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Gene: Cant1 (calcium activated nucleotidase 1) Rattus norvegicus

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Symbol:

Cant1

Name:

calcium activated nucleotidase 1

RGD ID:

628743

Description:

Predicted to enable calcium ion binding activity; nucleoside diphosphate phosphatase activity; and protein homodimerization activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction and proteoglycan biosynthetic process. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Desbuquois dysplasia and multiple epiphyseal dysplasia 7. Orthologous to human CANT1 (calcium activated nucleotidase 1); PARTICIPATES IN beta-ureidopropionase deficiency pathway; dihydropyrimidinase deficiency pathway; Glut1 deficiency syndrome pathway; INTERACTS WITH 2,4-dinitrotoluene; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

apyrase; apyrase homolog; ectonucleoside triphosphate diphosphohydrolase 8; Entpd8; SCAN-1; soluble calcium-activated nucleotidase 1; srapy

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CANT1 (calcium activated nucleotidase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Cant1 (calcium activated nucleotidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cant1 (calcium activated nucleotidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CANT1 (calcium activated nucleotidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cant1 (calcium activated nucleotidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CANT1 (calcium activated nucleotidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CANT1 (calcium activated nucleotidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cant1 (calcium activated nucleotidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Cant1 (calcium activated nucleotidase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	CANT1 (calcium activated nucleotidase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cant1a (calcium activated nucleotidase 1a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5276	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZK563.7	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	apy-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cant1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dynlt3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	104,135,676 - 104,148,854 (-)	NCBI		GRCr8
mRatBN7.2	10	103,637,079 - 103,650,240 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	103,531,504 - 103,650,109 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	108,737,622 - 108,750,771 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	108,200,770 - 108,213,920 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	103,557,779 - 103,570,797 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	107,432,500 - 107,445,634 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	107,432,506 - 107,445,522 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	107,067,498 - 107,080,632 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	108,405,355 - 108,420,225 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	108,419,858 - 108,434,729 (-)	NCBI
Celera	10	102,197,201 - 102,210,219 (-)	NCBI		Celera
Cytogenetic Map	10	q32.3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Desbuquois dysplasia (ISO,ISS)

Desbuquois Dysplasia 1 (ISO)

Dwarfism (ISO)

genetic disease (ISO)

idiopathic generalized epilepsy (ISO)

multiple epiphyseal dysplasia (ISO)

multiple epiphyseal dysplasia 7 (ISO)

osteochondrodysplasia (ISO)

pityriasis rubra pilaris (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

acrolein (ISO)

actinomycin D (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

aspartame (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

coumestrol (ISO)

deguelin (ISO)

dexamethasone (ISO)

fenthion (ISO)

folic acid (ISO)

gentamycin (EXP)

indometacin (ISO)

ketamine (EXP)

L-methionine (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

methidathion (ISO)

monosodium L-glutamate (ISO)

Nutlin-3 (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

silicon dioxide (ISO)

sodium dodecyl sulfate (ISO)

Soman (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of canonical NF-kappaB signal transduction (ISO)

proteoglycan biosynthetic process (IBA,ISO,ISS)

Cellular Component

endoplasmic reticulum membrane (IDA)

Golgi apparatus (ISO)

Golgi cisterna membrane (IEA)

membrane (ISO)

Molecular Function

ADP phosphatase activity (ISO)

calcium ion binding (IEA,ISO)

GDP phosphatase activity (IBA,ISO)

nucleoside diphosphate phosphatase activity (IEA)

protein binding (ISO)

protein homodimerization activity (ISO)

UDP phosphatase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

beta-ureidopropionase deficiency pathway (ISO)

dihydropyrimidinase deficiency pathway (ISO)

Glut1 deficiency syndrome pathway (ISO)

lactose biosynthetic pathway (ISO)

mitochondrial neurogastrointestinal encephalopathy syndrome pathway (ISO)

orotic aciduria 1 pathway (ISO)

purine metabolic pathway (IEA)

pyrimidine metabolic pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Cloning, expression, and functional characterization of a Ca(2+)-dependent endoplasmic reticulum nucleoside diphosphatase.	Failer BU, etal., J Biol Chem 2002 Oct 4;277(40):36978-86.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:12761501	PMID:16758353	PMID:16835225	PMID:19169047	PMID:22539336	PMID:23376485	PMID:23533145

Genomics

Comparative Map Data

Cant1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	104,135,676 - 104,148,854 (-)	NCBI		GRCr8
mRatBN7.2	10	103,637,079 - 103,650,240 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	103,531,504 - 103,650,109 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	108,737,622 - 108,750,771 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	108,200,770 - 108,213,920 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	103,557,779 - 103,570,797 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	107,432,500 - 107,445,634 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	107,432,506 - 107,445,522 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	107,067,498 - 107,080,632 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	108,405,355 - 108,420,225 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	108,419,858 - 108,434,729 (-)	NCBI
Celera	10	102,197,201 - 102,210,219 (-)	NCBI		Celera
Cytogenetic Map	10	q32.3	NCBI

