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Gene: Tlk2 (tousled-like kinase 2) Rattus norvegicus
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Symbol: Tlk2
Name: tousled-like kinase 2
RGD ID: 1310907
Description: Predicted to have ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to gamma radiation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and peptidyl-serine phosphorylation. Predicted to localize to intermediate filament; nucleus; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human TLK2 (tousled like kinase 2); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC303592; serine/threonine-protein kinase tousled-like 2; tousled-like kinase 2 (Arabidopsis)
Orthologs:
Homo sapiens (human) : TLK2 (tousled like kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Tlk2 (tousled-like kinase 2 (Arabidopsis))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlk2 (tousled like kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TLK2 (tousled like kinase 2)
Canis lupus familiaris (dog) : TLK2 (tousled like kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlk2 (tousled like kinase 2)
Sus scrofa (pig) : TLK2 (tousled like kinase 2)
Chlorocebus sabaeus (African green monkey) : TLK2 (tousled like kinase 2)
Heterocephalus glaber (naked mole-rat) : Tlk2 (tousled like kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01093,410,181 - 93,507,277 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1093,415,399 - 93,507,277 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01093,171,277 - 93,265,759 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41094,583,881 - 94,675,624 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11094,598,540 - 94,690,015 (+)NCBI
Celera1088,840,363 - 88,931,499 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Tlk2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1310907
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.