Krt14 (keratin 14) - Rat Genome Database

Name: Krt14
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Krt14 (keratin 14) Rattus norvegicus

Analyze

Symbol:

Krt14

Name:

keratin 14

RGD ID:

1307463

Description:

Predicted to have keratin filament binding activity. Involved in epithelial cell differentiation; response to ionizing radiation; and response to zinc ion. Localizes to keratin filament. Biomarker of esophagus small cell carcinoma. Human ortholog(s) of this gene implicated in Naegeli-Franceschetti-Jadassohn syndrome; dermatopathia pigmentosa reticularis; and epidermolysis bullosa simplex (multiple). Orthologous to human KRT14 (keratin 14); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

CK-14; cytokeratin-14; K14; Ka14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14, type I; keratin complex 1, acidic, gene 14; keratin, type I cytoskeletal 14; keratin-14; Krt1-14; LOC287701; type I keratin Ka14

RGD Orthologs

Human

Mouse

Bonobo

Dog

Pig

Green Monkey

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KRT14 (keratin 14)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Krt14 (keratin 14)	HGNC	Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100975309 (keratin, type I cytoskeletal 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KRT14 (keratin 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC100737030 (keratin, type I cytoskeletal 42)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	LOC103243443 (keratin, type I cytoskeletal 14)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	KRT16 (keratin 16)	HGNC	OrthoDB
Homo sapiens (human):	KRT17 (keratin 17)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	KRT14 (keratin 14)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Krt14 (keratin 14)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	krtt1c19e (keratin type 1 c19e)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	krt1-19d (keratin, type 1, gene 19d)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	krt97 (keratin 97)	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	krt91 (keratin 91)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	krt17 (keratin 17)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	si:ch211-156l18.7	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	krt15 (keratin 15)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	krt98	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	85,137,932 - 85,141,990 (-)	NCBI
Rnor_6.0 Ensembl	10	88,055,823 - 88,122,233 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	10	88,118,029 - 88,122,233 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	10	87,910,658 - 87,914,716 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	89,144,357 - 89,148,415 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	10	89,158,726 - 89,162,785 (-)	NCBI
Celera	10	83,857,265 - 83,861,323 (-)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

dermatopathia pigmentosa reticularis (ISO)

epidermolysis bullosa simplex (ISO)

epidermolysis bullosa simplex Dowling-Meara type (ISO)

epidermolysis bullosa simplex generalized type (ISO)

epidermolysis bullosa simplex localized type (ISO)

Epidermolysis Bullosa Simplex, Autosomal Recessive 1 (ISO)

esophagus small cell carcinoma (IEP)

esophagus squamous cell carcinoma (ISO)

Naegeli-Franceschetti-Jadassohn syndrome (ISO)

Neoplasm Metastasis (IEP)

Neoplastic Cell Transformation (ISO)

Parakeratosis (IEP)

pigmentation disease (ISO)

Sjogren-Larsson syndrome (ISO)

squamous cell carcinoma (ISO)

Tongue Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (ISO)

9-cis-retinoic acid (ISO)

aflatoxin B1 (ISO)

all-trans-4-oxoretinoic acid (ISO)

all-trans-retinoic acid (ISO)

alpha-naphthoflavone (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

aristolochic acid (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (EXP,ISO)

beta-naphthoflavone (EXP)

bexarotene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

cadmium sulfate (ISO)

calcidiol (EXP)

chloropicrin (ISO)

copper atom (EXP)

copper(0) (EXP)

dexamethasone (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

dibutyl phthalate (ISO)

diuron (EXP)

endosulfan (EXP)

enzyme inhibitor (ISO)

fenamic acid (EXP)

folic acid (ISO)

furan (EXP)

genistein (ISO)

graphite (ISO)

indole-3-methanol (EXP)

isotretinoin (ISO)

lead nitrate (ISO)

lead(0) (ISO)

lead(2+) (ISO)

methamphetamine (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosomorpholine (EXP)

nickel atom (ISO)

pentane-2,3-dione (ISO)

perfluorododecanoic acid (EXP)

phenobarbital (EXP)

phenyl isocyanate (ISO)

phenylbutazone (EXP)

silicon dioxide (ISO)

sodium arsenite (EXP,ISO)

sodium fluoride (ISO)

sulindac sulfide (ISO)

titanium dioxide (ISO)

toluene 2,4-diisocyanate (ISO)

zinc atom (EXP,ISO)

zinc(0) (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aging (ISO)

epithelial cell differentiation (IDA,ISO)

hair cycle (ISO)

intermediate filament bundle assembly (ISO,ISS)

response to ionizing radiation (IEP)

response to zinc ion (IEP)

Cellular Component

basal part of cell (ISO)

cell periphery (ISO)

cytoplasm (ISO,ISS)

intermediate filament (IEA,ISO)

keratin filament (IDA,ISO)

nucleus (ISO,ISS)

Molecular Function

keratin filament binding (ISO)

molecular_function (ND)

protein binding (ISO)

structural molecule activity (IEA)

References

References - curated


1.	Bisgaard HC, etal., Invasion Metastasis. 1997;17(5):240-50.
2.	Burns FJ, etal., J Radiat Res (Tokyo). 2002 Dec;43 Suppl:S229-32.
3.	Coulombe PA, etal., Cell. 1991 Sep 20;66(6):1301-11.
4.	GOA data from the GO Consortium
5.	Iwasaki S, etal., Arch Oral Biol. 2006 May;51(5):416-26. Epub 2005 Nov 4.
6.	Kaisho Y, etal., Biochem Biophys Res Commun. 2005 May 13;330(3):653-7.
7.	Liu CG, etal., Cancer Res. 2005 Sep 1;65(17):7790-9.
8.	MGD data from the GO Consortium
9.	Ogawa Y, etal., Anat Embryol (Berl). 1999 Aug;200(2):215-28.
10.	OMIM Disease Annotation Pipeline
11.	RGD automated data pipeline
12.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	RGD automated import pipeline for gene-chemical interactions
14.	RGD comprehensive gene curation
15.	Wang DY, etal., Cancer Lett 1996 Nov 12;108(1):119-27.

Additional References at PubMed

PMID:7679677	PMID:10852826	PMID:11698679	PMID:11724817	PMID:14673151	PMID:15057822	PMID:15085952	PMID:16489008	PMID:16682203	PMID:17960487	PMID:18262229	PMID:18692037
PMID:19199708	PMID:19303854	PMID:19487454	PMID:20346438	PMID:21464233	PMID:21630459	PMID:21916889	PMID:23284756	PMID:23599337	PMID:26956522

Genomics

Comparative Map Data

Krt14
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	85,137,932 - 85,141,990 (-)	NCBI
Rnor_6.0 Ensembl	10	88,055,823 - 88,122,233 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	10	88,118,029 - 88,122,233 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	10	87,910,658 - 87,914,716 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	89,144,357 - 89,148,415 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	10	89,158,726 - 89,162,785 (-)	NCBI
Celera	10	83,857,265 - 83,861,323 (-)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

KRT14
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	17	41,582,279 - 41,586,895 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	17	41,582,279 - 41,586,895 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	17	39,738,531 - 39,743,147 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	36,992,059 - 36,996,673 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	17	36,992,058 - 36,996,673	NCBI
Celera	17	36,391,486 - 36,396,102 (-)	NCBI
Cytogenetic Map	17	q21.2	NCBI
HuRef	17	35,501,649 - 35,506,252 (-)	NCBI		HuRef
CHM1_1	17	39,973,838 - 39,978,454 (-)	NCBI		CHM1_1

Krt14
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	100,093,988 - 100,098,336 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	11	100,093,988 - 100,098,374 (-)	Ensembl
GRCm38	11	100,203,162 - 100,207,510 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	100,203,162 - 100,207,548 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	100,064,476 - 100,068,824 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	11	100,019,252 - 100,023,600 (-)	NCBI			mm8
Celera	11	110,819,617 - 110,823,965 (-)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	63.43	NCBI

LOC100975309
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	17	15,948,570 - 15,953,191 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	15,948,596 - 15,953,191 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	17	15,730,066 - 15,734,665 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

KRT14
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	21,190,672 - 21,195,060 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	21,156,045 - 21,265,564 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	20,652,119 - 20,656,507 (+)	NCBI
ROS_Cfam_1.0	9	21,911,274 - 21,915,662 (+)	NCBI
UMICH_Zoey_3.1	9	20,697,290 - 20,701,678 (+)	NCBI
UNSW_CanFamBas_1.0	9	20,963,294 - 20,967,682 (+)	NCBI
UU_Cfam_GSD_1.0	9	21,067,094 - 21,071,483 (+)	NCBI