CANT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	78,991,716 - 79,009,764 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	78,991,716 - 79,009,867 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	76,987,798 - 77,005,846 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	74,499,394 - 74,517,433 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	74,499,393 - 74,517,433	NCBI
Celera	17	73,585,975 - 73,604,118 (-)	NCBI		Celera
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	72,408,348 - 72,414,909 (-)	NCBI		HuRef
CHM1_1	17	77,051,715 - 77,069,816 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	79,886,485 - 79,904,693 (-)	NCBI		T2T-CHM13v2.0

Cant1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	118,297,115 - 118,309,971 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	118,297,115 - 118,309,912 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	118,406,289 - 118,419,134 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	118,406,289 - 118,419,086 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	118,267,603 - 118,280,366 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	118,222,379 - 118,235,142 (-)	NCBI		MGSCv36	mm8
Celera	11	130,151,661 - 130,164,477 (-)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	83.15	NCBI

Cant1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955506	3,713,277 - 3,722,390 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955506	3,707,028 - 3,722,339 (+)	NCBI	ChiLan1.0	ChiLan1.0

CANT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	95,040,674 - 95,059,450 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	99,870,738 - 99,889,512 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	73,068,196 - 73,086,900 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	78,612,406 - 78,626,174 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	78,614,244 - 78,618,317 (-)	Ensembl	panpan1.1		panPan2

Cant1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	3,086,869 - 3,093,499 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	3,318,425 - 3,332,973 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	3,318,460 - 3,325,677 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CANT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	3,188,626 - 3,204,488 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	3,188,622 - 3,207,014 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CANT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	70,961,172 - 70,979,915 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	70,960,301 - 70,979,857 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	42,171,445 - 42,236,048 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cant1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	8,326,220 - 8,341,240 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624801	8,326,928 - 8,341,231 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cant1
62 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	473
Count of miRNA genes:	230
Interacting mature miRNAs:	291
Transcripts:	ENSRNOT00000066303
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354641	Bvd2	Brain ventricular dilatation QTL 2	6.36	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	10	93223816	107057807	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63221094	107211142	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
1579915	Bp280	Blood pressure QTL 280		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	90404397	107211142	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	72224939	107211142	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76452683	107211142	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	82685200	107211142	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	53797385	107211142	Rat
10450493	Bp382	Blood pressure QTL 382		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	94759759	107211142	Rat
1578672	Bmd16	Bone mineral density QTL 16	6.2		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	96703043	107057807	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62057807	107057807	Rat
2293646	Bss25	Bone structure and strength QTL 25	10.96	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	10	69738412	107211142	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
2300172	Bmd57	Bone mineral density QTL 57	9.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	10	69738412	107211142	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72224939	107211142	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62057807	107057807	Rat
61363	Oia3	Oil induced arthritis QTL 3		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87307617	107211142	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
724530	Bp149	Blood pressure QTL 149		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	90627439	107211142	Rat
1300137	Bp186	Blood pressure QTL 186	3.57		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	10	90627439	107057807	Rat
2293663	Bss33	Bone structure and strength QTL 33	9.34	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	10	69738412	107211142	Rat
1578663	Bss18	Bone structure and strength QTL 18	3.6		femur width (VT:1000666)	femoral neck width (CMO:0001695)	10	96703043	107057807	Rat
7387312	Bw125	Body weight QTL 125	3	0.0047	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight (CMO:0000356)	10	64890616	107211142	Rat
12880384	Cm107	Cardiac mass QTL 107		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)		90404397	107211142	Rat
12880385	Cm108	Cardiac mass QTL 108		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)		90404397	107211142	Rat
2317029	Aia19	Adjuvant induced arthritis QTL 19	2.98		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	66978955	107211142	Rat
2303589	Bw87	Body weight QTL 87	2		body mass (VT:0001259)	body weight (CMO:0000012)	10	81285008	107211142	Rat
12880396	Am13	Aortic mass QTL 13		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	90404397	107211142	Rat
12880398	Kidm67	Kidney mass QTL 67		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	90404397	107211142	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	51770177	107211142	Rat
2317039	Aia6	Adjuvant induced arthritis QTL 6	4.31		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	66978955	107211142	Rat
12880395	Cm109	Cardiac mass QTL 109		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	10	90404397	107211142	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68420376	107211142	Rat
634320	Niddm49	Non-insulin dependent diabetes mellitus QTL 49	4.41		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	10	88539139	107211142	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
10450498	Bp384	Blood pressure QTL 384		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	67750049	107211142	Rat
4889492	Pancm2	Pancreatic morphology QTL 2	3.2		pancreatic beta cell morphology trait (VT:0005217)	ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)	10	76748906	107211142	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70199100	107211142	Rat
2293698	Bss43	Bone structure and strength QTL 43	5.33	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	10	59209888	104209888	Rat
1576313	Pia25	Pristane induced arthritis QTL 25			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	96120911	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1576307	Cia28	Collagen induced arthritis QTL 28			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	96120911	104060283	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
2292438	Bp311	Blood pressure QTL 311			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76246085	107211142	Rat
2292436	Bp310	Blood pressure QTL 310			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	94759759	107211142	Rat
1600367	Mcs15	Mammary carcinoma susceptibility QTL 15	4.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	85565469	103884409	Rat
631539	Oia6	Oil induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	97010147	104670812	Rat
631538	Oia5	Oil induced arthritis QTL 5			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87055121	107211142	Rat
61436	Cia5	Collagen induced arthritis QTL 5	4.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	91228102	104060283	Rat
1642980	Bp300	Blood pressure QTL 300			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68383129	107211142	Rat

