CALCIUM/CALMODULIN DEPENDENT KINASE 2 SIGNALING PATHWAY (PW:0001185)

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Description

Calmodulin (CaM), the small and ubiquitous protein expressed from three identical genes in higher organisms, is the main cellular calcium (Ca2+) sensor. Important effectors are the calcium/calmodulin dependent protein kinases (CAMKs) and the only calcium/calmodulin dependent protein phosphatase calcineurin. Some CAMKs have unique targets while others are multifunctional, effectively orchestrating signaling pathways that exert many and important cellular functions. These pathways are represented

Pathway Diagram:

Ariadne Genomics Inc. Calm3 Calm1 Calm2 calmodulin Ca2+ ---- Calm3 Ca2+ Ca2+ ---- Calm1 Ca2+ ---- calmodulin Ca2+ ---- Calm2 Grin2b other Camk2 partners Camk2 phosphatases Cacng2 Gria1 Hdac5 Hdac4 Ryr2 Scn5a Cacna1c Cacng2 ---> Gria1 Camk2a ---> long-term synaptic potentiation Camk2b ---- other Camk2 partners Camk2a ---- other Camk2 partners Camk2a ---> Cacng2 Camk2a ---> Gria1 Camk2b ---> long-term synaptic potentiation long-term synaptic potentiation Camk2n1 ---| Camk2a Camk2n2 ---| Camk2a Camk2a Camk2n2 Camk2n1 Camk2a ---- Grin2b Camk2b ---- Grin2b Camk2b Camk2d ---> Ryr2 Camk2 phosphatases ---| Camk2a Camk2 phosphatases ---| Camk2g Camk2 phosphatases ---| Camk2b Camk2g Camk2 phosphatases ---| Camk2d calmodulin --+> Camk2b calmodulin --+> Camk2g calmodulin ---- Camk2g calmodulin --+> Camk2a calmodulin ---- Camk2a calmodulin --+> Camk2d calmodulin ---- Camk2d ROS ROS --+> Camk2d calmodulin ---- Camk2b Camk2d ---> Cacna1c Camk2d ---> excitation-contraction coupling Camk2d ---> Scn5a Camk2d ---> excitation-transcription coupling excitation-contraction coupling excitation-transcription coupling Camk2d ---> Hdac4 Camk2d Camk2d ---> Hdac5 Cacnb2 Camk2d ---> Cacnb2
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Genes in Pathway:

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calcium/calmodulin dependent kinase 2 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:7240708
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 JBrowse link 17 81,673,862 82,019,219 RGD:7240708
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 JBrowse link 7 119,228,112 119,353,332 RGD:7240704
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:7240705
RGD:7240708
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:7240705
RGD:7240708
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:7240705
RGD:7240708
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:7240704
RGD:7240705
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:7240704
RGD:7240705
G Camk2d calcium/calmodulin-dependent protein kinase II delta JBrowse link 2 230,900,907 231,132,207 RGD:7240705
RGD:7240708
G Camk2g calcium/calmodulin-dependent protein kinase II gamma JBrowse link 15 3,936,721 3,995,740 RGD:7240705
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 JBrowse link 5 156,876,706 156,878,486 RGD:7240706
RGD:7240707
G Camk2n2 calcium/calmodulin-dependent protein kinase II inhibitor 2 JBrowse link 11 83,975,430 83,976,557 RGD:7240706
RGD:7240707
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link 11 72,164,566 72,378,895 RGD:7240705