LOC100737030
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	12	21,014,182 - 21,022,123 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	21,315,911 - 21,324,008 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103243443
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	64,654,988 - 64,660,327 (+)	NCBI
ChlSab1.1 Ensembl	16	64,655,807 - 64,660,319 (+)	Ensembl
Vero_WHO_p1.0	NW_023666077	35,500,284 - 35,505,086 (+)	NCBI

Position Markers

AI626930

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	85,137,852 - 85,137,946 (+)	MAPPER
Rnor_6.0	10	88,118,096 - 88,118,189	NCBI	Rnor6.0
Rnor_5.0	10	87,910,579 - 87,910,672	UniSTS	Rnor5.0
RGSC_v3.4	10	89,144,278 - 89,144,371	UniSTS	RGSC3.4
Celera	10	83,857,186 - 83,857,279	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

Krt1-14

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	85,137,787 - 85,138,011 (+)	MAPPER
Rnor_6.0	10	88,118,031 - 88,118,254	NCBI	Rnor6.0
Rnor_5.0	10	87,910,514 - 87,910,737	UniSTS	Rnor5.0
RGSC_v3.4	10	89,144,213 - 89,144,436	UniSTS	RGSC3.4
Celera	10	83,857,121 - 83,857,344	UniSTS
Cytogenetic Map	10	q32.1	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6429075	99492409	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9841807	108540162	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14827894	92423564	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14827894	107857673	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14827894	110992275	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	20170031	102897474	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	21523906	90312401	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	21523906	90312401	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	21523906	90312401	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	21523906	90312401	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	21523906	90312401	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22901497	93886300	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	23861015	112626471	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	24483076	107857673	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	24483076	107857673	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	24483076	107857673	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	27237530	101482600	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	27237530	102427718	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	36185929	95845311	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	41260363	106105607	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	41260363	107857673	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	41260363	107857673	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	43289657	108540162	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	43704955	88704955	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	46593021	98939209	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	46848346	91848346	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	46848346	91848346	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	46848346	91848346	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	50638337	95638337	Rat
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	53104718	98104718	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	53621375	112626471	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	53621375	112626471	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	53625815	98939209	Rat
631535	Cm51	Cardiac mass QTL 51	3		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	53637485	94807701	Rat
1359017	Hrtrt21	Heart rate QTL 21	2.4		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	10	55224855	100224855	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	55678976	112626471	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	55679084	102427604	Rat
1354608	Cm33	Cardiac mass QTL 33	2.8		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	10	56698730	101698730	Rat
1549831	Bss6	Bone structure and strength QTL 6	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	10	60450007	105450007	Rat
2312662	Slep8	Serum leptin concentration QTL 8		0.05	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	10	60875260	105875260	Rat
2312668	Scl65	Serum cholesterol level QTL 65		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	60875260	105875260	Rat
2312672	Insul15	Insulin level QTL 15		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	10	60875260	105875260	Rat
2293698	Bss43	Bone structure and strength QTL 43	5.33	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	10	62096293	107096293	Rat
2306970	Anxrr22	Anxiety related response QTL 22	5.95		fear/anxiety-related behavior trait (VT:1000241)	number of periods of voluntary immobility (CMO:0001045)	10	64648175	101691360	Rat
1558643	Cm44	Cardiac mass QTL 44	4.8	0.0000368	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	64648175	102149713	Rat
6893336	Cm75	Cardiac mass QTL 75	0.1	0.87	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	64648175	102149713	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	65590122	110590122	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	65992275	110992275	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	65992275	110992275	Rat
7387312	Bw125	Body weight QTL 125	3	0.0047	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight (CMO:0000356)	10	67880046	112626471	Rat
1581559	Eae18	Experimental allergic encephalomyelitis QTL 18		0.00002	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	10	67988218	110992091	Rat
1357344	Bp249	Blood pressure QTL 249		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	69123603	101482600	Rat
2317029	Aia19	Adjuvant induced arthritis QTL 19	2.98		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	69385595	112626471	Rat
2317039	Aia6	Adjuvant induced arthritis QTL 6	4.31		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	69385595	112626471	Rat
10450498	Bp384	Blood pressure QTL 384		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	70166960	112626471	Rat
1642980	Bp300	Blood pressure QTL 300			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	70800069	112626471	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	71692298	112626471	Rat
2300172	Bmd57	Bone mineral density QTL 57	9.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	10	73008136	112626471	Rat
2293646	Bss25	Bone structure and strength QTL 25	10.96	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	10	73008136	112626471	Rat
2293663	Bss33	Bone structure and strength QTL 33	9.34	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	10	73008136	112626471	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	73467158	112626471	Rat
2306793	Ean5	Experimental allergic neuritis QTL 5	4.7		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	75045391	97308358	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	75544754	112626471	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	75544754	112626471	Rat
1358188	Ept9	Estrogen-induced pituitary tumorigenesis QTL 9	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	75983805	99492217	Rat
2292617	Ept18	Estrogen-induced pituitary tumorigenesis QTL 18	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	75983805	99492217	Rat
1579919	Bp281	Blood pressure QTL 281		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	77055741	98282519	Rat
631537	Oia4	Oil induced arthritis QTL 4			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	78343027	90042115	Rat
10450495	Bp383	Blood pressure QTL 383		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	78970279	98282519	Rat
2292438	Bp311	Blood pressure QTL 311			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	78970279	112626471	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	79927661	112626471	Rat
4889492	Pancm2	Pancreatic morphology QTL 2	3.2		pancreatic beta cell morphology trait (VT:0005217)	ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)	10	80239190	112626471	Rat
724516	Uae17	Urinary albumin excretion QTL 17	3.6		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	10	80946110	88200662	Rat
1300107	Rf18	Renal function QTL 18	3.41		urine output (VT:0003620)	timed urine volume (CMO:0000260)	10	81515116	101758478	Rat
1358915	Stresp7	Stress response QTL 7	3.52		blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	81649775	90297007	Rat
634354	Rends3	Renal damage susceptibility QTL 3		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	10	82675233	88141097	Rat
631555	Bp134	Blood pressure QTL 134		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	83389828	94488181	Rat
6893357	Bw102	Body weight QTL 102	0.5	0.36	body mass (VT:0001259)	body weight (CMO:0000012)	10	83389828	104994768	Rat
2303589	Bw87	Body weight QTL 87	2		body mass (VT:0001259)	body weight (CMO:0000012)	10	85079943	112626471	Rat
4889948	Bss91	Bone structure and strength QTL 91	4		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	10	85513822	95638337	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	86566908	112626471	Rat
2301398	Kidm38	Kidney mass QTL 38		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	86962563	99303173	Rat
12880055	Am11	Aortic mass QTL 11		0.004	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	86962563	99303173	Rat
2306792	Ean4	Experimental allergic neuritis QTL 4	4		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	86977861	97308569	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	120
Count of miRNA genes:	90
Interacting mature miRNAs:	96
Transcripts:	ENSRNOT00000005285
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			8		8
Low	1	10			2		1	1	4	14	19	10	1
Below cutoff	2	26	31	27	8	27	2	3	4	19	18	1	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597135	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BK004047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000005285 ⟹ ENSRNOP00000005285

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	10	88,118,175 - 88,122,233 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000083895 ⟹ ENSRNOP00000070301

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	10	88,055,823 - 88,122,233 (-)	Ensembl

RefSeq Acc Id:

NM_001008751 ⟹ NP_001008751

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	85,137,932 - 85,141,990 (-)	NCBI
Rnor_6.0	10	88,118,175 - 88,122,233 (-)	NCBI
Rnor_5.0	10	87,910,658 - 87,914,716 (-)	NCBI
RGSC_v3.4	10	89,144,357 - 89,148,415 (-)	RGD
Celera	10	83,857,265 - 83,861,323 (-)	RGD

Sequence:

show sequence

ATGGCCACCTGCAGCCGTCAGTTCACCTCCTCCAGCTCCATGAAGGGCTCCTGTGGCATCGGTG
GTGGCTCTAGCCGCATGTCCTCCGTCCTGGCTGGAGGATCCTGCCGGGCTCCCAGCACCTACGG
GGGCATGTCTCGTTTCTCCTCTGCGGGAGCCTATGCGGTTGGAAGTGGCTATGGTGGGGGCTTC
AGCAGCAGCAGTTTTGGTGGTGGATTTGGTGGAGGAATTGGTGGTGGTATTGGTGGAGGACTTG
GTGGTGGTATTGGTGGTGGATTTGGTGGTGGTATTGGTGGTGGATTTGGTGGTGGTATTGGTAG
TGGATTTGGTGGTGGTCTTGGCGATGGGCTCCTGGTTGGCAGTGAGAAAGTGACCATGCAGAAC
CTCAATGACCGCTTGGCCACCTACCTGGATAAGGTGCGTGCCCTGGAAGAGGCCAACAGTGACC
TGGAGGTGAAGATCCGTGACTGGTACCAGAGGCAGCGCCCCACTGAGATCAAAGACTACAGCCC
CTACTTCAAGACCATCGAGGACCTGAAGAGCAAGATCCTGGCAGCCACTGTGGACAATGCCAAT
GTCCTCCTGCAGATTGACAATGCCCGCCTGGCGGCTGATGACTTCCGTACCAAGTTTGAGACAG
AGCAGAGCCTGCGCATAAATGTGGAGTCTGACATCAATGGCCTACGCCGGGTGCTGGATGAGCT
GACCCTGGCCAGAGCTGACCTGGAGATGCAGATTGAGAGCCTCAAGGAAGAGCTGGCCTACCTG
AAGAAGAACCACGAGGAGGAAATGGCTTCCATGAGAGGCCAGGTGGGCGGGGACGTCAACGTGG
AGATGGATGCGGCCCCTGGTGTGGACCTGAGCCGCATCCTGAACGAGATGCGGGATCAGTATGA
GAAGATGGCAGAGAAGAACCGCAAGGATGCCGAAGATTGGTTCTTCACCAAGACAGAGGAGCTG
AACCGCGAGGTGGCCACCAACAGCGAACTGGTGCAGAGCGGCAAGAGCGAGATCTCCGAGCTCC
GGCGCACGATGCAGAACCTGGAGATCGAGCTGCAGTCCCAGCTCAGCATGAAAGCATCCCTGGA
GAATAACCTGGAGGAGACCAAAGGCCGTTACTGCATGCAGCTGGCCCAGATCCAGGAGATGATC
GGCAGCGTGGAGGAGCAGCTGGCTCAGCTGCGCTGCGAGATGGAGCAGCAGAATCAGGAGTACA
AGATCCTGCTGGATGTGAAGACTCGGCTGGAGCAGGAGATCGCCACCTACCGCCGTCTGCTGGA
GGGCGAGGATGCTCACCTTTCATCTGCCCAATTCTCCTCATCGTCTCAATTCTCCTCTGGCTCT
CAATCATCCAGAGATGTGACCTCCACCAACCGCCAGATCCGCACCAAGGTCATGGATGTGCACG
ATGGCAAGGTGGTCTCCACCCACGAGCAGGTCCTGCGCACCAAGAACTAA

hide sequence

RefSeq Acc Id:

XM_017597135 ⟹ XP_017452624

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	88,118,029 - 88,120,997 (-)	NCBI

Sequence:

show sequence

TTCTAATCCTCTGGGCAAGTTAGGTTTTGTATTTTGGGAAAGTCCCACCTGAGGTCCATGCCCC
ATGGGCTTAGAAAGGAATGCATGTGTCTGCAGAGGGTTGATCTGTACCGAGAGGAGGATCCAGA
CAATGAAGGCTCTGTAGGGAGCCTTAGGGGGACTTTAAAACCCCGAGACCCCTGTCAGGCTTTA
CAGATCCTGGCAGCCACTGTGGACAATGCCAATGTCCTCCTGCAGATTGACAATGCCCGCCTGG
CGGCTGATGACTTCCGTACCAAGTTTGAGACAGAGCAGAGCCTGCGCATAAATGTGGAGTCTGA
CATCAATGGCCTACGCCGGGTGCTGGATGAGCTGACCCTGGCCAGAGCTGACCTGGAGATGCAG
ATTGAGAGCCTCAAGGAAGAGCTGGCCTACCTGAAGAAGAACCACGAGGAGGAAATGGCTTCCA
TGAGAGGCCAGGTGGGCGGGGACGTCAACGTGGAGATGGATGCGGCCCCTGGTGTGGACCTGAG
CCGCATCCTGAACGAGATGCGGGATCAGTATGAGAAGATGGCAGAGAAGAACCGCAAGGATGCC
GAAGATTGGTTCTTCACCAAGACAGAGGAGCTGAACCGCGAGGTGGCCACCAACAGCGAACTGG
TGCAGAGCGGCAAGAGCGAGATCTCCGAGCTCCGGCGCACGATGCAGAACCTGGAGATCGAGCT
GCAGTCCCAGCTCAGCATGAAAGCATCCCTGGAGAATAACCTGGAGGAGACCAAAGGCCGTTAC
TGCATGCAGCTGGCCCAGATCCAGGAGATGATCGGCAGCGTGGAGGAGCAGCTGGCTCAGCTGC
GCTGCGAGATGGAGCAGCAGAATCAGGAGTACAAGATCCTGCTGGATGTGAAGACTCGGCTGGA
GCAGGAGATCGCCACCTACCGCCGTCTGCTGGAGGGCGAGGATGCTCACCTTTCATCTGCCCAA
TTCTCCTCATCGTCTCAATTCTCCTCTGGCTCTCAATCATCCAGAGATGTGACCTCCACCAACC
GCCAGATCCGCACCAAGGTCATGGATGTGCACGATGGCAAGGTGGTCTCCACCCACGAGCAGGT
CCTGCGCACCAAGAACTAAGGCTGCTAGATGCTGCTCAGGCTTGAGGGGCTCCTGCGTCGATGC
AGATACTGTTGGAAGAGCCCCTGCATTGTCCCTACATGCTTCACCCCCTGCTTGACCCTCGTCC
TGGCAAGCAATAAAGCTTCTTTTTCTGAGTTGCACAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001008751	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	DAA04481	(Get FASTA)	NCBI Sequence Viewer
	EDM06022	(Get FASTA)	NCBI Sequence Viewer
	Q6IFV1	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001008751 ⟸ NM_001008751

- UniProtKB:

Q6IFV1 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MATCSRQFTSSSSMKGSCGIGGGSSRMSSVLAGGSCRAPSTYGGMSRFSSAGAYAVGSGYGGGF
SSSSFGGGFGGGIGGGIGGGLGGGIGGGFGGGIGGGFGGGIGSGFGGGLGDGLLVGSEKVTMQN
LNDRLATYLDKVRALEEANSDLEVKIRDWYQRQRPTEIKDYSPYFKTIEDLKSKILAATVDNAN
VLLQIDNARLAADDFRTKFETEQSLRINVESDINGLRRVLDELTLARADLEMQIESLKEELAYL
KKNHEEEMASMRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFTKTEEL
NREVATNSELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENNLEETKGRYCMQLAQIQEMI
GSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSAQFSSSSQFSSGS
QSSRDVTSTNRQIRTKVMDVHDGKVVSTHEQVLRTKN

hide sequence

RefSeq Acc Id:

XP_017452624 ⟸ XM_017597135

- Peptide Label:

isoform X1

- Sequence:

show sequence

MPHGLRKECMCLQRVDLYREEDPDNEGSVGSLRGTLKPRDPCQALQILAATVDNANVLLQIDNA
RLAADDFRTKFETEQSLRINVESDINGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEM
ASMRGQVGGDVNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAEDWFFTKTEELNREVATNS
ELVQSGKSEISELRRTMQNLEIELQSQLSMKASLENNLEETKGRYCMQLAQIQEMIGSVEEQLA
QLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSAQFSSSSQFSSGSQSSRDVTS
TNRQIRTKVMDVHDGKVVSTHEQVLRTKN

hide sequence

RefSeq Acc Id:

ENSRNOP00000005285 ⟸ ENSRNOT00000005285

RefSeq Acc Id:

ENSRNOP00000070301 ⟸ ENSRNOT00000083895

Protein Domains

IF rod

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697710

Promoter ID:

EPDNEW_R8235

Type:

single initiation site

Name:

Krt14_1

Description:

keratin 14

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	88,122,297 - 88,122,357	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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CSV

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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CSV

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307463	AgrOrtholog
Ensembl Genes	ENSRNOG00000003899	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000005285	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000070301	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005285	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000083895	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.1160	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	IF_conserved	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IF_rod_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IF_rod_dom_coil1B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Keratin_I	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:287701	UniProtKB/Swiss-Prot
NCBI Gene	287701	ENTREZGENE
PANTHER	PTHR23239	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Filament	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Krt14	PhenoGen
PRINTS	TYPE1KERATIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	IF_ROD_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IF_ROD_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	Filament	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JXJ9_RAT	UniProtKB/TrEMBL
	K1C14_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	O35813	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-15	Krt14	keratin 14	Krt14	keratin 14, type I	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-01-28	Krt14	keratin 14, type I	Krt14	keratin 14	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-11	Krt14	keratin 14	Krt14	keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-09	Krt14	keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)	Krt14	keratin 14	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Krt14	keratin 14	Krt1-14	keratin complex 1, acidic, gene 14	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Krt1-14	keratin complex 1, acidic, gene 14	Krt1-14_predicted	keratin complex 1, acidic, gene 14 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Krt1-14_predicted	keratin complex 1, acidic, gene 14 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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