Ppm1e (protein phosphatase, Mg2+/Mn2+ dependent, 1E) - Rat Genome Database

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Gene: Ppm1e (protein phosphatase, Mg2+/Mn2+ dependent, 1E) Rattus norvegicus
Analyze
Symbol: Ppm1e
Name: protein phosphatase, Mg2+/Mn2+ dependent, 1E
RGD ID: 735028
Description: Enables protein serine/threonine phosphatase activity. Predicted to be involved in cellular response to lipopolysaccharide; cellular response to xenobiotic stimulus; and positive regulation of stress fiber assembly. Located in nucleus. Orthologous to human PPM1E (protein phosphatase, Mg2+/Mn2+ dependent 1E); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; calcium/calmodulin dependent kinase 2 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ca(2+)/calmodulin-dependent protein kinase phosphatase N; calmodulin-dependent protein kinase phosphatase N; caMKN; caMKP-N; caMKP-nucleus; partner of PIX 1; partner of PIX-alpha; partner of PIXA; protein phosphatase 1E; protein phosphatase 1E (PP2C domain containing)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bp308
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21072,051,643 - 72,187,439 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,055,208 - 72,187,282 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1076,665,709 - 76,797,777 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,170,612 - 76,302,689 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01071,635,130 - 71,767,204 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01074,548,270 - 74,679,858 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1074,548,270 - 74,679,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01075,421,043 - 75,552,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41075,516,706 - 75,674,452 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11075,531,075 - 75,688,822 (-)NCBI
Celera1070,971,343 - 71,103,804 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleolus  (IEA,ISO)
nucleoplasm  (ISO,TAS)
nucleus  (IBA,IDA)
protein-containing complex  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Identification of major Ca(2+)/calmodulin-dependent protein kinase phosphatase-binding proteins in brain: biochemical analysis of the interaction. Ishida A, etal., Arch Biochem Biophys. 2005 Mar 1;435(1):134-46.
3. Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases. Ishida A, etal., Br J Pharmacol. 2008 Jun;154(4):729-40. doi: 10.1038/bjp.2008.127. Epub 2008 May 5.
4. Subcellular distributions of rat CaM kinase phosphatase N and other members of the CaM kinase regulatory system. Kitani T, etal., J Neurochem 2003 Jul;86(1):77-85.
5. Post-translational excision of the carboxyl-terminal segment of CaM kinase phosphatase N and its cytosolic occurrence in the brain. Kitani T, etal., J Neurochem. 2006 Jan;96(2):374-84. Epub 2005 Nov 3.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Identification and characterization of CaMKP-N, nuclear calmodulin-dependent protein kinase phosphatase. Takeuchi M, etal., J Biochem. 2001 Dec;130(6):833-40.
11. Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. Voss M, etal., Cell Signal. 2011 Jan;23(1):114-24. doi: 10.1016/j.cellsig.2010.08.010. Epub 2010 Aug 27.
Additional References at PubMed
PMID:11864573   PMID:23088624   PMID:30053369  