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 10 42,441,723 42,760,200 RGD:7240704
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 3 2,507,745 2,534,664 RGD:7240705
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:7240705
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 4 169,541,620 170,000,216 RGD:7240704
RGD:7240705
G Hdac4 histone deacetylase 4 JBrowse link 9 99,052,945 99,299,715 RGD:7241019
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:7241019
G Lrrc7 leucine rich repeat containing 7 JBrowse link 2 264,910,594 265,300,860 RGD:7240705
G Pln phospholamban JBrowse link 20 34,633,157 34,642,904 RGD:7240708
G Ppm1e protein phosphatase, Mg2+/Mn2+ dependent, 1E JBrowse link 10 74,548,270 74,679,858 RGD:7241020
G Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F JBrowse link 11 88,313,709 88,343,726 RGD:7241020
G Ppp1cc protein phosphatase 1 catalytic subunit gamma JBrowse link 12 39,864,302 39,882,030 RGD:7241020
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:7241020
G Ryr2 ryanodine receptor 2 JBrowse link 17 65,533,998 65,955,606 RGD:7240708
G Scn5a sodium voltage-gated channel alpha subunit 5 JBrowse link 8 128,169,191 128,266,681 RGD:7240708
G Syngap1 synaptic Ras GTPase activating protein 1 JBrowse link 20 5,535,434 5,564,657 RGD:7240705

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Functional ClassCamk2 phosphatases
Gene Groupother Camk2 partnersCamk2 partners in the postsynaptic density

Pathway Gene Annotations

Disease Annotations Associated with Genes in the calcium/calmodulin dependent kinase 2 signaling pathway
Disease TermsGene Symbols
acute kidney failureHdac5
adjustment disorderHdac5
alcohol use disorderGrin1 , Grin2b
Alzheimer's diseaseCacna1c , Calm1 , Camk2a , Grin1 , Grin2a , Grin2b
amyotrophic lateral sclerosisHdac4
Animal Disease ModelsGrin1
aniridiaCamk2d
aortic aneurysmHdac4
arrhythmogenic right ventricular cardiomyopathyPln , Ryr2 , Scn5a
arrhythmogenic right ventricular dysplasia 1Ryr2
arrhythmogenic right ventricular dysplasia 2Ryr2
arrhythmogenic right ventricular dysplasia 9Pln , Ryr2
asthmaPpp2ca
astigmatismGrin2b
astrocytomaCamk2g
AtaxiaGrin2b
ataxia telangiectasiaHdac4
atrial fibrillationScn5a
Atrial StandstillScn5a
atrioventricular blockScn5a
attention deficit hyperactivity disorderGrin2b , Hdac5
autism spectrum disorderCacnb2 , Grin2b , Ryr2
autistic disorderCacna1c , Camk2g , Gria1 , Grin2a , Grin2b , Pln , Syngap1
Autosomal Dominant Mental Retardation 5Syngap1
autosomal dominant mental retardation 53Camk2a
autosomal dominant mental retardation 54Camk2b
autosomal dominant non-syndromic intellectual disability 10Cacng2
autosomal dominant non-syndromic intellectual disability 5Syngap1
autosomal dominant non-syndromic intellectual disability 6Grin2b
autosomal dominant non-syndromic intellectual disability 8Grin1
benign epilepsy with centrotemporal spikesGrin1 , Grin2a
bipolar disorderCacna1c , Camk2a , Grin2a , Grin2b
brachydactylyHdac4
Brachydactyly, Type EHdac4
brain ischemiaScn5a
breast ductal carcinomaCacna1c
Brugada syndromeCacna1c , Cacnb2 , Scn5a
Brugada syndrome 1Ryr2 , Scn5a
Brugada syndrome 3Cacna1c
Brugada syndrome 4Cacnb2
