Sstr2 (somatostatin receptor 2) - Rat Genome Database

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Gene: Sstr2 (somatostatin receptor 2) Rattus norvegicus
Symbol: Sstr2
Name: somatostatin receptor 2
RGD ID: 3763
Description: Enables PDZ domain binding activity and somatostatin receptor activity. Involved in several processes, including brain development; cellular response to lipid; and peristalsis. Located in cytoplasm and plasma membrane. Orthologous to human SSTR2 (somatostatin receptor 2); INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
Previously known as: Smstr2; somatostatin receptor subtype 2; somatostatin receptor type 2; somatotropin release-inhibiting factor receptor; SRIF-1; SS-2-R; SS2-R; SS2R
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21098,664,204 - 98,671,370 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1098,664,216 - 98,674,351 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10103,716,316 - 103,723,467 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010103,179,358 - 103,186,509 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01098,584,256 - 98,591,422 (+)NCBIRnor_WKY
Rnor_6.010102,136,283 - 102,143,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10102,136,283 - 102,143,434 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010101,816,029 - 101,823,337 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410103,246,880 - 103,254,444 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110103,261,249 - 103,268,805 (+)NCBI
Celera1097,271,562 - 97,278,691 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bleomycin A2  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
furan  (EXP)
glycidol  (EXP)
graphite  (EXP)
hydrogen chloride  (ISO)
lanreotide  (EXP)
lipopolysaccharide  (ISO)
methamphetamine  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
octreotide  (ISO)
parathion  (ISO)
pasireotide  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
picrotoxin  (EXP)
propanal  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
somatostatin  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
valproic acid  (EXP,ISO)
vincristine  (ISO)
zolpidem  (EXP)


References - curated
# Reference Title Reference Citation
1. Somatostatin sst(2) receptors inhibit peristalsis in the rat and mouse jejunum. Abdu F, etal., Am J Physiol Gastrointest Liver Physiol 2002 Apr;282(4):G624-33.
2. Gain of chromosome arm 17q is associated with unfavourable prognosis in neuroblastoma, but does not involve mutations in the somatostatin receptor 2(SSTR2) gene at 17q24. Abel F, etal., Br J Cancer 1999 Dec;81(8):1402-9.
3. Identification of multiple somatostatin receptors in the rat somatosensory cortex during development. Bologna E and Leroux P, J Comp Neurol. 2000 May 15;420(4):466-80.
4. Expression changes of somatostatin receptor subtypes sst2A, sst2B, sst3 and sst4 after a cortical contusion trauma in rats. Braun H, etal., Brain Res. 2002 Mar 15;930(1-2):191-9.
5. Pituitary and hypothalamic somatostatin receptor subtype messenger ribonucleic acid expression in the food-deprived and diabetic rat. Bruno JF, etal., Endocrinology. 1994 Nov;135(5):1787-92.
6. Intra-islet somatostatin regulates glucagon release via type 2 somatostatin receptors in rats. Cejvan K, etal., Diabetes 2003 May;52(5):1176-81.
7. Inhibitory control of growth hormone secretion by somatostatin in rat pituitary GC cells: sst(2) but not sst(1) receptors are coupled to inhibition of single-cell intracellular free calcium concentrations. Cervia D, etal., Neuroendocrinology 2002 Aug;76(2):99-110.
8. Effect of 17beta-estradiol on somatostatin receptor expression and inhibitory effects on growth hormone and prolactin release in rat pituitary cell cultures. Djordjijevic D, etal., Endocrinology. 1998 May;139(5):2272-7.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Expression cloning of a rat brain somatostatin receptor cDNA. Kluxen FW, etal., Proc Natl Acad Sci U S A 1992 May 15;89(10):4618-22.
11. Identification of proteins interacting with the rat somatostatin receptor subtype 2. Kreienkamp HJ, etal., J Physiol Paris. 2000 May-Aug;94(3-4):193-8.
12. Expression of the five somatostatin receptor (SSTR1-5) subtypes in rat pituitary somatotrophes: quantitative analysis by double-layer immunofluorescence confocal microscopy. Kumar U, etal., Endocrinology. 1997 Oct;138(10):4473-6.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. Role of glucocorticoids in the regulation of pituitary somatostatin receptor subtype (sst1-sst5) mRNA levels: evidence for direct and somatostatin-mediated effects. Park S, etal., Neuroendocrinology. 2003 Sep;78(3):163-75.
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Somatostatin immunoreactivity in axon terminals in rat nucleus tractus solitarii arising from central nucleus of amygdala: coexistence with GABA and postsynaptic expression of sst2A receptor. Saha S, etal., J Chem Neuroanat 2002 Jun;24(1):1-13.
18. Spinal somatostatin SSTR2A receptors are preferentially up-regulated and involved in thermonociception but not mechanonociception. Song P, etal., Exp Neurol 2002 Dec;178(2):280-7.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Differential expression of multiple somatostatin receptors in the rat cerebellum during development. Viollet C, etal., J Neurochem. 1997 Jun;68(6):2263-72.
21. Differential gene expression in the rat caudate putamen after "binge" cocaine administration: advantage of triplicate microarray analysis. Yuferov V, etal., Synapse 2003 Jun 15;48(4):157-69.
22. The localization of messenger ribonucleic acids for somatostatin receptors 1, 2, and 3 in rat testis. Zhu LJ, etal., Endocrinology. 1998 Jan;139(1):350-7.
23. Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain. Zitzer H, etal., J Biol Chem. 1999 Nov 12;274(46):32997-3001.
Additional References at PubMed
PMID:1346068   PMID:1348934   PMID:7929134   PMID:8386508   PMID:9166719   PMID:9437026   PMID:10373412   PMID:11250922   PMID:12403839   PMID:12639941   PMID:12665520   PMID:12895520  
PMID:15601946   PMID:15728843   PMID:16000155   PMID:16280179   PMID:16379030   PMID:16543371   PMID:17327372   PMID:17347306   PMID:17521381   PMID:17603546   PMID:17617126   PMID:17706880  
PMID:17706924   PMID:18363859   PMID:18566118   PMID:18793718   PMID:18795252   PMID:19001189   PMID:19434240   PMID:19910453   PMID:20814067   PMID:21539874   PMID:21795688   PMID:23073237  
PMID:23473742   PMID:23913690   PMID:24368669   PMID:24412308   PMID:24828612   PMID:24846611   PMID:24978951   PMID:25926390   PMID:26311777   PMID:26462807   PMID:28991052   PMID:29380671  
PMID:29522573   PMID:30291955   PMID:30544226   PMID:30609928   PMID:31809712   PMID:32315148   PMID:33045023   PMID:34487822  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21098,664,204 - 98,671,370 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1098,664,216 - 98,674,351 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10103,716,316 - 103,723,467 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010103,179,358 - 103,186,509 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01098,584,256 - 98,591,422 (+)NCBIRnor_WKY
Rnor_6.010102,136,283 - 102,143,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10102,136,283 - 102,143,434 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010101,816,029 - 101,823,337 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410103,246,880 - 103,254,444 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110103,261,249 - 103,268,805 (+)NCBI
Celera1097,271,562 - 97,278,691 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381773,165,010 - 73,176,633 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1773,165,010 - 73,176,633 (+)EnsemblGRCh38hg38GRCh38
GRCh371771,161,149 - 71,172,772 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361768,672,755 - 68,679,689 (+)NCBINCBI36Build 36hg18NCBI36
Build 341768,672,754 - 68,679,655NCBI
Celera1767,744,235 - 67,751,169 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1766,570,255 - 66,577,187 (+)NCBIHuRef
CHM1_11771,225,325 - 71,232,224 (+)NCBICHM1_1
T2T-CHM13v2.01774,054,801 - 74,066,425 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3911113,510,153 - 113,516,854 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11113,510,168 - 113,516,854 (+)EnsemblGRCm39 Ensembl
GRCm3811113,619,327 - 113,626,028 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11113,619,342 - 113,626,028 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711113,485,571 - 113,486,950 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611113,435,574 - 113,441,985 (+)NCBIMGSCv36mm8
Celera11125,379,798 - 125,381,177 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1179.05NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495547860,489 - 90,209 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547861,126 - 123,806 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11772,549,167 - 72,556,106 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1772,553,506 - 72,554,615 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01767,093,013 - 67,099,086 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.196,989,488 - 7,004,851 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl96,996,874 - 7,000,778 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha97,620,598 - 7,621,707 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.097,662,314 - 7,677,653 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.197,712,309 - 7,713,418 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.097,815,153 - 7,816,262 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.097,876,175 - 7,877,284 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244056027,552,830 - 7,558,761 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366551,051,447 - 1,052,556 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366551,050,835 - 1,056,609 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl127,783,431 - 7,789,488 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1127,783,401 - 7,789,483 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2128,063,456 - 8,069,876 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11648,462,472 - 48,470,586 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1648,464,342 - 48,465,451 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607719,280,096 - 19,290,449 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248013,198,204 - 3,206,481 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248013,198,137 - 3,205,936 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Sstr2
42 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:77
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000003734, ENSRNOT00000003735
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1090910316107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1092238497101012337Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21098,665,236 - 98,665,482 (+)MAPPERmRatBN7.2
Rnor_6.010102,137,316 - 102,137,561NCBIRnor6.0
Rnor_5.010101,817,062 - 101,817,307UniSTSRnor5.0
RGSC_v3.410103,247,913 - 103,248,158UniSTSRGSC3.4
Celera1097,272,595 - 97,272,840UniSTS
Cytogenetic Map10q32.1UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21098,669,935 - 98,670,339 (+)MAPPERmRatBN7.2
Rnor_6.010102,142,015 - 102,142,418NCBIRnor6.0
Rnor_5.010101,821,903 - 101,822,306UniSTSRnor5.0
RGSC_v3.410103,253,010 - 103,253,413UniSTSRGSC3.4
Celera1097,277,257 - 97,277,660UniSTS
Cytogenetic Map10q32.1UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 44
Low 2 10 2 3 2 1 1 30 15 17 8 1
Below cutoff 1 16 33 27 15 27 5 5 18 20 3 5


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003735   ⟹   ENSRNOP00000003735
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1098,664,357 - 98,671,080 (+)Ensembl
Rnor_6.0 Ensembl10102,136,283 - 102,143,434 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116317   ⟹   ENSRNOP00000094133
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1098,664,216 - 98,674,351 (+)Ensembl
RefSeq Acc Id: NM_019348   ⟹   NP_062221
Rat AssemblyChrPosition (strand)Source
mRatBN7.21098,664,204 - 98,671,370 (+)NCBI
Rnor_6.010102,136,283 - 102,143,449 (+)NCBI
Rnor_5.010101,816,029 - 101,823,337 (+)NCBI
RGSC_v3.410103,246,880 - 103,254,444 (+)RGD
Celera1097,271,562 - 97,278,691 (+)RGD
Reference Sequences
RefSeq Acc Id: NP_062221   ⟸   NM_019348
- UniProtKB: P30680 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003735   ⟸   ENSRNOT00000003735
RefSeq Acc Id: ENSRNOP00000094133   ⟸   ENSRNOT00000116317

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30680-F1-model_v2 AlphaFold P30680 1-369 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3763 AgrOrtholog
BioCyc Gene G2FUF-22761 BioCyc
Ensembl Genes ENSRNOG00000002793 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000003735 UniProtKB/Swiss-Prot
  ENSRNOP00000094133 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003735 UniProtKB/Swiss-Prot
  ENSRNOT00000116317 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Somatstn_rcpt UniProtKB/Swiss-Prot
  Somatstn_rcpt_2 UniProtKB/Swiss-Prot
KEGG Report rno:54305 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Sstr2 PhenoGen
  SOMATOSTTN2R UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
TIGR TC223639
UniProt P30680 ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Sstr2  somatostatin receptor 2      Symbol and Name updated 629477 APPROVED
2003-03-12 Sstr2  somatostatin receptor 2  Smstr2  somatostatin receptor 2  Data Merged 628472 PROVISIONAL
2002-08-07 Smstr2  somatostatin receptor 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Sstr2  somatostatin receptor subtype 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain cortex and hippocampus 70025
gene_physical_interaction binds to somatotropin release-inhibiting factor (SRIF) 70025
gene_process inhibits peristalsis in the jejunum upon binding to somatostatin 737668
gene_process may modulate activity of neurons in nucleus tractus solitarii from the central nucleus of the amygdala in response to fear or emotional stimuli 730237
gene_process activation with somatostatin inhibits release of glucagon but not insulin in islets 1299053
gene_product putative transmembrane G-protein coupled receptor 70025