Tbx2 (T-box transcription factor 2)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Tbx2 (T-box transcription factor 2) Rattus norvegicus

Analyze

Symbol:

Tbx2

Name:

T-box transcription factor 2

RGD ID:

1311014

Description:

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Predicted to be involved in several processes, including circulatory system development; embryonic morphogenesis; and lung development. Predicted to act upstream of with a negative effect on pigment metabolic process involved in pigmentation. Predicted to act upstream of or within several processes, including heart development; mammary placode formation; and ureteric peristalsis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in vertebral anomalies and variable endocrine and T-cell dysfunction. Orthologous to human TBX2 (T-box transcription factor 2); INTERACTS WITH 1,2-dimethylhydrazine; aldehydo-D-glucose; bis(2-ethylhexyl) phthalate.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

T-box 2; T-box transcription factor TBX2

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TBX2 (T-box transcription factor 2)	HGNC	Ensembl, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tbx2 (T-box 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tbx2 (T-box transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TBX2 (T-box transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TBX2 (T-box transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tbx2 (T-box transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TBX2 (T-box transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TBX2 (T-box transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tbx2 (T-box transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ESS2 (ess-2 splicing factor homolog)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	TBX2 (T-box transcription factor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OrthoFinder\|PhylomeDB)
Mus musculus (house mouse):	Tbx2 (T-box 2)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tbx2b (T-box 2b)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Danio rerio (zebrafish):	tbx2a (T-box 2a)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	tbx-2	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector)
Drosophila melanogaster (fruit fly):	bi	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	tbx2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	70,679,670 - 70,688,868 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	70,679,518 - 70,688,529 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	75,299,645 - 75,308,837 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	74,804,435 - 74,813,625 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	70,269,072 - 70,278,263 (+)	NCBI	Rnor_WKY
Rnor_6.0	10	73,278,932 - 73,290,764 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	73,279,119 - 73,289,921 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	73,184,210 - 73,193,085 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	74,085,203 - 74,092,988 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	74,096,142 - 74,107,239 (+)	NCBI
Celera	10	69,604,924 - 69,612,748 (+)	NCBI		Celera
Cytogenetic Map	10	q26	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 43 (ISO)

coronary artery disease (ISO)

genetic disease (ISO)

Joubert syndrome (ISO)

megacolon (ISO)

microcephaly (ISO)

neuroblastoma (ISO)

vertebral anomalies and variable endocrine and T-cell dysfunction (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (EXP,ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

aldehydo-D-glucose (EXP)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arotinoid acid (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (EXP)

C60 fullerene (EXP)

caffeine (ISO)

CHIR 99021 (ISO)

chlordecone (ISO)

choline (ISO)

clothianidin (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

cortisol (ISO)

cyclosporin A (ISO)

D-glucose (EXP)

decabromodiphenyl ether (EXP)

dibutyl phthalate (EXP)

diethyl phthalate (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

dioxygen (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

flutamide (ISO)

folic acid (ISO)

folpet (ISO)

fulvestrant (ISO)

gentamycin (EXP)

glucose (EXP)

L-ascorbic acid (ISO)

L-ascorbic acid 2-phosphate (ISO)

L-methionine (ISO)

lead nitrate (ISO)

menadione (ISO)

nitrofen (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

phosgene (ISO)

raloxifene (ISO)

retinyl acetate (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tebuconazole (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vorinostat (ISO)

XAV939 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aorta morphogenesis (ISO)

apoptotic process (ISO)

atrioventricular canal development (ISO)

atrioventricular canal morphogenesis (ISO)

cardiac jelly development (ISO)

cardiac muscle cell myoblast differentiation (ISO)

cardiac muscle tissue development (ISO)

cellular senescence (ISO)

cochlea morphogenesis (ISO)

developmental growth involved in morphogenesis (ISO)

embryonic camera-type eye morphogenesis (ISO)

embryonic digit morphogenesis (ISO)

endocardial cushion formation (ISO)

endocardial cushion morphogenesis (ISO)

epithelial tube branching involved in lung morphogenesis (ISO)

fibroblast growth factor receptor signaling pathway (ISO)

heart morphogenesis (ISO)

mammary placode formation (ISO)

melanocyte proliferation (ISO)

mesenchymal cell proliferation involved in lung development (ISO)

muscle cell fate determination (ISO)

negative regulation of cardiac chamber formation (ISO)

negative regulation of cellular senescence (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of heart looping (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

neurogenesis (ISO)

