209 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha936,905,070 - 36,906,419 (-)NCBI
ROS_Cfam_1.0938,491,608 - 38,492,957 (-)NCBI
ROS_Cfam_1.0 Ensembl938,487,223 - 38,520,522 (-)Ensembl
UMICH_Zoey_3.1937,273,230 - 37,274,579 (-)NCBI
UNSW_CanFamBas_1.0937,560,499 - 37,561,848 (-)NCBI
UU_Cfam_GSD_1.0937,647,662 - 37,649,011 (-)NCBI
CCL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,478,885 - 39,557,358 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11239,479,190 - 39,480,511 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,048,660 - 41,049,981 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Position Markers
PMC108024P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371734,432,621 - 34,432,934UniSTSGRCh37
Build 361731,456,734 - 31,457,047RGDNCBI36
Celera1731,342,173 - 31,342,486RGD
Cytogenetic Map17q12UniSTS
HuRef1730,617,360 - 30,617,673UniSTS
STS-X53683  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371734,432,712 - 34,432,929UniSTSGRCh37
Build 361731,456,825 - 31,457,042RGDNCBI36
Celera1731,342,264 - 31,342,481RGD
Cytogenetic Map17q12UniSTS
HuRef1730,617,451 - 30,617,668UniSTS
GeneMap99-GB4 RH Map17298.86UniSTS
NCBI RH Map17413.0UniSTS
G28333  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371734,432,766 - 34,432,967UniSTSGRCh37
Build 361731,456,879 - 31,457,080RGDNCBI36
Celera1731,342,318 - 31,342,519RGD
Cytogenetic Map17q12UniSTS
HuRef1730,617,505 - 30,617,706UniSTS
RH11493  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371734,432,720 - 34,432,931UniSTSGRCh37
Build 361731,456,833 - 31,457,044RGDNCBI36
Celera1731,342,272 - 31,342,483RGD
Cytogenetic Map17q12UniSTS
HuRef1730,617,459 - 30,617,670UniSTS
GeneMap99-GB4 RH Map17295.52UniSTS
NCBI RH Map17397.7UniSTS
PMC152049P1  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q12UniSTS
STS-M69203  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q12UniSTS
GeneMap99-GB4 RH Map17297.07UniSTS
NCBI RH Map17420.9UniSTS
RH17517  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q12UniSTS
GeneMap99-GB4 RH Map17296.36UniSTS
NCBI RH Map17418.9UniSTS
UniSTS:489733  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371734,431,229 - 34,432,856UniSTSGRCh37
Celera1731,340,781 - 31,342,408UniSTS
HuRef1730,615,968 - 30,617,595UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR195hsa-miR-195-5pMirtarbaseexternal_infoELISA//Immunoprecipitaion//qRT-PCR//Western blotFunctional MTI20952681

Predicted Target Of
Summary Value
Count of predictions:411
Count of miRNA genes:241
Interacting mature miRNAs:250
Transcripts:ENST00000250151, ENST00000394495, ENST00000591883
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High 10 10 1
Medium 223 865 250 54 896 36 197 25 186 15 127 713 18 470 116
Low 1939 1770 1165 334 277 190 2930 1416 2271 87 965 517 144 729 1880
Below cutoff 53 294 4 867 643 1015 8 19 5 736

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_033066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA362169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC069363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC243829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY312578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY766446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY766448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY766459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M23502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M57503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000613947
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1736,103,841 - 36,105,614 (+)Ensembl
RefSeq Acc Id: ENST00000615863   ⟹   ENSP00000482259
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1736,103,827 - 36,105,614 (+)Ensembl
RefSeq Acc Id: ENST00000621626   ⟹   ENSP00000480569
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1736,103,827 - 36,105,621 (+)Ensembl
RefSeq Acc Id: NM_002984   ⟹   NP_002975
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381736,103,827 - 36,105,614 (+)NCBI
GRCh371734,431,220 - 34,433,014 (+)ENTREZGENE
Build 361731,455,333 - 31,457,127 (+)NCBI Archive
HuRef1730,615,959 - 30,617,753 (+)ENTREZGENE
CHM1_11734,495,398 - 34,497,192 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002975   ⟸   NM_002984
- Peptide Label: precursor
- UniProtKB: P13236 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000480569   ⟸   ENST00000621626
RefSeq Acc Id: ENSP00000482259   ⟸   ENST00000615863

Promoters
RGD ID:7234705
Promoter ID:EPDNEW_H23099
Type:multiple initiation site
Name:CCL4_2
Description:C-C motif chemokine ligand 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23100  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381736,103,590 - 36,103,650EPDNEW
RGD ID:7234709
Promoter ID:EPDNEW_H23100
Type:multiple initiation site
Name:CCL4_1
Description:C-C motif chemokine ligand 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H23099  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381736,103,830 - 36,103,890EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh37/hg19 17q12(chr17:34360168-36248859)x1 copy number loss See cases [RCV000140228] Chr17:34360168..36248859 [GRCh37]
Chr17:31384281..33322972 [NCBI36]
Chr17:17q12
pathogenic
GRCh38/hg38 17q12(chr17:36104374-36421711)x3 copy number gain See cases [RCV000138455] Chr17:36104374..36421711 [GRCh38]
Chr17:34431767..34790268 [GRCh37]
Chr17:31455880..31864381 [NCBI36]
Chr17:17q12
likely benign
GRCh37/hg19 17q12(chr17:34431767-34775684)x3 copy number gain See cases [RCV000139674] Chr17:34431767..34775684 [GRCh37]
Chr17:31455880..31849797 [NCBI36]
Chr17:17q12
likely benign
NC_000017.10:g.(34360227_34437475)_(36214026_36473024)del deletion Chromosome 17q12 deletion syndrome [RCV000191150] Chr17:34437475..36214026 [GRCh37]
Chr17:17q12
pathogenic
GRCh37/hg19 17q12(chr17:34310998-36297053)x3 copy number gain See cases [RCV000051912] Chr17:34310998..36297053 [GRCh37]
Chr17:31335111..33373530 [NCBI36]
Chr17:17q12
pathogenic
GRCh37/hg19 17q12(chr17:34360168-36209228)x3 copy number gain See cases [RCV000051914] Chr17:34360168..36209228 [GRCh37]
Chr17:31384281..33283341 [NCBI36]
Chr17:17q12
pathogenic
GRCh37/hg19 17q12(chr17:34425362-36410559)x3 copy number gain See cases [RCV000447719] Chr17:34425362..36410559 [GRCh37]
Chr17:17q12
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q12(chr17:34425362-36283612)x3 copy number gain not provided [RCV000683920] Chr17:34425362..36283612 [GRCh37]
Chr17:17q12
pathogenic
GRCh37/hg19 17q12(chr17:34426244-36225988)x3 copy number gain not provided [RCV000683921] Chr17:34426244..36225988 [GRCh37]
Chr17:17q12
pathogenic
GRCh37/hg19 17q12(chr17:32351496-34455576)x1 copy number loss not provided [RCV000683918] Chr17:32351496..34455576 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3
pathogenic
GRCh37/hg19 17q12(chr17:34151183-34477480)x3 copy number gain not provided [RCV000846470] Chr17:34151183..34477480 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17p11.2-q21.2(chr17:21690653-38772647)x3 copy number gain not provided [RCV000846852] Chr17:21690653..38772647 [GRCh37]
Chr17:17p11.2-q21.2
pathogenic
GRCh37/hg19 17q12(chr17:34158619-34477480)x4 copy number gain not provided [RCV001006895] Chr17:34158619..34477480 [GRCh37]
Chr17:17q12
uncertain significance
GRCh37/hg19 17q12(chr17:34405241-34823294)x1 copy number loss not provided [RCV001259893] Chr17:34405241..34823294 [GRCh37]
Chr17:17q12
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10630 AgrOrtholog
COSMIC CCL4 COSMIC
Ensembl Genes ENSG00000275302 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000275824 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000277943 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000478708 UniProtKB/Swiss-Prot
  ENSP00000479974 UniProtKB/TrEMBL
  ENSP00000480345 UniProtKB/Swiss-Prot
  ENSP00000480569 UniProtKB/TrEMBL
  ENSP00000482259 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000483068 UniProtKB/TrEMBL
Ensembl Transcript ENST00000610612 UniProtKB/TrEMBL
  ENST00000613036 UniProtKB/TrEMBL
  ENST00000615863 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000617322 UniProtKB/Swiss-Prot
  ENST00000621600 UniProtKB/Swiss-Prot
  ENST00000621626 UniProtKB/TrEMBL
GTEx ENSG00000275302 GTEx
  ENSG00000275824 GTEx
  ENSG00000277943 GTEx
HGNC ID HGNC:10630 ENTREZGENE
Human Proteome Map CCL4 Human Proteome Map
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:388372 UniProtKB/Swiss-Prot
  hsa:6351 UniProtKB/Swiss-Prot
NCBI Gene 6351 ENTREZGENE
OMIM 182284 OMIM
PANTHER PTHR12015 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PharmGKB PA35562 PharmGKB
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt CCL4_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q6JSE0_HUMAN UniProtKB/TrEMBL
  Q7M4M2_HUMAN UniProtKB/TrEMBL
UniProt Secondary P22617 UniProtKB/Swiss-Prot
  Q13704 UniProtKB/Swiss-Prot
  Q3SXL8 UniProtKB/Swiss-Prot
  Q6FGI8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 CCL4  C-C motif chemokine ligand 4    chemokine (C-C motif) ligand 4  Symbol and/or name change 5135510 APPROVED