Genomics

Comparative Map Data
Ppm1e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21072,051,643 - 72,187,439 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,055,208 - 72,187,282 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1076,665,709 - 76,797,777 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,170,612 - 76,302,689 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01071,635,130 - 71,767,204 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01074,548,270 - 74,679,858 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1074,548,270 - 74,679,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01075,421,043 - 75,552,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41075,516,706 - 75,674,452 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11075,531,075 - 75,688,822 (-)NCBI
Celera1070,971,343 - 71,103,804 (-)NCBICelera
Cytogenetic Map10q26NCBI
PPM1E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381758,755,854 - 58,985,179 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1758,755,854 - 58,985,179 (+)EnsemblGRCh38hg38GRCh38
GRCh371756,833,215 - 57,062,540 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361754,188,231 - 54,417,319 (+)NCBINCBI36Build 36hg18NCBI36
Build 341754,188,230 - 54,417,314NCBI
Celera1753,295,075 - 53,524,883 (+)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1752,193,756 - 52,423,036 (+)NCBIHuRef
CHM1_11756,898,743 - 57,127,990 (+)NCBICHM1_1
T2T-CHM13v2.01759,623,935 - 59,853,253 (+)NCBIT2T-CHM13v2.0
Ppm1e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,117,724 - 87,249,884 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,117,732 - 87,249,849 (-)EnsemblGRCm39 Ensembl
GRCm381187,226,906 - 87,358,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1187,226,906 - 87,359,023 (-)EnsemblGRCm38mm10GRCm38
MGSCv371187,040,408 - 87,172,496 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361187,043,101 - 87,175,189 (-)NCBIMGSCv36mm8
Celera1196,828,758 - 96,961,052 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.99NCBI
Ppm1e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554513,986,715 - 4,137,134 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554513,989,575 - 4,137,400 (-)NCBIChiLan1.0ChiLan1.0
PPM1E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11779,737,401 - 79,964,254 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01752,832,291 - 53,057,157 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11757,682,786 - 57,903,877 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1757,874,629 - 57,903,205 (+)Ensemblpanpan1.1panPan2
PPM1E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1933,350,379 - 33,560,523 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl933,350,614 - 33,560,272 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha932,584,866 - 32,798,194 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0934,156,099 - 34,369,774 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl934,156,276 - 34,369,771 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1932,942,375 - 33,155,670 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0933,231,422 - 33,444,675 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0933,317,898 - 33,531,250 (+)NCBIUU_Cfam_GSD_1.0
Ppm1e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560232,646,823 - 32,791,722 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364904,287,309 - 4,428,504 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364904,285,770 - 4,428,213 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPM1E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1235,051,952 - 35,262,703 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11235,051,936 - 35,262,698 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21236,437,167 - 36,478,098 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPM1E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11634,433,918 - 34,647,076 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660775,233,404 - 5,447,972 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppm1e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624871753,292 - 898,362 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624871753,327 - 902,384 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppm1e
399 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:87
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000003859
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106750210873579767Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
12903245Cm110Cardiac mass QTL 1100.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)107111521772606468Rat
12903246Cm111Cardiac mass QTL 1110.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)107111521772606468Rat
12903247Cm112Cardiac mass QTL 1120.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107111521772606468Rat
12903248Am14Aortic mass QTL 140.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107111521772606468Rat
12903249Kidm68Kidney mass QTL 680.02kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)107111521772606468Rat
12902615Bw185Body weight QTL 1850.01body mass (VT:0001259)body weight (CMO:0000012)107111521772606468Rat
1579918Bp279Blood pressure QTL 2790.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107111521772606468Rat

Markers in Region
RH129417  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,075,306 - 72,075,510 (+)MAPPERmRatBN7.2
Rnor_6.01074,568,376 - 74,568,579NCBIRnor6.0
Rnor_5.01075,532,084 - 75,532,287UniSTSRnor5.0
RGSC_v3.41075,536,812 - 75,537,015UniSTSRGSC3.4
Celera1070,991,397 - 70,991,600UniSTS
Cytogenetic Map10q26UniSTS
BF392813  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,141,754 - 72,141,904 (+)MAPPERmRatBN7.2
Rnor_6.01074,634,315 - 74,634,464NCBIRnor6.0
Rnor_5.01075,466,270 - 75,466,419UniSTSRnor5.0
RGSC_v3.41075,628,639 - 75,628,788UniSTSRGSC3.4
Celera1071,058,384 - 71,058,533UniSTS
Cytogenetic Map10q26UniSTS
RH140321  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,067,928 - 72,068,050 (+)MAPPERmRatBN7.2
Rnor_6.01074,560,996 - 74,561,117NCBIRnor6.0
Rnor_5.01075,539,546 - 75,539,667UniSTSRnor5.0
RGSC_v3.41075,529,432 - 75,529,553UniSTSRGSC3.4
Celera1070,984,017 - 70,984,138UniSTS
Cytogenetic Map10q26UniSTS
D11Fpm104  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,138,629 - 72,139,155 (+)MAPPERmRatBN7.2
Rnor_6.01074,631,190 - 74,631,715NCBIRnor6.0
Rnor_5.01075,469,019 - 75,469,544UniSTSRnor5.0
RGSC_v3.41075,625,514 - 75,626,039UniSTSRGSC3.4
Celera1071,055,265 - 71,055,790UniSTS
Cytogenetic Map10q26UniSTS
ksks326  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,062,155 - 72,062,446 (+)MAPPERmRatBN7.2
Rnor_6.01074,555,223 - 74,555,513NCBIRnor6.0
Rnor_5.01075,545,150 - 75,545,440UniSTSRnor5.0
RGSC_v3.41075,523,659 - 75,523,949UniSTSRGSC3.4
Celera1070,978,244 - 70,978,534UniSTS
Cytogenetic Map10q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 8 5 74 2 7
Low 3 37 32 24 14 24 8 9 33 34 11 8
Below cutoff 14 14 14 2

Sequence


RefSeq Acc Id: ENSRNOT00000003859   ⟹   ENSRNOP00000003859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1072,055,208 - 72,187,282 (-)Ensembl
Rnor_6.0 Ensembl1074,548,270 - 74,679,858 (-)Ensembl
RefSeq Acc Id: NM_198773   ⟹   NP_942068
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21072,055,208 - 72,187,282 (-)NCBI
Rnor_6.01074,548,270 - 74,679,858 (-)NCBI
Rnor_5.01075,421,043 - 75,552,393 (+)NCBI
RGSC_v3.41075,516,706 - 75,674,452 (-)RGD
Celera1070,971,343 - 71,103,804 (-)RGD
Sequence:
RefSeq Acc Id: XM_039086379   ⟹   XP_038942307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21072,051,643 - 72,187,439 (-)NCBI
RefSeq Acc Id: XM_039086380   ⟹   XP_038942308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21072,051,643 - 72,135,143 (-)NCBI
RefSeq Acc Id: XM_039086381   ⟹   XP_038942309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21072,057,266 - 72,187,437 (-)NCBI
RefSeq Acc Id: NP_942068   ⟸   NM_198773
- UniProtKB: Q80Z30 (UniProtKB/Swiss-Prot),   A6HHT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003859   ⟸   ENSRNOT00000003859
RefSeq Acc Id: XP_038942307   ⟸   XM_039086379
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038942308   ⟸   XM_039086380
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038942309   ⟸   XM_039086381
- Peptide Label: isoform X3
Protein Domains
PPM-type phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80Z30-F1-model_v2 AlphaFold Q80Z30 1-750 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735028 AgrOrtholog
BioCyc Gene G2FUF-23772 BioCyc
Ensembl Genes ENSRNOG00000024730 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055025516 UniProtKB/Swiss-Prot
  ENSRNOG00060030322 UniProtKB/Swiss-Prot
  ENSRNOG00065018797 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003859 ENTREZGENE
  ENSRNOT00000003859.3 UniProtKB/Swiss-Prot
  ENSRNOT00055044030 UniProtKB/Swiss-Prot
  ENSRNOT00060052656 UniProtKB/Swiss-Prot
  ENSRNOT00065031566 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2C_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM-type-like_dom_sf UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  PPM-type_phosphatase-like_dom UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
KEGG Report rno:360593 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 360593 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE 2C UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam PP2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppm1e PhenoGen
PROSITE PPM_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024730 RatGTEx
  ENSRNOG00055025516 RatGTEx
  ENSRNOG00060030322 RatGTEx
  ENSRNOG00065018797 RatGTEx
SMART PP2Cc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PP2C-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6HHT3 ENTREZGENE, UniProtKB/TrEMBL
  PPM1E_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Ppm1e  protein phosphatase, Mg2+/Mn2+ dependent, 1E  Ppm1e  protein phosphatase 1E (PP2C domain containing)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ppm1e  protein phosphatase 1E (PP2C domain containing)      Symbol and Name status set to approved 1299863 APPROVED