Notch signaling pathway (ISO)

outflow tract morphogenesis (ISO)

outflow tract septum morphogenesis (ISO)

pharynx development (ISO)

pigment metabolic process involved in pigmentation (ISO)

positive regulation of cardiac muscle cell proliferation (ISO)

positive regulation of cell cycle G1/S phase transition (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of transcription by RNA polymerase II (ISO)

response to retinoic acid (ISO)

roof of mouth development (ISO)

smooth muscle cell differentiation (ISO)

ureteric peristalsis (ISO)

Cellular Component

cytoplasm (ISO)

nucleus (ISO)

transcription regulator complex (ISO)

Molecular Function

DNA binding (ISO)

DNA-binding transcription factor activity (ISO)

DNA-binding transcription factor binding (ISO)

DNA-binding transcription repressor activity, RNA polymerase II-specific (ISO)

histone deacetylase binding (ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (ISO)

sequence-specific DNA binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis.	Cai CL, etal., Development. 2005 May;132(10):2475-87. Epub 2005 Apr 20.
2.	T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers.	Christoffels VM, etal., Dev Dyn. 2004 Apr;229(4):763-70.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor.	Prince S, etal., Cancer Res. 2004 Mar 1;64(5):1669-74.
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas.	Vance KW, etal., Cancer Res. 2005 Mar 15;65(6):2260-8.

Additional References at PubMed

PMID:10468588	PMID:11111039	PMID:11748239	PMID:12023302	PMID:12733958	PMID:15459098	PMID:15831366	PMID:16222716	PMID:18285513	PMID:19769959	PMID:22002537	PMID:23117660
PMID:29726930	PMID:30478225

Genomics

Comparative Map Data

Tbx2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	70,679,670 - 70,688,868 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	70,679,518 - 70,688,529 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	75,299,645 - 75,308,837 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	74,804,435 - 74,813,625 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	70,269,072 - 70,278,263 (+)	NCBI	Rnor_WKY
Rnor_6.0	10	73,278,932 - 73,290,764 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	73,279,119 - 73,289,921 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	73,184,210 - 73,193,085 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	74,085,203 - 74,092,988 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	74,096,142 - 74,107,239 (+)	NCBI
Celera	10	69,604,924 - 69,612,748 (+)	NCBI		Celera
Cytogenetic Map	10	q26	NCBI

TBX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	61,399,843 - 61,409,466 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	17	61,399,843 - 61,409,466 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	59,477,204 - 59,486,827 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	56,832,039 - 56,841,609 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	56,832,038 - 56,841,607	NCBI
Celera	17	58,578,306 - 58,587,856 (+)	NCBI		Celera
Cytogenetic Map	17	q23.2	NCBI
HuRef	17	54,844,115 - 54,856,411 (+)	NCBI		HuRef
CHM1_1	17	59,541,779 - 59,551,327 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	62,268,710 - 62,278,311 (+)	NCBI		T2T-CHM13v2.0

Tbx2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	85,723,441 - 85,732,774 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	85,723,377 - 85,732,774 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	85,832,615 - 85,841,948 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	85,832,551 - 85,841,948 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	85,646,117 - 85,655,450 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	85,649,273 - 85,657,325 (+)	NCBI		MGSCv36	mm8
Celera	11	95,458,950 - 95,468,278 (+)	NCBI		Celera
Cytogenetic Map	11	C	NCBI
cM Map	11	51.34	NCBI

Tbx2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	2,457,568 - 2,466,639 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	2,458,612 - 2,466,264 (+)	NCBI	ChiLan1.0	ChiLan1.0

TBX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	17	82,410,375 - 82,419,751 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	55,501,932 - 55,511,537 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	60,617,169 - 60,631,148 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	60,622,098 - 60,630,189 (+)	Ensembl	panpan1.1		panPan2

