RGD Reference Report - Molecular cloning and posttranscriptional regulation of macrophage inflammatory protein-1 alpha in alveolar macrophages. - Rat Genome Database

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Molecular cloning and posttranscriptional regulation of macrophage inflammatory protein-1 alpha in alveolar macrophages.

Authors: Shi, MM  Godleski, JJ  Paulauskis, JD 
Citation: Shi MM, etal., Biochem Biophys Res Commun 1995 Jun 6;211(1):289-95.
RGD ID: 728269
Pubmed: PMID:7779098   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1995.1809   (Journal Full-text)

Macrophage inflammatory protein-1 alpha (MIP-1 alpha) belongs to the "chemokine" superfamily of chemoattractant pro-inflammatory cytokines. MIP-1 alpha is chemotactic for monocytes and neutrophils and thus, plays an important role in initiation and control of inflammation. We have isolated and sequenced a cDNA clone encoding rat MIP-1 alpha. This 0.75 kb cDNA includes a single open reading frame of 92 amino acids. Expression of MIP-1 alpha mRNA was characterized in NR8383, a rat alveolar macrophage cell line (RAM). In resting RAM cells, MIP-1 alpha mRNA decayed rapidly, with a half life of less than 2 hours. Lipopolysaccharide (LPS) treatment of RAM cells resulted in a dose-dependent increase in MIP-1 alpha steady state mRNA expression. The induction of MIP-1 alpha mRNA by LPS was partially the result of mRNA stabilization, as half life increased to over 6 hours.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chemokine activity  TAS 728269 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl3  (C-C motif chemokine ligand 3)


Additional Information