Markers in Region

D11Bwg0554e

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	103,637,078 - 103,637,290 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	107,432,500 - 107,432,711	NCBI	Rnor6.0
Rnor_5.0	10	107,067,498 - 107,067,709	UniSTS	Rnor5.0
RGSC_v3.4	10	108,405,351 - 108,405,562	UniSTS	RGSC3.4
Celera	10	102,197,197 - 102,197,408	UniSTS
Cytogenetic Map	10	q32.3	UniSTS

RH133048

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	103,637,140 - 103,637,357 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	107,432,562 - 107,432,778	NCBI	Rnor6.0
Rnor_5.0	10	107,067,560 - 107,067,776	UniSTS	Rnor5.0
RGSC_v3.4	10	108,405,413 - 108,405,629	UniSTS	RGSC3.4
Celera	10	102,197,259 - 102,197,475	UniSTS
Cytogenetic Map	10	q32.3	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_144754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006247790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ312207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097279	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000066303 ⟹ ENSRNOP00000059931

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	103,531,504 - 103,650,109 (-)	Ensembl
Rnor_6.0 Ensembl	10	107,432,506 - 107,445,522 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100303 ⟹ ENSRNOP00000089084

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	103,637,086 - 103,642,095 (-)	Ensembl

RefSeq Acc Id:

NM_144754 ⟹ NP_653355

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	104,135,680 - 104,148,698 (-)	NCBI
mRatBN7.2	10	103,637,083 - 103,650,101 (-)	NCBI
Rnor_6.0	10	107,432,504 - 107,445,522 (-)	NCBI
Rnor_5.0	10	107,067,498 - 107,080,632 (-)	NCBI
RGSC_v3.4	10	108,405,355 - 108,420,225 (-)	RGD
Celera	10	102,197,201 - 102,210,219 (-)	RGD

Sequence:

show sequence

GCCCTACGCAGGTAGGCGGCAGCCCGCGGGCTCCGGAGCCAGGCTCTCAGTGGGTCCTGTCCAG
TGTGCAGTCTGATGCCCATCCAGCCCTTTGACCAGCGGGAATGGAATGAGCCTATGCACTCCCT
CCGGATCAGTGTAGGGGGCCTTCCAGTGCTGGCATCCATGACCAAGGCCACGGACCCTCGCTTC
CGTCCCCGCTGGAGGGTGATTCTGACGTCCTTTGTGGGTGCTGCCCTCCTCTGGCTGCTGTATT
CCCACCATCAGACCCCAGTATCGGGCAGGCCCCCCATCCACAACGCACACAACTGGAGGCTCAG
GCAGGAGCGCATCTCTCAATACAATGACACCTACCCCCTATCACCCCCACAGAGGACTCCAGGT
GGGATTCGGTACCGAATTGCAGTCATTGCTGACTTGGACACGGGGTCCAAGGCCCAGGAGGAGA
ACACTTGGTTTAGTTACCTTAAGAAAGGCTACCTGACCCTGTCGGACAGTGGGGACAGGGTCAG
TGTGGAGTGGGATAAAGACCGTGGAGTCCTGGAGTCCCACCTGGCAGAAAAGGGGCGGGGCATG
GAGCTCTCGGACCTGATCGTCTTCAACGGGAAACTCTACTCTGTGGATGACCGCACGGGGGTCA
TCTACCAGATCGAAGGTACCAAAGCAGTGCCCTGGGTGATCCTTTCTGATGGCGATGGAGCTGT
GGAGAAGGGCTTCAAAGCGGAATGGCTGGCTGTGAAGGACGAGCATCTGTACGTGGGTGGCCTG
GGCAAGGAGTGGACGACCACAACGGGGGAGGTGGTGAACGAGAACCCTGAGTGGGTGAAGGTGG
TGGGCCACAGGGGCAGTGTGGAACACGAGAACTGGGTGTCCAGCTACAATGCCCTGAGAGCTGC
CGCAGGGATCCAACCGCCAGGCTACCTCATTCATGAGTCCGCCTGCTGGAGCGACACACTGCAG
CGCTGGTTCTTCCTGCCACGACGGGCGAGCCACGAGCGCTACAGCGAAAGGGAGGACGAGCGAA
AGGGCAGCAACCTGCTGCTGAGCGCAGCCCAGGACTTCAGGGACATCTCTGTGAGGCAAGTGGG
GGCGCTGGTCCCCACCCATGGCTTCTCATCCTTCAAGTTCATCCCCAACACGGATGACCAGATC
ATCGTGGCTCTCAAGTCAGAAGAGGACAATGGCAGGATTGCCACCTATGTCATGGCCTTTACGC
TGGACGGCCGCTTCCTGCTTCCAGAGACCAAGATCGGCAGTGTGAAGTATGAAGGAATAGAATT
CATCTAGAGTAAGCTTGCACCCCAGCAGGGCTGGGGCCGGTGACCGCAATACACCAGGACTCAG
TTTCATAAAAACCGGGAGCTCTTCCACTCGTTTGCTTTTTCCTTTTTTGAACTAAGAGCTGTGT
GCCTGGCTAGAGTTCCAGAATAGGGAGCTGCGCCTGGCCCTTACGGGTGTGCGTGCTGCTTGGA
GACTGGGAGCAGGGACCGCACTGGACCCCAGGTGCTCACTTGCACTGCCACCTGGTGGTAGGGA
CTGGTCACTGCTGCAGGCACCTTCCGAGCCTCTGGCCTTTGAATCCAGCCATGCCTTTCCTTCC
CTGGTCTCTGACCTTTCTATGAGTTCTCTGTCCAGTGTTTTTGAAGCAGCCAGGTGTTAAACCC
TAGCCTAACCATGGGAGTATGAGACAGTGTGAGGTGGGCCTGCCAGACAGGCACTCGGAGGCCC
CCTCCTCCTCCACGAGACCCTGGCATTCCATACTCTGGAAAGTGAATGTTTACATGACAGGGTG
AGGACCCACCCCTTGGGAGACGCCTGCCCACACTCTGAAGCCACTCTAGCACAGGATTCCTTAC
GAGCTGATCATAACTTCATTTCTCCCCTCAGGAGGATTTTGTGCTGTACAGCCTTTTAAAGTCT
GATTACCAACTTATTTTTATTAAAGCAATTTCTCTTCCTGAAGTACAGAGTCACTAAACTTCAC
CACACGGTGAAGGAGTCCCCATACCTACTTGCAGGAGCAAGGGGCTTGTCCCTACAGCCACGAT
GGCAGCCCCAGCTTTTACAGAACGGGCTTCAGGATCCTGGGCCCCTGTCTTCTAGCAACTTCCA
AAAGTTGCCATGCTCTCACCCCTCAGCAGTGGCTGAGGGAGGGACTGTGTCTGACTAGAGATCG
GCCCTCGCTGGCTCTTGGTGAGTGTTTGGTAACCTTCTCTCCAGGGGAGCCTCACTGTCTTCTG
CTTTCCTGTTCAGTCCCTGTTCAAGAGAGCCTAGGCAGCCGAGTCGGGCTCAGAGGTTGTTCTG
TAGGTAACAGCCACCTTAGCTGTCTGCAACACAGGATGCAGGTACTGTCGTGGGCTCAGGGCCC
TGATGAGCATCGCAAACCCCTTCCACAGGAAGCTAGGAGAGCCATTGCCACTGGGGCCTGACTG
CCCTCAGTCCGACAGGCTGTTTCTGTCTTGTGCTGAGGTCTTGGTGTACTTGTGCTGGGAGCTC
AGCCAAACTTTGGTGTGTGTCAGCTGTGTTAGATTGTGTGATTCTGAACTGAAAGAGATGAGAG
GTGGAGAGACCTGGGCCCCCTTGCTAAGAAGCCTTCCACACACCTTCCTTTCCCTAATGTGAGC
AGAATGATTGTGTCTCTCCGTTTTGTAAACAATAAAGTGTCAGGGGAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006247789 ⟹ XP_006247851

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	104,135,676 - 104,145,149 (-)	NCBI
mRatBN7.2	10	103,637,079 - 103,646,545 (-)	NCBI
Rnor_6.0	10	107,432,500 - 107,442,432 (-)	NCBI
Rnor_5.0	10	107,067,498 - 107,080,632 (-)	NCBI

Sequence:

show sequence

AAAAAAATAGAAGGATCTGAGTGTGAGGAGGAGTGGTCTCTGAAGTCCTTAGAGCACACATTGG
CGTTCTTCTCTTTTCCCTGGGCTATCCACCTGGTCTAAGTGGGGAAGGTACAGTGCTGAGCTCG
GCAAAGCACAAAACCAGGAGCCAGATCCCATGTCGTAGTGCCTAGCTGTGGCTGTACACAGGTC
TGTGCTTCATAAGGACCTGCCATCTGAGGCTGCTGGGAAGCCAAGGTATCTGCCTACTTCTTCC
CAGCAGTCAGTGCCGGCCATGGGCTTTGGGCTGTACCGTGTGGTAAGGAAACAAGCTCCAAAGT
GAACAGAGTAAACGTGAGGCCTGTCCACCCTGGTGTGGAAGGAGTGGGGAAGCCCTTTCTGCAG
GAATGAGGTGTGGCAAGAGAGTAGCACCGAGAACTGCCCTTCCTTGATCCTGGAGGGGAGGAGT
CAACTGCCTTGAACCTGTTTGAGCCTCCACCTGTCACACAGGCCACTTGTGAAGGAAGCAAGGA
GACAGGCCACCTTGGCTGTAGCTCTATAGGGTGTGTACAGACCCGAGGGTGCCCATGGAGGTCC
TGTCCAGTGTGCAGTCTGATGCCCATCCAGCCCTTTGACCAGCGGGAATGGAATGAGCCTATGC
ACTCCCTCCGGATCAGTGTAGGGGGCCTTCCAGTGCTGGCATCCATGACCAAGGCCACGGACCC
TCGCTTCCGTCCCCGCTGGAGGGTGATTCTGACGTCCTTTGTGGGTGCTGCCCTCCTCTGGCTG
CTGTATTCCCACCATCAGACCCCAGTATCGGGCAGGCCCCCCATCCACAACGCACACAACTGGA
GGCTCAGGCAGGAGCGCATCTCTCAATACAATGACACCTACCCCCTATCACCCCCACAGAGGAC
TCCAGGTGGGATTCGGTACCGAATTGCAGTCATTGCTGACTTGGACACGGGGTCCAAGGCCCAG
GAGGAGAACACTTGGTTTAGTTACCTTAAGAAAGGCTACCTGACCCTGTCGGACAGTGGGGACA
GGGTCAGTGTGGAGTGGGATAAAGACCGTGGAGTCCTGGAGTCCCACCTGGCAGAAAAGGGGCG
GGGCATGGAGCTCTCGGACCTGATCGTCTTCAACGGGAAACTCTACTCTGTGGATGACCGCACG
GGGGTCATCTACCAGATCGAAGGTACCAAAGCAGTGCCCTGGGTGATCCTTTCTGATGGCGATG
GAGCTGTGGAGAAGGGCTTCAAAGCGGAATGGCTGGCTGTGAAGGACGAGCATCTGTACGTGGG
TGGCCTGGGCAAGGAGTGGACGACCACAACGGGGGAGGTGGTGAACGAGAACCCTGAGTGGGTG
AAGGTGGTGGGCCACAGGGGCAGTGTGGAACACGAGAACTGGGTGTCCAGCTACAATGCCCTGA
GAGCTGCCGCAGGGATCCAACCGCCAGGCTACCTCATTCATGAGTCCGCCTGCTGGAGCGACAC
ACTGCAGCGCTGGTTCTTCCTGCCACGACGGGCGAGCCACGAGCGCTACAGCGAAAGGGAGGAC
GAGCGAAAGGGCAGCAACCTGCTGCTGAGCGCAGCCCAGGACTTCAGGGACATCTCTGTGAGGC
AAGTGGGGGCGCTGGTCCCCACCCATGGCTTCTCATCCTTCAAGTTCATCCCCAACACGGATGA
CCAGATCATCGTGGCTCTCAAGTCAGAAGAGGACAATGGCAGGATTGCCACCTATGTCATGGCC
TTTACGCTGGACGGCCGCTTCCTGCTTCCAGAGACCAAGATCGGCAGTGTGAAGTATGAAGGAA
TAGAATTCATCTAGAGTAAGCTTGCACCCCAGCAGGGCTGGGGCCGGTGACCGCAATACACCAG
GACTCAGTTTCATAAAAACCGGGAGCTCTTCCACTCGTTTGCTTTTTCCTTTTTTGAACTAAGA
GCTGTGTGCCTGGCTAGAGTTCCAGAATAGGGAGCTGCGCCTGGCCCTTACGGGTGTGCGTGCT
GCTTGGAGACTGGGAGCAGGGACCGCACTGGACCCCAGGTGCTCACTTGCACTGCCACCTGGTG
GTAGGGACTGGTCACTGCTGCAGGCACCTTCCGAGCCTCTGGCCTTTGAATCCAGCCATGCCTT
TCCTTCCCTGGTCTCTGACCTTTCTATGAGTTCTCTGTCCAGTGTTTTTGAAGCAGCCAGGTGT
TAAACCCTAGCCTAACCATGGGAGTATGAGACAGTGTGAGGTGGGCCTGCCAGACAGGCACTCG
GAGGCCCCCTCCTCCTCCACGAGACCCTGGCATTCCATACTCTGGAAAGTGAATGTTTACATGA
CAGGGTGAGGACCCACCCCTTGGGAGACGCCTGCCCACACTCTGAAGCCACTCTAGCACAGGAT
TCCTTACGAGCTGATCATAACTTCATTTCTCCCCTCAGGAGGATTTTGTGCTGTACAGCCTTTT
AAAGTCTGATTACCAACTTATTTTTATTAAAGCAATTTCTCTTCCTGAAGTACAGAGTCACTAA
ACTTCACCACACGGTGAAGGAGTCCCCATACCTACTTGCAGGAGCAAGGGGCTTGTCCCTACAG
CCACGATGGCAGCCCCAGCTTTTACAGAACGGGCTTCAGGATCCTGGGCCCCTGTCTTCTAGCA
ACTTCCAAAAGTTGCCATGCTCTCACCCCTCAGCAGTGGCTGAGGGAGGGACTGTGTCTGACTA
GAGATCGGCCCTCGCTGGCTCTTGGTGAGTGTTTGGTAACCTTCTCTCCAGGGGAGCCTCACTG
TCTTCTGCTTTCCTGTTCAGTCCCTGTTCAAGAGAGCCTAGGCAGCCGAGTCGGGCTCAGAGGT
TGTTCTGTAGGTAACAGCCACCTTAGCTGTCTGCAACACAGGATGCAGGTACTGTCGTGGGCTC
AGGGCCCTGATGAGCATCGCAAACCCCTTCCACAGGAAGCTAGGAGAGCCATTGCCACTGGGGC
CTGACTGCCCTCAGTCCGACAGGCTGTTTCTGTCTTGTGCTGAGGTCTTGGTGTACTTGTGCTG
GGAGCTCAGCCAAACTTTGGTGTGTGTCAGCTGTGTTAGATTGTGTGATTCTGAACTGAAAGAG
ATGAGAGGTGGAGAGACCTGGGCCCCCTTGCTAAGAAGCCTTCCACACACCTTCCTTTCCCTAA
TGTGAGCAGAATGATTGTGTCTCTCCGTTTTGTAAACAATAAAGTGTCAGGGGAATGTG

