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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3647
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl3
Name: C-C motif chemokine ligand 3
Acc ID: CHEBI:149836
Term: tigecycline
Definition: Tetracycline in which the hydroxy group at position 5 and the methyl group at position 6 are replaced by hydrogen, and with a dimethylamino substituent and an (N-tert-butylglycyl)amino substituent at positions 7 and 9, respectively. A glycylcycline antibiotic, it has activity against a broad range of Gram-positive and Gram-negative bacteria, including tetracycline-resistant organisms. It is used for the intravenous treatment of complicated skin and skin structure infections caused by susceptible organisms.
Chemical ID: MESH:C119092
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl3multiple interactionsISOCCL3 (Homo sapiens)6480464CTDtigecycline inhibits the reaction [enterotoxin B, staphylococcal results in increased expression of CCL3 protein]; tigecycline inhibits the reaction [enterotoxin F, Staphylococcal results in increased expression of CCL3 protein]PMID:19874226
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