Bundle-Branch BlockScn5a
cannabis abuseCalm1 , Calm2 , Camk2b
cardiac arrestCacnb2 , Pln , Ryr2 , Scn5a
Cardiac ArrhythmiasCacna1c , Cacnb2 , Ryr2 , Scn5a
Cardiac Complexes, PrematureCacna1c , Cacnb2 , Ryr2 , Scn5a
Cardiac Conduction DefectRyr2
Cardiac Conduction Defect, NonprogressiveScn5a
Cardiac Conduction Defect, NonspecificCacnb2 , Scn5a
cardiomyopathyPln , Ryr2 , Scn5a
Carotid Artery InjuriesHdac4
catecholaminergic polymorphic ventricular tachycardiaCalm1 , Ryr2 , Scn5a
catecholaminergic polymorphic ventricular tachycardia 1Calm1 , Ryr2 , Scn5a
catecholaminergic polymorphic ventricular tachycardia 2Ryr2
catecholaminergic polymorphic ventricular tachycardia 4Calm1
central core myopathyRyr2
Central Nervous System Viral DiseasesGria1 , Grin2a
centronuclear myopathyPln
cerebellar ataxiaSyngap1
cerebral infarctionGrin1
childhood absence epilepsyCacng2
Childhood SchizophreniaRyr2
Chromosome 2q37 Deletion SyndromeHdac4
cleft palateDlg1
Cocaine-Related DisordersCalm1 , Calm2 , Camk2a , Camk2b , Gria1 , Grin1 , Hdac4 , Hdac5 , Lrrc7
cognitive disorderGrin1 , Grin2a , Grin2b
Colonic NeoplasmsHdac5
Colorectal NeoplasmsGrin2a , Ppm1e
congenital heart diseaseRyr2
Congenital Limb DeformitiesCacna1c
congenital myasthenic syndromeCacna1c
congenital myasthenic syndrome 10Cacna1c
congestive heart failurePln , Ppp1cc , Ppp2ca , Ryr2 , Scn5a
contact dermatitisHdac4
Currarino TriadCamk2n2
Cutaneous Malignant Melanoma, Susceptibility To, 1Cacna1c , Grin2b , Ppp2ca , Ryr2 , Scn5a
DeathScn5a
Developmental DisabilitiesGrin2a , Syngap1
Diabetes ComplicationsPln
Diabetes Mellitus, Experimental Grin2b , Hdac4 , Ryr2
Diabetic CardiomyopathiesPln , Ryr2
Diabetic NephropathiesHdac4 , Hdac5
Diastolic DysfunctionRyr2
dilated cardiomyopathyCacna1c , Cacnb2 , Pln , Ryr2 , Scn5a
dilated cardiomyopathy 1AARyr2
dilated cardiomyopathy 1EScn5a
dilated cardiomyopathy 1PPln
Dilated Cardiomyopathy with Left Ventricular NoncompactionRyr2 , Scn5a
Early Infantile Epileptic Encephalopathy, 27Grin2b
eating disorderHdac4
Ebstein anomalyPln
egg allergyGrin2b
EpendymomaCacng2
epilepsyCacna1c , Gria1 , Grin2a , Grin2b , Syngap1
Experimental Liver CirrhosisCamk2d
Experimental Liver NeoplasmsPpp2ca
familial atrial fibrillationScn5a
Familial Atrial Fibrillation 10Scn5a
familial hypertrophic cardiomyopathyCalm3 , Pln , Ryr2 , Scn5a
Familial Ventricular TachycardiaRyr2
fetal alcohol spectrum disorderGrin2b
Fetal Growth RetardationGria1 , Grin2a , Grin2b
FibrosisHdac4
focal epilepsyGrin2a
Focal Epilepsy, with Speech Disorder and with or without Mental RetardationGrin2a , Grin2b
Generalized EpilepsyGrin2a , Grin2b , Syngap1
genetic diseaseCacna1c , Calm2 , Camk2b , Grin1 , Grin2a , Grin2b , Hdac4 , Ryr2 , Scn5a , Syngap1
glycogen storage disease IIIPln
Gonadal Dysgenesis, XX Type, with DeafnessPln
Hearing Loss, Cisplatin-InducedCamk2a , Camk2b
heart diseasePln , Ppp2ca , Ryr2
HemimegalencephalyGrin1
hemiplegiaScn5a
hepatic encephalopathyGria1
hepatocellular carcinomaHdac4
HepatomegalyCamk2a
Hereditary Neoplastic SyndromesCamk2a , Gria1 , Ppp2ca
hereditary spastic paraplegia 7Scn5a
Huntington's diseaseGrin2a , Grin2b
HyperalgesiaCamk2a , Grin1 , Grin2a , Grin2b , Ppp2ca
hyperhomocysteinemiaGria1 , Grin2a , Grin2b