hide sequence

RefSeq Acc Id:

XM_006247790 ⟹ XP_006247852

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	104,135,676 - 104,148,854 (-)	NCBI
mRatBN7.2	10	103,637,079 - 103,650,240 (-)	NCBI
Rnor_6.0	10	107,432,500 - 107,445,634 (-)	NCBI
Rnor_5.0	10	107,067,498 - 107,080,632 (-)	NCBI

Sequence:

show sequence

GCGGGTGCAGAGCAGAGGCTGCCGGGAGCGCGCCGCTAGAGTGGGGCGCAGGCGCAGAGCAGAG
GCTGCCGGGAGCGCGCGGCCGGGCGGAAGTGGCCGCCCGCCCTGTCCGGCCCTACGCAGGTCCT
GTCCAGTGTGCAGTCTGATGCCCATCCAGCCCTTTGACCAGCGGGAATGGAATGAGCCTATGCA
CTCCCTCCGGATCAGTGTAGGGGGCCTTCCAGTGCTGGCATCCATGACCAAGGCCACGGACCCT
CGCTTCCGTCCCCGCTGGAGGGTGATTCTGACGTCCTTTGTGGGTGCTGCCCTCCTCTGGCTGC
TGTATTCCCACCATCAGACCCCAGTATCGGGCAGGCCCCCCATCCACAACGCACACAACTGGAG
GCTCAGGCAGGAGCGCATCTCTCAATACAATGACACCTACCCCCTATCACCCCCACAGAGGACT
CCAGGTGGGATTCGGTACCGAATTGCAGTCATTGCTGACTTGGACACGGGGTCCAAGGCCCAGG
AGGAGAACACTTGGTTTAGTTACCTTAAGAAAGGCTACCTGACCCTGTCGGACAGTGGGGACAG
GGTCAGTGTGGAGTGGGATAAAGACCGTGGAGTCCTGGAGTCCCACCTGGCAGAAAAGGGGCGG
GGCATGGAGCTCTCGGACCTGATCGTCTTCAACGGGAAACTCTACTCTGTGGATGACCGCACGG
GGGTCATCTACCAGATCGAAGGTACCAAAGCAGTGCCCTGGGTGATCCTTTCTGATGGCGATGG
AGCTGTGGAGAAGGGCTTCAAAGCGGAATGGCTGGCTGTGAAGGACGAGCATCTGTACGTGGGT
GGCCTGGGCAAGGAGTGGACGACCACAACGGGGGAGGTGGTGAACGAGAACCCTGAGTGGGTGA
AGGTGGTGGGCCACAGGGGCAGTGTGGAACACGAGAACTGGGTGTCCAGCTACAATGCCCTGAG
AGCTGCCGCAGGGATCCAACCGCCAGGCTACCTCATTCATGAGTCCGCCTGCTGGAGCGACACA
CTGCAGCGCTGGTTCTTCCTGCCACGACGGGCGAGCCACGAGCGCTACAGCGAAAGGGAGGACG
AGCGAAAGGGCAGCAACCTGCTGCTGAGCGCAGCCCAGGACTTCAGGGACATCTCTGTGAGGCA
AGTGGGGGCGCTGGTCCCCACCCATGGCTTCTCATCCTTCAAGTTCATCCCCAACACGGATGAC
CAGATCATCGTGGCTCTCAAGTCAGAAGAGGACAATGGCAGGATTGCCACCTATGTCATGGCCT
TTACGCTGGACGGCCGCTTCCTGCTTCCAGAGACCAAGATCGGCAGTGTGAAGTATGAAGGAAT
AGAATTCATCTAGAGTAAGCTTGCACCCCAGCAGGGCTGGGGCCGGTGACCGCAATACACCAGG
ACTCAGTTTCATAAAAACCGGGAGCTCTTCCACTCGTTTGCTTTTTCCTTTTTTGAACTAAGAG
CTGTGTGCCTGGCTAGAGTTCCAGAATAGGGAGCTGCGCCTGGCCCTTACGGGTGTGCGTGCTG
CTTGGAGACTGGGAGCAGGGACCGCACTGGACCCCAGGTGCTCACTTGCACTGCCACCTGGTGG
TAGGGACTGGTCACTGCTGCAGGCACCTTCCGAGCCTCTGGCCTTTGAATCCAGCCATGCCTTT
CCTTCCCTGGTCTCTGACCTTTCTATGAGTTCTCTGTCCAGTGTTTTTGAAGCAGCCAGGTGTT
AAACCCTAGCCTAACCATGGGAGTATGAGACAGTGTGAGGTGGGCCTGCCAGACAGGCACTCGG
AGGCCCCCTCCTCCTCCACGAGACCCTGGCATTCCATACTCTGGAAAGTGAATGTTTACATGAC