TBX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	35,237,323 - 35,245,066 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	35,235,649 - 35,245,736 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	34,466,401 - 34,475,666 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	36,048,354 - 36,057,619 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	36,049,321 - 36,057,591 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	34,829,267 - 34,838,524 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	35,114,884 - 35,124,167 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	35,202,696 - 35,211,975 (-)	NCBI		UU_Cfam_GSD_1.0

Tbx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	34,296,708 - 34,306,109 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	2,769,231 - 2,805,238 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936490	2,769,264 - 2,778,342 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TBX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	36,878,675 - 36,887,513 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	36,878,662 - 36,887,513 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	38,329,004 - 38,337,845 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TBX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	32,627,296 - 32,636,797 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	32,627,819 - 32,636,880 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	3,378,641 - 3,388,263 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tbx2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624871	2,429,407 - 2,437,447 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624871	2,428,757 - 2,437,447 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tbx2
22 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	56
Count of miRNA genes:	55
Interacting mature miRNAs:	56
Transcripts:	ENSRNOT00000004698
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6154182	73453136	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	26944628	71944628	Rat
10402859	Bp381	Blood pressure QTL 381		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
2292441	Bp308	Blood pressure QTL 308			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	27606468	72606468	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28453136	73453136	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	30632053	75632053	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31224026	75632053	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31297439	76297439	Rat
1576319	Cia29	Collagen induced arthritis QTL 29			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	33973921	78973921	Rat
2317042	Aia20	Adjuvant induced arthritis QTL 20	3.38		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	37565079	82565079	Rat
2317043	Aia7	Adjuvant induced arthritis QTL 7	3.82		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	37565079	82565079	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40035094	102359817	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	41142633	86142633	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41333258	86333258	Rat
8552805	Bw145	Body weight QTL 145	2.2		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	10	41944526	78307017	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	42323132	87323132	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42323132	87323132	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42323132	87323132	Rat
6893342	Cm78	Cardiac mass QTL 78	0.1	0.88	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	42876766	79813922	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44441699	89441699	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44441699	89441699	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44441699	89441699	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45029650	95600334	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	47369470	92369470	Rat
2293705	Bmd25	Bone mineral density QTL 25	7.1	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	49444551	81709989	Rat
7207811	Bmd90	Bone mineral density QTL 90	5.2		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	10	49444551	81709989	Rat
2293652	Bmd22	Bone mineral density QTL 22	4.9	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	49444551	81709989	Rat
2293669	Bmd33	Bone mineral density QTL 33	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	10	49444551	81709989	Rat
2293679	Bmd30	Bone mineral density QTL 30	3.5	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	49444551	81709989	Rat
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	50574707	95574707	Rat
70364	Bp72	Blood pressure QTL 72			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	51121100	96121100	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	51770177	107211142	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	51770177	107211142	Rat
1359017	Hrtrt21	Heart rate QTL 21	2.4		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	10	51772940	96772940	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	51774612	95600334	Rat
631535	Cm51	Cardiac mass QTL 51	3		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	51786282	91669536	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	53797385	107211142	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	53797494	98952626	Rat
1354608	Cm33	Cardiac mass QTL 33	2.8		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	10	54809292	99809292	Rat
2312662	Slep8	Serum leptin concentration QTL 8		0.05	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	10	57134272	102134272	Rat
2312668	Scl65	Serum cholesterol level QTL 65		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	57134272	102134272	Rat
2312672	Insul15	Insulin level QTL 15		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	10	57134272	102134272	Rat
1549831	Bss6	Bone structure and strength QTL 6	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	10	57576521	102576521	Rat
2293698	Bss43	Bone structure and strength QTL 43	5.33	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	10	59209888	104209888	Rat
70363	Bp71	Blood pressure QTL 71		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	61345276	81714865	Rat
2306970	Anxrr22	Anxiety related response QTL 22	5.95		fear/anxiety-related behavior trait (VT:1000241)	number of periods of voluntary immobility (CMO:0001045)	10	61345276	98211570	Rat
6893336	Cm75	Cardiac mass QTL 75	0.1	0.87	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	61345276	99703528	Rat
1558643	Cm44	Cardiac mass QTL 44	4.8	0.0000368	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	61345276	99703528	Rat
61402	Niddm3	Non-insulin dependent diabetes mellitus QTL 3	4.58		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	61345413	82564856	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62057807	107057807	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62057807	107057807	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63221094	107211142	Rat
2298481	Eau9	Experimental allergic uveoretinitis QTL 9		0.0169	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	65927233	82565079	Rat
1357344	Bp249	Blood pressure QTL 249		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	66743655	98003205	Rat
631565	Hcuc4	Hepatic copper content QTL 4	4.15		liver copper amount (VT:0003065)	liver copper weight to liver dry weight ratio (CMO:0001512)	10	66941813	73452992	Rat
2317029	Aia19	Adjuvant induced arthritis QTL 19	2.98		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	66978955	107211142	Rat
2317039	Aia6	Adjuvant induced arthritis QTL 6	4.31		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	66978955	107211142	Rat
2289985	Bp305	Blood pressure QTL 305			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	67502108	73579767	Rat
10450498	Bp384	Blood pressure QTL 384		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	67750049	107211142	Rat
1642980	Bp300	Blood pressure QTL 300			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68383129	107211142	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68420376	107211142	Rat
2300172	Bmd57	Bone mineral density QTL 57	9.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	10	69738412	107211142	Rat
2293646	Bss25	Bone structure and strength QTL 25	10.96	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	10	69738412	107211142	Rat
2293663	Bss33	Bone structure and strength QTL 33	9.34	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	10	69738412	107211142	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70199100	107211142	Rat

