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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3647
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl3
Name: C-C motif chemokine ligand 3
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl3decreases expressionEXP 6480464CTDresveratrol results in decreased expression of CCL3 proteinPMID:20709957
Ccl3decreases expressionISOCcl3 (Mus musculus)6480464CTDresveratrol results in decreased expression of CCL3 proteinPMID:17872969
Ccl3decreases expressionISOCCL3 (Homo sapiens)6480464CTDresveratrol results in decreased expression of CCL3 mRNAPMID:23224687
Ccl3multiple interactionsISOCcl3 (Mus musculus)6480464CTD[resveratrol co-treated with Catechin co-treated with caffeic acid] results in decreased expression of CCL3 mRNA; resveratrol inhibits the reaction [C5 protein results in increased expression of CCL3 protein]; resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]PMID:16806235 PMID:19284563 PMID:19346296 PMID:21284090
Ccl3multiple interactionsISOCCL3 (Homo sapiens)6480464CTD[Plant Extracts co-treated with Resveratrol] results in decreased expression of CCL3 mRNA; Resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of CCL3 protein]; Resveratrol inhibits the reaction [C5 protein results in increased expression of CCL3 protein]; Resveratrol inhibits the reaction [CCL3 protein affects the localization of Calcium]PMID:16212921 PMID:19284563 PMID:19346296 PMID:23557933 PMID:24895526
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