AGGGTGAGGACCCACCCCTTGGGAGACGCCTGCCCACACTCTGAAGCCACTCTAGCACAGGATT
CCTTACGAGCTGATCATAACTTCATTTCTCCCCTCAGGAGGATTTTGTGCTGTACAGCCTTTTA
AAGTCTGATTACCAACTTATTTTTATTAAAGCAATTTCTCTTCCTGAAGTACAGAGTCACTAAA
CTTCACCACACGGTGAAGGAGTCCCCATACCTACTTGCAGGAGCAAGGGGCTTGTCCCTACAGC
CACGATGGCAGCCCCAGCTTTTACAGAACGGGCTTCAGGATCCTGGGCCCCTGTCTTCTAGCAA
CTTCCAAAAGTTGCCATGCTCTCACCCCTCAGCAGTGGCTGAGGGAGGGACTGTGTCTGACTAG
AGATCGGCCCTCGCTGGCTCTTGGTGAGTGTTTGGTAACCTTCTCTCCAGGGGAGCCTCACTGT
CTTCTGCTTTCCTGTTCAGTCCCTGTTCAAGAGAGCCTAGGCAGCCGAGTCGGGCTCAGAGGTT
GTTCTGTAGGTAACAGCCACCTTAGCTGTCTGCAACACAGGATGCAGGTACTGTCGTGGGCTCA
GGGCCCTGATGAGCATCGCAAACCCCTTCCACAGGAAGCTAGGAGAGCCATTGCCACTGGGGCC
TGACTGCCCTCAGTCCGACAGGCTGTTTCTGTCTTGTGCTGAGGTCTTGGTGTACTTGTGCTGG
GAGCTCAGCCAAACTTTGGTGTGTGTCAGCTGTGTTAGATTGTGTGATTCTGAACTGAAAGAGA
TGAGAGGTGGAGAGACCTGGGCCCCCTTGCTAAGAAGCCTTCCACACACCTTCCTTTCCCTAAT
GTGAGCAGAATGATTGTGTCTCTCCGTTTTGTAAACAATAAAGTGTCAGGGGAATGTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_653355	(Get FASTA)	NCBI Sequence Viewer
	XP_006247851	(Get FASTA)	NCBI Sequence Viewer
	XP_006247852	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97279	(Get FASTA)	NCBI Sequence Viewer
	CAC85467	(Get FASTA)	NCBI Sequence Viewer
	EDM06757	(Get FASTA)	NCBI Sequence Viewer
	EDM06758	(Get FASTA)	NCBI Sequence Viewer
	EDM06759	(Get FASTA)	NCBI Sequence Viewer
	EDM06760	(Get FASTA)	NCBI Sequence Viewer
	EDM06761	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000059931.2
	ENSRNOP00000089084.1
	ENSRNOP00065005082
GenBank Protein	Q8K4Y7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_653355 ⟸ NM_144754

- UniProtKB:

Q4V8N9 (UniProtKB/Swiss-Prot), Q8K4Y7 (UniProtKB/Swiss-Prot), A6HL53 (UniProtKB/TrEMBL), A0A8I6AAU4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPIQPFDQREWNEPMHSLRISVGGLPVLASMTKATDPRFRPRWRVILTSFVGAALLWLLYSHHQ
TPVSGRPPIHNAHNWRLRQERISQYNDTYPLSPPQRTPGGIRYRIAVIADLDTGSKAQEENTWF
SYLKKGYLTLSDSGDRVSVEWDKDRGVLESHLAEKGRGMELSDLIVFNGKLYSVDDRTGVIYQI
EGTKAVPWVILSDGDGAVEKGFKAEWLAVKDEHLYVGGLGKEWTTTTGEVVNENPEWVKVVGHR
GSVEHENWVSSYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPRRASHERYSEREDERKGSN
LLLSAAQDFRDISVRQVGALVPTHGFSSFKFIPNTDDQIIVALKSEEDNGRIATYVMAFTLDGR
FLLPETKIGSVKYEGIEFI