Markers in Region

D10Chm140

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Celera	10	69,607,002 - 69,607,189	UniSTS
Cytogenetic Map	10	q26	UniSTS

RH143853

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	70,687,722 - 70,688,010 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	73,289,619 - 73,289,906	NCBI	Rnor6.0
Rnor_5.0	10	73,191,940 - 73,192,227	UniSTS	Rnor5.0
RGSC_v3.4	10	74,092,667 - 74,092,954	UniSTS	RGSC3.4
Celera	10	69,612,427 - 69,612,714	UniSTS
Cytogenetic Map	10	q26	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		16	6	6		6			4	35	31	11
Low	3	27	50	35	18	35	8	11	69		10		8
Below cutoff			1		1				1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001401806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000004698 ⟹ ENSRNOP00000004698

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	70,679,518 - 70,688,529 (+)	Ensembl
Rnor_6.0 Ensembl	10	73,279,119 - 73,289,921 (+)	Ensembl

RefSeq Acc Id:

NM_001107033 ⟹ NP_001100503

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	70,680,227 - 70,688,044 (+)	NCBI
Rnor_6.0	10	73,278,999 - 73,289,940 (+)	NCBI
Rnor_5.0	10	73,184,210 - 73,193,085 (+)	NCBI
RGSC_v3.4	10	74,085,203 - 74,092,988 (+)	RGD
Celera	10	69,604,924 - 69,612,748 (+)	RGD

Sequence:

show sequence

CCCGCCGCGCATCTGCGCTCGCTCAAGAGCCTGGAACCCGAGGACGAGGTGGAGGACGACCCCA
AGGTGACGCTGGAGGCCAAGGAGCTGTGGGACCAGTTCCACAAGCTGGGCACCGAGATGGTCAT
CACCAAGTCCGGGAGGCGGATGTTCCCCCCCTTCAAGGTGCGAGTCAGCGGCCTGGACAAGAAG
GCCAAGTACATCCTGCTGATGGACATTGTGGCTGCCGATGACTGCCGATATAAGTTTCACAACT
CGAGATGGATGGTGGCAGGCAAAGCCGACCCCGAGATGCCTAAACGCATGTACATCCACCCGGA
CAGTCCGGCCACGGGGGAGCAGTGGATGGCCAAGCCCGTGGCCTTCCACAAACTGAAGCTAACC
AACAACATTTCTGACAAGCATGGCTTCACCATCCTGAACTCCATGCACAAGTACCAGCCGCGCT
TCCACATCGTGCGAGCCAACGACATCTTGAAGCTCCCATACAGTACCTTTCGCACCTATGTCTT
CCCAGAGACTGACTTCATCGCTGTCACTGCCTACCAGAATGACAAGATTACACAACTGAAGATC
GACAACAACCCTTTTGCCAAGGGCTTCCGGGACACCGGGAACGGCCGTCGGGAGAAAAGGAAGC
AGCTAACGCTGCCCACTCTCCGTTTGTATGAGGAGCACTGTAAACCGGAGCGTGACGGCGCTGA
ATCCGATGCCTCGTCCTGCGACCCTCCGCCTGCGCGCGAACCACCGCCCTCCCCCAGCGCAGCG
CCCAGCCCTCTACGCCTGCACCGGGCCCGAGCCGAGGAGAAGCCGTGCGCAGCCGACAGCGACC
CTGAGCCGGAGCGGTCGGGCGAGGAGCGCGCCGCAGCGCCCCTGGGCCGCAGCTCTTCGCGGGA
CGCCAGCCCCGCTCGCCTGACCGAACCCGAACGCTCCCGGGAGCGGCGCAGCCCGGAGAGGGGC
AGCAAGGAACCGACGGAGGGCGGTGGGGACGGCCCATTTAGTCTGCGGAGCCTGGAGAAGGAGC
GCGCGGAGGCCCGGAGGAAGGATGAGGGGCGCAAGGACGTGGGCGAAGGCAAGGACGAGCCCTC
TCCCCCGGCCGGGAGTCTCCCAAGTGAGGGACCGCTTGGCTGCTGCGCTGCCACACGAGCCTGT
CGGGCTGGGCTCTCTGCCTCGGCTGTTTGGGACGTGTACAGCACAGAATGGGTATTTATTTAAA
TAAAGAAGCAAAAGCAGG