HyperkinesisGria1
hypertensionCacna1c , Cacnb2
hypertrophic cardiomyopathyCacnb2 , Pln , Ryr2 , Scn5a
hypertrophic cardiomyopathy 1Cacna1c
hypertrophic cardiomyopathy 18Pln
hypertrophic cardiomyopathy 4Ryr2
HypoalgesiaHdac4
hypoglycemiaCacna1c , Grin2b
HypotensionGria1 , Grin2b
HypoxiaGrin2b
Hypoxia-Ischemia, BrainGrin1 , Grin2a , Grin2b
impotenceHdac4
Infant DeathRyr2 , Scn5a
InflammationCamk2a
intellectual disabilityCamk2a , Camk2b , Camk2g , Grin1 , Grin2a , Grin2b , Hdac4 , Lrrc7 , Pln , Syngap1
invasive ductal carcinomaDlg1
Joint InstabilityGrin2b
Joubert syndrome 9Pln
Landau-Kleffner syndromeGrin2a
Language Development DisordersGrin2a , Grin2b , Pln , Syngap1
learning disabilityGria1
left ventricular noncompactionRyr2
long QT syndromeCacna1c , Cacnb2 , Ryr2 , Scn5a
long QT syndrome 1Calm2 , Calm3 , Scn5a
long QT syndrome 14Calm1
long QT syndrome 15Calm2
long QT syndrome 2Scn5a
long QT syndrome 3Scn5a
Macular Dystrophy, Concentric AnnularRyr2
major depressive disorderCalm2
malignant gliomaCamk2a , Camk2b
malignant mesotheliomaHdac4 , Ryr2
melanomaCacna1c , Grin2a , Grin2b , Ppp2ca , Ryr2 , Scn5a
mental depressionHdac5
Mental Retardation, Autosomal Recessive 5Syngap1
MENTAL RETARDATION, AUTOSOMAL RECESSIVE 63Camk2a
methylmalonic aciduria and homocystinuria type cblCRyr2
methylmalonic aciduria due to methylmalonyl-CoA mutase deficiencyScn5a
microcephalyPln
middle cerebral artery infarctionCamk2a , Grin1 , Hdac4 , Hdac5
migraineScn5a
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1Scn5a
morphine dependenceGria1 , Grin2a
Multiple AbnormalitiesCacna1c , Grin1 , Grin2b
Muscle HypotoniaSyngap1
myocardial infarctionPln
Myocardial IschemiaCamk2d , Ppp2ca , Ryr2
Myocardial Reperfusion InjuryPln
myocardial stunningPln
Nerve InjuriesCacnb2
NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT HYPERKINETIC MOVEMENTS AND SEIZURES, AUTOSOMAL RECESSIVEGrin1
Neurodevelopmental DisordersGrin2b , Syngap1
Nonprogressive Heart BlockScn5a
obesityHdac4
oligodendrogliomaCamk2b
Ovarian NeoplasmsPpp1cc
PainGrin1
Parkinson's diseaseDlg1 , Ppp2ca
Paroxysmal Ventricular FibrillationCacna1c , Cacnb2 , Ryr2 , Scn5a
phencyclidine abuseCalm1 , Calm2 , Camk2b
phenylketonuriaGrin2b
placental insufficiencyGrin1 , Grin2a , Grin2b
pleomorphic xanthoastrocytomaCamk2b
polycystic ovary syndromeCamk2d
precursor lymphoblastic lymphoma/leukemiaHdac4
PrehypertensionPln
primary coenzyme Q10 deficiency 7Scn5a
Primary Hyperoxaluria Type 1Hdac4
primary immunodeficiency diseaseCacna1c
primary pulmonary hypertensionHdac4 , Hdac5
progressive familial heart blockScn5a
Progressive Familial Heart Block Type IScn5a
progressive familial heart block type IAScn5a
Progressive Myoclonic Epilepsy 6Scn5a
prostate cancerGrin1 , Ppp2ca
Prostatic NeoplasmsPpp2ca
psychotic disorderGrin1
ptosisSyngap1
pulmonary hypertensionHdac4 , Hdac5
Pyridoxine-Dependent EpilepsyGrin2a
Reperfusion InjuryGria1 , Grin2a , Grin2b
restrictive cardiomyopathyCacna1c
retinal degenerationHdac4
retinitis pigmentosaGrin2b
Right Ventricular HypertrophyHdac5
Rolandic Epilepsy, Mental Retardation, and Speech Dyspraxia, Autosomal DominantGrin2a
Romano-Ward SyndromeCalm2 , Calm3 , Scn5a
schizoaffective disorderGria1