hide sequence

RefSeq Acc Id:	XP_006247852 ⟸ XM_006247790
- Peptide Label:	isoform X1
- UniProtKB:	Q4V8N9 (UniProtKB/Swiss-Prot), Q8K4Y7 (UniProtKB/Swiss-Prot), A6HL53 (UniProtKB/TrEMBL), A0A8I6AAU4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPIQPFDQREWNEPMHSLRISVGGLPVLASMTKATDPRFRPRWRVILTSFVGAALLWLLYSHHQ TPVSGRPPIHNAHNWRLRQERISQYNDTYPLSPPQRTPGGIRYRIAVIADLDTGSKAQEENTWF SYLKKGYLTLSDSGDRVSVEWDKDRGVLESHLAEKGRGMELSDLIVFNGKLYSVDDRTGVIYQI EGTKAVPWVILSDGDGAVEKGFKAEWLAVKDEHLYVGGLGKEWTTTTGEVVNENPEWVKVVGHR GSVEHENWVSSYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPRRASHERYSEREDERKGSN LLLSAAQDFRDISVRQVGALVPTHGFSSFKFIPNTDDQIIVALKSEEDNGRIATYVMAFTLDGR FLLPETKIGSVKYEGIEFI hide sequence

RefSeq Acc Id:	XP_006247851 ⟸ XM_006247789
- Peptide Label:	isoform X1
- UniProtKB:	Q4V8N9 (UniProtKB/Swiss-Prot), Q8K4Y7 (UniProtKB/Swiss-Prot), A6HL53 (UniProtKB/TrEMBL), A0A8I6AAU4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPIQPFDQREWNEPMHSLRISVGGLPVLASMTKATDPRFRPRWRVILTSFVGAALLWLLYSHHQ TPVSGRPPIHNAHNWRLRQERISQYNDTYPLSPPQRTPGGIRYRIAVIADLDTGSKAQEENTWF SYLKKGYLTLSDSGDRVSVEWDKDRGVLESHLAEKGRGMELSDLIVFNGKLYSVDDRTGVIYQI EGTKAVPWVILSDGDGAVEKGFKAEWLAVKDEHLYVGGLGKEWTTTTGEVVNENPEWVKVVGHR GSVEHENWVSSYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPRRASHERYSEREDERKGSN LLLSAAQDFRDISVRQVGALVPTHGFSSFKFIPNTDDQIIVALKSEEDNGRIATYVMAFTLDGR FLLPETKIGSVKYEGIEFI hide sequence

Ensembl Acc Id:

ENSRNOP00000059931 ⟸ ENSRNOT00000066303

Ensembl Acc Id:

ENSRNOP00000089084 ⟸ ENSRNOT00000100303

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8K4Y7-F1-model_v2	AlphaFold	Q8K4Y7	1-403	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13697937

Promoter ID:

EPDNEW_R8462

Type:

multiple initiation site

Name:

Cant1_1

Description:

calcium activated nucleotidase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	107,445,542 - 107,445,602	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628743	AgrOrtholog
BioCyc Gene	G2FUF-22516	BioCyc
Ensembl Genes	ENSRNOG00000003239	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00065004998	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000066303.3	UniProtKB/Swiss-Prot
	ENSRNOT00000100303.1	UniProtKB/TrEMBL
	ENSRNOT00065007322	UniProtKB/Swiss-Prot
Gene3D-CATH	2.120.10.100	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7443057	IMAGE-MGC_LOAD
InterPro	Apyrase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Apyrase_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:246272	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:114258	IMAGE-MGC_LOAD
NCBI Gene	246272	ENTREZGENE
PANTHER	PTHR13023	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Apyrase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Cant1	PhenoGen
RatGTEx	ENSRNOG00000003239	RatGTEx
	ENSRNOG00065004998	RatGTEx
Superfamily-SCOP	SSF101887	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AAU4	ENTREZGENE, UniProtKB/TrEMBL
	A6HL53	ENTREZGENE, UniProtKB/TrEMBL
	A6HL54_RAT	UniProtKB/TrEMBL
	A6HL55_RAT	UniProtKB/TrEMBL
	CANT1_RAT	UniProtKB/Swiss-Prot
	Q4V8N9	ENTREZGENE
	Q8K4Y7	ENTREZGENE
UniProt Secondary	Q4V8N9	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-07-14	Cant1	calcium activated nucleotidase 1	Entpd8	ectonucleoside triphosphate diphosphohydrolase 8	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2004-09-10	Entpd8	ectonucleoside triphosphate diphosphohydrolase 8	srapy	apyrase	Symbol and Name updated	1299863	APPROVED
2003-02-27	srapy	apyrase			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	associated with the endoplasmic reticulum and also with pre-Golgi intermediates
gene_regulation	activated by Ca(2+) but is insensitive to Mg(2+), and has a K(m) for UDP of 216 microm

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)