hide sequence

RefSeq Acc Id:

XM_017597309 ⟹ XP_017452798

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	70,679,670 - 70,688,868 (+)	NCBI
Rnor_6.0	10	73,278,932 - 73,290,764 (+)	NCBI

Sequence:

show sequence

CGGCTGCAGCGGGCGGCGCGCGCAGCCGAGGCGGGGCTGCACGTCCTCGGCACTCGGCCCGCAC
CCGCCCGCCGCGCATCTGCGCTCGCTCAAGAGCCTGGAACCCGAGGACGAGGTGGAGGACGACC
CCAAGGTGACGCTGGAGGCCAAGGAGCTGTGGGACCAGTTCCACAAGCTGGGCACCGAGATGGT
CATCACCAAGTCCGGGAGGCGGATGTTCCCCCCCTTCAAGGTGCGAGTCAGCGGCCTGGACAAG
AAGGCCAAGTACATCCTGCTGATGGACATTGTGGCTGCCGATGACTGCCGATATAAGTTTCACA
ACTCGAGATGGATGGTGGCAGGCAAAGCCGACCCCGAGATGCCTAAACGCATGTACATCCACCC
GGACAGTCCGGCCACGGGGGAGCAGTGGATGGCCAAGCCCGTGGCCTTCCACAAACTGAAGCTA
ACCAACAACATTTCTGACAAGCATGGCTTCACCATCCTGAACTCCATGCACAAGTACCAGCCGC
GCTTCCACATCGTGCGAGCCAACGACATCTTGAAGCTCCCATACAGTACCTTTCGCACCTATGT
CTTCCCAGAGACTGACTTCATCGCTGTCACTGCCTACCAGAATGACAAGATTACACAACTGAAG
ATCGACAACAACCCTTTTGCCAAGGGCTTCCGGGACACCGGGAACGGCCGTCGGGAGAAAAGGA
AGCAGCTAACGCTGCCCACTCTCCGTTTGTATGAGGAGCACTGTAAACCGGAGCGTGACGGCGC
TGAATCCGATGCCTCGTCCTGCGACCCTCCGCCTGCGCGCGAACCACCGCCCTCCCCCAGCGCA
GCGCCCAGCCCTCTACGCCTGCACCGGGCCCGAGCCGAGGAGAAGCCGTGCGCAGCCGACAGCG
ACCCTGAGCCGGAGCGGTCGGGCGAGGAGCGCGCCGCAGCGCCCCTGGGCCGCAGCTCTTCGCG
GGACGCCAGCCCCGCTCGCCTGACCGAACCCGAACGCTCCCGGGAGCGGCGCAGCCCGGAGAGG
GGCAGCAAGGAACCGACGGAGGGCGGTGGGGACGGCCCATTTAGTCTGCGGAGCCTGGAGAAGG
AGCGCGCGGAGGCCCGGAGGAAGGATGAGGGGCGCAAGGACGTGGGCGAAGGCAAGGAGCCCAG
CCTGGCGCCTCTGGTGGTGCAGACAGACAGTGCGTCCCCCCTGGGTGCGGGCCATCTGCCCGGC
TTGGCCTTCTCCAGCCACCTGCACGGGCAGCAGTTCTTTGGGCCGTTGGGAGCTGGCCAGCCCC
TCTTCCTGCACCCAGGACAATTTGCCATGGGCCCCGGAGCCTTCTCCGCCATGGGCATGGGTCA
TCTGCTAGCCTCGGTGGCAGGCGGCGGTGGCAATAGCGGGGGCGCTGCGCCCGGAACCGCGGCG
GGGCTGGACGCAGGCGGGCTGGGTCCCGCAGCCAGCGCAGCAAGCACCGCGACTCCCTTCCCGT
TCCACCTCTCCCAGCACATGCTGGCATCTCAGGGAATCCCAATGCCCACTTTCGGAGGCCTCTT
