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Gene: Tlk2 (tousled-like kinase 2) Rattus norvegicus
Symbol: Tlk2
Name: tousled-like kinase 2
RGD ID: 1310907
Description: Predicted to have ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to gamma radiation; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and peptidyl-serine phosphorylation. Predicted to localize to intermediate filament; nucleus; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human TLK2 (tousled like kinase 2); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC303592; serine/threonine-protein kinase tousled-like 2; tousled-like kinase 2 (Arabidopsis)
Homo sapiens (human) : TLK2 (tousled like kinase 2)  HGNC  Alliance
Mus musculus (house mouse) : Tlk2 (tousled-like kinase 2 (Arabidopsis))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlk2 (tousled like kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TLK2 (tousled like kinase 2)
Canis lupus familiaris (dog) : TLK2 (tousled like kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlk2 (tousled like kinase 2)
Sus scrofa (pig) : TLK2 (tousled like kinase 2)
Chlorocebus sabaeus (African green monkey) : TLK2 (tousled like kinase 2)
Heterocephalus glaber (naked mole-rat) : Tlk2 (tousled like kinase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01093,410,181 - 93,507,277 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1093,415,399 - 93,507,277 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01093,171,277 - 93,265,759 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41094,583,881 - 94,675,624 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11094,598,540 - 94,690,015 (+)NCBI
Celera1088,840,363 - 88,931,499 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Tlk2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1310907
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.