schizophreniaCacna1c , Camk2b , Dlg1 , Grin1 , Grin2a , Grin2b , Syngap1
sciatic neuropathyGrin1 , Grin2b
SepsisGrin2a , Hdac4
sexual disorderGria1
short QT syndromeCacna1c , Cacnb2
sick sinus syndromeScn5a
Sick Sinus Syndrome 1, Autosomal RecessiveScn5a
Sleep DeprivationGrin2b
Smith-Magenis syndromeHdac5 , Ppm1e
Spastic Paraplegia Type 7Scn5a
speech disorderGrin2a
Spinal Cord InjuriesPpp1cc
spinal muscular atrophyHdac4
status epilepticusGria1 , Grin1 , Grin2a
StrokeHdac4
substance-induced psychosisCamk2b
Sudden DeathRyr2 , Scn5a
Sudden Death, CardiacCacna1c , Pln , Ryr2 , Scn5a
sudden infant death syndromeScn5a
SyncopeScn5a
TachycardiaRyr2
temporal lobe epilepsyGrin2b
Timothy syndromeCacna1c
Torsades de PointesScn5a
transient cerebral ischemiaCamk2a
Trauma, Nervous SystemGrin2b
TremorPln
trigeminal neuralgiaGrin1
type 2 diabetes mellitusCalm1 , Pln , Ppp2ca
urinary bladder cancerHdac4
Usher syndrome type 2APln
vascular dementiaGrin1 , Grin2a , Grin2b
Ventricular Dysfunction, LeftPln
Ventricular FibrillationCacnb2 , Ryr2 , Scn5a
Ventricular Fibrillation, Paroxysmal Familial, 1Cacna1c , Ryr2 , Scn5a
Ventricular TachycardiaCacna1c , Ryr2 , Scn5a
visual epilepsyCamk2d , Gria1 , Grin2b , Hdac4
Weight GainCalm1
Wilson diseaseCamk2a
withdrawal disorderGria1 , Grin2a
Wolff-Parkinson-White syndromeCacna1c , Ryr2 , Scn5a
Pathway Annotations Associated with Genes in the calcium/calmodulin dependent kinase 2 signaling pathway
Pathway TermsGene Symbols
acebutolol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayCalm1 , Calm2 , Calm3 , Ppm1e , Ppm1f , Ppp2ca
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
alfentanil pharmacodynamics pathwayGrin1 , Grin2a
Alzheimer's disease pathwayCacna1c , Calm1 , Calm2 , Calm3 , Grin1 , Grin2a , Grin2b
amiodarone pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
amlodipine pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
amyotrophic lateral sclerosis pathwayGria1 , Grin1 , Grin2a , Grin2b
arrhythmogenic right ventricular cardiomyopathy pathwayCacna1c , Cacnb2 , Cacng2 , Ryr2
ataxia telangiectasia-mutated (ATM) signaling pathwayPpp2ca
atenolol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
betaxolol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
bisoprolol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
bupivacaine pharmacodynamics pathwayGrin1 , Grin2a
bupranolol drug pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
bupranolol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
buprenorphine pharmacodynamics pathwayGrin1 , Grin2a
calcium transport pathwayCacna1c , Cacnb2 , Ryr2
calcium/calcium-mediated signaling pathwayCacna1c , Cacnb2 , Calm1 , Calm2 , Calm3 , Camk2a , Camk2b , Camk2d , Camk2g , Grin1 , Grin2a , Pln , Ryr2
calcium/calmodulin dependent kinase 2 signaling pathwayCacna1c , Cacnb2 , Cacng2 , Calm1 , Calm2 , Calm3 , Camk2a , Camk2b , Camk2d , Camk2g , Camk2n1 , Camk2n2 , Dlg1 , Gria1 , Grin1 , Grin2a , Grin2b , Hdac4 , Hdac5 , Lrrc7 , Pln , Ppm1e , Ppm1f , Ppp1cc , Ppp2ca , Ryr2 , Scn5a , Syngap1
carvedilol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
Chagas disease pathwayPpp2ca
chloroprocaine pharmacodynamics pathwayGrin1 , Grin2a