CCCCTACCCGTACACTTACATGGCAGCAGCGGCCGCCGCCGCCTCCGCTTTACCCGCCACCAGC
GCTGCAGCTGCCGCCGCCGCCGCCGCTGGTTCTCTATCACGGAGCCCATTTCTGGGCAGTGCCC
GGCCCCGCCTGCGCTTCAGCCCCTACCAGATCCCGGTCACCATCCCACCTAGCACTAGCCTCCT
TACCACTGGGCTGGCGGCGGAGAGCTCCAAGGGTGGAAATAGCCGTGAGCCCAGTCCACTGCCT
GAGCTGGCTCTCCGAAAAGTGGGGGGCCCATCCCGCGGGGCCCTATCGCCCAGCGGCTCAGCCA
AAGAGGCGGCCAGTGAACTGCAGAGCATCCAGAGACTGGTGAGTGGACTAGAGAGCCAGCGAGC
CCTCTCCCCCGGCCGGGAGTCTCCCAAGTGAGGGACCGCTTGGCTGCTGCGCTGCCACACGAGC
CTGTCGGGCTGGGCTCTCTGCCTCGGCTGTTTGGGACGTGTACAGCACAGAATGGGTATTTATT
TAAATAAAGAAGCAAAAGCAGGCTTCAGCGGTCAGAATAGACCCTCGCGTGGCAGGTCGGGGGT
CTGGGCCGCTACCCTGGGGTCTTAGCGAGGAAATCAGTCTACCCGGAACACAGTCACTCTGGAG
CCCCTGGATGTGATGCGGATTTCTGTTCGAGAGTCAACTCCCAGGGCACCTCCTTCTTTCAACA
CTATGGGGGTGGCCTCTTTCCGGCGGTCCCTTTGGAAGCCAAAAGGTGCATAGGGTAGAGGTGT
TCACTTCGGAAAGCATCCCAGGATCCTGGCCTTAGGCCTGAATGTCGTGCGAAACTGGTGTGGA
CGATGCTGGAGGCAGGGAAGCCTGAACTCAGCGTAGACTTGAGCTAAGAGGAGTCCTGTCCGGT
TGGTCTTCCCACCTCTATCCCACAAAAGACAGGCGCCATTCCTACTTCCACTTCTGGGTCAGCG
GAGGAAGTTGCACTTCTGCTTTGAGTCCCCAGGGGGCAAAAGATATTTATGAAATAAATGGTAA
TTTGTGTAAATAAGTTTTAAGGTTCCCAGAAGATACAAATTCGTATTAATTTATTCGAAGGTGT
ACATTGCTGTGTACATATATTTAGAGATTAACTCATAGCATTTAATTTTTTTTTCATTTTACAT
GAGCATCTATATTGTACAGGGTCCCGGGATCCTTGGCTGCTGGGGTAGGGGGAGGCACCGAACC
CCAGGGAAGGCCCACCCCGCGGGCCCCTCAGCCTCTGCGCCCCGGTTTTGCCCGCCCAGCCCAC
GGGCCCCACCTCAGGTTTTCACTTTTTGCTCCAGAGGGAGAACGAAGCGAGAAAATAATAAAAA
CGCTACCATGCGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100503	(Get FASTA)	NCBI Sequence Viewer
	NP_001388735	(Get FASTA)	NCBI Sequence Viewer
	XP_017452798	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM05554	(Get FASTA)	NCBI Sequence Viewer
	EDM05555	(Get FASTA)	NCBI Sequence Viewer
	EDM05556	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001100503 ⟸ NM_001107033

- Sequence:

show sequence

MVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYI
HPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRT
YVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPTLRLYEEHCKPERD
GAESDASSCDPPPAREPPPSPSAAPSPLRLHRARAEEKPCAADSDPEPERSGEERAAAPLGRSS
SRDASPARLTEPERSRERRSPERGSKEPTEGGGDGPFSLRSLEKERAEARRKDEGRKDVGEGKD
EPSPPAGSLPSEGPLGCCAATRACRAGLSASAVWDVYSTEWVFI

hide sequence

RefSeq Acc Id:

XP_017452798 ⟸ XM_017597309

- Peptide Label:

isoform X1

- Sequence:

show sequence

MVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRWMVAGKADPEMPKRMYI
HPDSPATGEQWMAKPVAFHKLKLTNNISDKHGFTILNSMHKYQPRFHIVRANDILKLPYSTFRT
YVFPETDFIAVTAYQNDKITQLKIDNNPFAKGFRDTGNGRREKRKQLTLPTLRLYEEHCKPERD
GAESDASSCDPPPAREPPPSPSAAPSPLRLHRARAEEKPCAADSDPEPERSGEERAAAPLGRSS
SRDASPARLTEPERSRERRSPERGSKEPTEGGGDGPFSLRSLEKERAEARRKDEGRKDVGEGKE
PSLAPLVVQTDSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFAMGPGAFSAMGM
GHLLASVAGGGGNSGGAAPGTAAGLDAGGLGPAASAASTATPFPFHLSQHMLASQGIPMPTFGG
LFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSLSRSPFLGSARPRLRFSPYQIPVTIPPSTS
LLTTGLAAESSKGGNSREPSPLPELALRKVGGPSRGALSPSGSAKEAASELQSIQRLVSGLESQ
RALSPGRESPK

hide sequence

RefSeq Acc Id:

ENSRNOP00000004698 ⟸ ENSRNOT00000004698

Protein Domains

T-box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1M0C0-F1-model_v2	AlphaFold	F1M0C0	1-364	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311014	AgrOrtholog
BioCyc Gene	G2FUF-23814	BioCyc
Ensembl Genes	ENSRNOG00000003517	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000004698	ENTREZGENE
	ENSRNOP00000004698.7	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000004698	ENTREZGENE
	ENSRNOT00000004698.8	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.820	UniProtKB/TrEMBL
InterPro	p53-like_TF_DNA-bd	UniProtKB/TrEMBL
	T-box_DNA-bd	UniProtKB/TrEMBL
	T-box_sf	UniProtKB/TrEMBL
	TBX	UniProtKB/TrEMBL
	TF_Brachyury	UniProtKB/TrEMBL
	TF_T-box	UniProtKB/TrEMBL
	TF_T-box_CS	UniProtKB/TrEMBL
KEGG Report	rno:303398	UniProtKB/TrEMBL
NCBI Gene	303398	ENTREZGENE
PANTHER	T-BOX TRANSCRIPTION FACTOR TBX2	UniProtKB/TrEMBL
	TF_T-box	UniProtKB/TrEMBL
Pfam	T-box	UniProtKB/TrEMBL
	TBX	UniProtKB/TrEMBL
PhenoGen	Tbx2	PhenoGen
PRINTS	BRACHYURY	UniProtKB/TrEMBL
	TBOX	UniProtKB/TrEMBL
PROSITE	TBOX_1	UniProtKB/TrEMBL
	TBOX_2	UniProtKB/TrEMBL
	TBOX_3	UniProtKB/TrEMBL
SMART	TBOX	UniProtKB/TrEMBL
Superfamily-SCOP	P53_like_DNA_bnd	UniProtKB/TrEMBL
UniProt	F1M0C0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-05	Tbx2	T-box transcription factor 2	Tbx2	T-box 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Tbx2	T-box 2	Tbx2_predicted	T-box 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Tbx2_predicted	T-box 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM