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Gene: CCL4 (C-C motif chemokine ligand 4) Homo sapiens
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Symbol: CCL4
Name: C-C motif chemokine ligand 4
Description: Exhibits CCR1 chemokine receptor binding activity; CCR5 chemokine receptor binding activity; and identical protein binding activity. Involved in several processes, including negative regulation by host of viral transcription; positive regulation of calcium-mediated signaling; and positive regulation of natural killer cell chemotaxis. Predicted to localize to the extracellular space. Implicated in acquired immunodeficiency syndrome. Biomarker of several diseases, including Plasmodium falciparum malaria; bone disease (multiple); lung disease (multiple); nose disease (multiple); and rheumatic disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACT2; AT744.1; C-C motif chemokine 4; CC chemokine ligand 4; chemokine (C-C motif) ligand 4; G-26; G-26 T-lymphocyte-secreted protein; HC21; LAG-1; LAG1; lymphocyte activation gene 1 protein; lymphocyte-activation gene 1; macrophage inflammatory protein 1-beta; MGC104418; MGC126025; MGC126026; MIP-1-beta; MIP-1-beta(1-69); MIP1B; MIP1B1; PAT 744; SCYA2; SCYA4; secreted protein G-26; SIS-gamma; small inducible cytokine A4 (homologous to mouse Mip-1b); small-inducible cytokine A4; T-cell activation protein 2
Orthologs:
Mus musculus (house mouse) : Ccl4 (chemokine (C-C motif) ligand 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ccl4 (C-C motif chemokine ligand 4)  Alliance
Canis lupus familiaris (dog) : CCL4 (chemokine (C-C motif) ligand 4)
Sus scrofa (pig) : CCL4 (C-C motif chemokine ligand 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381736,103,827 - 36,105,614 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371734,431,220 - 34,433,014 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,455,333 - 31,457,127 (+)NCBINCBI36hg18NCBI36
Build 341731,455,332 - 31,457,127NCBI
Celera1731,340,772 - 31,342,566 (+)NCBI
Cytogenetic Map17q12NCBI
HuRef1730,615,959 - 30,617,753 (+)NCBIHuRef
CHM1_11734,495,398 - 34,497,192 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CCL4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353278
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.