citalopram pharmacodynamics pathwayGrin1 , Grin2a
cocaine pharmacodynamics pathwayGrin1 , Grin2a
codeine and morphine pharmacodynamics pathwayGrin1 , Grin2a
desipramine pharmacodynamics pathwayGrin1 , Grin2a
dilated cardiomyopathy pathwayCacna1c , Cacnb2 , Cacng2 , Pln , Ryr2
diltiazem pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
diphenoxylate pharmacodynamics pathwayGrin1 , Grin2a
disopyramide pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
dobutamine pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
dopamine signaling pathwayPpp1cc , Ppp2ca
E-cadherin signaling pathwayDlg1
ephrin - ephrin receptor bidirectional signaling axisGria1
epidermal growth factor/neuregulin signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g
escitalopram pharmacodynamics pathwayGrin1 , Grin2a
esmolol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
ethylmorphine pharmacodynamics pathwayGrin1 , Grin2a
excitatory synaptic transmission pathwayGrin1 , Grin2a , Grin2b
felodipine pharmacokinetics pathwayCacna1c
fentanyl pharmacodynamics pathwayGrin1 , Grin2a
fibroblast growth factor signaling pathwayCamk2a
flecainde pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
fluoxetine pharmacodynamics pathwayGrin1 , Grin2a
fosphenytoin pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
fosphenytoin pharmacokinetics pathwayScn5a
glioma pathwayCalm1 , Calm2 , Calm3 , Camk2a , Camk2b , Camk2d , Camk2g
glutamate signaling pathwayCacna1c , Gria1 , Grin1 , Grin2a , Grin2b
glycogen biosynthetic pathwayPpp1cc
glycogen degradation pathwayCalm1 , Calm2 , Calm3 , Ppp1cc
gonadotropin-releasing hormone signaling pathwayCacna1c , Calm1 , Calm2 , Calm3 , Camk2a , Camk2b , Camk2d , Camk2g
hepatitis C pathwayPpp2ca
heroin pharmacodynamics pathwayGrin1 , Grin2a
histone modification pathwayHdac4 , Hdac5
Huntington's disease pathwayGrin1 , Grin2b
hydrocodone pharmacodynamics pathwayGrin1 , Grin2a
hydromorphone pharmacodynamics pathwayGrin1 , Grin2a
hypertrophic cardiomyopathy pathwayCacna1c , Cacnb2 , Cacng2 , Ryr2
ibutilide pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
imipramine pharmacodynamics pathwayGrin1 , Grin2a
insulin responsive facilitative sugar transporter mediated glucose transport pathwayCalm1 , Calm2 , Calm3 , Ppp1cc
insulin secretion pathwayCacna1c
insulin signaling pathwayCalm1 , Calm2 , Calm3 , Ppp1cc
isoprenaline pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
isradipine pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
levacetylmethadol pharmacodynamics pathwayGrin1 , Grin2a
levobunolol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
levobupivacaine phgarmacodynamics pathwayGrin1 , Grin2a
levorphanol pharmacodynamics pathwayGrin1 , Grin2a
lidocaine pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Grin1 , Grin2a , Pln , Ryr2 , Scn5a
long term depressionGria1 , Grin2a , Ppp2ca
long term potentiationCacna1c , Calm1 , Calm2 , Calm3 , Camk2a , Camk2b , Camk2d , Camk2g , Gria1 , Grin1 , Grin2a , Grin2b , Ppp1cc
mepivacaine pharmacodynamics pathwayGrin1 , Grin2a
methadone pharmacodynamics pathwayGrin1 , Grin2a
methadone pharmacokinetics pathwayGrin1 , Grin2a
metoprolol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
mexiletine pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
mitogen activated protein kinase signaling pathwayCacna1c , Cacnb2 , Cacng2
mRNA decay pathwayPpp2ca
N-cadherin signaling pathwayCalm1 , Calm2 , Calm3 , Camk2g
nadolol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
nalbuphine pharmacodynamics pathwayGrin1 , Grin2a
naloxone pharmacodynamics pathwayGrin1 , Grin2a
naltrexone pharmacodynamics pathwayGrin1 , Grin2a
nebivolol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
neurotrophic factor signaling pathwayCalm1 , Calm2 , Calm3 , Camk2a , Camk2b , Camk2d , Camk2g
nicotine pharmacodynamics pathwayGrin1 , Grin2a
nifedipine pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
nimodipine pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
nisoldipine pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
nitrendipine pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
oxybuprocaine pharmacodynamics pathwayGrin1 , Grin2a
oxycodone pharmacodynamics pathwayGrin1 , Grin2a
oxymorphone pharmacodynamics pathwayGrin1 , Grin2a
p38 MAPK signaling pathwayCalm1 , Calm2 , Calm3 , Camk2b
p53 signaling pathwayPpp2ca
penbutolol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
pentazocine pharmacodynamics pathwayGrin1 , Grin2a
phenytoin pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
phosphatidylinositol 3-kinase signaling pathwayCalm1 , Calm2 , Calm3
phosphatidylinositol 3-kinase-Akt signaling pathwayPpp2ca
pindolol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
platelet-derived growth factor signaling pathwayPpp2ca
prilocaine pharmacodynamics pathwayGrin1 , Grin2a
procainamide pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
procaine pharmacodynamics pathwayGrin1 , Grin2a
propranolol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
quinidine pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
Reelin signaling pathwayGria1 , Grin2a , Grin2b
remifentanil pharmacodynamics pathwayGrin1 , Grin2a
ropivacaine pharmacodynamics pathwayGrin1 , Grin2a
sotalol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
systemic lupus erythematosus pathwayGrin2a , Grin2b
T cell receptor signaling pathwayDlg1
timolol pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
tramadol pharmacodynamics pathwayGrin1 , Grin2a
transforming growth factor-beta Smad dependent signaling pathwayCamk2a , Ppp2ca
transforming growth factor-beta superfamily mediated signaling pathwayPpp2ca
tuberculosis pathwayCalm1 , Calm2 , Calm3 , Camk2a , Camk2b , Camk2d , Camk2g
type 2 diabetes mellitus pathwayCacna1c
type II interferon signaling pathwayCalm1 , Calm2 , Calm3 , Camk2a , Camk2b , Camk2d , Camk2g
vascular endothelial growth factor signaling pathwayCalm1 , Calm2 , Calm3
verapamil pharmacodynamics pathwayCacna1c , Calm1 , Dlg1 , Pln , Ryr2 , Scn5a
visual phototransduction pathwayCalm1 , Calm2 , Calm3
Wnt signaling pathwayCamk2a , Camk2b , Camk2d , Camk2g , Ppp2ca
Wnt signaling, non-canonical pathwayCamk2a
Phenotype Annotations Associated with Genes in the calcium/calmodulin dependent kinase 2 signaling pathway

References Associated with the calcium/calmodulin dependent kinase 2 signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: